本课题组主要基于生物医用材料的卒中诊治与康复技术与创新器械研究，具体包括

（1）面向卒中诊断的化学物理方法：基于电阻抗技术，开发血栓识别导丝、电凝取栓导丝与动脉瘤栓塞导丝，融合电化学与生物电阻抗技术，实现血管内病变的精准识别与干预。

（2）面向卒中救治的化学材料体系：基于可降解医用金属，设计新型颅内支架、弹簧圈、颅骨再生支架及硬脑膜再生贴片，探索材料结构、降解行为与神经组织修复的协同机制。

（3）面向卒中康复的化学生物策略：基于神经调控技术，构建有线与无线脑机接口支架，研究神经电生理调控机制，推动基于微电流刺激的神经功能重塑与康复。

1 2025-2027 宣武汇智人才 培育计划-学科带头人 HZ2025PYDTR008 项目负责人

2 2025-2027 北京市卫健委 高创计划-青苗人才 G202522131 项目负责人

3 2025-2027 北京市朝阳区数字医疗概念验证计划 脑静脉电刺激卒中康复与脑机接口系统 2025SLZD011 项目负责人

4 2025-2026 首发脑专项 基于镁离子调控的靶向低温脑损伤序贯神经保护介入技术与器械研究 2024-3-2062 项目负责人

5 2026-2030 国家自然科学基金重点项目 可降解钼合金的关键基础科学问题 52531008 合作单位负责人

6 2025-2028 北京市科委医药创新品种及平台培育 基于脑静脉窦生理解剖特点的专用支架研制 Z251100004625085 合作单位韩晓霏

7 2024-2026 首都医科大学优青项目 首度医科大学优秀青年人才项目 B2305 项目负责人

8 2023-2025 中国医学科学院健康长寿 基于神经介入技术的自体血低温脑损伤神经保护

系统研制 2023-JKCS-09 项目负责人

9 2023-2025 北京市医管中心扬帆医工3.0 神经介入血管内光学成像系统研制及其应用研究 YGLX202325 项目负责人

10 2022-2025 北京市科委首都临床特色诊疗技术研究及转化应用 基于体外循环技术的血管内靶向脑低温神经保护系统研制 Z221100007422023 项目负责人

11 2022-2024 国家自然科学基金青年项目 基于丝素蛋白结构调控的低温脑保护用介入导管表面纳米复合隔热涂层构建及其性能研究 82102220 项目负责人

12 2022-2024 北京市科协 北京市科协青年托举人才 BYESS2022081 项目负责人

13 2020-2022 北京市教育委员会科技计划一般项目 亚低温脑保护用导管表面纳米复合隔热涂层制备及其生物相容性研究 KM202010025023 项目负责人

14 2019-2020 北京市科学技术协会项目 低温脑保护用血管内介入导管制备 金桥工程种子项目 ZZ19046 项目负责人

15 2019-2020 北京市医院管理局 低温脑保护项目 “青苗”人才项目 QML20180802 项目负责人

16 2019-2020 首都医科大学科研培育基金 低温介入导管隔热涂层 PYZ2018128 项目负责人

17 2017-2020 国家重点研发计划 “数字诊疗装备研发”江苏数字创新诊疗装备应用示范研究-子课题脑卒中临床解决方案示范应用 2017YFC0114302 子课题负责人

18 2016-2017 北京自然科学基金青年基金 石墨烯/丝素蛋白仿生纳米复合涂层在骨修复领域中的应用探索 2164074 项目负责人

1     2025-2027     宣武汇智人才       培育计划-学科带头人  HZ2025PYDTR008 项目负责人

2     2025-2027     北京市卫健委       高创计划-青苗人才     G202522131   项目负责人

3     2025-2027     北京市朝阳区数字医疗概念验证计划       脑静脉电刺激卒中康复与脑机接口系统    2025SLZD011       项目负责人

4     2025-2026     首发脑专项    基于镁离子调控的靶向低温脑损伤序贯神经保护介入技术与器械研究       2024-3-2062       项目负责人

