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陈欧阳，现任首都医科大学宣武医院神经疾病高创中心医师及副研究员。于第二军医大学获得临床医学学士学位，并在Duke University取得神经生物学博士学位。专注于中枢与周围神经系统相互作用对阿尔茨海默病发病机制的影响研究。曾独立负责多个重要课题，包括探索淋巴瘤小鼠模型中神经性瘙痒的机制和治疗方法，并指导多名本科生和研究生。在Cell、Journal of Clinical Investigation、Science Immunology、Neuron、Trends in Neuroscience、Pain等知名期刊发表多篇研究论文。此外，还拥有一项国家发明专利和三项实用新型专利。通过结合临床实践与前沿科学研究，致力于推动神经科学的发展。邮箱：chenouyang@xwhosp.org。
国家自然科学基金青年项目，82401407，“阿尔茨海默病中脊髓小胶质细胞TLR4 激活导致慢性疼痛的机制研究”，2025.1-2027.12
首都医科大学优秀青年人才项目（B类），“中枢与周围神经系统相互作用在阿尔茨海默病发病机制中的作用”，2025.1-2027.12
1. Chen O*, He Q*, Han Q*, Furutani K*, Gu Y, Olexa M, Ji RR. Mechanisms and treatments of neuropathic itch in a mouse model of lymphoma. J Clin Invest. 2023 Feb 15;133(4):e160807. （共同第一作者）
2.Guo R*, Chen O*, Zhou Y, Bang S, Chandra S, Li Y, Chen G, Xie RG, He W, Xu J, Zhou R, Song S, Person KL, Moore MN, Alwin AR, Spasojevic I, Jackson MR, Olson SH, Caron MG, Slosky LM, Wetsel WC, Barak LS, Ji RR. Arrestin-biased allosteric modulator of neurotensin receptor 1 alleviates acute and chronic pain. Cell. 2025 May 15:S0092-8674(25)00508-2. （共同第一作者）
3. Chen O, Jiang C, Berta T, Powell Gray B, Furutani K, Sullenger BA, Ji RR. MicroRNA let-7b enhances spinal cord nociceptive synaptic transmission and induces acute and persistent pain through neuronal and microglial signaling. Pain. 2024 Aug 1;165(8):1824-1839. （第一作者）
4.Furutani K*, Chen O*, McGinnis A, Wang Y, Serhan CN, Hansen TV, Ji RR. Novel proresolving lipid mediator mimetic 3-oxa-PD1n-3 docosapentaenoic acid reduces acute and chronic itch by modulating excitatory and inhibitory synaptic transmission and astroglial secretion of lipocalin-2 in mice. Pain. 2023 Jun 1;164(6):1340-1354. （共同第一作者）
5. Bao C, Chen O, Sheng H, Zhang J, Luo Y, Hayes BW, Liang H, Liedtke W, Ji RR, Abraham SN. A mast cell-thermoregulatory neuron circuit axis regulates hypothermia in anaphylaxis. Sci Immunol. 2023 Mar 17;8(81):eadc9417. （其他情况）
6. Chen O*, Ye Z*, Cao Z, Manaenko A, Ning K, Zhai X, Zhang R, Zhang T, Chen X, Liu W, Sun X. Methane attenuates myocardial ischemia injury in rats through anti-oxidative, anti-apoptotic and anti-inflammatory actions. Free Radic Biol Med. 2016 Jan;90:1-11. (共同第一作者)
7. Chen O, Donnelly CR, Ji RR. Regulation of pain by neuro-immune interactions between macrophages and nociceptor sensory neurons. Curr Opin Neurobiol. 2020 Jun;62:17-25. （第一作者）
8. Luo X, Chen O, Wang Z, Bang S, Ji J, Lee SH, Huh Y, Furutani K, He Q, Tao X, Ko MC, Bortsov A, Donnelly CR, Chen Y, Nackley A, Berta T, Ji RR. IL-23/IL-17A/TRPV1 axis produces mechanical pain via macrophage-sensory neuron crosstalk in female mice. Neuron. 2021 Sep 1;109(17):2691-2706.（其他情况）
