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王萍,首都医科大学附属北京友谊医院,研究员,教授,博导。中国免疫学会感染免疫学分会第四届委员,中华医学会肝病学分会第六届青年委员,《临床肝胆病杂志》编委。主要从事慢性肝病肝纤维化的基础研究工作,获得国家自然科学基金项目3项,北京市自然科学基金项目1项,2011年入选北京市科技新星。第一/通讯作者发表SCI英文论文15篇,获得国家发明专利1项(第一完成人)。“肝纤维化逆转机制、评价体系及应用推广”获得2020年北京市科技进步一等奖(第七完成人)。
(1). 国家自然科学基金面上项目,82370603、GITRL通过mTORC1/Myc信号通路抑制肝脏前体细胞衰老促进PBC胆管细胞再生的机制研究、2024/01-2027/12、49万元、主持。
(2). 北京市科技新星交叉合作课题,20240484541、宏观超分子组装构建肝小叶组织芯片的研究、2024/09-2026/09、20万元、合作。
(1).Wang P, Wang M, Liu L, Li H, Liu H, Ren J, Liu T, Cong M, Zhu Z,Zhao X, Sun L, Jia J. Targeting NPM1 inhibits proliferation and promotesapoptosis of hepatic progenitor cells via suppression of mTOR signallingpathway. Stem Cell Res Ther. 2024;15(1):292.
(2).Li L#, He Y#, Liu K, Liu L, Shan S, Liu H, Ren J, SunS, Wang M, Jia J*, Wang P*. GITRL impairs hepatocyte repopulationby liver progenitor cells to aggravate inflammation and fibrosis by GITR+CD8+ Tlymphocytes in CDE Mice. Cell Death Dis. 2024;15(2):114.
(3).He Y#, Pei Y#, Liu K#, Liu L, Tian Y, Li H, Cong M, Liu T, Ma H, You H, Jia J*,Zhang D*, Wang P*. GITR/GITRL reverse signalling modulates theproliferation of hepatic progenitor cells by recruiting ANXA2 to phosphorylateERK1/2 and Akt. Cell Death Dis. 2022;13(4):297.
(4).Wang P#, Cui Y#, Wang J, Liu D, Tian Y, Liu K, Wang X, Liu L, HeY, Pei Y, Li L, Sun L, Zhu Z, Chang D*, Jia J*, You H*. Mesenchymal stem cellsprotect against acetaminophen hepatotoxicity by secreting regenerative cytokinehepatocyte growth factor. Stem Cell Res Ther. 2022;13(1):94.
(5).Wang P, Cong M, Liu T, Li Y, Liu L, Sun S, Sun L, Zhu Z, Ma H,You H*, Zhang H*, Jia J*. FoxA2 inhibits the proliferation of hepaticprogenitor cells by reducing PI3K/Akt/HK2-mediated glycolysis. J CellPhysiol. 2020;235(12):9524-9537.
(6).Wang P, Jia J*, Zhang D*. Purinergic signalling in liverdiseases: Pathological functions and therapeutic opportunities. JHEP Rep.2020;2(6):100165.
(7).Xu H, Liu L, Cong M, Liu T, Sun S, Ma H, You H, Jia J, Wang P*. EGFneutralization antibodies attenuate liver fibrosis by inhibiting myofibroblastproliferation in bile duct ligation mice. Histochem Cell Biol. 2020;154(1):107-116.
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