5     2026-2030     国家自然科学基金重点项目       可降解钼合金的关键基础科学问题    52531008       合作单位负责人

6     2025-2028     北京市科委医药创新品种及平台培育       基于脑静脉窦生理解剖特点的专用支架研制       Z251100004625085       合作单位韩晓霏

7     2024-2026     首都医科大学优青项目       首度医科大学优秀青年人才项目       B2305     项目负责人

8     2023-2025     中国医学科学院健康长寿    基于神经介入技术的自体血低温脑损伤神经保护

系统研制       2023-JKCS-09       项目负责人

9     2023-2025     北京市医管中心扬帆医工3.0      神经介入血管内光学成像系统研制及其应用研究    YGLX202325       项目负责人

10    2022-2025     北京市科委首都临床特色诊疗技术研究及转化应用       基于体外循环技术的血管内靶向脑低温神经保护系统研制    Z221100007422023       项目负责人

11    2022-2024     国家自然科学基金青年项目       基于丝素蛋白结构调控的低温脑保护用介入导管表面纳米复合隔热涂层构建及其性能研究    82102220       项目负责人

12    2022-2024     北京市科协    北京市科协青年托举人才    BYESS2022081       项目负责人

13    2020-2022     北京市教育委员会科技计划一般项目       亚低温脑保护用导管表面纳米复合隔热涂层制备及其生物相容性研究       KM202010025023  项目负责人

14    2019-2020     北京市科学技术协会项目    低温脑保护用血管内介入导管制备 金桥工程种子项目  ZZ19046 项目负责人

15    2019-2020     北京市医院管理局       低温脑保护项目 “青苗”人才项目      QML20180802       项目负责人

16    2019-2020     首都医科大学科研培育基金       低温介入导管隔热涂层       PYZ2018128   项目负责人

17    2017-2020     国家重点研发计划       “数字诊疗装备研发”江苏数字创新诊疗装备应用示范研究-子课题脑卒中临床解决方案示范应用    2017YFC0114302   子课题负责人

18    2016-2017     北京自然科学基金青年基金       石墨烯/丝素蛋白仿生纳米复合涂层在骨修复领域中的应用探索       2164074  项目负责人

第一作者/通讯作者（含共同）研究论文列表

1.       Miaowen Jiang, Chunhao Yu, Yiming Huang, Xing Zhao, ShiyiXu,, Hongkang Zhang,, Yunong Shen, Xiaofei Han, Duo Chen*, Kun Wang,** ,Xunming,*** , Ming Li****, Hydrodynamic-derived centrifugal blood pump designfor stable-low-ffow-rate rate performance: from surface to structure, BioactiveMaterials 54 (2025) 730–743

2.       Yuqing Li, Ming Li*(共同通讯), Yuan Gao, Shousheng Tang, Miaowen Jiang, Zhongshan Deng, MultistageBlood Heat Exchanger With a Thermoelectric Cooler Array for Local Brain Cooling, J. Med. Devices. Dec 2025, 19(4): 041009 (11 pages)

3.       Hongkang Zhang, Yang Zhang, Lili Sheng, Xiaofeng Cao,Chuanjie Wu, Baoying Song, Yunong Shen, Zikai Xu, Ge Song, Hao Sun, Qing Liu,Xunming Ji*, Miaowen Jiang*, Ming Li*(共同通讯) & Yufeng Zheng*. Mechanically robustneuroprotective stent by sequential Mg ions release for ischemic stroketherapy. Nature Communication 16, 6557 (2025).

4.       Shen Y, Huang Y, Zhang Y, Yu C, Liu H, Bian D, Wu D, Wang W,Ji X*, Zheng Y*, Jiang M*, Li M*. UltrafineMolybdenum Wire Braided Neurointerventional Implants: Bridging Biodegradabilityand Neurovascular Safety for Stroke Treatment. Advanced Science. 2025 Sep29:e11466.

