导师风采
牟雯君
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Personal Information

  • 副研究员
  • 导师类别:硕士生导师
  • 性别: 女
  • 学历:博士研究生
  • 学位:博士

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Contact Information

  • 所属院系:附属北京儿童医院
  • 所属专业:
  • 邮箱 : jenywenjun@126.com
  • 工作电话 : -
  • 研究方向Research Directions
原发性免疫缺陷
2. 机电结构优化与控制 研究内容:在对机电结构进行分析和优化的基础上,运用控制理论进行结构参数的调整,使结构性能满足设计要求。1. 仿生结构材料拓扑优化设计, 仿生机械设计 研究内容:以仿生结构为研究对象,运用连续体结构拓扑优化设计理论和方法,对多相仿生结构(机构)材料进行2. 机电结构优化与控制 研究内容:在对机电结构进行分析和优化的基础上,运用控制理论进行结构参数的调整,使结构性能满足设计要求。1. 仿生结构材料拓扑优化设计, 仿生机械设计 研究内容:以仿生结构为研究对象,运用连续体结构拓扑优化设计理论和方法,对多相仿生结构(机构)材料进行整体布局设计。 整体布局设计。
研究成果

1.     Lu Z.J., Mou W.J., He J.X., Ge X.D., Wang X.L., Gui J.G., Spontaneous NETosis and type I IFN signaling activation in resting neutrophils of chronic granulomatous disease patients with CYBB mutations. Genes & diseases. 2024 Nov;11(6):101118. PMID: 39070548

2.     Lu Z.J., Wang X.L., Feng J., Chai W.J., Wang W., Wang Q.X., Yang S., Yang W., Su Y., Mou W.J., Peng Y., Wang H.M., Gui J.G., Intratumoral CXCR4hi neutrophils display ferroptotic and immunosuppressive signatures in hepatoblastoma. Front Immunol. 2024 Feb 29:15:1363454. PMID: 38487536

3.     Mou W.J., Zhao Z.P., Gao L.W., Fu L.B., Jiao A.X., Guo Y., Chen L.Q., Wang H., Liu J., Qin Q., Xu B.P., Liu X.Y., He J.X., Gui J.G., An Atypical Incontinentia Pigmenti Female with Persistent Mucocutaneous Hyperinflammation and Immunodeficiency Caused by a Novel Germline IKBKG Missense Mutation. J Clin Immunol. 2023 Nov;43(8):2165-2180. PMID: 37831401

4.     Cheng H.Y., Zhang L., Yang S., Ren Q.H., Chang S.S., Jin Y.Q., Mou W.J., Qin H., Yang W., Zhang X.W., Zhang W.C., Wang H.M., Integration of clinical characteristics and molecular signatures of the tumor microenvironment to predict the prognosis of neuroblastoma. J Mol Med (Berl). 2023 Nov;101(11):1421-1436. PMID: 37712965

5.     Mou W.J., Yang Z.X., Wang X.J., Hei M.Y., Wang Y.J., Gui J.G., Immunological Assessment of a Patient with Omenn Syndrome Resulting from Compound Heterozygous Mutations in the RAG1 Gene. Immunogenetics. 2023 Aug;75(4):385-393. PMID: 37269334

6.     Xiao H.J., Mou W.J. (co-first author), Zhang R., Guo X., Chen H.Y., Zhang L.Q., Liu G., Gui J.G., Manifestations of B-cell expansion with NF-kB and T-cell Anergy disease overlapping with Hemophagocytic Lymphohistiocytosis. Scand J Immunol. 2023 Apr;97(4):e13256. PMID: 37401643

7.     Gu H., Mou W.J. (co-first author), Chen Z.P., Xie X.J., Yao J.F., Zhang R., Wu R.H., Gui J.G., Case report: Effectiveness of sirolimus in treating partial DiGeorge Syndrome with Autoimmune Lymphoproliferative Syndrome (ALPS)-like features. Front Pediatr. 2023 Jan 18:10:1014249. PMID: 36741091

8.     Yao J.F., Gu H., Mou W.J. (co-first author), Chen Z.P., Ma J., Ma H.H., Li N., Zhang R., Wang T.Y., Jiang J., Wu R.H., Various phenotypes of LRBA gene with compound heterozygous variation: A case series report of pediatric cytopenia patients. Int J Immunopathol Pharmacol. 2022 Jan-Dec;36:3946320221125591. PMID: 36074705

9.     Liu R.N., Muliadi V., Mou W.J., Li H.X., Yuan J., Holmberg J., Chambers B.J., Ullah N., Wurth J., Alzrigat M., Schlisio S., Carow B., Larsson L.G., Rottenberg M.E., HIF-1 stabilization in T cells hampers the control of Mycobacterium tuberculosis infection. Nat Commun. 2022 Sep 05;13(1):5093. PMID: 36064840

10.  Pei M.M., Chai W.J., Wang X.L., Duan Y.L., Wang H., Xi Y., Mou W.J., Wang W., Chen X., Zhang H., Li Q.L., Song W.Q., Wang H.M., Ma X.L., Gui J.G., The transcription factor TOX is involved in the regulation of T-cell exhaustion in neuroblastoma. Immunol Lett. 2022 Jun 09; 248 :16-25. PMID: 35691410

