欢迎访问首都医科大学导师主页

个人简介

Personal Profile

以第一作者或通讯作者（含共同）累计发表论文36篇，包括Nature、Am J Respir Crit Care Med、Allergy（x6）及J Allergy Clin Immunol（x6）等国际顶尖期刊论文。ESI高被引论文1篇，5项研究成果入选8项国际指南；2项研究成果入选期刊“主编精选”；获国家专利和软件作授权5项；作为主要完成人获北京市科技进步一等奖1项（6/15）、华夏医学科技奖一等奖等1项（7/15）。主持国家自然科学基金4项、省部级项目6项，入选教育部青年长江学者计划、北京市“海聚工程“青年项目、“北京市科技新星”、“北京市优秀人才青年拔尖项目”和“北京市医管局“青苗计划”等人才项目。担任亚太地区过敏哮喘和临床免疫协会（APAAACI）委员，中国医促会过敏医学分会委员，中国医师协会耳鼻咽喉头颈外科医师分会青年副组长，中华医学会耳鼻咽喉头颈外科分会青年委员，中华医学会变态反应分会青年委员。担任Frontiers In Allergy副主编，Allergy、iScience和inflammation等多个杂志审稿专家。

研究方向Research Directions

鼻病免疫学

2. 机电结构优化与控制研究内容：在对机电结构进行分析和优化的基础上，运用控制理论进行结构参数的调整，使结构性能满足设计要求。1. 仿生结构材料拓扑优化设计, 仿生机械设计研究内容：以仿生结构为研究对象，运用连续体结构拓扑优化设计理论和方法，对多相仿生结构(机构)材料进行2. 机电结构优化与控制研究内容：在对机电结构进行分析和优化的基础上，运用控制理论进行结构参数的调整，使结构性能满足设计要求。1. 仿生结构材料拓扑优化设计, 仿生机械设计研究内容：以仿生结构为研究对象，运用连续体结构拓扑优化设计理论和方法，对多相仿生结构(机构)材料进行整体布局设计。整体布局设计。