9. Wang K, Gu Y, Liao Y, Bang S, Donnelly CR, Chen O, Tao X, Mirando AJ, Hilton MJ, Ji RR. PD-1 blockade inhibits osteoclast formation and murine bone cancer pain. J Clin Invest. 2020 Jul 1;130(7):3603-3620. （其他情况）
10. Donnelly CR*, Chen O*, Ji RR. How Do Sensory Neurons Sense Danger Signals? Trends Neurosci. 2020 Oct;43(10):822-838. （共同第一作者）
11. Wang Z, Jiang C, Yao H, Chen O, Rahman S, Gu Y, Zhao J, Huh Y, Ji RR. Central opioid receptors mediate morphine-induced itch and chronic itch via disinhibition. Brain. 2021 Mar 3;144(2):665-681. （其他情况）
12. Ye Z, Chen O, Zhang R, Nakao A, Fan D, Zhang T, Gu Z, Tao H, Sun X. Methane Attenuates Hepatic Ischemia/Reperfusion Injury in Rats Through Antiapoptotic, Anti-Inflammatory, and Antioxidative Actions. Shock. 2015 Aug;44(2):181-7. （其他情况）
13. Wang L, Yao Y, He R, Meng Y, Li N, Zhang D, Xu J, Chen O, Cui J, Bian J, Zhang Y, Chen G, Deng X. Methane ameliorates spinal cord ischemia-reperfusion injury in rats: Antioxidant, anti-inflammatory and anti-apoptotic activity mediated by Nrf2 activation. Free Radic Biol Med. 2017 Feb;103:69-86. （其他情况）
14. Li H*, Chen O*, Ye Z, Zhang R, Hu H, Zhang N, Huang J, Liu W, Sun X. Inhalation of high concentrations of hydrogen ameliorates liver ischemia/reperfusion injury through A2A receptor mediated PI3K-Akt pathway. Biochem Pharmacol. 2017 Apr 15;130:83-92. （共同第一作者）
15. Chen O*, Cao Z*, Li H, Ye Z, Zhang R, Zhang N, Huang J, Zhang T, Wang L, Han L, Liu W, Sun X. High-concentration hydrogen protects mouse heart against ischemia/reperfusion injury through activation of thePI3K/Akt1 pathway. Sci Rep. 2017 Nov 1;7(1):14871. （共同第一作者）
16. Zhai X, Lin H, Chen Y, Chen X, Shi J, Chen O, Li J, Sun X. Hyperbaric oxygen preconditioning ameliorates hypoxia-ischemia brain damage by activating Nrf2 expression in vivo and in vitro. Free Radic Res. 2016;50(4):454-66. （其他情况）
17. Li H, Wang YJ, Wang SR, Chen OY. Comments and hypotheses on the mechanism of methane against ischemia/reperfusion injury. Med Gas Res. 2017 Jun 30;7(2):120-123. （通讯作者）
18. Chandra S, Wang Z, Tao X, Chen O, Luo X, Ji RR, Bortsov AV. Computer-aided Discovery of a New Nav1.7 Inhibitor for Treatment of Pain and Itch. Anesthesiology. 2020 Sep;133(3):611-627. （其他情况）
19. Chen O, Luo X, Ji RR. Macrophages and microglia in inflammation and neuroinflammation underlying different pain states. Med Rev (2021). 2023 Nov 1;3(5):381-407. （第一作者）
20. Nesman JI, Chen O, Luo X, Ji RR, Serhan CN, Hansen TV. A new synthetic protectin D1 analog 3-oxa-PD1n-3 DPA reduces neuropathic pain and chronic itch in mice. Org Biomol Chem. 2021 Mar 28;19(12):2744-2752. （其他情况）
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