11.  Wang H., Wang X.L., Wang W., Chai W.J., Song W.Q., Zhang H., Mou W.J., Pei M.M., Su Y., Ma X.L., Gui J.G., Interleukin-15 enhanced the survival of human γδT cells by regulating the expression of Mcl-1 in neuroblastoma. Cell Death Discov. 2022 Mar 29;8(1):139. PMID: 35351861

12.  Chen X., Liu F., Zheng B.Y., Kang X.H., Wang X.L., Mou W.J., Zhang H., Jiao A.X., Zhao S.Y., Gui J.G., Exhausted and Apoptotic BALF T Cells in Proinflammatory Airway Milieu at Acute Phase of Severe Mycoplasma Pneumoniae Pneumonia in Children. Front Immunol. 2022 Jan 17:12:760488. PMID: 35111152

13.  Mou W.J., Yang S., Guo R.L., Fu L.B., Zhang L., Guo W.H., Du J.B., He J.X., Ren Q.H., Hao C.J., Gui J.G., Huang J.S., A novel homozygous TTC7A missense mutation results in familial multiple intestinal atresia and combined immunodeficiency. Front Immunol. 2021 Dec 15;12:759308. PMID: 34975848

14.  Mou W.J., Gao L.W., He J.X., Yin J., Xu B.P., Gui J.G., Compound heterozygous DCLRE1C mutations lead to clinically typical Severe Combined Immunodeficiency presenting with Graft Versus Host Disease. Immunogenetics.2021 Dec;73(6):425-434. PMID: 34406419

15.  Wang W., Xu Z.F., Zhang J., Wang S.C., Ge W.T., Li X.D., Mou W.J., Wang X.L., Chai W.J., Zhao J., Wang G.X., Xi Y., Qiu Y., Ji T.T., Gui J.G., Tai J., Ni X., Tim-3 is a potential regulator that inhibits monocyte inflammation in response to intermittent hypoxia in children with obstructive sleep apnea syndrome. Clin Immunol. 2021 Jan;222:108641. PMID: 33271370

16.  Basile J.I., Liu R.N., Mou W.J., Gao Y., Carow B., Rottenberg M.E., Mycobacteria-Specific T Cells Are Generated in the Lung During Mucosal BCG Immunization or Infection with Mycobacterium tuberculosis. Front Immunol. 2020 Oct 22;11:566319. PMID: 33193338

17.  Chai W.J., Wang X.L., Wang W., Wang H., Mou W.J., Gui J.G., Decreased glycolysis induced dysfunction of NK cells in Henoch-Schonlein purpura patients. BMC Immunol. 2020 Oct 9;21(1):53. PMID: 33036556

18.  Zhang H., Chai W.J., Yang W., Han W., Mou W.J., Xi Y., Chen X., Wang H., Wang W., Qin H., Wang H.M., Ma X.L., Wang X.L., Gui J.G., The increased IL-17-producing γδT cells promote tumor cell proliferation and migration in neuroblastoma. Clin Immunol. 2020 Feb;211:108343. PMID: 31931123

19.  Wang X.L., Mou W.J., Han W., Xi Y., Chen X., Zhang H., Qin H., Wang H.M., Ma X.L., Gui J.G., Diminished cytolytic activity of γδ T cells with reduced DNAM-1 expression in neuroblastoma patients. Clin Immunol. 2019Jun;203:63-71. PMID: 30999035

20.  Wang X.L., Mou W.J. (co-first author), Qi Z., Chen X., Zhang H., Jiao H., Wang X.J., Wang Y.J., Gui J.G., Neonates are armed with deviated immune cell proportion and cytokine reduction but higher T cell proliferation potentiality. Acta Biochim Biophys Sin (Shanghai). 2018 Sep 1;50(9):934-937. PMID: 30052714

21.  Wang S., Mou W.J. (co-first author), Xu Z., Gui J.G., Ma L., Autosomal recessive hyper-IgE syndrome in two brothers of a Chinese family with a novel mutation in DOCK8 gene. J Eur Acad Dermatol Venereol. 2018 Aug;32(8): e302-e304. PMID: 29419892

22.  Mou W.J., Han W., Ma X.L., Wang X.L., Qin H., Zhao W., Ren X.Y., Chen X., Yang W., Cheng H.Y., Wang X.S., Zhang H., Ni X., Wang H.M., Gui J.G., γδTFH Cells Promote B cell Maturation and Antibody Production in Neuroblastoma. BMC Immunol. 2017 Jul 7;18(1):36. PMID: 28687069

23.  Ren X.Y., Mou W.J. (co-first author), Su C., Chen X., Zhang H., Cao B.Y., Li X.Q., Wu D., Ni X., Gui J.G., Gong C.X., Increase in Peripheral Blood Intermediate Monocytes is Associated with the Development of Recent-Onset Type 1 Diabetes Mellitus in Children. Int J Biol Sci. 2017 Feb 5;13(2):209-218. PMID: 28255273

