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曹园园,首都医科大学公共卫生学院副教授,硕士生导师,长期从事功能纳米材料合成,神经电化学检测及肿瘤诊疗的研究。近年来主持国家自然科学基金青年项目1项、北京市自然科学基金面上项目2项、国家重点研发计划任务级课题1项,累计经费125万元。发表论文 40余篇,以第一或通讯作者在Chemistry of Materials, ACS Applied Materials Interfaces,CemSusChem等期刊发表 SCI论文 25篇,他引 1000余次,入选ESI全球TOP 1%高被引论文2篇,授权国家发明专利2项。
(1)北京市自然科学基金面上项目,高分散MnO2-自组装脂质多级靶向递送CRISPR-Cas9用于低温光热免疫治疗,20万元,在研,主持。
(2)北京市自然科学基金面上项目,基于聚多巴胺多功能复合纳米粒子构筑温和条件下的光热治疗,20万元,已结题,主持。
(3)国家重点研发计划任务级课题,穿戴式设备自供电系统研制,60万元,已结题,主持。
(4)国家自然科学基金青年项目,基于萘酰亚胺类分子J聚集组装构筑智能响应型光热治疗,25万元,已结题,主持。
(1)北京市自然科学基金面上项目,高分散MnO2-自组装脂质多级靶向递送CRISPR-Cas9用于低温光热免疫治疗,20万元,在研,主持。
(2)北京市自然科学基金面上项目,基于聚多巴胺多功能复合纳米粒子构筑温和条件下的光热治疗,20万元,已结题,主持。
(3)国家重点研发计划任务级课题,穿戴式设备自供电系统研制,60万元,已结题,主持。
(4)国家自然科学基金青年项目,基于萘酰亚胺类分子J聚集组装构筑智能响应型光热治疗,25万元,已结题,主持。
(1)Caixia Ren,# Haoyuan Zhang,#Min Yang, Yanjun Huang, Juan Guo, Kexin Chen, Yaning Fu, Huan Chen, YuanyuanCao,* Rongzhang Hao,* and Hongwei Hou*. Membrane-coated hollow manganese nitrogencarbon nanocomposites synergize phototherapy and STING activation for immunogenictumor microenvironment remodeling. ACS Appl. Mater. Interfaces, 2025,17, 37053−37067.
(2)Keying Yu#, Sirui Yang#, Hongxu Song, Zhou Sun,Kaichao Wang, Yuqi Zhu, Chengkai Yang, Rongzhang Hao* and Yuanyuan Cao*. High-resolutiontracking of aging-related small molecules: bridging pollutant exposure, brain agingmechanisms, and detection innovations. Biosensors, 2025, 15, 242.
(3)Yuanyuan Cao*, Chengkai Yang, Chenning Liu, Zixuan Fan, Sirui Yang, Hongxu Song,Rongzhang Hao. Advanced electrochemical detection methodologies for assessingneuroactive substance variability induced by environmental pollutants exposure. Environmental Technology & Innovation, 2025, 37, 10396.
(4)YilinLi, Mingjie Sun, Yanbo Cao, Keying Yu, Zixuan Fan, Yuanyuan Cao*. Designing lowtoxic deep eutectic solvents for the green recycle of lithium-ion batteriescathodes. ChemSusChem, 2024, 17, e202301953.
(5)YuanyuanCao*, Yilin Li, CaixiaRen, Chengkai Yang, Rongzhang Hao*, Tiancheng Mu*. Manganese-basednanomaterials promote synergistic photo-immunotherapy: the green synthesis,underlying mechanism, and multiple application. Journal ofMaterials Chemistry B, 2024, 12, 4097-4117.
(6)JinjingWu#, Xiaobo Lin#, Chengkai Yang, Sirui Yang, Chenning Liuand Yuanyuan Cao*. Wearable sensors based on miniaturized high-performancehybrid nanogenerator for medical health monitoring. Biosensors,2024, 14, 361.
(7)Yuanyuan Cao, Quanzhong Ren, Rongzhang Hao*, Zhiwei Sun*. Innovativestrategies to boost photothermal therapy at mild temperature mediated byfunctional nanomaterials. Materials & Design, 2022, 214,110391.
(8)Yilin Li#, Jialu Luo#, ShuyiShan, Yuanyuan Cao*. High toxicity of amino acid-based deep eutecticsolvents. Journal of Molecular Liquids, 2023,370,121044.
(9)Yuanyuan Cao*, Shuyi Shan,Yitong Lu, Jialu Luo, Yilin Li, Rongzhang Hao*. Tuning toxic properties of polyethylene glycol-based deepeutectic solvents for achieving greener solvents. Journal of Molecular Liquids, 2023,369, 120879.
(10)YuanyuanCao*, Yilin Li, Mingjie Sun, Yufan Xu, Li Chen*.Unexpectedly superhigh toxicity of superbase-derived deep eutectic solventsalbeit high efficiency for CO2 capture and conversion. Industrial& Engineering Chemistry Research, 2023, 62, 3338−3347.
(11)YuanyuanCao*, Xinglei Tao, ShuqinJiang, Naiwei Gao, Zhiwei Sun*. Tuning thermodynamic properties of deep eutecticsolvents for achieving highly efficient photothermal sensor. Journalof Molecular Liquids, 2020,308,113163.
(12)Yuanyuan Cao*, Jing Wang, Bo Jiang, Shuqin Jiang, Zhiwei Sun*. Cheapand green deep eutectic solvents with favorable physical properties forsignificantly improved near-infrared light detection. Journal of Molecular Structure, 2021, 1245: 130988.
(13)Rui Qin, Zeyu Wang, YuanyuanCao*, Yurun Tian, Fengyi Zhou, Zhiyong Li, Tiancheng Mu*. Task-specificdeep eutectic solvent for efficient dissolution and further acceleratingalkaline hydrolysis of polyesters into their monomers. ChemSusChem, 2024,18, e202401470.

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