2017年-2025年，在中国医学科学院北京协和医院培养硕士研究生7名，培养博士研究生4名，直博1名，在研期间学生作为第一作者在脓毒症相关领域发表论文26篇，其中SCI论著22篇，总影响因子140，单篇最高影响因子17.66。

1. 中央保健科研课题，2024YB18，20万元，在研，主持。

2. 中央高水平医院临床科研专项专科提升项目，2022-PUMCH-B-126，230万元，在研，主持。

3. “十三五”国家科技部重点研发专项，2022YFC2009803，178万元，在研，主持。

4. 国家自然科学基金委员会，面上项目，82072226，55万元，已结题，主持。

5. 北京市科学技术委员会，协同创新重大专项，Z201100005520049，60万元，已结题，主持。

6. 中国医学科学院，中央级公益性科研院所基本科研业务费，中国医学科学院临床与转化医学研究基金项目，2019XK320040，40万元，已结题，主持。

7. 西藏自治区自然科学基金委员会，组团式援藏项目，XZ2019ZR-ZY12(Z)，17.7万元，已结题，主持。

8. 吴阶平医学基金委员会，重点项目，320.6750.18419，5万，已结题，主持。

9. 国家自然科学基金委员会，青年科学基金项目，81601657，17万元，已结题，主持。

10. 北京市自然科学基金委员会，面上项目，7152119，18万元，已结题，主持。

11.中华医学会临床医学科研专项基金，14030250562，20万，已结题，主持。

1. 中央保健科研课题，2024YB18，20万元，在研，主持。

2. 中央高水平医院临床科研专项专科提升项目，2022-PUMCH-B-126，230万元，在研，主持。

3. “十三五”国家科技部重点研发专项，2022YFC2009803，178万元，在研，主持。

4. 国家自然科学基金委员会，面上项目，82072226，55万元，已结题，主持。

5. 北京市科学技术委员会，协同创新重大专项，Z201100005520049，60万元，已结题，主持。

6. 中国医学科学院，中央级公益性科研院所基本科研业务费，中国医学科学院临床与转化医学研究基金项目，2019XK320040，40万元，已结题，主持。

7. 西藏自治区自然科学基金委员会，组团式援藏项目，XZ2019ZR-ZY12(Z)，17.7万元，已结题，主持。

8. 吴阶平医学基金委员会，重点项目，320.6750.18419，5万，已结题，主持。

9. 国家自然科学基金委员会，青年科学基金项目，81601657，17万元，已结题，主持。

10. 北京市自然科学基金委员会，面上项目，7152119，18万元，已结题，主持。

11.中华医学会临床医学科研专项基金，14030250562，20万，已结题，主持。

2022-2025年，通信作者SCI论著：

1. Lei XL Zhao GY, Xie YW, Cui N. mTOR pathway mediates the endoplasmicreticulum stress -apoptosis of CD4+T cell through inhibiting autophagy flux insepsis. (Corresponding author) Inflammation Research 2025; ( IF: 5.4)

2. Xie YW, ZhangJH, Zhao GY, Lei XL, Wang H, He HW,Cui N. T cell exhaustion and functional state correlatewith outcomes in patients with intra-abdominal candidiasis. (Correspondingauthor) Mycoses2025; 68: e70113 (IF: 3.1)

3. Cheng W, Zhang JH, Li DK, Xie YW, Lei XL, Wang H, Cui N. The Endoplasmic Reticulum Stress Statusof CD4+ T lymphocytes and Its Association with mTOR-mediatedAutophagic-lysosomal Disorder in Elderly Sepsis Patients. (Correspondingauthor) Frontiers in Immunology 2025; 16: 1648075 ( IF: 5.9)

4. Li DK, Hou JT, Shi Z, Li X, Zhang JH, Cheng W, Zhao GY, Lei XL, Xie YW,  Wang YF, Wang H, Chang ZG, Cui N. FrailtyIndex-laboratory and Lymphocyte Subset Patterns in Predicting 28-day MortalityAmong Elderly Sepsis Patients: A Multicenter Observational Cohort Study. (Correspondingauthor) Frontiers in Immunology 2025; 16: 1624655 ( IF: 5.9)

5. ZhangJH, Cheng W, Li DK, Zhao GY, Cui N. Dynamic alterations oflymphocyte subsets following sepsis in octogenarian and old patients. (Correspondingauthor) Journal of Intensive Medicine2025; ( IF: 3.3)