5.       Guo Yin, Yufeng Zheng*, Ming Li(共同通讯)*, Guanghao Wu*, Yumin Luo*, Breaking through barrier: Theemerging role of nucleic acids-based drug delivery in stroke, Progress inMaterials Science, 2025;151: 101436

6.       Ming Li#(并列一作), Baoying Song#,Yan Wu#, Yang Zhang, Xiaofeng Cao, Hongkang Zhang, Yi Xu, ChuanjieWu, Chuanhui Li, Chen Zhou, Lu Liu, Feng Yan, Sijie Li, Jian Chen, Ran Meng,Jiangang Duan, Di Wu, Lin Zuo, Zikai Xu, Zhou Li*, Yufeng Zheng*, MiaowenJiang*, Xunming Ji*. Dumbbell-shaped thrombectomy devicefor cerebral venous sinus thrombus removal with controllable axial andlongitudinal maneuverability. National Science Review.2025;12(3):nwaf015.

7.       Yang Zhang# , Yunong Shen# , MiaowenJiang#, Guiyou Liu, Hongkang Zhang , Baoying Song, Yufeng Zheng* ,Xunming Ji* , Ming Li (共同通讯). (2025). Gene-based safety evaluationof molybdenum-containing biomaterials for cardiovascular and cerebrovasculardiseases. Genes & Diseases. doi.org/10.1016/j.gendis.2025.101516.(Just accepted in press)

8.       Yang Zhang, Miaowen Jiang, Ming Wei, Chuanjie Wu, YimingHuang, Baoying Song, Yi Xu, Hongkang Zhang, Yunong Shen, Di Wu *, Yufeng Zheng*, Ming Li *（通讯作者）, Xunming Ji*, MgSO4 as a novel hypothermia infusion solution promotesischemic stroke recovery through Ca2+ regulation of neurovascularunits. Theranostics ( IF12.4 ) Theranostics. 2025 Jan2;15(5):1896-1913.

9.       Ming Li#(并列一作), Xiaofeng Cao#, Hongkang Zhang , Ang Li , WenhaoZhou*, Yuanhao Wu*,Yufeng Zheng*. Improved biocompatibility and osteogenesis ofporous graphene oxide/silk fbroin scaffold for potential applications in bonetissue engineering, Materials Today Communications 40 (2024) 109480

10.   Zhang, Yang, Sifei Wang, Yiming Huang, Miaowen Jiang, BaoyingSong, Di Wu, Ming Wei,  Ming Li *（通讯作者）, Xunming Ji*.“Analysis of causal relationship between immune cells and intracranialaneurysm: a Mendelian randomization study.” Journal ofNeurorestoratology (2024): n. pag.

11.   Kan Y, Song B, Jiang M, Zhang Y, Li C, Wu C, Zhou W, Li A,Zhao W, Zhang B, Wu Y*, Li M*（通讯作者）, Ji X*. Evolution andadvances in endovascular mechanical thrombectomy of cerebral venous sinusthrombosis. Int J Med Sci. 2024 Sep 23;21(13):2450-2463. (IF= 3.2) Q3

12.   Feng Y, Wu C, Song B, Zhang Y, Jiang M, Qi Z, Chen L, Li A,Ye H, Liu B, Feng Y, Ji X, Ma Z*, Li M*（通讯作者）. Investigation ofneuroprotective effects of H2 by CiteSpace-based bibliometricanalysis. Brain Circ. 2024 Sep 26;10(3):229-239

13.    Yi Xu# , Miaowen Jiang# , BaoyingSong#, Chuanhui Li , Chuanjie Wu , JiangangDuan, Ran Meng , Chen Zhou , Sijie Li , FengYan , Jian Chen* , Ming Li *（通讯作者）, Xunming Ji*，Efficacy and Safety of a Dedicated Device for Cerebral VenousThrombectomy: A Pilot Randomized Clinical Trial. Stroke.  2025;56(1):5-13.

