1、ACO2调控帕金森病线粒体和自噬功能异常的新机制研究。国家自然科学基金面上项目(No. 82371259)，49万元，2024- 2027，负责人。

2、PCDHA9基因突变介导的肌萎缩侧索硬化症分子机制研究。国家自然科学基金面上项目(No. 82171412)，55万元，2022-2025，负责人。

3、乌头酸酶ACO2调控LRRK2介导的帕金森病机制研究。国家自然科学基金面上项目(No. 81771212)，54万元，2018-2021，负责人。

4、帕金森病的发病机制与危险因素研究。国家重点研发计划项目（2016YFC1306000），国家科技部，220万元，2016.7-2020.12，子课题负责人。

5、老年神经疾病新致病基因的发现和机制研究。国家科技部临床医学研究中心后补助项目，150万元，2023-2025，负责人。

6、免疫相关GTP酶-1介导的自噬调节在多发性硬化发病机制中的作用。国家自然科学基金面上项目(No. 81371320)，70万元，2014-2017，负责人。

7、帕金森病分子分型和早期预测模式的初步建立和随访验证。国家自然科学基金面上项目(No. 81271249)，16万元，2012-2013，负责人。

8、LRG-47在多发性硬化小鼠模型发病机制中的关键作用研究。国家自然基金面上项目（No. 30870885），30万元，2009-2011，负责人。

9、老年（脊柱外科）患者围术期综合管理方案和创新技术研究。北京市属医学科学院所公益发展改革试点项目（首医研No.2019-2），2020-2022，子课题负责人。

10、神经系统慢性疾病易感、致病基因突变及代谢组筛查方法体系建立。合作课题(202103-202312), 60.00万元, 负责人。

11、眼动技术在神经遗传和退行性疾病早期预警和辅助中的应用研究方案，合作课题（2023.4-2025.4），50.00万元，负责人。

12、慢性肾病透析治疗的神经系统并发症发生机制及关键诊疗技术研究，合作课题（2024.1-2026.12），50.00万元，负责人。

科技奖励：

1. 高龄外科围手术期关键技术创新体系的建设，2021年度中国医院科技创新奖三等奖

2. 帕金森病及运动障碍性疾病的分子诊断和功能影像研究，2016年度中华医学科技奖二等奖

3.  帕金森病的发病机制、预警和干预研究，2015年度北京市科学技术奖一等奖

4. 多发性硬化的临床和遗传学研究与应用，2011年度江西省科技进步三等奖

5. 免疫相关GTP酶家族成员IRGM1在多发性硬化及脑血管疾病中的多重调节机制，2014年度福建三明市科技进步一等奖

1. Zhong J*, Wang C*,#, Zhang D*, Yao X*, Zhao Q, Huang X, Lin F, Xue C, Wang Y, He R, Li XY, Li Q, Wang M, Zhao S, Afridi SK, Zhou W, Wang Z, Xu Y#, & Xu Z#. PCDHA9 as a candidate gene for amyotrophic lateral sclerosis. Nature Communications, 2024 Mar 11;15(1):2189. *Co-first; #Co-corresponding author.

2. Li Y*, Ying Y*, Yao T*, Jia X, Liang H, Tang W, Jia X, Song H, Shao X, Wang DJJ, Wang C#, Cheng X#, Yang Q#. Decreased water exchange rate across blood-brain barrier in hereditary cerebral small vessel disease. Brain. 2023: 146; 3079–3087. #Co-corresponding author.

3. Ying Y, Li Y, Yao T, Shao X, Tang W, Montagne A, Chabriat H, Wang DJJ, Wang C#, Yang Q#, Cheng X#. Heterogeneous blood-brain barrier dysfunction in cerebral small vessel diseases. Alzheimer's & Dementia, 2024, Jul; 20(7): 4527-4539. #Co-corresponding author.

4. Zhu J, Xu F, Lai H, Yuan H, Li XY, Hu J, Li W, Liu L# & Wang C#. ACO2 deficiency increases vulnerability to Parkinson’s disease via dysregulating mitochondrial function and histone acetylation-mediated transcription of autophagy genes. Communications Biology. 2023 Nov 25;6(1):1201. (https://doi.org/10.1038/s42003-023-05570-y; www. nature. Com /commsbio).

5. Wang C*, Liu H*, Li XY, Ma J, Gu Z, Feng X, Xie S, Tang B, Chen S, Wang W, Wang J, Zhang J, Chan P. High-depth whole-genome sequencing identifies structure variants, copy number variants and short tandem repeats associated with Parkinson’s disease. npj Parkinson’s Disease, 2024, July 23, 10:134:1-14.