6. Mao JY, Xie YW, Lei XL, Zhang JH, Cheng W, Cui N. Effects of neutrophil granule proteinson sepsis-associated lymphopenia and their relationship with CD4+ T-cellpyroptosis. (Corresponding author) Frontiers in Immunology 2025; 16: 1507800 ( IF: 5.7)

7. Li DK, Zhang JH, ChengW, Zhao GY, Lei XL, Xie YW, Cui N, Wang H. Dynamic Changes inPeripheral Blood Lymphocyte Trajectory Predict the Clinical Outcomes of Sepsis.(Corresponding author) Frontiers in Immunology 2025; 16:1431066 ( IF: 5.7)

8. ZhangJH, Cheng W, Li DK, Zhao GY, Lei XL, Cui N. Establishment andvalidation of a machine-learning prediction nomogram based on lymphocytesubtyping for intra-abdominal candidiasis in septic patients. (Correspondingauthor) Clinical and Translational Science2025; 18: e70140 ( IF: 3.1)

9. Zhang JH, Zhao GY, Lei XL, Cui N. Predictingintra-abdominal candidiasis in elderly septic patients using machine learningbased on lymphocyte subtyping: A prospective cohort study. (Correspondingauthor) Frontiers in Pharmacology 2024; 1486346 ( IF: 4.4)

10. Li DK, Zhang JH, Cheng W, Cui N. Statusresearch of diagnosis and treatment of severe infection in sepsis patients. Journalof Medical Research 2024;53(8): 69-73

11. Zhao GY, Xie YW,Lei XL, Guo R, Cui N. mTOR aggravated CD4+ T cell pyroptosis byregulating the PPARγ-Nrf2 pathway in sepsis. (Corresponding author)International Immunopharmacology 2024; 140: 112822 ( IF: 4.8)

12. Cheng W, Zhang JH, Li DK, Lei XL, Wang H, Cui N. CTLA-4 expression on CD4+lymphocytes in patients with sepsis-associated immunosuppression and itsrelationship to mTOR mediated autophagic–lysosomal disorder. (Correspondingauthor) Frontiers in Immunology 2024; 15: 1396157 ( IF: 5.7)

13. Lei XL, Zhao GY, Xie YW, Cui N. mTOR deletion alleviate CD4+T-cell dysfunction in sepsis throughreducing CTLA4 accumulation mediated by rescuing autophagy. (Correspondingauthor) Mediatorsof Inflammation 2024;4233439 ( IF: 4.6)

14. Mao JY, Li DK,Zhang D, Yang QW, Long Y, Cui N. Utility of paired plasma and drainagefluid mNGS in diagnosing acute intra-abdominal infections with sepsis. (Correspondingauthor) BMC Infect Dis 2024; 24: 409 (IF: 3.7)

15. Liu SJ, Zhuge CJ, Zhang JH, Cui N,Long Y. Simplified immune-dysregulation index: A novel marker predicts28-day mortality of intensive care patients with sepsis. (Corresponding author)SHOCK 2024; 61(4): 570-576 (IF: 3.1)

16. Luo HB, Han W, ZhangJH, Cheng W, Li DK, Zhao MX, Cui N, Zhu HD.Effect of improved nursing strategy on prognosis of immunosuppressed patients withpneumonia and sepsis: a prospective cohort study. (Correspondingauthor) Journal of Intensive Care Medicine 2024;39(3): 257-267 (IF: 3.1)

17. Xie YW, LeiXL, Zhao GY, Cui N, Wang H. Advances in the regulatory mechanisms of mTOR innecroptosis. (Corresponding author) Frontiers in Immunology 2023; 14:1297408 ( IF: 7.3)

18. Guo R, Zhao GY, Bai GX, Chen JW, Han W, Cui N, Wang H.Depletion of mTOR ameliorates CD4+T cell pyroptosis by promoting autophagyactivity in septic mice. (Corresponding author) InternationalImmunopharmacology 2023; 124: 110964( IF: 5.6)

19.Xie YW, Lei XL, Zhao GY, Guo R, Cui N. mTORin programmed cell death and its therapeutic implications. (Correspondingauthor) Cytokine and Growth Factor Reviews 2023; 71-72: 66-81( IF: 17.66)

20. Guo R, Cui N. Intensive care unitreadmission and unexpected death after emergency general surgery. Heliyon 2023;9: e14278 ( IF: 4)

21. Zhao GY, Wang H, Cui N. Regulation of mammaliantarget of rapamycin on ferroptosis: from mechanism to therapeutics in septiccardiomyopathy. Chinese Medical Journal 2022; 135: 2815-2817 ( IF: 6.151)

