首都医科大学附属北京朝阳医院是北京市大型综合性三甲医院。内分泌科门诊量常年处于北京三甲医院前三名。作为首都医科大学内分泌代谢病专业博士生培养点，现有博士生导师2名、硕士生导师5名，可培养内分泌学专业学位/科学学位博士研究生、硕士生、8年制研究生以及全科医学专业硕士研究生。

课题组拥有从分子、细胞、菌株、动物、临床等多层次研究肠道微生物、脂质代谢及其在代谢性疾病中的作用的完整体系，包括分子生物学、肠道菌群遗传操作、药物筛选、SPF级和无菌级小动物功能评价等平台和生物样本库。基础研究将依托首都医科大学附属北京朝阳医院内分泌科、首都医科大学实验动物中心、北京朝阳医院医学研究中心完成。

主持国家自然科学基金2项，北京市自然科学基金、首发基金等10余项，累计科研经费350万元。

主持国家自然科学基金2项，北京市自然科学基金、首发基金等10余项，累计科研经费350万元。

重点从事肥胖、代谢综合征及甲状腺疾病的相关基础临床研究工作，取得了一定的研究结果，以第一/通讯作者在Science（Q1/56.9）、Cell Metabolism（Q1/29.0）、Metabolism（Q1/13.934）、Diabetes & Metabolism（Q1/8.254）、EuropeanJournal of Internal Medicine（Q1/7.749）、JCEM（Q1/5.799）等杂志发表SCI论文40余篇。

（以第一作者/通讯作者发表SCI 论文40余篇，累计影响因子近400分 ）

1.Wang K#, Zhang Z#, Hang J#, LiuJ#, Guo F#, Ding Y, Li M, Nie Q, Lin J, Zhuo Y, Sun L, Luo X, Zhong Q,Ye C, Yun C, Zhang Y, Wang J, Bao R, Pang Y, Wang G*, Gonzalez FJ*, Lei X*,Qiao J*, Jiang C*. Microbial-host-isozyme analyses reveal microbial DPP4 as apotential antidiabetic target. Science. 2023 Aug 4;381(6657):eadd5787. (IF:56.9, Q1)

2.Zhang Y#, Wang X#, Lin J#, Liu J#, Wang K, Nie Q, Ye C, Sun L, Ma Y, Qu R, Wang G*, Zhang Z*, Fu W*,Jiang C* and Pang Y*. A microbial metabolite inhibits the HIF-2a-ceramidepathway to mediate the beneficial effects of time-restricted feeding on MASH. Cell Metabolism.(IF: 27.7, Q1)

3.Wei Y#, LiuJ #, Wang G*, Wang Y*. Sex differences in theassociation between adipose insulin resistance and non-alcoholic fatty liverdisease in Chinese adults. BiolSex Differ. 2023 Oct 9;14(1):69. (IF:7.9, Q1)

4.Liu J#, Xu Y, Hu Y, Wang G*. The role of fibroblast growth factor 21 in the pathogenesis ofnon-alcoholic fatty liver disease and implications for therapy. Metabolism.2015;64(3):380-90. (IF: 13.9, Q1)

5.Y. Hu#, LiuJ #, H. Zhang, Y. Xu, T. Hong, G. Wang*. Exenatidetreatment decreases fasting fibroblast growth factor 21 levels in patients withnewly diagnosed type 2 diabetes mellitus. Diabetes& Metabolism. 2016;42(5):358-363. (IF:8.3, Q1)

6. Liu J#, Wang G#, Jia Y, Xu Y*. GLP-1 receptor agonists:effects on the progression of non-alcoholic fatty liver disease. Diabetes/metabolism Research and Reviews. 2015;31(4):329-35. (IF: 8.1, Q1)

7.Wang G#, LiuJ#, Yang N, Hu Y, Zhang H, Miao L, Yao Z, Xu Y*.Levothyroxine treatment restored the decreased circulating fibroblast growthfactor 21 levels in patients with hypothyroidism. European Journal of Internal Medicine. 2016;31:94-8. (IF: 7.8, Q1)

