首医科创中心优秀人才创新项目

课题名称：缺血性脑卒中转化研究与恒河猴模型

起止时间：2024年01月至2026年12月

课题经费：200万元

课题负责人

国家自然科学基金（面上项目）

课题名称：脑卒中后缺血半暗带Tmem30a高表达/外周AnnexinV反应性变化降低磷脂酰丝氨酸外翻所致神经损伤的作用及机制研究

课题编号：82371470

起止时间：2024.01-2027.12

课题经费：49万元

课题负责人

国家自然科学基金（面上项目）

课题名称：TMEM30A/STAT通路对脑卒中后缺血半暗带组织神经保护中的作用及相关机制研究

课题编号：82071466

起止时间：2021.01-2024.12

课题经费：55万元

1       Xu Yi, Duan Yunxia, Xu Shuaili, He Xiaoduo, Guo Jiaqi, ShiJingfei, Zhang Yang, Jia Milan, Li Ming, Wu Chuanjie, Wu Longfei, JiangMiaowen, Chen Xiaonong, Ji Xunming*, Wu Di*. Mild hypothermia therapyattenuates early BBB leakage in acute ischaemic stroke. J Cereb Blood FlowMetab. 2024. Accepted.

2       Chen X, Xu S, Li M, Wu D*, Ji X*. Transnasalcooling: New prospect of selective hypothermia in acute ischemic stroke. JCereb Blood Flow Metab. 2024;44:310-312.

3       He J, Zhang Y, Guo Y, Guo J, Chen X, Xu S, Xu X, Wu C, Liu C,Chen J, Ding Y, Fisher M, Jiang M*, Liu G*, Ji X*, Wu D*. Blood to braincommunication in brain diseases. Science Bulletin (Beijing). 2024 Sep19:S2095-9273(24)00672-8.

4       Chen J, Xu S, Lee H, Wu L, He X, Zhao W, Zhang M, Ma Y, DingY, Fu Y, Wu C, Li M, Jiang M, Cheng H, Li S, Ma T*, Ji X*, WuD*. Hypothermic neuroprotection by targeted cold autologous bloodtransfusion in a non-human primate stroke model. Sci Bull (Beijing). 2023 Jul30;68(14):1556-1566.

5       Xu S, Ji X, Li M, Wu D*. Expedited brain cooling:Persistent temperature management from first aid to interhospital treatment. JCereb Blood Flow Metab. 2023;43:319-321.

6       Wu D, Li M,Fisher M, Ji X*. Brain cytoprotection of ischemicstroke in the era of effective reperfusion.Sci Bull(Beijing). 2022; 67:2372-2375.

7       Wu D, Chen J, Wu L, Lee H, Shi J, Zhang M, Ma Y, He X, Zhu Z, YanF, Wu C, Duan Y, Fu Y, Li S, Zhi X, Zhang X, Li S, Ding Y, Ji X*. A clinicallyrelevant model of focal embolic cerebral ischemia by thrombus and thrombolysisin rhesus monkeys. Nat Protoc. 2022,17(9):2054-2084.

8       Zhao H#, Zhao J#, Wu D#, Sun Z#, Hua Y, ZhengM, Liu Y, Yang Q, Huang X, Li Y, Piao Y, Wang Y, Lam SM, Xu H, Shui G, Wang Y,Yao H, Lai L, Du Z, Mi J*, Liu E*, Ji X*, Zhang YQ*. Dogs lackingApolipoprotein E show advanced atherosclerosis leading to apparent clinicalcomplications. Sci China Life Sci. 2022;65(7):1342-1356.

9       Wu D, Chen J, Zhang X, Ilagan R, Ding Y, Ji X. Selectivetherapeutic cooling: To maximize benefits and minimize side effects related tohypothermia. J Cereb Blood Flow Metab. 2022;42(1):213-215.

10    Wang L, Wu L, Duan Y, Xu S, Yang Y, Yin J, Lang Y, Gao Z, WuC, Lv Z, Shi J, Wu D*, Ji X*. Phenotype Shifting inAstrocytes Account for Benefits of Intra-Arterial Selective Cooling Infusion inHypertensive Rats of Ischemic Stroke. Neurotherapeutics. 2022Jan;19(1):386-398.