22.Li DK, Gai W, ZhangJH, Cheng W, Cui N, Wang H.Multisite metagenomic next-generation sequencing improved diagnosticperformance for sepsis-associated lymphopenia patients. (Corresponding author)Microbiology Spectrum 2022; 10: e0353222(IF: 9.043)

23. Liu WL, Ding X, He HW, Long Y, CuiN. Screening for the Causes of Refractory Hypoxemia in Critically IllPatients – A Case Report. (Corresponding author) Frontiers in Medicine 2022; 9: 1065319 ( IF: 5.06)

24. Li DK, Liu SJ, Cui N, ZhangJH, Cheng W, Mao JY. Exploring dynamic change in arterial base excess withpatient outcome and lactate clearance in the intensive care unit byhierarchical time-series clustering. (Corresponding author)Frontiers in Medicine 2022; 9:1020806 ( IF: 5.06)

25. Bai GX, Cui N, Wang H, Cheng W,Han W, Chen JW, Guo Y, Wang F. T-lymphocyte subtyping: an early warning and apotential prognostic indicator of active cytomegalovirus infection in sepsispatients. (Corresponding author) Immunology and Cell Biology2022; 100(10): 777-790 ( IF: 5.853)

26. Mao JY, ZhaoH, Cui N. An unusual case of multisite embolism in a patient withadenovirus pneumoniae. (Corresponding author) Frontiers in Medicine 2022; 9: 939102(IF: 5.06)

27. Li X, Cheng W, Zhang JH, Li DK, Wang F, Cui N. EarlyAlteration of Peripheral Blood Lymphocyte Subsets as a Risk Factor for Deliriumin Critically Ill Patients after Cardiac Surgery: A Prospective ObservationalStudy. (Corresponding author) Frontiers in Aging Neuroscience 2022; 14: 950188 ( IF: 5.702)

28.Bai GX, Wang H, Cui N. mTOR pathway mediates endoplasmic reticulumstress-induced CD4+ T cell apoptosis in septic mice. (Corresponding author) APOPTOSIS 2022; 27: 740-750 (IF:7.2)

29. Wang H, Chen JW, BaiGX, Han W, Guo R, Cui N. mTOR Modulates the Endoplasmic ReticulumStress-Induced CD4+ T Cell Apoptosis Mediated by ROS in SepticImmunosuppression. (Corresponding author) Mediators ofInflammation 2022; 6077570 ( IF: 4.6)

30. Lei XL, ZhaoGY, Guo R, Cui N. Ferroptosis in sepsis: the mechanism, the role and thetherapeutic potential. (Corresponding author) Frontiers in Immunology 2022; 13: 956361 ( IF: 8.786)

31. Chen JW, Wang H, Guo R, Li HL, CuiN. Early expression of functional markers on CD4+ T cells predicts outcomesin ICU patients with sepsis. (Corresponding author) Frontiers in Immunology 2022; 13: 938538 ( IF: 8.786)

32. Zhang JH, Cheng W, Li DK, Chen JW, Zhao GY, Wang H, Cui N.Development and validation of a risk score for predicting invasive candidiasisin intensive care unit patients by incorporating clinical risk factors andlymphocyte subtyping. (Corresponding author) Frontiers in Cellular andInfection Microbiology 2022; 12: 829066 ( IF: 6.073)

33.Wang H, Bai GX, Chen JW, Han W, Guo R, Cui N. mTOR deletion amelioratesCD4+ T cell apoptosis during sepsis by improving autophagosome-lysosome fusion.(Corresponding author) APOPTOSIS 2022; 27: 401-408 (IF:7.2)

34. Cheng W, Chen JW, Sun JH, Zhang JH, Li DK, Wang H, Li ZZ, Cui N. Role of intensified lungphysiotherapy bundle on the occurrence of pneumonia after cardiac surgery. (Correspondingauthor) Frontiers in Medicine 2022; 9: 844094 ( IF: 5.06)

35. Sun JH, Han W, Cui N, Li Q, WangH, Li ZZ, Luo HB, Liu JB. Effect of nurse-led goal-directed lung 7physicaltherapy on the prognosis of pneumonia in sepsis patients in the ICU: aprospective cohort study. (Corresponding author) Journal of Intensive CareMedicine 2022; 37: 258-266 ( IF: 3.51)

36. Li DK, Gai W, ZhangJH, ChengW, Cui N, Wang H. Metagenomic next-generation sequencing for themicrobiological diagnosis of abdominal sepsis patients. (Corresponding author)Frontiers in Microbiology 2022; 13: 816631 (IF: 6.064)