实验室科研理念

1. 1. 开展兴趣驱动的基础研究，描绘真实世界的内在模样。
2. 2. 聚焦客观存在的实际问题，开发落地应用的技术产品。

1. 国家自然科学基金面上项目，82372257；金黄色葡萄球菌β溶血素抑制巨噬细胞吞噬功能的分子机制研究；2024年01月至2027年12月，49万元，在研, 负责人
2. 北京市卫生健康委员会自主创新项目, 2024-2G-1104, 黄热疫苗接种个体中和抗体系统性评价体系 的建立, 2024-01 至 2026-12, 32万元，在研, 负责人

3. 国家自然科学基金,  81871618, AprA蛋白通过降解NETs组分介导铜绿假单胞菌免疫逃逸的分子机制,2019.01-2022.12, 57万元,结题, 负责人

研究论文

1.      Liu, Yu; Mu, Rong; Gao, Ya-Ping; Dong, Jie; Zhu, Lei; Ma, Yuyuan; Li,Yu-Hui; Zhang, He-Qiu; Han, Dong; Zhang, Yu; McInnes, Iain B; Zhang, Jingang;Shen, Beifen; Yang, Guang(Corresponding Author); Li, Zhan-Guo(CorrespondingAuthor), A Cytomegalovirus Peptide-Specific Antibody Alters Natural Killer CellHomeostasis and Is Shared in Several Autoimmune Diseases, Cell Host Microbe,2016.3.9,19(3): 400~408  

2.     Yu Liu; Fang-Jie Liu;Zhang-Chun Guan; Fang-Ting Dong; Jian-Hua Cheng; Ya-Ping Gao; Di Li; Jun Yan;Cheng-Hua Liu; Dian-Peng Han; Chun-Mei Ma; Jian-Nan Feng; Bei-Fen Shen; GuangYang(Corresponding Author). The extracellulardomain of Staphylococcus aureus LtaS binds insulin and induces insulinresistance during infection. Nature Microbiology, 2018 May;3(5):622-631.

3.     Fangjie Liu; Zhangchun Guan; YuLiu; Jingjing Li; Chenghua Liu; Yaping Gao; Yuanfang Ma; Jiannan Feng; BeifenShen; Guang Yang(Corresponding Author). Identification of a human anti-alpha-toxinmonoclonal antibody against Staphylococcus aureus infection. Frontiers inMicrobiology. 2021 Jul 15;12:692279.

4.     Wenyan Fu; Yu Liu; Fangjie Liu;Chenghua Liu; Jingjing Li; Jiali Niu; Peng Han; Dan Xu; Jiaojiao Hou; YuanfangMa; Jiannan Feng; Zhanguo Li; Rong Mu(Corresponding Author); Guang Yang(Corresponding Author). Anovel autoantibody induced by bacterial biofilm conserved components aggravateslupus nephritis, Frontiers in Immunology, 2021 March 25;12:883-894. Doi.org/10.3389/fimmu.2021.656090

5.     Chendi Jing; Chenghua Liu; YuLiu; Ruli Feng; Run Cao; Zhangchun Guan; Bo Xuan; Yaping Gao; Qi Wang; NanaYang; Yuanfang Ma; Lefu Lan; Jiannan Feng; Beifen Shen; Hui Wang(CorrespondingAuthor); Yanyan Yu(Corresponding Author); GuangYang(Corresponding Author). Antibodies against Pseudomonas aeruginosaalkaline protease directly enhance disruption of neutrophil extracellular trapsmediated by this enzyme, Frontiers in Immunology, 2021 March 31;12: 1075-1091. DOI:10.3389/fimmu.2021.654649

6.     Zhangchun Guan; Yu Liu;Chenghua Liu; Huiting Wang; Jiannan Feng; GuangYang(Corresponding Author). Staphylococcus aureus β-hemolysinup-regulates the expression of IFN- γ by human CD56 bright NK cells,Frontiers in Cellular and Infection Microbiology, 2021 March 29; 11:251-261. doi.org/10.3389/fcimb.2021.658141.

7.     Yonggen Jia, Zhangchun Guan,Chenghua Liu, Minjun Huang, Jingjing Li, Jiannan Feng, Beifen Shen, GuangYang(Corresponding Author). Staphylococcus aureus β-hemolysincauses skin inflammation by acting as an agonist of epidermal growth factorreceptor. Microbiology Spectrum. 2024 Jan 11;12(1):e0222723.

8.     Dong Han, Lei Guan, YingyingZhang, Huan Yang, Libu Si, Tongyu Jia, Yangyang Wu, Kaikai Lv, Tao Song(CorrespondingAuthor), Guang Yang(Corresponding Author). FGF13A interacts with NPM1and UBF and inhibits the invasion of bladder cancer cells. Biochem Biophys ResCommun. 2023 Oct 20:678:1-10.

9.     Chao Xu , Zhao He, YongfengSong, Shanshan Shao, Guang Yang(Corresponding Author), Jiajun Zhao(CorrespondingAuthor). Atypical pituitary hormone-target tissue axis. Front Med. 2023Feb;17(1):1-17.

 授权专利

1.   杨光;黄敏君;郭东星;李晶晶, 用于检测黄热病毒血清中和抗体的试剂盒, 申请日：2024.01.04,   授权日期: 2024.09.13,中国, ZL202410013886.7

2.   杨光; 刘成华; 刘玉; 刘方杰; 高亚萍; 冯健男, 一种抗金黄色葡萄球菌肠毒素B的单克隆抗体YG11-1及其应用, 申请日：2018-12-19授权日期: 2022.03.15, 中国, ZL 201811554511.2

3.   杨光; 刘成华; 刘玉; 刘方杰; 高亚萍; 冯健男, 一种抗金黄色葡萄球菌肠毒素B的单克隆抗体YG11-2及其应用, 授权日期:2022.02.01, 中国, ZL201811558297.8

4.   杨光; 刘方杰; 刘玉; 刘成华; 高亚萍; 冯健男;沈倍奋, 一种抗金黄色葡萄球菌α溶血素单克隆抗体及应用, 授权日期:2020.12.18, 中国, ZL201710659435.0

5.   杨光;刘玉; 高亚萍;刘成华, eLtaS蛋白作为预防和治疗胰岛素抵抗相关疾病的药物靶点的应用, 授权日期2019.2.22, 中国, 201710047174.7