科研项目

研究成果

1. Lan F#, Li J#, Miao W#, Sun F#, Duan S, Song Y, Yao J, Wang X, Wang C, Liu X, Wang J, Zhang L, Qi H. GZMK-expressing CD8+ T cells promote recurrent airway inflammatory diseases. Nature. 2025 Feb;638(8050):490-498.
2. Zhao L#, Zhang S#, Zhang Y#, Liu Y, Guo Y, Li Y, Wang Q, Wang Z, Qu Z, Zhang N, Bachert C, Wang C*, Zhang L*, Lan F*. Amphiregulin Mediates Epithelial Cell-Eosinophil Interactions and Amplifies Inflammation in Chronic Rhinosinusitis With Nasal Polyps.Allergy. 2025 May;80(5):1335-1347.
3. Li Y#, Wang Z#, Duan S#, Wang X, Zhang Y, Bachert C, Zhang N, Wang W, Ying S, Lan F*, Wang C*, Zhang L*.TLR4+group 2 innate lymphoid cells contribute to persistent type 2 immunity in airway diseases.. 2025 Aug 2;16(1):7108.
4.XianM#, Lan F#, Yan B#, Shen S#, Liu S,Wan L, Song X, Jiang L, Jiang Y, Xue J, Chen J, Su L, Ye J, Yang Y, Fang H, TanG, Zhang Q, Qu S, Wei X, Luo X, Xu Y, Yu S, Xiao Z, Liu F, Li Q, Zhang Y, XieY, Wang L, Yang G, Yan H, Zhao G, Chen B, Wang C*, Zhang L*.An anti-TSLP monoclonal antibody for uncontrolled CRSwNP: the DUBHE randomizedclinical trial. Nat Commun. 2025 Sep 29;16(1):8607.
5.ZhangY#, Yang M#, Li Y, Wang Z, Zhang S, Zhao L, Liu Y, Li X,Wang X, Lan F*, Zhang L*. Role ofCD44+CCR2+CD64-monocyte-derived macrophage in chronic rhinosinusitis with nasalpolyps. Cell Immunol. 2025 May-Jun;411-412:104953.
6.Zheng M, Wu D, Piao Y, Tang J, Quan F, Guan B, Yu H, Zhang X, He G, Yang Y, Wan L, Li X, Liu W, Xu Z, Ye J, Liu W, Song X, Du Y, Xu Y, Chen J, Wang W, Lan F*, Wang C*, Zhang L*. Efficacy and safety of GR1802 in uncontrolled chronic rhinosinusitis with nasal polyps: Placebo-controlled phase 2 trial. J Allergy Clin Immunol. 2025 Feb 7:S0091-6749(25)00126-5.
7.Wang M, Li Y, Li J, Bing Yan B, Wang C, Zhang L, Lan F*. New insights into the endotypes of chronic rhinosinusitis in the biologic era. Journal of Allergy and Clinical Immunology. doi: doi.org/10.1016/j.jaci.2025.02.015.
8.Zhang Y, Li X, Li Y, Lan F. The role of macrophages in chronic rhinosinusitis with nasal polyps. Eye & ENT Research. 2025
9.Yan B#; Lan F#; Li J#; Wang C; Zhang L. The mucosal concept in chronic rhinosinusitis: Focus on the epithelial barrier. Journal of Allergy and Clinical Immunology. doi: 10.1016/j.jaci.2024.01.015., 2024.
10.Li Y, Qu Z, Wang X, Wang Q, Lv Z, Wang W, Ying S, Zhang L*, Lan F*. House dust mite allergen directly activates ILC2 cells via the TLR4 signaling pathway in allergic airway diseases. Cell Immunol. 2024 Nov-Dec;405-406:104884.
11.Liu Y; Wang Z; Zhao L; Wang X; Li X; Qu Z; Zeng Y; Liu Y; Hao L; Yang M; Zhang Y; Zhang S; Wang Q; Li Y; Lan F*; Zhang L*. Dynamic changes of nasal tight junctions in patients with convalescent COVID-19 with allergic rhinitis. International Forum of Allergy & Rhinology. DOI:10.1002/alr.23258, 2023.
12. Zhang Y; Lan F*; Zhang L*. Update on pathomechanisms and treatments in allergic rhinitis. Allergy, 2022, 77(11): 3309 - 3319.
13.Li Y#; Lan F#; Yang Y; Xu Y; Chen Y; Qin X; Lv Z; Wang W; Sun Y; Zhang L. The absence of IL-9 reduces allergic airway inflammation by reducing ILC2, Th2 and mast cells in murine model of asthma. BMC Pulmonary Medicine, 2022, 22(1): 180.
14.Wang Z; Wang Q; Du S; Zhang Y; Zhao L; Zhang S; Hao L; Li Y; Wang X; Wang C; Zhang N; Bachert C; Zhang L; Lan F*. A diagnostic model for predicting type 2 nasal polyps using biomarkers in nasal secretion. Frontier Immunology, 2022, 13: 1054201.
15.Zhang Y, Shen S, Liu Y, Wang Z, Wang Q, Li Y, Wang C, Lan F*, Zhang L. The Influence of Body Mass Index on Glucocorticoid Insensitivity in Chronic Rhinosinusitis with Nasal Polyps.Journal of Personalized Medicine. DOI: 2022 Nov 21;12(11):1935.
