本团队依托呼吸疾病国家重点实验室及三甲医院临床资源，聚焦呼吸系统感染与免疫疾病的发病机制与精准诊疗研究，长期致力于探索病原体-宿主互作机制。团队学术氛围活跃，鼓励学科交叉探索，欢迎有志于呼吸疾病研究的青年加入，共同破解感染免疫难题！

1.     北京市卫健委，研究型病房卓越临床研究计划项目，BRWEP2024W042180100艾滋病脆弱人群全程管理的综合诊疗研究，2024.11至2026-11，1000万元，，在研，主持。

2.     国家自然科学基金委员会, 面上项目, 81873761, 小胶质细胞免疫反应介导的HIV-1 gp120神经自噬及机制研究, 2019.01. 至 2022.12, 56万元, 结题, 主持。

3.     北京市卫健委，北京重大呼吸道传染病研究中心项目，BJRID2024-001，下呼吸道病原快速精准诊断及病原-宿主免疫互作高通量一体化研，2024.03-2024.12，134.99万元，结题，主持。

4.     北京市自然科学基金, 面上项目, 7222095, 基于RNA-seq 技术肺孢子菌肺炎肺微生物组及宿主-微生物互作研究, 2022.01至2024.12, 20万元, 结题, 主持。

5.     首都卫生发展科研专项项目，2022-1-2152，分子分型指导下外周 T 细胞淋巴瘤临床治疗路径的优化治疗，2022.01-2024.12，5万元，结题，主持。

一、重要学术论文

1.      Chen X, Wei J, Zhang L, Wang H, Zhang Y, Li Z, Wang X,Liu L, Zhang Y*, Zhang T*. Association between plasma short-chain fattyacids and inflammation in human immunodeficiency virus-associatedneurocognitive disorder: a pilot study. Lipids Health Dis. 2025 Feb21;24(1):66.

2.      Liang Y, Chang J, Gao Y, Zhang L, Chen X, Zheng C,Sun Y, Zhang X, Guo C*, Zhang Y*. Development of a novel prognosticnomogram for AIDS-associated diffuse large B-cell lymphoma: a retrospectivestudy from northern China. Clin Exp Med. 2025 Feb 18;25(1):62.

3.      Xiang H, Zhang L, Yang L, Cai M, Ma Y, Zhang Y*. Asymptomaticlung abscess of aspergillus in a female without previous lung diseases orimmunocompromise: a case report. BMC Infect Dis. 2025 Jan 14;25(1):66.

4.      Zhang L, Zheng C, Sun Y, Chen X, Wang Y, Xiang H,Liang Y, Wei F*, Zhang Y*. Diagnostic testsperformance in detecting Pneumocystis jirovecii: A systematic review andmeta-analysis. Eur J Clin Microbiol Infect Dis. 2025 Feb 3.

5.      Zhang X, Li Z, Ji J, Ma Y, Sun G, Chen X, Zhang L,Zhang T, Zhang Y*, Zhang Y*. CD8T cells andmonocytes were associated with brain alterations in human immunodeficiencyvirus-infected individuals with cognitive impairment. Brain Res Bull. 2025Jan 30:222:111231.

6.      Zhang X, Zheng C, Zhang L, Sun Y, Liang Y, Chen X,Pang L*, Zhang Y*.  Safetyand recommendation of voriconazole for invasive pulmonary aspergillosis insevere liver disease patients: a retrospective cohort study. BMC Infect Dis. 2025Jan 16;25(1):70.

7.      Shan Y, Sun G, Ji J, Li Z, Chen X, Zhang X, Ma Y, ZhangY, Zhang T* and Zhang Y*. Brain function abnormalities and neuroinflammationin people living with HIV-associated anxiety disorders. Front. Psychiatry 15:1336233.

8.       Zhang L, Cai M,Zhang X, Wang S, Pang L, Chen X, Zheng C, Sun Y, Liang Y, Guo S, Wei F*, ZhangY*. Integrated analysis of microbiome and host transcriptome unveilscorrelations between lung microbiota and host immunity in bronchoalveolarlavage fluid of pneumocystis pneumonia patients. Microbes Infect. 2024 Jun6:105374.

9.       Liang Y, ChenX, Zhang X, Guo C*, Zhang Y*. Virus-driven dysregulation of the BCRpathway: a potential mechanism for the high prevalence of HIV related B-celllymphoma. Ann Hematol. 2024 Dec;103(12):4839-4849.

