(1) 国家自然科学基金委员会，面上项目，82370522，MRC1-BMP4介导肠道多细胞中枢切换参与短段型先天性巨结肠的机制研究，2024-01至2027-12，49万元，在研，主持；

(2) 国家自然科学基金委员会，面上项目，82070532，从基因、组织水平的相互作用探究先天性巨结肠患者症状差异的分子机制，2021-01至2024-12，61万元，已结题，主持；

(3) 国家自然科学基金委员会，面上项目，81771620，RET基因新发突变和体细胞突变在先天性巨结肠的致病作用及机制研究，2018-01至2021-12，66万元，已结题，主持；

(4) 北京市科委，2017年度北京市科技新星计划交叉学科合作课题，Z171100001117125，先天性巨结肠患者分子遗传学病因初筛、精细分型方法的建立及相关试剂盒开发，2017-01至2018-12，25万元，已结题，主持；

(5) 北京市科委，2015北京市科技新星B类项目，Z151100000315091，肠道微环境分子组成/调控异常在肠神经系统发育中的作用及其与先天性巨结肠的关系，2015-01至2017-12，35万元，已结题，主持；

(6) 北京市自然科学基金委员会，面上项目，7142029，轴突导向因子突变干扰胚胎期肠神经系统发育的实验研究，2014-01至2016-12，18万元，已结题，主持 ；

(7) 国家自然科学基金委员会，青年项目，81300266，先天性巨结肠患者SEMA3C/D基因功能失活突变影响肠神经系统发育的细胞和分子机制，2014-01至2016-12，23万元，已结题，主持

重要学术论文（第一及通讯作者JCR分区已标出）

· Ge Y#, Liu L#, Wu L#, Liu X, Hao Y, Wang S, Xiong Y, Yang Z, Zhang Z, Li Q, Li B, Wu J*, Ren G*, Jiang Q*. Impaired nutrient absorption, reduced bone mass and alterations in the gut microbiome contribute to postnatal growth retardation in a mouse model of MWS. Sci Rep, 2025; 15 (1): 30890  (*corresponding author) Q1 

· Wu L#, Gao Y# Zhou R, Xiao P. Zhang Z, Li B, Pierro A, Li Long, Jiang Q*, Li Q*. Predictive value of plasma zonulin for postoperative Hirschsprung-associated enterocolitis. World J Pediatr Surg, 2025; 8 (3): e001057 (*co-corresponding author) Q3

· Zhang Z#, Gao Y#, Ma Y, Zhou R, Chen Y, Li L, Jiang Q*, Li Q*. Intraoperative quantitative analysis of intestinal perfusion by ICG fluorescence in Hirschsprung disease: a single-center retrospective cohort study. Pediatr Surg Int, 2025; 41 (1): 227 (*co-corresponding author) Q2    

· Wang X, Li J, Wang X, Huang B, Jiang Q, Ren G, Liu Y. Efficacy and safety of rhGH in JDM children with glucocorticoid-related growth failure. Rheumatology, 2025; keaf236

· Zhang Z#, Lee D#, Liu L#, Xiong Y#, Lee C, Kim JE, Chusilp S, Lau E, Tian Y, Feizi M, Alganabi M, Lafreniere A, Cheng T, Zhou R, Han L, Wu L, Xiao P, Gao Y, Benedetti G, Holland L, Tullie L, Giobbe GG, Li L, Li Q, Yamataka A, Li VSW, De Coppi P, Jiang Q*, Pierro A*, Li B*. Impairment of stromal-epithelial regenerative cross-talk in Hirschsprung disease primes for the progression to enterocolitis. Sci Transl Med, 2025; 17 (809): eadp4679 (*co-corresponding author) Q1

· Cheng T#, Zhang Z#, Zhou R, Liu W, Xiao P, Wu L, Ma Y, Niu W, Chen Y, Li B, Pierro A, Li L, Jiang Q*, Li Q*. Clinical characteristics and postoperative functional outcomes in children with Mowat-Wilson Syndrome and Hirschsprung's Disease: a single-center study. J Pediatr Surg, 2025; 60 (4): 16221 (*co-corresponding author) Q1 

· Huang B#, Li H#, Jiang Q#, Li Y, Jiang Zh, Cao H, Wang Sh, Wang X*, Li J*, Li G*. Elevated type I IFN signalling directly affects CD8+ T-cell distribution and autoantigen recognition of the skeletal muscles in active JDM patients. J Autoimmun, 2024; 146:103232 (#co-first author) Q1