16.Li Y, Wang Q, Zhang Y, Duan S, Zhang H, Wang X, Lan F. Clinical characteristics of chronic rhinosinusitis with nasal polyps with diffeent body mass index. Journal of Capital Medical University. 2022,43(6):899-904. (In Chinese)
17.Lan F, Limin Z, Yan M, Zhang Y, Wang Q, Wang X, Zhang L. Clinical feature and tissue remodeling in type 2 and non-type 2 chronic rhinosinusitis without nasal polyps. Chinese Journal of Otorhinolaryngology Head and Neck Surgery. 2022,29(5):304-308. (In Chinese)
18.Zhang S, Zhang Y, Limin Z, Lan F. Identification, differentiation, and regulation of Th17 cells and their relationship to refractory chronic rhinosinusitis with nasal polyps. International Journal of Otolaryngology-Head and Neck Surgery. 2022,46(2):80-83. (In Chinese)
19.Zhang Y Lan F*, Zhang L. Advances and highlights in allergic rhinitis. Allergy, 2021, 76(11): 3383 - 3389.
20.Li Y; Wang W; Ying S; Lan F*; Zhang Luo. A potential role of group 2 innate lymphoid cells in eosinophilic chronic rhinosinusitis with nasal polyps. Allergy Asthma Immunology Research, 2021, 13(3): 363 - 374.
21.Duan S, Zhao L, Zhang Y, Zhang N, Zheng M, Wang Q, Zhang X, Wang X, Ying S, Bachert C, Zhang L, Lan F*. Tropomyosin in mugwort cross-reacts to house dust mite, eliciting non-Th2 response in allergic rhinitis patients sensitized to house dust mite. Clinical and Molecular Allergy.DOI: 2021 Apr 2;19(1):2.
22.Zhao L, Zhang Y, Zhang S, Zhang L, Lan F*. The effect of immunotherapy on cross-reactivity between house dust mite and other allergens in house dust mite -sensitized patients with allergic rhinitis. Expert Rev Clin Immunol. 2021 Sep;17(9):969-975.
23.Lan F#, Wang Q, Zhang L. Gene transcriptome analysis of nasal epithelial cells in chronic rhinosinusitis with nasal polyps. Chinese Journal of Otorhinolaryngology Head and Neck Surgery. 2021,56(10):1066-1072. (In Chinese)
24.Lan F#*; Zhang N; Bachert C; Zhang L. Stability of regulatory T cells in T helper 2biased allergic airway diseases. Allergy, 2020, 75(8): 1918 - 1926.
25.Lan F#, Zhang L. Understanding the Role of Neutrophils in Refractoriness of Chronic Rhinosinusitis With Nasal Polyps. Allergy Asthma Immunol Res. 2020 Jan;12(1):1-3.
26. Lan F#; Zhong H; Zhang N; Johnston S; Wen W; Papadopoulos NG; Zhang L; Bachert C. IFN - lambda1 enhances Staphylococcus aureus clearance in healthy nasal mucosa but not in nasal polyps. Journal of Allergy and Clinical Immunology, 2019, 143(4): 1416 - 1425.e4.
27.Lan F#; Zhang N; Holtappels G; De RN; Krysko O; Van CK; Braun H; Johnston SL.; Papadopoulos NG.; Zhang L; Bachert C. Staphylococcus aureus induces a mucosal type 2 immune response via epithelial cell - derived cytokines. American Journal of Respiratory and Critical Care Medicine, 2018, 198(4): 452 - 463.
28.Altunbulakli C; Costa R; Lan F#; Zhang N; Akdis M; Bachert C; Akdis CA. Staphylococcus aureus enhances the tight junction barrier integrity in healthy nasal tissue, but not in nasal polyps. Journal of Allergy and Clinical Immunology, 2018, 142(2): 665 - 668.e8.
29. Lan F#; Zhang N; Gevaert E; Zhang L; Bachert C. Viruses and bacteria in Th2 - biased allergic airway disease. Allergy, 2016, 71(10): 1381 - 1392.
30.Lan F#; Wang X; Nauwynck HJ; Holtappels G; Zhang L; Johnston Sebastian L; Papadopoulos NG; Bachert C; Zhang N. Th2 biased upper airway inflammation is associated with an impaired response to viral infection with Herpes simplex virus 1. Rhinology, 2016, 54(2): 141 - 149.
31.Lan F#; Zhang N; Zhang J; Krysko O; Zhang Q; Xian J; Derycke L; Qi Y; Li K; Liu S; Lin P; Bachert C. Forkhead box protein 3 in human nasal polyp regulatory T cells is regulated by the protein suppressor of cytokine signaling 3. Journal of Allergy and Clinical Immunology, 2013, 132(6): 1314 - 1321.

学生信息

当前位置：教师主页 > 学生信息

入学日期

所学专业

学号

学位

招生信息

当前位置：教师主页 > 招生信息

招生学院

招生专业

研究方向

招生人数

推免人数

考试方式

招生类别

招生年份