1. 国家自然科学基金面上项目，82272760，Mac-1/FAK/p38αMAPK在ICAM-1募集肿瘤相关巨噬细胞致肝癌不完全射频消融后血管通透性增加的机制，主持

2. 北京市自然科学基金面上项目，7212044，内皮细胞源性CXCL8结合CXCR1/2抑制氧化磷酸化调控肝癌不完全射频消融后血管生成拟态的机制，主持

3. 北京市医院管理中心青苗计划，QML20190306，ATPase抑制因子1/波形蛋白调控肝细胞癌血管生成拟态的机制研究，主持。

4. 首都医科大学校自然科学基金，2020，内皮细胞源性CXCL8通过CXCR1/ATPase inhibitory factor 1/Vimentin途径调控肝癌不完全射频消融后血管生成拟态的机制研究，主持

5. 国家自然科学基金青年基金项目，81502650，ATPase抑制因子1在索拉非尼抑制肝癌射频消融后残留癌EMT中的作用机制，主持

6. 国家自然科学基金面上项目，81572957，ICAM-1介导的肿瘤相关内皮细胞与血小板相互作用在肝癌射频消融后残留癌进展中的作用机制，参加

7. 国家自然科学基金面上项目，81172320，肿瘤相关内皮细胞不完全热消融后功能改变及其对肝细胞癌侵袭转移的影响，参加

8. 国家自然科学基金面上项目，30872490，肝癌射频消融后残留癌快速进展及机制的实验研究，参加

发表文章

1. Yao C#, Kong J#, Xu F, Wang S, Wu S, Sun W, Gao J. Heme-inducing endothelial pyroptosis plays a key role in radiofrequency ablation of hepatic hemangioma leading to systemic inflammatory response syndrome. J Inflamm Res. 2024;17:371-385

2. Kong J, Xia Q, Xu L, Jin D and Sun W. Case report: Cancer-free survival after chemotherapy, targeted immunotherapy combination with proton therapy following space making technique in a patient with cholangiocarcinoma after choledochal cyst resection. Front Immunol. 15:1520248. doi: 10.3389/fimmu.2024.1520248

3. Jian Kong, Ruhang Zhu, Wenbing Sun. Management of acute cholecystitis with concomitant liver abscess. Chirurgia 2023 October;36(5):300-4. DOI: 10.23736/S0394-9508.22.05513-9.

4. Wu S, Li Z, Yao C, Dong S, Gao J, Ke S, Zhu R, Huang S, Wang S, Xu L, Ye C, Kong J*, Sun W*. Progression of hepatocellular carcinoma after radiofrequency ablation: Current status of research. Front Oncol. 2022 Nov 22;12:1032746. doi: 10.3389/fonc.2022.1032746. PMID: 36483051; PMCID: PMC9723167.

5. Kong J, Gao R, Wu S, Shi Y, Yin T, Guo S, Xin Z, Li A, Kong X, Ma D, Zhai B, Sun W, Gao J. Safety and efficacy of microwave versus radiofrequency ablation for large hepatic hemangioma: a multicenter retrospective study with propensity score matching. Eur Radiol. 2022;32(5):3309-3318. doi: 10.1007/s00330-021-08425-4. Epub 2022 Jan 29. Erratum in: Eur Radiol. 2022 Mar 3;: PMID: 35091785.

6. Dong S#, Li Z#, Kong J#, Wu S, Gao J, Sun W. Arsenic trioxide inhibits angiogenesis of hepatocellular carcinoma after insufficient radiofrequency ablation via blocking paracrine angiopoietin-1 and angiopoietin-2. Int J Hyperthermia. 2022;39(1):888-896. doi: 10.1080/02656736.2022.2093995. PMID: 35848416.

7. Kong J, Yao C, Ding X, Dong S, Wu S, Sun W, Zheng L. ATPase Inhibitory Factor 1 Promotes Hepatocellular Carcinoma Progression After Insufficient Radiofrequency Ablation, and Attenuates Cell Sensitivity to Sorafenib Therapy. Front Oncol. 2020 Jun 25;10:1080. doi: 10.3389/fonc.2020.01080. PMID: 32670888; PMCID: PMC7330926.

8. Kong J, Yao C, Dong SY, Wu S, Xu Y, Li K, Ji L, Shen Q, Zhang Q, Zhan R, Cui H, Zhou C, Niu H, Li G, Sun W, Zheng L. ICAM-1 Activates Platelets and Promotes Endothelial Permeability through VE-cadherin after Insufficient Radiofrequency Ablation. Adv Sci. 2021, 8(4):202002228.

9. Jia G#, Kong J#, Yao C, Wu S, Sun W. Platelet lysates in Hepatocellular Carcinoma patients after radiofrequency ablation facilitate tumor proliferation, invasion and vasculogenic mimicry. Int J Med Sci. 2020 Jul 29;17(14):2104-2112. doi: 10.7150/ijms.44405. PMID: 32922171; PMCID: PMC7484666.