24.  Mou W.J., He J.X., Chen X., Zhang H., Ren X.Y., Wu X.Y., Ni X., Xu B.P., Gui J.G., A novel deletion mutation in IL2RG gene results in X-linked severe combined immunodeficiency with an atypical phenotype. Immunogenetics.2017 Jan; 69(1):29-38. PMID: 27566612

25.  Chen X., Zhang H., Mou W.J., Qi Z., Ren X.Y., Wang G.L., Jiao H., Kong X.H., Gui J.G., Flow cytometric analysesof the viability, surface marker expression and function of lymphocytes from children following cryopreservation.Mol Med Rep. 2016 Nov;14(5):4301-4308. PMID: 27665781

26.  Zhang Z.H., Yin J., Yang J., Shen W.Z., Zhang C.Y., Mou W.J., Luo J.H., Yan H., Sun P.Q., Luo Y.P., Tian Y.P., Xiang R., miR-885-5p suppresses hepatocellular carcinoma metastasis and inhibits Wnt/β-catenin signaling pathway.Oncotarget. 2016 Nov 15;7(46):75038-75051. PMID: 27738331

27.  Sun Q.Y., Jia X.W., Gao J., Zhang P.J., Mou W.J., Yang C.E., Tong H.L., Wen X.Y., Tian Y.P., Identification and characterization of novel serum microRNAs in unstable angina pectoris and subclinical atherosclerotic patients. Exp Cell Res. 2015 May 1;333(2):220-227. PMID: 25728006

28.  Mou W.J., Xu Y.X., Ye Y.J., Chen S., Li X.F., Gong K.Z., Liu Y.H., Chen Y.N., Li X.R., Tian Y.P., Xiang R., Li N., Expression of Sox2 in breast cancer cells promotes the recruitment of M2 macrophages to tumor microenvironment. Cancer Lett. 2015 Mar 28;358(2):115-123. PMID: 25444903

29.  Qi Z., Mou W.J., He J.X., Gui J.G., General Characteristics of Human Neonate Immunity. Am. J. Biomed. Sci. 2014, 6 (4), 265-277.

30.  Mou W.J., Liu Z.Q., Luo Y., Zou M., Ren C., Zhang C.Y., Wen X.Y., Wang Y., Tian Y.P., Development and cross-validation of prognostic models to assess the treatment effect of cisplatin/pemetrexed chemotherapy in lung adenocarcinoma patients. Med Oncol. 2014 Sep;31(9):59. PMID: 25119500

31.  Sun Q.Y., Jia X.W., Gao J., Mou W.J., Tong H.L., Wen X.Y., Tian Y.P., Association of serum homocysteine levels with the severity and calcification of coronary atherosclerotic plaques detected by coronary CT angiography. Int Angiol. 2014 Aug;33(4):316-323. PMID: 25056163

32.  Mou W.J., Xue H., Tong H.L., Sun S.J., Zhang Z.H., Zhang C.Y., Sun Q.Y., Dong J., Wen X.Y., Yan G.T., Tian Y.P., Prognostic value of serum leptin in advanced lung adenocarcinoma patients with cisplatin/pemetrexed chemotherapy. Oncol Lett. 2014 Jun;7(6):2073-2078. PMID: 24932291

33.  Mou W.J., Tong H.L., Ren C., Zhang C.Y., Gao Y.H., Wen X.Y., Tian Y.P., Serum Proteomic Profiling of Lung Adenocarcinoma with Brain Metastasis Based on Matrix-Assisted Laser Ionization Time of Flight Mass Spectrometry Analysis. Am. J. Biomed. Sci. 2014, 6(2), 105-116.

34.  Chen S., Li X.F., Lu D., Xu Y.X., Mou W.J., Wang L.N., Chen Y.N., Li X.Y., Li L.Y., Liu L., Stupack D., ReisfeldR.A., Xiang R., Li N.. SOX2 regulates apoptosis through MAP4K4-survivin signaling pathway in human lung cancer cells. Carcinogenesis. 2014 Mar;35(3):613-623. PMID: 24233838

35.  Zhang C.Y., Wang S.H., Huang W.R., Guo G.H., Zhang Z.H., Mou W.J., Yu Li, Tian Y.P., A Novel Differential Predict Model Based on Matrix-Assisted Laser Ionization Time-of-Flight Mass Spectrometry and Serum Ferritin for Acute Graft-versus-Host Disease. Biomed Res Int. 2013;2013:563751. PMID: 24195075

36.  Chen S., Xu Y.X., Chen Y.N., Li X.F., Mou W.J., Wang L.N., Liu Y.H., Reisfeld R.A., Xiang R., Lv D., Li N., SOX2 gene regulates the transcriptional network of oncogenes and affects tumorigenesis of human lung cancer cells. PloS One. 2012;7(5):e36326. PMID: 22615765

37.  Jia X.P., Li X.F., Xu Y.X., Zhang S., Mou W.J., Liu Y.H., Liu Y., Lv D., Liu C.H., Tan X.Y., Xiang R., Li N., SOX2 promotes tumorigenesis and increases the anti-apoptotic property of human prostate cancer cell. J Mol Cell Biol. 2011Aug;3(4):230-238. PMID: 21415100


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