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高娜娜,女,1983 年 5 月生,中共党员,北京协和医学院微生物与生化药学专业博士,国家卫生健康委科学技术研究所博士后,副研究员、副教授、硕士研究生导师。现任职于首都医科大学附属北京世纪坛医院科技处,曾在医院中心实验室从事抗抑郁药物药理学评价工作;发表多篇高质量学术论文,其中多篇发表于 CNS Neuroscience & Therapeutics 等国际期刊,主持国家自然科学基金青年科学基金、中国博士后基金面上项目等多项课题。
1.国家自然科学基金青年科学基金—新型化合物GW117通过5-HT2C受体抗焦虑作用的机制研究(82204351,2023.01-2026.12,30万元,在研)
2.中国博士后基金面上项目—以人BRDT为靶点的抗生育药物筛选模型的建立和优化(2014M550678,2014.04-2015.12,5万元,结题
3.中国铁路总公司科技研究开发计划—以BRDT为靶点的新型非甾体男性抗生育药物的理性化筛选和先导化合物的发现(J2016Z031 ,2016.06-2017.12,5万元,结题)
4.北京世纪坛医院青年科学基金—锶(Sr)拮抗糖皮质激素性骨质疏松症的机制研究(2016-q08,2017.01-2018.12,1.5万元,结题
1.Nana Gao; Wei Zheng; Tiliwaerdi.Murezhate; Wei Gu; Xiaorong Li; Zengliang Jin*; GW117: A novel serotonin (5-HT2C ) receptor antagonist and melatonin (MT1/MT2)receptor agonist with potential antidepressant like activity in rodents. cns Neuroscience & Therapeutics, 2021 Jun;27(6):702-713.影响因子:7.035
2.Nana Gao; Murezati Tiliwaerde; Wei Zheng; Jie Xiong; Xiaorong Li; Zengliang Jin*;Neuropharmacological and antidepressant-like effects of ZY1408: A novel serotonin/norepinephrine reuptake inhibitor and serotonin receptor 2C antagonist. Neuropharmacology, 2021 Jan;182:108376. 影响因子:5.273
3.Tiliwaerde M, Gao N, Yang Y, Jin Z. A novel NMDA receptor modulator: the antidepressant effect and mechanism of GW043. CNS Neurosci Ther. 2024 Feb;30(2):e14598. 影响因子:4.8
4.Yang YQ, Tiliwaerde M, Gao NN, Zhang TT, Ji HX, Gu W, Jin ZL. Mechanism of GW117 antidepressant action: melatonin receptor-mediated regulation of sleep rhythm. Eur J Pharmacol. 2024 Feb 5;964:176299. 影响因子:4.2
5.Gao Nana; Ren Jixia; Hou Li; Zhou Yue; Xin Ling; Wang Jiedong; Yu Heming; Xie Yong#*; Wang Huiping*; Identification of novel potent human testis-specific and bromodomain containing protein (BRDT) inhibitors using crystal structure based virtual screening, International Journal of Molecular Medicine, 2016, 38(1): 39-4.影响因子:3.098
6.Nana Gao ;Wei Jiang; Hai Gao; Zhong Cheng; Huolian Qian; Shuyi Si* and Yong Xie*.Structural Basis of Human Transcription Factor Sry-related Box 17 Binding to DNA. Protein & Peptide Letters. 2012, 4(20): 484-488.影响因子:1.735
7.Wang Yong#,Ma Ting-Ting#,Gao Na Na#Zhou Xiaoling,Jiang Hong, ,Guo Rui, Jia Lina, Chang Hong, Gao Ying, Gao Zhimin,
Pan Lei.(共同第一作者) Effect of Tongxinluo onpulmonary hypertension and pulmonary vascular remodeling in rats exposed to a low pressure hypoxic environment, Journal of Ethopharmacology, 2016, 194:668-673. 影响因子:3.055.
8.高娜娜,贾平平,石汉平.酰基甘油激酶敲低对结直肠肿瘤细胞HCT116增殖迁移的影响[J].肿瘤代谢与营养电子杂志,2021,8(01):62-66.

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