6. Jiao J, Gao G, Zhu J, Wang C#, Liu L#, Yang H#. Binding of α-synuclein to ACO2 promotes progressive mitochondrial dysfunction in Parkinson's disease models. Redox Biol. 2024 Oct 17; 77:103399. doi: 10.1016/j.redox.2024.103399. #Co-corresponding author.

7. Zhu J, Yao T, Wang C#. Mitochondrial and autophagic dysfunctions of skin fibroblasts derived from pantothenate kinase-associated neurodegeneration patients carrying PANK2 mutations and the rescuing effects of allantoin. Parkinsonism and Related Disorders, 2025, 134:107806.

8. Li XY, Lai H, Li X, Xu F, Song Y, Wang Z, Li Q, Lin R, Xu Z#, Wang C#. Genetic profiles of multiple system atrophy revealed by exome sequencing, long-read sequencing and SCA repeat expansion analysis. European Journal of Neurology, 2024, Aug 17: e16441. doi: 10.1111/ene.16441.

9. Shen J, Sun X, Chu Y, Kong C, Wang C#. Relationship between the use of high-risk perioperative medications and postoperative cardiac complications in older adults undergoing spinal surgery: A retrospective cohort study. Maturitas. 2025 Apr 4; 197:108255.

10. Li XY, Wang Z, Yang Y, Lin R, Wang C#. Domain-specific phenotypes in LINS1 -related disorder—a Chinese family with the Q92X variant and literature review. American Journal of Medical Genetics Part C, 2024; e3208:1-10.

11. Dong Y, Jia M, Tan S, Li XY, Song Y, Wang X, Wang Z, Wang C#. Clinical, genetic, and neuroimaging profiles of autosomal recessive spinocerebellar ataxia type 4 caused by novel VPS13D variants in Chinese. American Journal of Medical Genetics Part A, 2024, 2024 Jul 26:e63828. doi: 10.1002/ajmg.a.63828.

12. Li X*, Lai H*, Wang P, Feng S, Feng X, Kong C, Wu, Yin C, Shen J, Yan S, Han R, Liu J, Ren X, Li Y, Huang H, Li X, Zhang Y, Lu S, Wang T, Zhao G, Wang C#, the APPLE-MDT Research Team, Xuanwu Hospital, National Clinical Research Center for Geriatric Diseases. Risk factors for postoperative cognitive decline after orthopedic surgery in elderly Chinese patients: a retrospective cohort study. Clinical Interventions in Aging, 2024:19 491–502.

13. Li XY, Teng X, Lai H, Dai J, Peng F, Xu F, Zhu J, Li X, Hu J, Li W, He R, Chen L, Chen Y, Ding C, Zhao G, Chen X#, Ye Q#, Xu Z# and Wang C#. Pyruvate is modified by tea/coffee metabolites and reversely correlated with multiple system atrophy and Parkinson's disease. Heliyon, 2024;10(5): e26588. #Co-corresponding author.

14. He R*, Zeng Y*, Wang C*, Chen L, Cai G, Chen Y, Wang Y, Ye Q and Chen X. Associative Role of HLA-DRB1 as a Protective Factor for Susceptibility and Progression of Parkinson's Disease: A Chinese Cross-Sectional and Longitudinal Study. Frontiers in Aging Neuroscience, section Parkinson’s Disease and Aging-related Movement Disorders, Published 22 February 2024, https://doi.org/10.3389/fnagi.2024.1361492. *Co-first author.

15. Shen J, Yan S, Chhetri JK, Chu Y, Wang P, Feng S, Wang T, Wang C*, Zhao G. A Relationship between perioperative medication and prolonged postoperative hospital stay in older adults with spinal surgery: a retrospective cohort study. Canadian Geriatrics Journal, 2024, Dec 1;27(4):500-518. *Corresponding author.

16. Lai H, Li XY, Xu F, Zhu J, Li X, Song Y, Wang X, Wang Z, Wang C#. Applications of Machine Learning to Diagnosis of Parkinson's Disease. Brain Sci. 2023 Nov 3;13(11):1546.

17. Zhang L*, Li XY*, Xu F*, Gao L, Wang Z, Wang X, Li X, Liu M, Zhu J, Yao T, Ye J, Qi XH, Wang Y, Zhao G#, Wang C#; Xuanwu Molecular Counselling Group for Neurogenetic Diseases. Multidisciplinary molecular consultation increases the diagnosis of pediatric epileptic encephalopathy and neurodevelopmental disorders. Mol Genet Genomic Med. 2023 Jul 24; e2243. #Co-corresponding author.