10. Zhang Q#, Kong J#, Dong S, Xu W, Sun W. Metformin exhibits the anti-proliferation and anti-invasion effects in hepatocellular carcinoma cells after insufficient radiofrequency ablation. Cancer Cell Int. 2017 Apr 24;17:48. doi: 10.1186/s12935-017-0418-6. PMID: 28450808; PMCID: PMC5404300.

11. Kong J, Kong F, Gao J, Zhang Q, Dong S, Gu F, Ke S, Pan B, Shen Q, Sun H, Zheng L, Sun W. YC-1 enhances the anti-tumor activity of sorafenib through inhibition of signal transducer and activator of transcription 3 (STAT3) in hepatocellular carcinoma. Mol Cancer. 2014 Jan 13;13:7. doi: 10.1186/1476-4598-13-7. PMID: 24418169; PMCID: PMC3895679.

12. Kong J, Kong L, Kong J, Ke S, Gao J, Ding X, Zheng L, Sun H, Sun W. After insufficient radiofrequency ablation, tumor-associated endothelial cells exhibit enhanced angiogenesis and promote invasiveness of residual hepatocellular carcinoma. J Transl Med. 2012 Nov 21;10:230. doi: 10.1186/1479-5876-10-230. PMID: 23171368; PMCID: PMC3543343.

13. Dong S#, Kong J#, Kong F, Kong J, Gao J, Ji L, Pan B, Chen L, Zheng L, Sun W. Sorafenib suppresses the epithelial-mesenchymal transition of hepatocellular carcinoma cells after insufficient radiofrequency ablation. BMC Cancer. 2015 Nov 30;15:939. doi: 10.1186/s12885-015-1949-7. PMID: 26620566; PMCID: PMC4663721.

14. Kong J, Kong J, Pan B, Ke S, Dong S, Li X, Zhou A, Zheng L, Sun WB. Insufficient radiofrequency ablation promotes angiogenesis of residual hepatocellular carcinoma via HIF-1α/VEGFA. PLoS One. 2012;7(5):e37266. doi: 10.1371/journal.pone.0037266. Epub 2012 May 15. PMID: 22615958; PMCID: PMC3352883.

15. Chai ZT#, Kong J#, Zhu XD#, Zhang YY, Lu L, Zhou JM, Wang LR, Zhang KZ, Zhang QB, Ao JY, Wang M, Wu WZ, Wang L, Tang ZY, Sun HC. MicroRNA-26a inhibits angiogenesis by down-regulating VEGFA through the PIK3C2α/Akt/HIF-1α pathway in hepatocellular carcinoma. PLoS One. 2013 Oct 23;8(10):e77957. doi: 10.1371/journal.pone.0077957. PMID: 24194905; PMCID: PMC3806796.

16. Dong S#, Kong J#, Kong J, Shen Q, Kong F, Sun W, Zheng L. Low Concentration of Caffeine Inhibits the Progression of the Hepatocellular Carcinoma via Akt Signaling Pathway. Anticancer Agents Med Chem. 2015;15(4):484-92. doi: 10.2174/1871520615666150209110832. PMID: 25666502.

17. Kong J, Zhang Q, Liang X, Sun W. FOXK2 downregulation suppresses EMT in hepatocellular carcinoma. Open Med, 2020, 15:702-708.

18. Dong S#, Kong J#, Kong F, Kong J, Gao J, Ke S, Wang S, Ding X, Sun W, Zheng L. Insufficient radiofrequency ablation promotes epithelial-mesenchymal transition of hepatocellular carcinoma cells through Akt and ERK signaling pathways. J Transl Med. 2013 Oct 29;11:273. doi: 10.1186/1479-5876-11-273. PMID: 24168056; PMCID: PMC3842745.

19. 孔健, 张文轩, 孙文兵. 肿瘤内皮细胞来源CXC趋化因子配体8对肝细胞癌血管生成拟态的影响. 中华实验外科, 2020, 37(12): 2229-2231.

20. 孔健, 孙文兵. 胆总管结石的内科治疗. 中国医刊, 2020, 55(11): 1171-1173.

21. 孔健, 孙文兵. 18 F-FDG PET-CT在肝细胞癌诊断中的应用价值. 中国医刊, 2014, 12:10-12.

22. 孔健, 柯山, 孙文兵, 高君, 丁雪梅, 王劭宏. 47℃恒温不完全热消融后肝癌细胞对血管内皮细胞功能的影响及机制. 中华实验外科杂志, 2011, 28(10):1659-1661.

23. 孔健, 高君, 王劭宏, 钟玉萍, 秦晓新, 丁雪梅, 柯山, 孙文兵. 肝血管瘤射频消融致严重溶血和明显肾功能损害一例. 中华普通外科杂志，2010, 25(8):691-692. 

获得奖项

1. 孔健(2/8); 肝癌射频消融后残留癌进展的机制和防治研究, 首都医科大学, 自然科学奖三等奖, 2021 (孙文兵; 孔健; 姚常玉; 董姝英; 高君; 柯山; 武世伦; 丁雪梅 )。