1.       北京市自然科学基金项目“叶酸缺乏干扰shh通路诱发神经管畸形的表观调控机制研究”（7202018）2020～2022

2.       国家自然科学基金项目“Dlk-Gtl2印记基因网络调控在叶酸缺乏干扰胚胎发育健康中的作用研究” (81670802/H0724)  2017～2020 

3.       国家重点研发计划项目“中国人群重大出生缺陷的成因、机制和早期干预”“课题2：母体内分泌、代谢和营养对出生缺陷的影响及分子机制” 2016~2020

4.       国家自然科学基金项目“叶酸缺乏引起的甲基化差异区域的印记改变在胚胎发育中的作用研究”（81370967/H0724） 2014～2017

5.       北京市卫生系统高层次卫生技术人才项目 学科骨干 201412-201712

6.       国家自然科学基金青年项目“神经管畸形中LINE-1甲基化修饰与基因组的稳定性”(81000249/H0417), 2011～2013

7.       北京市自然科学基金资助项目“神经管畸形基因组中非长末端重复序列的转座重排和调控机制的研究”(7132036), 2012～2014

8.  北京市卫生局青年项目“发育早期叶酸水平与基因印记的关联分析” 2010.7-2012.6

1.   Wei J, Zhang D, Lu X, Zhang K, Liu R, Wu X, Zhu J, Lai J, Su G, Wang L. Transition of CELF2 PAS usage promotes recovery of refractory JDM through alternative splicing regulation of CTSB. Mol Ther Nucleic Acids. 2025 Jul 1;36(3):102624. 

2.   Zhang, M.,Lu, X. L.,Mi,L.L.,Song, M.Y.,Wang, L.,& Wang,X.Y. Investigation of amino acid profile alterations in maternal serum for early diagnosis of anembryonic pregnancy with high performance liquid chromatography-mass spectrometry. European Journal of Obstetrics, Gynecology and Reproductive Biology,(2024).294,6.

3.   Yang S, Cao S, Xu X, Li Q, Li J, Guo J, Wang F, Bao Y, Jiang Z, Zhang T, Wang L, Sun S.adducin 1 is essential for the survival of erythroid precursors via regulating p53 transcription in zebrafish. iScience. 2023,29;26(9):107516.

4.   Chang S, Min J, Lu X, Zhang Q, Shangguan S, Zhang T, Wang L. Effect of epigenetic activating of Dlk1-Dio3 imprinted cluster on miR-370 expression due to folate deficiency during nerve development. J Nutr Biochem. 2023;116:109297.

5.   Xiaolin Lu, Ling Jiang, Qizong Zhang, Junshen Huo, Jie Min, Qiuju Liang, Lijiao Zhao, Yan Li, Shaoyan Chang, Ting Zhang, Chunyi Zhang, Li Wang. An effective restoration of one-carbon metabolism in folate-deficient mice with a high-folate corn inbred line. Journal of Functional Foods,2022，99:105317

6.   Xiaolin Lu, Shuyan Yang, Min Jie, Shan Wang, Chunrong Sun, Lihua Wu, Shaoyan Chang, Pei Pei, Shuowen Wang, Ting Zhang and Li Wang. Folate deficiency disturbs PEG10 methylation modifications in human spina bifida. Pediatric Research 2022, 92, pages 987–994

7.   Shaoyan Chang, Jia Jing, Shaofang Shangguan, Baiyi Li, Xiuying Yao, Xinli Liu, Ting Zhang, Jianxin Wu & Li Wang，The effect of folic acid deficiency on Mest/Peg1 in neural tube defects. INTERNATIONAL JOURNAL OF NEUROSCIENCE 2021, 131(5) 468-477

8.   Xiaolei Zhao, Shaoyan Chang, Xinli Liu, Shuangxing Wang, Yueran Zhang, Xiaolin Lu, Ting Zhang, Hui Zhang, Li Wang. Imprinting aberrations of SNRPN, ZAC1 and INPP5F genes involved in the pathogenesis of Congenital Heart Disease with Extracardiac Malformations. Journal of Cellular and Molecular Medicine 2020, 24,（17）：9898-9907

9.   Shaoyan Chang, Xiaolin Lu, Shan Wang, Zhigang Wang, Junsheng Huo, Jian Huang, Shaofang Shangguan, Shen Li, Jizhen Zou, Yihua Bao, Jin Guo, Fang Wang, Bo Niu, Ting Zhang, Zhiyong Qiu, Jianxin Wu, Li Wang，The effect of folic acid deficiency on FGF pathway via Brachyury regulation in neural tube defects. FASEB Journal, 2019, 33(4):4688-4702.