14.   Neuroprotection on ischemic brain injury by Mg2+/H2 releasedfrom endovascular Mg implant. Yang Zhang, HongkangZhang, Miaowen Jiang, Xiaofeng Cao, Xiaoxiao Ge, Baoying Song, Jing Lan, WenhaoZhou, Zhengfei Qi, Xuenan Gu, Juzhe Liu, Yufeng Zheng*, Ming Li*（通讯作者）, Xunming Ji*,BioactiveMaterials (42) 2024, 124-139 (IF= 18) Q1

15.   Neuroprotective effects of intraperitoneally injected Mgalloy extracts on middle cerebral artery occluded mouse with reperfusioninjury. Lanjing Wang, Yue Hu, Hongkang Zhang, Miaowen Jiang, Yang Zhang, YuminLuo, Xunming Ji, Yufeng Zheng*, Sijie Li*, Ming Li*（通讯作者）. Journal of Magnesiumand Alloys. https://doi.org/10.1016/j.jma.2024.05.025. Just Accept (IF= 15.8) Q1

16.   Miaowen Jiang, Yang Zhang, Yuan Gao, Shuaili Xu, Zhengfei Qi,Chuanjie Wu, Baoying Song, Yan Wu, Ang Li, Tao Huang, Di Wu*, YufengZheng*, Xunming Ji*, Ming Li*（通讯作者）, A computationally guidedstudy of a blood heat exchanger and the construction of an extracorporealcirculation system for selective brain cooling. Cell Reports PhysicalScience, 2024 (5) 6,102029 (IF= 7.9) Q1

17.   Yang Zhang, Miaowen Jiang, Song Baoying, Yuan Gao, Yi Xu,Zhengfei Qi, Di Wu, Ming Li*（通讯作者）, Xunming Ji*, Trends and hotspots of theneuroprotection of hypothermia treatment: A bibliometric and visualizedanalysis of research from 1992 to 2023. CNS Neuroscience & Therapeutics2024;30:e14795. (IF=4.8) Q1

18.   Song B, Jiang M, Zhang Y, Xu Y, Wu C, Wu D, Zhou C, MingLi*（通讯作者）, Xunming Ji*. Research hotpots and frontier trends ofneuroprotective effects of magnesium from 1999 to 2023: A bibliometricanalysis. CNS Neuroscience & Therapeutics 2024;30(2):e14597. (IF=4.8)Q1

19.   Yang Zhang, Ben Liang, Hongkang Zhang, Yunong Shen, XiaofengCao, Yufeng Zheng, Dongdong Chen, Jianliang Zheng, Xuemin Zhang, Tao Wang, YanWu, Miaowen Jiang*, Ming Li*（通讯作者）, Xunming Ji*. (2023).Research progress and future development trends of venous sinus stents. Journalof Translational Neuroscience, 8(2), 7-12

20.   Yang Zhang, Miaowen Jiang, Yuan Gao, Yi Xu, Yifan Zhou, DiWu, Chen Zhou, Guiyou Liu, Ming Li*（通讯作者）, Xunming Ji*，Causal effect oflipoprotein-associated phospholipase A2 activity on ischemic stroke : aMendelian randomization study，Cerebrovascular Disease. 2023 Dec 19. doi:10.1159/000535286. Epub ahead of print. PMID: 38113871. (IF=2.2)

21.   Yanhua Sun, Yange Zhang, Yujiao Hou, Hui Gong, Yifei Pang,Xiaoxiao Ge** Ming Li*（通讯作者）, Molecularly imprintedpolymers based on calcined rape pollen and deep eutectic solvents for efficientsinapic acid extraction from rapeseed meal extract, Food Chemistry, August 1(416) , 2023,135811. (IF= 8.5) Q1

22.   Ming Li#(并列一作), Yuan Gao#, MiaowenJiang#, Hongkang Zhang, Yang Zhang, Yan Wu, Wenhao Zhou, Di Wu, Chuanjie Wu,Longfei Wu, Luzi Bao, Xiaoxiao Ge, Zhengfei Qi, Ming Wei, Ang Li, Yuchuan Ding,Jicheng Zhang, Guangzhen Pan, Yu Wu, Yan Cheng, Yufeng Zheng*, Xunming Ji*, Dual-sized hollow particle incorporated fibroin thermalinsulating coatings on catheter for cerebral therapeutic hypothermia,Bioactive Materials, 26 (2023) 116–127 (IF=18.0) Q1

