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始终坚持党的领导，系统学习习近平新时代中国特色社会主义思想，通过参加专题培训、党组织生活等形式深化理论认知。在学术活动中严守意识形态安全底线，积极传播社会主义核心价值观。恪守“严谨治学、诚信为本”原则，在科研立项、论文发表等环节严格执行学术规范。学科建设方面，依托儿童发育营养组学北京市重点实验室，以提高儿童出生与发育素质为目标，立足于理论与技术的双创新模式，建立儿童发育营养睡眠适宜的技术交叉体系与模式。主要研究方向为儿童发育健康的表观遗传前沿与基础研究，儿童膳食营养与睡眠的应用性基础研究。
1. 国家自然科学基金项目 蛋白酶体激活因子REG γ 与泛素化连接酶Smurf1 的相互作用研究 2011.01-2013.12
2. 国家自然科学基金项目 组蛋白甲基化修饰在叶酸引起的神经管畸形中的作用和分子机制研究 2016.01-2019.12
3. 国家自然科学基金项目 DNA甲基化异常修饰协同转录激活因子p300 介导的基因调控作用在叶酸缺乏引起的神经管畸形中的机制研究 2021.01-2024.12
4. 北京自然科学基金项目 DNA 6mA 甲基化介导的Hox 基因通路在叶酸缺乏引起的神经管畸形中的机制研究 2024.01-2026.12
1. 国家自然科学基金项目 蛋白酶体激活因子REG γ 与泛素化连接酶Smurf1 的相互作用研究 2011.01-2013.12
2. 国家自然科学基金项目 组蛋白甲基化修饰在叶酸引起的神经管畸形中的作用和分子机制研究 2016.01-2019.12
3. 国家自然科学基金项目 DNA甲基化异常修饰协同转录激活因子p300 介导的基因调控作用在叶酸缺乏引起的神经管畸形中的机制研究 2021.01-2024.12
4. 北京自然科学基金项目 DNA 6mA 甲基化介导的Hox 基因通路在叶酸缺乏引起的神经管畸形中的机制研究 2024.01-2026.12
1.Wang, S., Peng, Z., Wang, S., Yang, L., Chen, Y., Kong, X., Song, S., Pei, P., Tian, C., Yan, H., Ding, P., Hu, W., Liu, C. H., Zhang, X., He, F., & Zhang, L. (2018). KRAB type zinc finger proteins PITA and PISA specifically regulate p53 dependent glycolysis and mitochondrial respiration. Cell Res, 28(5), 572-592.
2.Cheng, X., Pei, P., Yu, J., Zhang, Q., Li, D., Xie, X., Wu, J., Wang, S., & Zhang, T. (2019). Fbox protein FBXO30 mediates retinoic acid receptor gamma ubiquitination and regulates BMP signaling in neural tube defects. Cell Death Dis, 10(8), 551.
3.Qian, P., Ma, F., Zhang, W., Cao, D., Li, L., Liu, Z., Pei, P., Zhang, T., Wang, S., & Wu, J. (2022). Chronic exercise remodels the lysine acetylome in the mouse hippocampus. Front Mol Neurosci, 15, 1023482.
4. Wang, S., Zeng, Y., He, X., Liu, F., Pei, P., & Zhang, T. (2022). Folate-deficiency induced acyl-CoA synthetase short-chain family member 2 increases lysine crotonylome involved in neural tube defects. Front Mol Neurosci, 15, 1064509.
5. Han, X., He, X., Zhan, X., Yao, L., Sun, Z., Gao, X., Wang, S., & Wang, Z. (2023). Disturbed microbiota-metabolites-immune interaction network is associated with olfactory dysfunction in patients with chronic rhinosinusitis. Front Immunol, 14, 1159112.
6.Wang, S., He, X., Wang, Y., Zeng, Y., Pei, P., Zhan, X., Zhang, M., & Zhang, T. (2023). Intergenerational association of gut microbiota and metabolism with perinatal folate metabolism and neural tube defects. iScience, 26(9), 107514.
7.Xie, X., Li, C., Yu, J., Chang, S., Cheng, X., Wang, F., Bao, Y., Zhang, T., & Wang, S. (2023). MTHFD1 is critical for the negative regulation of retinoic acid receptor signalling in anencephaly. Brain, 146(8), 3455-3469.
8.Yan, W., Jiang, M., Hu, W., Zhan, X., Liu, Y., Zhou, J., Ji, J., Wang, S., & Tai, J. (2023). Causality Investigation between Gut Microbiota, Derived Metabolites, and Obstructive Sleep Apnea: A Bidirectional Mendelian Randomization Study. Nutrients, 15(21).
9.Li, X., Pei, P., Shen, J., Yu, J., Wang, F., Wang, L., Liu, C., & Wang, S. (2023). Folate deficiency reduced aberrant level of DOT1L-mediated histone H3K79 methylation causes disruptive SHH gene expression involved in neural tube defects. Epigenetics Chromatin, 16(1), 50.
10. Wang, R., Liang, J., Wang, Q., Zhang, Y., Lu, Y., Zhan, X., Wang, S., & Gu, Q. (2024). m6A mRNA methylation-mediated MAPK signaling modulates the nasal mucosa inflammatory response in allergic rhinitis. Front Immunol, 15, 1344995.
11.Kong, Y., Ji, J., Zhan, X., Yan, W., Liu, F., Ye, P., Wang, S., & Tai, J. (2024). Tet1mediated 5hmC regulates hippocampal neuroinflammation via wnt signaling as a novel mechanism in obstructive sleep apnoea leads to cognitive deficit. J Neuroinflammation, 21(1), 208.
12.Zeng, Y., Shen, J., He, X., Liu, F., Wang, Y., Wang, Y., Qiao, Y., Pei, P., & Wang, S. (2025). Gut Microbiota Dysbiosis Remodels the Lysine Acetylome of the Mouse Cecum in Early Life. Biology (Basel), 14(8).
13.Zeng, Y., Wei, Y., Chen, C., Shen, J., Qian, J., Ma, X., Su, M., Zhang, T., Yu, B., Zhu, C., & Wang, S. (2025). SSHPT nanocarrier delivery of Hif1 alpha shRNA reduces pathological lactylation and alleviates inflammation in a sustained hypoxia mouse model. Int J Biol Macromol, 325, 146903.
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