8.Su C#, Tian J, He X, Chang X, Wang G*,Liu J*. Novel Insights into Causal Effects of Lipid andLipid-Lowering Targets with Autoimmune Thyroid Disease: A MendelianRandomization Study. Immunotargets Ther. 2024 Nov 23;13:631-641. (IF:6.2, Q1)

9.Cui R#, WeiY#, Liu J*, Wang G*. Hepatic insulinresistance affects the efficacy of metformin in patients with newly diagnosedtype 2 diabetes: A Sub-Analysis of the MARCH trial. Diabetes Res ClinPract. 2024 Aug;214:111788. (IF: 6.1,Q1)

10.Liu S#, Sun H#, Liu J*,Wang G*. Accessing the relationship between six surrogate insulin resistanceindexes and the incidence of rapid kidney function decline and the progressionto chronic kidney disease among middle-aged and older adults in China: Resultsfrom the China health and retirement longitudinal study. Diabetes ResClin Pract. 2024 Jun;212:111705. (IF: 6.1, Q1)

 11.Ding X#, Wang Y, LiuJ*, Wang G*. Impaired sensitivity tothyroid hormones is associated with elevated homocysteine levels in theeuthyroid population. Journal of clinicalendocrinology and metabolism. 2022 Jun16;dgac371. (IF: 5.8, Q1)

12.Wen X#, Chang X#, He X, Cai Q, WangG*, Liu J*. Increased Thyroid DPP4 Expression is Associated with InflammatoryProcess in Patients with Hashimoto's Thyroiditis. J Clin Endocrinol Metab. 2023 Dec 21:dgad723. (IF: 5.8, Q1)

13.Liu J#, An Y#, Yang N, Xu Y*, Wang G*. Longitudinal associations of dietary fiber and its source with48-week weight loss maintenance, cardiometabolic risk factors and glycemicstatus under metformin or acarbose treatment: a secondary analysis of the Marchrandomized trial. Nutr Diabetes. 2024 Oct 2;14(1):81. (IF:4.6, Q1)

14.Wei Y#, WuZ#, Wang Y, Wang G*, Liu J*. Interaction ofsex and diabetes on the association between hemoglobin glycation index,hemoglobin A1c and serum uric acid. DiabetolMetab Syndr. 2022 Dec 4;14(1):185. (IF:4.8, Q2)

15.Liu J#, Yuan J, Zhao J, Zhang L, Wang Q, Wang G*.Serum metabolomic patterns in young patients with ischemic stroke: a casestudy. Metabolomics. 2021;17(2):24. (IF: 4.8, Q2)

16.Liu J#, Chang X, Ding X, He X, Wang J, Wang G*. Effect of dapagliflozin onproteomics and metabolomics of serum from patients with type 2 diabetes. Diabetol Metab Syndr. 2023 Dec 4;15(1):251. (IF: 4.8,Q2)

17.Li J#, Sun H#, Wang Y, LiuJ*, Wang G*. Apolipoprotein C3 is negativelyassociated with estrogen and mediates the protective effect of estrogen onhypertriglyceridemia in obese adults. LipidsHealth Dis. 2023 Feb 28;22(1):29. (IF:4.5, Q2)

18.Chang X#, Ding X, Wang J, Cai Q, WangG*, Liu J*. The serum concentration and activity of DPP4 is positively relatedwith the severity of hyperthyroidism in patients with Graves' disease. Ann Med. 2023Dec;55(1):2226910. (IF: 4.4, Q2)

19.Wu X#, WangY, Jia Y, Liu J*, Wang G*. Risk Factors for Nonalcoholic Fatty Liver Disease with DifferentInsulin Resistance in a Nonobese Chinese Population.J Diabetes Res. 2022 Dec 14;2022:9060405. (IF:3.6, Q2)

20.Ding X#, Bian N, Wang J, Chang X, AnY, Wang G*, Liu J*. Serum Ferritin Levels Are Associated with Adipose TissueDysfunction-Related Indices in Obese Adults. BiolTrace Elem Res. 2023 Feb;201(2):636-643. (IF:3.9, Q3)