23.   Di Wu# , MingLi#(并列一作), Marc Fisher, Xunming Ji*，Brain cytoprotection ofischemic stroke in the era of effective reperfusion，Science Bulletin 67 (2022) 2372–2375 (IF=18.0)Q1

24.   Juanning Si#, Ming Li#(并列一作), Xin Zhang, Ruquan Han, Xunming Ji & Tianzi Jiang；Cerebral tissue oximetersuitable for real-time regional oxygen saturation monitoring in multipleclinical settings. Cognitive Neurodynamics   2023Jun;17(3):563-574 (IF=3.1)

25.   Miaowen Jiang#, Ming Li#(并列一作), Yuan Gao, Longfei Wu, Wenbo Zhao, Chuanhui Li, ChengbeiHou, Zhengfei Qi, Kun Wang, Shiqiang Zheng, Zhichen Yin, Chuanjie Wu*, XunmingJi* ,The intra-arterial selective cooling infusion system: a mathematicaltemperature analysis and in vitro experiments for acute ischemic stroke therapy.CNS Neuroscience & Therapeutics, 2022 Sep;28(9):1303-1314 (IF：4.8) Q1

26.   Miaowen Jiang , Yuan Gao , Chuanjie Wu, Longfei Wu ,Shoucheng Tang, Zhichen Yin ,Ang Li , Kun Wang, Shiqiang Zheng, Hangil Lee ,Yuchuan Ding , Ming Li*（通讯作者），Xunming Ji*, The bloodheat exchanger in intra-arterial selective cooling infusion for acute ischemicstroke: A computational fluid-thermodynamics performance, experimentalassessment and evaluation on the brain temperature, Computers in Biology andMedicine, 2022, 145: 105497. (IF=7.0) Q1

27.   Ming Li# (并列一作), Yi Xu#,Jiaqi Wu, Chuanjie Wu, Ang Li and Xunming Ji,Circulating N-Terminal ProbrainNatriuretic Peptide Levels in Relation to Ischemic Stroke and Its Subtypes: AMendelian Randomization Study, Frontiers in Genetics 2022 13:795479. (IF=2.8)

28.   Jin Ma# , Ming Li# (并列一作), Mengke Zhang, MiuwenJiang, Yuan Gao, Ruchi Mangal, Yuchuan Ding, Zhichen Yin*, Xunming Ji*，Protection of multipleischemic organs by controlled reperfusion, Brain Circulation 2021;7:2416(IF=2.3)

29.   Miaowen Jiang, Ming Li* （通讯作者）, Yuan Gao, Zhichen Yin,Yuchuan Ding, Yufeng Zheng ,Shiqiang Zheng , Chuanjie Wu , Ang Li , JianchengFang , Xunming Ji*,Design and evaluation of an air-insulated catheter forintra-arterial selective cooling infusion from numerical simulation and in vitroexperiment, Medical Engineering and Physics 99 (2022) 103736 (IF=1.7)

30.   Ming Li#，Miaowen Jiang#(并列一作)，Yuan Gao， YufengZheng*， Zhi Liu， Chen Zhou，Tao Huang, Xuenan Gu,AngLi, Jiancheng Fang, Xunming Ji*. Current status and outlook of biodegradablemetals in neuroscience and their potential applications as cerebral vascularstent materials, Bioactive Materials, 2021.11:140-153. (IF=18.0) Q1

31.   Ming Li, Luzi Bao,Zhichen Yin, Xunming Ji*, Heparin-Mediated Growthof Self-Organized ZnO Heparin-Mediated Growth of Self-Organized ZnO, ChemistrySelect2019, 4(27): 7805 -7810 (IF=1.9)

32.   Feng Yan#, Ming Li#(并列一作), HongqiZhang, Guilin Li, Yang Hua, Ying Shen, Xunming Ji*, Chuanjie Wu, Hong An, MingRen, Collagen-chitosan scaffold impregnated with bone marrow mesenchymal stemcells for treatment of traumatic brain injury, Neural RegenerationResearch, 2019,14(10):1780-1786 (IF= 5.9)Q1