· Dai D#, Gu S#, Han X#, Ding H, Jiang Y, Zhang X, Yao C, Hong S, Zhang J, Shen Y, Hou G, Qu B, Zhou H, Qin Y, He Y, Ma J, Yin Z, Ye Z, Qian J, Jiang Q, Wu L, Guo Q, Chen S, Huang C, Kottyan LC, Weirauch MT, Vinuesa CG*, Shen N*. The transcription factor ZEB2 drives the formation of age-associated B cells. Science, 2024; 383 (6681): 413-421

· Wang H, Wang Z, Ji T, Tai J*, Jiang Q*. Novel STAMBP mutations in a Chinese girl with rare symptoms of Microcephaly-capillary malformation syndrome and Mowat-Wilson syndrome. Heliyon, 2023; 9 (12): e22989 (*co-corresponding author) Q1

· Bai B#, Jiang Q#, Liu L, Liu C*, Zhang Q*. Double whammy: the genetic variants in CECR2 and high Hcy on the development of neural tube defects. Front Genet, 2023; 14: 1189847 (#co-first author) Q2

· Cao Y, Chen L, Chen H, Cun Y, Dai X, Du H, Gao F, Guo F, Guo Y, Hao P, He S, He S, He X, Hu Z, Hoh BP, Jin X, Jiang Q, Jiang Q, Khan A, Kong HZ, Li J, Li SC, Li Y, Lin Q, Liu J, Liu Q, Lu J, Lu X, Luo S, Nie Q, Qiu Z, Shi T, Song X, Su J, Tao SC, Wang C, Wang CC, Wang GD, Wang J, Wu Q, Wu S, Xu S, Xue Y, Yang W, Yang Z, Ye K, Ye YN, Yu L, Zhao F, Zhao Y, Zhai W, Zhang D, Zhang L, Zheng H, Zhou Q, Zhu T, Zhang YP*. Was Wuhan the early epicenter of the COVID-19 pandemic?-A critique. Natl Sci Rev, 2023; 10 (4): nwac287

· Wu L#, Wang J#, Wang L, Xu Q, Zhou B, Zhang Z, Li Q, Wang H, Han L, Jiang Q*, Wang L*. Physical, language, neurodevelopment and phenotype-genotype correlation of Chinese patients with Mowat-Wilson syndrome. Front Genet, 2022; 13: 1016677 (*co-corresponding author) Q2

· Ma Y, Jiang Q, Zhang Z, Xiao P, Yan Y, Liu J, Li Q*, Wang Z*. Diagnosis of Hirschsprung disease by hydrocolonic sonography in children. Eur Radiol, 2022; 32 (3): 2089-2098  

· Jiang Q#, Wang Y#, Gao Y, Wang H, Zhang Z, Li Q, Xu S, Cai W*, Li L*. RET compound inheritance in Chinese patients with Hirschsprung disease: lack of penetrance from insufficient gene dysfunction. Hum Genet, 2021; 140 (5): 813-825 (#co-first author) Q1

· Zhang Q, Wu L, Bai B, Li D, Xiao P, Li Q, Zhang Z, Wang H, Li L, Jiang Q*. Quantitative proteomics reveal neuron projection development genes ARF4, KIF5B and RAB8A associated with Hirschsprung disease. Mol Cell Proteomics, 2020; 20:100007 Q1

获得学术奖励

(1) 姜茜（5/10）；先天肛肠畸形新理论与精准治疗的体系建立及应用，中国医疗保健国际交流促进会，华夏医学科技奖科学技术奖，二等奖，2025（李龙，刁美，陈震，李颀，姜茜，张金山，张震，李旭，冯翠竹）

(2) 姜茜（6/15）；儿童语言言语发育障碍性疾病的筛查和诊治规范化体系及推广应用，中国宋庆龄基金会，儿科医学奖，成果奖，2024（王琳，王建红，高立群，许琪，王曦，姜茜，刘军廷，张丽丽，程大志，孔令志，段海凤，关宏岩，周波，田宇，王蕾） 

(3) 姜茜（5/10）；儿童生长发育偏离早期筛查评估和精准诊断体系的建立，中国妇幼健康研究会，妇幼健康科学技术奖科技成果奖，二等奖，2023