目前团队工作人员3人，博士2人，硕士3人。

近5年获批课题

1.  北京市自然基金面上项目（7232008），2023/01-2025/12,  CECR2基因突变与高同型半胱氨酸协同致神经管畸形的机制研究，主持

2.  国家自然科学基金项目（82171652），2022/01-2025/12，高同型半胱氨酸神经管畸形中RNA剪切相关蛋白HNRNPAB异常表达的致病机制研究，主持

3.  国家自然科学基金项目（81971397），2020/01-2023/12，：同型半胱氨酸与基因突变协同调控染色质重塑基因SMARCA4导致神经管畸形的机制研究，主持

近3年通讯作者SCI文章共12篇

1)     Hui Wang1#, Yuting Wang#, HaojieWu, Chen Shen, Yaqi Li,Baoling Bai, Xiaodong  Sun, Yanyan Liu,Qin Zhang*,Lin Shi*，High-fat Diet-induced Obesity-relatedHypertension via Altered Gut  Microbiota-mediated Histone Butyrylation，science China.life science，2025 Aug 28. doi:10.1007/s11427-024-2826-5. IF=9.5，Q1

2)    Baoling Bai # , Lingyun Liu # ,Yanyan Liu # ,Shuangshuang Yang , Haojie Wu , Kexin Zhang , Lin Shi*, QinZhang* High Hcy regulates fluid shear stress pathway activitythrough histoneH3K79 homocysteinylation in hyperhomocysteinemia-related childhypertension，Journal ofTranslational Medicine . 2025 May9;23(1):525.doi:10.1186/s12967-025-06483-6.. IF=7.5，Q1

3)    Yaqi Li1† , YaoLin1†, ChenShen1†, Jing Zhang1, Hui Wang1, Qin Zhang2* and Lin Shi1* Dynamicchanges ofserum matrix metalloproteinases and tissue inhibitors in Kawasakidisease: implicationsfor coronary artery lesions persistence， ItalianJournal of Pediatrics, 2025 Jun 2;51(1):169.doi:10.1186/s13052-025-01990-0. IF=3.1, Q1

4)     Tingjuan Lin, Wenqing Jiang, YaoLin, Mingming Zhang,Tong Zheng, He Jiang, Baosheng Liang, Yan Liua, Yu Chen,Qin Zhang*, and LinShia*，Associationbetweencardiorespiratory fitness and pediatric primary hypertension: acase–controlstudy in China，J Hypertens.2025Aug;43(8):1360-1366. doi:10.1097/HJH.0000000000004036.Epub 2025 May21.IF=4.2 Q1

5)    Hangyu Lv †, Lingyun Liu †,Baoling Bai, Kexin Zhang andQin Zhang * ，CYP1A1/20-HETE/GPR75Axis-MediatedArachidonic Acid Metabolism Dysregulation in H-Type HypertensionPathogenesis，InternationalJournal of Molecular Sciences，2025，Jun20;26(13):5947.doi: 10.3390/ijms26135947. IF 4.9，Q1

6)     Yang Zheng ,† , Baoling Bai ,†,Zhimiao Wei , MingmingZhang , Qin Zhang ,* and Xiaohui Li ,* Plasma ExosomalSERPINA1 and GNAI2Downregulation: Po-tential Diagnostic Markers for KawasakiDisease withCoro-nary Artery Aneurysms，InternationalJournal of Molercular Sciences，2025 Mar16;26(6):2668.doi: 10.3390/ijms26062668，IF=4.9，Q1

7)     Kexin Zhang*, Shengxiong Wang*,Ying Qiu*, Baoling Bai1#, Qin Zhang#,Xianghui Xie#, Retrospective studiesandquantitative proteomics reveal that abnormal expression of bloodpressure,blood lipids, and coagulation related proteins is associated withhypospadias,Human Genetics, 2024 Oct;143(9-10):1175-1191. doi:10.1007/s00439-024-02676-z,IF=3.8,Q2

8)    Baoling Bai* · Chunlei Wan ·Zonghui Xiao · Dan Li·Lingyun Liu · Kexin Zhang · Ting Zhang · QinZhang# HighHomocysteine‑Thiolactone Leadsto Reduced MENIN Protein Expression and anImpaired DNA Damage Response:Implications for Neural Tube Defects. MolecularNeurobiology, 2024Oct;61(10):7369-7383.doi:10.1007/s12035-024-04033-7.IF=4.3,Q1

9)     Yaqi Li*, Baoling Bai, Hui Wang,Haojie Wu, Yanjun Deng,Chen Shen, Qin Zhang# and Lin Shi#,Plasma metabolomicprofile in orthostatic intolerance children with high levelsof plasmahomocysteine, Italian Journal of Pediatrics, 2024 Mar14;50(1):52.doi: 10.1186/s13052-024-01601-4,IF=3.2,Q1

10)  Baoling Bai*; KangGao*; Kexin Zhang; Lingyun Liu;Xiaobo Chen#;Qin Zhang#; Pathological mechanisms of type 1diabetes in children:investigation of the exosomal protein expression profile，Frontiers in Endocrinology, 2023 Oct 11:14:1271929，2023.10.11，IF=5.2,Q1

11) Baoling Bai* ,Qian Jiang* , Lingyun Liu , Changyun Liu#, Qin Zhang#Double whammy: the genetic variants in CECR2 and high Hcy on thedevelopment ofneural tube defects, Frontiers in genetics, 2023 Jun22;14:1189847. IF=3.7，Q2

12) Kexin Zhang* , Yanyan Liu*, Lingyun Liu , Baoling Bai ,Lin Shi# , Qin Zhang#，Untargeted Metabolomics AnalysisUsingUHPLC-Q-TOF/MS Reveals Metabolic Changes Associated with HypertensioninChildren，Nutrients. 2023 Feb 6;15(4):836.doi:10.3390/nu15040836.IF：6.706，Q1