33.   Ming Li, Pan Xiong, Feng Yan, Sijie Li, Changhong Ren, Zhichen Yin,Ang Li, Huafang Li, Xunming Ji, Yufeng Zheng, Yan Cheng*, An overview ofgraphene-based hydroxyapatite composites for orthopedic applications, BioactiveMaterials, 2018 , 3 (1) :1-18 (IF=18.0)Q1

34.   Ming Li#, Yang Li #(并列一作), Changhong Ren, Hong An, Fang Jiang, Feng Yan, Sijie Li, DiWu, Changqing Xia, Xunming Ji*, The effects of hypoxia on major bloodcomponents-a brief review, Journal of Translational Neuroscience,2017, 2(1): 31-36

35.   MingLi#, Xuchen Xu#(并列一作), Zhaojun Jia, Yuying Shi, Yan Cheng*,Yufeng Zheng, Rapamycin-loaded nanotubular α-Fe2O3as an endothelial favorable and thromboresistant coating forbiodegradable drug-eluting Fe stent, Journal ofMaterials Chemistry B ,2017 , 5 (6)1182-1194 (IF=6.1) Q1

36.   Ming Li, Pan Xiong, Maosong Mo*, Yan Cheng*, Yufeng Zheng,Electrophoretic-deposited novel ternary silk fibroin/graphene oxide/hydroxyapatite nanocomposite coatings on Titanium substrate for orthopedicapplications, Frontiers of Materials Science, 2016 (10):270-280 (IF=2.5)

37.   Ming Li, Qian Liu, Zhaojun Jia, Xuchen Xu, Yuying Shi, Yan Cheng*,Yufeng Zheng. Polydopamine-induced nanocomposite Ag/CaP coatings on titaniananotubes surface for antibacterial and osteointegration function, Journalof Materials Chemistry B 2015. 3 (45), 8796-8805 (IF=6.1) Q1

38.   Ming Li, Qian Liu, Zhaojun Jia, Xuchen Xu, Yan Cheng*, Yufeng Zheng,Tingfei Xi, Shicheng Wei. Graphene oxide/hydroxyapatite composite coatingsfabricated by electrophoretic nanotechnology for biological applications,Carbon ,67 (2014)185-197 (IF=10.5) Q1

39.   Ming Li, Qian Liu, Zhaojun Jia, Xuchen Xu, Yuying Shi, Yan Cheng*,Yufeng Zheng, Tingfei Xi, Shicheng Wei. Electrophoretic deposition andelectrochemical behavior of novel graphene oxide-hyaluronic acid-hydroxyapatitenanocomposite coatings, Applied Surface Science , 284 (2013)804-810 (IF=6.3) Q1

40.   Ming Li, Yanbo Wang, Qian Liu, Qiuhong Li, Yan Cheng*, YufengZheng*, Tingfei Xi, Shicheng Wei. In situ Synthesis and Biocompatibilityof Nano Hydroxyapatite on Pristine and Chitosan Functionalized Graphene Oxide, Journalof Materials Chemistry B, 1 (2013) 475-484 (IF=6.1) Q1

41.   Ming Li, Yan Cheng*, Yufeng Zheng*, Xin Zhang, Tingfei Xi, ShichengWei. Surface Characteristics and Corrosion Behavior of WE43 Magnesium AlloyCoated by SiC Film, Applied Surface Science, 258 (2012) 3074-3081 (IF=6.3) Q1

42.   Ming Li, Yan Cheng*, Yufeng Zheng*, Xin Zhang, Tingfei Xi, ShichengWei. Plasma Enhanced Chemical Vapor Deposited Silicon Coatings on Mg Alloy forBiomedical Application, Surface and Coatings Technology ,Suppl.1, 228(2013) s262-s265 (IF=5.3) Q1

43.   Ming Li, Yanbo Wang, Xin Zhang, Qiuhong Li, Yan Cheng*, YufengZheng*, Tingfei Xi, Shicheng Wei. Surface Characteristics and ElectrochemicalCorrosion Behavior of NiTi Alloy Coated with IrO2, MaterialsScience and Engineering: C, 33 (2013) 15-20 (IF=8.1) Q1