10.  X. Huang, Z. Wang, N. Jia, S. Shangguan, J. Lai, X. Cui, F. Wu, L. Wang. Association between STAT4 polymorphisms and the risk of juvenile idiopathic arthritis in Han Chinese populations[J]. Clinical and experimental rheumatology, 2019, 37(2):333-337.

11.    Yu Xin , Lihua Wu, Xiaolin Lu, Shaofang Shangguan, Zhen Wang, Shaoyan Chang, Jiyong Yin, Wei Piao, Ting Zhang, Li Wang，Effects of MTHFR A1298C polymorphism on peripheral blood folate concentration in healthy populations: a meta-analysis of observational studies. ASIA PACIFIC JOURNAL OF CLINICAL NUTRITION, 2018 27（3）718-727

12.  J. Zhu, Z. Wang, G. Song, T. Zhang, L. Wang, F. Wu，The association of endothelial nitric oxide synthase gene single nucleotide polymorphisms with paediatric systemic lupus erythematosus. Clinical and Experimental Rheumatology 2018; 36: 000-000.（Co-corresponding author）

13.  Wang, L., Chang, S., Wang, Z., Wang, S., Huo, J., & Ding, G., et al. Altered gnas imprinting due to folic acid deficiency contributes to poor embryo development and may lead to neural tube defects. Oncotarget, (2017) 8(67)

14.  Li Wang, Shaofang Shangguan, Yu Xin, Shaoyan Chang, Zhen Wang, Xiaolin Lu, Lihua Wu,Bo Niu,Ting Zhang. Folate deficiency disturbs hsa-let-7 g level through methylation regulation in neural tube defects. Journal of Cellular & Molecular Medicine, 2017，（12）：3244-3253

15.  Wang L, Chang S, Guan J, Shangguan S, Lu X, Wang Z, Wu L, Zou J, Zhao H, Bao Y, Qiu Z, Niu B, Zhang T. Tissue-Specific Methylation of Long Interspersed Nucleotide Element-1 of Homo Sapiens (L1Hs) During HumanEmbryogenesis and Roles in Neural Tube Defects. Curr Mol Med. 2015;15(5):497-507.

16.  Wang L, Shangguan S, Chang S, et al. Determining the association between methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms and genomic DNA methylation level: A meta‐analysis[J]. Birth Defects Research Part A Clinical & Molecular Teratology, 2016, 106 (8) :667

17.  Zhu Jia, Huang Xiaolan, Su Gaixiu, Wang Li, Wu Fengqi, Zhang Ting, Song Guowei. High expression levels of microRNA-629, microRNA-525-5p and microRNA-516a-3p in paediatric systemic lupus erythematosus. Clin Rheumatol. 2014,33(6):807-15. （corresponding author）

18.  Wang Li, Shangguan Shaofang, Chang Shaoyan, Wang Zhen, Lu Xiaolin, Wu Lihua, Li Rui, Bao Yihua, Qiu Zhiyong, Niu Bo, Zhang Ting. Impaired methylation modifications of FZD3 alter chromatin accessibility and are involved in congenital hydrocephalus pathogenesis. Brain Res. 2014,20;1569:48-56

19.  Xiaolan HUANG, Gaixiu SU, Zhen WANG,  Shaofang SHANGGUAN, Xiaodai CUI, Jia ZHU,Min KANG, Shengnan LI, Ting ZHANG, Fengqi WU and Li WANG，Hypomethylation of long interspersed nucleotide element-1 in peripheral mononuclear cells of juvenile systemic lupuserythematosus patients in China. International Journal of Rheumatic Diseases 2013, DOI: 10.1111/1756-185X.12239 （Corresponding author）

20.  Xiaolin Lu, Zhen Wang, Jianhua Wang, Shaofang Shangguan, Yihua Bao, Ping Lu, and Li Wang, An association study between SUFU gene polymorphisms and neural tube defects.，International Journal of Neuroscience, DOI: 10.3109/00207454. 2013.（Corresponding author）