10.   Liu P, Ben H, Guo J, Pang L, Liu N, Wang Y, Shi Y, Yang P,Gao Y, Guan Y, Lu S, Zhang Y*, Li B*, Chen D*. Highly sensitivesingle-molecule counting technology for cytokeratin 18 detection innon-alcoholic fatty liver disease using novel antibodies. Microchemical Journal.2024;198:0026-265X.

11.    Chen X, Wei J, LiZ, Zhang Y, Zhang X, Zhang L, Wang X, Zhang Y*, Zhang T*. Dysregulationof Gut Microbiota-Derived Neuromodulatory Amino Acid Metabolism in HumanImmunodeficiency Virus-Associated Neurocognitive Disorder: An IntegrativeMetagenomic and Metabolomic Analysis. Ann Neurol 2024 Aug;96(2):306-320.

12.    Chen X, Wei J,Zhang Y, Zhang Y*, Zhang T*. Crosstalk between gut microbiome andneuroinflammation in pathogenesis of HIV-associated neurocognitive disorder. J Neurol Sci 2024Feb 15:457:122889.

13.    Zhang L, Cai M, SuB, Ma Y*, Zhang Y*. Mitochondrial Metabolism in Alveolar Macrophages ofPatients Infected with HIV, Tuberculosis, and HIV/Tuberculosis. AIDS Res HumRetroviruses. 2024 Mar;40(3):148-157.

14.   Cui X, Chen F , Zhao J, Li D, Hu M, Chen X, Zhang Y*, Han L* . Involvement of JNK signaling in Aspergillus fumigatus-inducedinflammatory factors release in bronchial epithelial cells. Sci Rep. 2023 Jan23;13(1):1293.

15.   Zhang X, Chen X, Zhang L, Sun Y, Liang Y, Li H, ZhangY*. Role of trigger receptor 2 expressed on myeloid cells inneuroinflammation－neglectedmultidimensional regulation of microglia. Neurochem Int. 2023 Nov 3;171:105639.

16.    Sun Y, Cai M,Liang Y, Zhang Y*. Disruption of blood-brain barrier: effects of HIV Taton brain microvascular endothelial cells and tight junction proteins. J Neurovirol. 2023Dec;29(6):658-668.5.      

17.    Zhao L, Wang Y,Chen X, Yang L, Cai M, Zhang Z, Zhang Y*, Ma Y*. Clinicalcharacteristics of adult inpatients with Measles in Beijing from 2010 to 2021:a retrospective analysis. BMC Infect Dis. 2023 May 9;23(1):312.

18.   Qiao L, Cui X, Jia L, Gao Y, Wang W, Wei F, Zhang Z, ChenD*, Ma Y*, Zhang Y*. Peripheral immune phenotypes and T cell receptorrepertoire in pneumocystis pneumonia in HIV-1 infected patients. Clin Immunol.2022 Apr; 237:108985.

19.    Chen X, Jia L,Zhang X, Zhang T*, Zhang Y*. One arrow for two targets: potentialco-treatment regimens for lymphoma and HIV. Blood Rev. 2022 Sep; 55:100965.

20.    Zhang Y, Chen X,Jia L, Zhang Y*. Potential mechanism of SARS-CoV-2-associated centraland peripheral nervous system impairment. Acta Neurol Scand. 2022Sep;146(3):225-236.

21.    Zhang Z, Zhang X,Chen X, Cui X, Cai M, Yang L, Zhang Y*. Clinical Features of HumanBrucellosis and Risk Factors for Focal Complications: A Retrospective Analysisin a Tertiary-Care Hospital in Beijing, China. Int J Gen Med. 2022 Sep 19;15:7373-7382.

22.    Chen X, Ding W,Cui X, Wei J, Zhang Y, Zhang T*, Zhang Y*. HIV protease inhibitorattenuated astrocyte autophagy involvement in inflammation via p38 MAPKpathway, Antiviral Research, 2022, 208(105463).

23.    Zhang Y, Gao Y, Qiao L,Wang W, Chen D. Inflammatory Response Cells During Acute Respiratory DistressSyndrome in Patients with Coronavirus Disease 2019 (COVID-19). Annals ofinternal medicine 2020; 173(5):402-404.

二、重要奖项

中华医学科技二等奖和北京市科技二等奖各1项。

三、专利

渠亚超; 杨丽珺; 刘梅; 张玉林; 马霞; 孙蕊芸; 王金环; 刘松涛; 魏乔欣 ; 一种用于辅助静脉穿刺的装置, 2023-3-21, 中国, ZL 2022 2 2065244.0