18. Si L, Wang Z, Li XY, Song Y, Yao T, Xu E, Wang X, Wang C#. Novel mutations and molecular pathways identified in patients with brain iron accumulation disorders. Neurogenetics, 2023, Jul 15. doi: 10.1007/s10048-023-00725-9.

19. Li W, Luo J, Peng F, Liu R, Bai X, Wang T, Zhang X, Zhu J, Li XY, Wang Z, Liu W, Wang J, Zhang L, Chen X, Xue T, Ding C, Wang C#, Jiao L#. Metabolomics identifies lipid profiles of human carotid atherosclerosis. Atherosclerosis. 2023 Jan; 364:20-28. #Co-corresponding author.

20. Yao T, Zhu J, Wu X, Li X, Fu Y, Wang Y, Wang Z, Xu F, Lai H, He A, Teng L#, Wang C#, Song H#. Heterozygous HTRA1 Mutations Cause Cerebral Small Vessel Diseases: Genetic, Clinical, and Pathologic Findings From 3 Chinese Pedigrees. Neurol Genet, 2022 Dec 5;8(6):e200044. #Co-corresponding author.

21. Xu F, Huang S, Li XY, Lin J, Feng X, Xie S, Wang Z, Li X, Zhu J, Lai H, Xu Y, Huang X, Yao X# and Wang C#. Identification of TARDBP Gly298Ser as a founder mutation for amyotrophic lateral sclerosis in Southern China. BMC Medical Genomics, 2022, 15:173.

22. Lai H, Li XY, Hu J, Li W, Xu F, Zhu J, He R, Weng H, Chen L, Yu J, Li X, Song Y, Wang X, Wang Z, Li W, Kang R, Li Y, Xu J, Deng Y#, Ye Q#, Wang C#. Development and validation of a predictive nomogram for possible REM sleep behavior disorders. Frontiers in Neurology, 2022 Jun 29;13:903721. #Co-corresponding author.

23. Yao T, Qiao H, Sun J, Li X, Song Y, Xu F, Gao L, Zhang D, Yan Z, Ye C, Lai H, Liang Z*, Wu T#, Wang C#. Clinical and preclinical neuroimaging changes in spinocerebellar ataxia type 12-a study of three Chinese pedigrees. European Neurology, 2022, Jul 19:1-11. #Co-corresponding author.

24. Li W, Hu J, Li X, Lu Z, Li X, Wang C# and Yu S#. Receptor-Dependent Endocytosis Mediates a-Synuclein Oligomer Transport Into Red Blood Cells. Frontiers in Aging Neuroscience. 2022 May 20;14:899892. #Co-Corresponding author.

25. Zhu J, Xu F, Wang C#, Li XY, Zhao G#. A novel loss-of-function compound heterozygous mutation of MYORG causes idiopathic basal ganglia calcification 7. Parkinsonism Relat Disord. 2022 Mar 21;97:65-67. #Co-Corresponding author.

26. Ma R, Ye J, Han J, Gao L#, Wang C#, Wang Y#. Case Report: A Novel Missense Mutation c.517G>C in the UMPS Gene Associated With Mild Orotic Aciduria. Front Neurol. 2022 Mar 9;13:819116. #Co-Corresponding author.

27. Li W, Wang T, Zhang X, Zhu J, Li XY, Peng F, Dai J, Wang J，Zhang L, Wang Y, Chen X, Xue T, Ding C#, Wang C#, Jiao L#. Distinct lipid profiles of radiation-induced carotid plaques from atherosclerotic carotid plaques revealed by UPLC-QTOF-MS and DESI-MSI. Radiotherapy and Oncology. 2022 Feb;167:25-33. #Co-Corresponding author.

28. Ma R, Duan Y, Zhang L, Qi X, Zhang L, Pan S, Gao L#, Wang C#, Wang Y#.  SCN1A-Related Epilepsy: Novel Mutations and Rare Phenotypes. Front Mol Neurosci. 2022 May 19 ;15:826183. #Co-Corresponding author.

29. Wang X, Li XY, Piao Y, Yuan G, Lin Y, Chen H, Wang Z, Li C, Wang C*. Hartnup disease presenting as hereditary spastic paraplegia and severe peripheral neuropathy. Am J Med Genet A. 2022 Jan;188(1):237-242. *Corresponding author. 