21.  Li Wang, Fang Wang, Jing Guan, Jing Le, Lihua Wu, Jizhen Zou, Huizhi Zhao, Lijun Pei, Xiaoying Zheng, and Ting Zhang. Relation between hypomethylation of long interspersed nucleotide elements and risk of neural tube defects. Am J Clin Nutr. (2010) 91:1359-1367

22.  Li Wang，Yi-Min Liu，Yan Li. Comparison of F-actin fluorescent labeling methods in pollen tubes of Lilium davidii. Plant Cell Rep (2005) 24: 266–270

23.  Xiao-Lin Lu ∙ Li Wang ∙ Shao-Yan Chang ∙ Shao-Fang Shangguan ∙ Zhen Wang ∙ Li-Hua Wu ∙ Ji-Zhen Zou ∙ Ping Xiao ∙ Rui Li ∙ Yi-Hua Bao ∙ Z-Y Qiu ∙ Ting Zhang, Sonic Hedgehog Signaling Affected by Promoter Hypermethylation Induces Aberrant Gli2 Expression in Spina Bifida. Mol Neurobiol，2015, 53 (8) :1-12（Co-first&corresponding author）

24.  Shaofang Shangguan, Li Wang, Shaoyan Chang, Xiaoling Lu, Zhen Wang, Lihua Wu,Jianhua Wang, Xiuwei Wang, Zhen Guan, Yihua Bao, Huizhi Zhao, Jizhen Zou,Bo Niu, and Ting Zhang. DNA Methylation Aberrations Rather Than Polymorphisms of FZD3 Gene Increase the Risk of Spina Bifida in a High-Risk Region for Neural Tube Defects. Birth Defects Research Part A: Clinical and Molecular Teratology 103:37–44, 2015. （Co-first author）

25.  Jian Wu, Xiaolin Lu, Zhen Wang, Shaofang Shangguan, Shaoyan Chang, Rui Li1, Lihua Wu, Yihua Bao, Bo Niu, Li Wang, Ting Zhang,  Association between PKA gene polymorphism and NTDs in high risk Chinese population in Shanxi.  Int J Clin Exp Pathol 2013;6(12):2968-2974（Corresponding author）

26.  Zhen Wang, Shaofang Shangguan, Xiaolin Lu, Shaoyan Chang, Rui Li, Lihua Wu, Yihua Bao, Bo Niu, Li Wang, Ting Zhang Association of SMO polymorphisms and neural tube defects in the Chinese population from Shanxi Province Int J Clin Exp Med 2013;6(10):960-966（Corresponding author）

27.  Tran, Susanna, Wang, Li, Le, Jing, Guan, Jing, Wu, Lihua, Zou, Jizhen, Wang, Zhen, Wang, Jianhua, Wang, Fang, Chen, Xiaoli, Cai, Lingling, Lu, Xiaolin, Zhao, Huizhi, Guo, Jin, Bao, Yihua，Ting, Zhang. Altered Methylation of the DNA Repair Gene MGMT Is Associated with Neural Tube Defects. Journal of Molecular Neuroscience,(2012) 47(1), pp 42-51（Co-first author）

28.  Shaoyan Chang, Li Wang, Yunqian Guan, Shaofang Shangguan, Qingan Du, Yang Wang, Ting Zhang, and Yu Zhang, Long interspersed nucleotide element-1 hypomethylation in folate-deficient mouse embryonic stem cells. Journal of Cellular Biochemistry (2013) 114(7):1549-58（Co-first author）

29.  Zhen Wang, Li Wang, Shaofang Shangguan, Xiaolin Lu, Shaoyan Chang, Jianhua Wang, Jizhen Zou, Lihua Wu, Ting Zhang, and Yi Luo, An association between ptch1 polymorphisms and risk of neural tube defects in a Chinese population, Birth Defects Research Part A: Clinical and Molecular Teratology, 97(6):409-15 (Co-first author)

30.  L-H Wu, L Wang, S-F Shangguan, S-Y Chang, Z Wang, X-L Lu, Q Zhang, J-H Wang, H-Z Zhao, F Wang, J Guo, B Nv, J-Z Guom and T Zhang, Methylation analysis of IGF2 DMR0 and 2 in the brain tissue of NTD-affected fetuses., Molecular and Cellular Biochemistry,2013,380:33-42 (Co-first author)