30. Li W, Hu J, Li X, Lu Z, Li X, Wang C#, Yu S#. Receptor-Dependent Endocytosis Mediates α-Synuclein Oligomer Transport Into Red Blood Cells. Front Aging Neurosci. 2022 May 20;14:899892. #Co-Corresponding author.

31. Dong Y, Li XY, Wanga XL, Xu F, Wang ZJ, Song Y, Li Q, Lin R, Wang C#. Genetic, clinical and neuroimaging profiles of sporadic and autosomal recessive hereditary spastic paraplegia cases in Chinese. Neuroscience Letters, 2021, Jul 10;761:136108.

32. Wang Z, Wu H，Piao Y，Wang C#. Cervical cord hemorrhage in cerebral cavernous malformations. Journal of Clinical Neurology, 2021;17:576-578.

33. Wang Z, Song Y, Wang X, Li X, Xu F, Si L, Dong Y, Yao T, Zhu J, Lai H, Li W, Lin F, Huang H, Wang C#. Autosomal recessive spastic ataxia of Charlevoix-Saguenay caused by novel mutations in SACS gene: A report of two Chinese families. Neuroscience Letters. 2021;752:135831.

34. Wang Z, Song Y, Zhu W, Wang X, Li X, Xu F, Si L, Yao T, Zhu J, Lai H, Li W, Lin F, Wang C#. A novel FBXO7-R345P mutation in a Chinese family with autosomal recessive parkinsonian-pyramidal syndrome. Parkinsonism and Related Disorders, 2021, 88:62–67. *Corresponding author.

35. Liu L, Cui B, Chu M, Cui Y, Jing DL, Li D, Xie K, Kong Y, Xia T, Wang C#, Wu L#. The frequency of genetic mutations associated with behavioral 2 variant frontotemporal dementia in Chinese Han patients. Frontiers in Aging Neuroscience, 2021, Jul 8;13:699836. #Co-Corresponding author.

36. Li XY, Li W, Li X, Li XR, Sun L, Yang W, Cai Y, Chen Z, Wu J, Wang C# and Yu S#. Alterations of Erythrocytic Phosphorylated Alpha-Synuclein in Different Subtypes and Stages of Parkinson’s Disease. Frontiers in Aging Neuroscience. 2021, Sep 29;13:623977. doi: 10.3389/fnagi.2021.623977. #Co-corresponding author.

37. Pan S, Li X, Li L, Lin H, Wang D, Zhang X, Zhao X, Ye J, Huang Z, Lin Y, Duan Y, Ma R, Gao L#, Wang C#, Wang Y#. Comprehensive genetic, clinical and electrophysiological studies of familial cortical myoclonic tremor with epilepsy 1 highlight the role of gene configurations. Seizure. 2021 Feb 23;87:69-74. doi: 10.1016 /j. Seizure. 2021.02.026. #Co-corresponding author.

38. Li Y, Sun B, Wang Z, He Z, Yang F, Wang H, Fang C, Chen Z, Ling L, Wang C#, Huang X#. Mutation screening of the GLE1 gene in a large Chinese cohort of amyotrophic lateral sclerosis patients. Frontiers in Neuroscience, section Neurogenomics. 2021;15:595775. #Co-corresponding author.

39. Li XY, Yang W, Li X, Li XR, Li W, Song Q, Sun L, Lin F, Chen Z, Wang C#, Yu S#. Phosphorylated alpha-synuclein in red blood cells as a potential diagnostic biomarker for multiple system atrophy: A pilot study. Parkinson’s Disease 2020; 8740419. #Co-corresponding author. 

发明专利：

1、帕金森病代谢组学标志物及其应用。发明人：王朝东，李旭颖，李娴。发明专利，专利号：ZL 2022 1 0274266.X。

2、神经疾病辅助诊疗决策系统(IOS版)v1.0。著作权人：王朝东。证书号：软著登字第2417426号。

3、神经专科体检辅助系统。著作权人：王朝东。证书号：软著登字第2055493号

4、神经科专家助手（NeuroAid）平台。著作权人：王朝东。证书号：软著登字第2707111号。

5. 帕金森病精准表型采集分析系统 v2.0。著作权人：王朝东。证书号：软著登字第2021SR0493259号。

6. 运动神经元病的表型采集分析系统 v1.0。著作权人：王朝东。证书号：软著登字第2021SR0433137号。

7. 癫痫的表型采集分析系统 v1.0。著作权人：王朝东。证书号：软著登字第2021SR0433140号。