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赵晖副教授长期从事孤独症的大动物如食蟹猴和家犬模型的构建和机制研究，主持国自然青年基金一项，成果以第一作者和通讯作者（共同）发表在Cell Research, Cell Discovery,National Science Review, Molecular Psychiatry, Molecular Autism, Translational Psychiatry等国际刊物。主持参与了SHANK3突变猴，CHD8突变猴，VPA药物诱导猴模型研究孤独症。孤独症是一类神经发育异常，影响了大约1%的儿童，虽然找到了大量致病基因和风险因子并构建了啮齿动物模型，但是仍缺乏明确的共性病理变化机制，孤独症小鼠模型的发现与病人脑组织变化吻合性差。赵晖于2017年博士毕业后开始构建Shank3突变犬模型并大量繁育，希望通过研究更接近人类的大动物，复现病人中出现的病理变化和行为异常，并给出区别于小鼠模型的新机制解释。针对新的病理机制解释，在家犬模型开发孤独症干预措施和治疗手段。
团队成员享受每天撸狗的福利。
国家自然科学基金委员会, 青年科学基金项目, 32100783, 自闭症相关基因CHD8在非人灵长类大脑发育中的作用, 2022-01-01 至 2024-12-31, 30万元, 结题, 主持
中国博士后科学基金会, 面上资助, 2019M653106, Shank3突变自闭症家犬模型的创建, 2019-05 至 2020-11, 8万元, 结题, 主持
国家自然科学基金委员会, 青年科学基金项目, 32100783, 自闭症相关基因CHD8在非人灵长类大脑发育中的作用, 2022-01-01 至 2024-12-31, 30万元, 在研, 主持
中国博士后科学基金会, 面上资助, 2019M653106, Shank3突变自闭症家犬模型的创建, 2019-05 至2020-11, 8万元, 结题, 主持
1. Hui Zhao*, Yong-hui Jiang,Yong Q Zhang#. Gene-edited caninesas emerging models for studies on mental disorders, National ScienceReview, 2025, nwaf263. https://doi.org/10.1093/nsr/nwaf263
2. Feipeng Zhu*, Qi Shi*, Yong-Hui Jiang, Yong Q Zhang#, Hui Zhao#. Impairedsynaptic function and hyperexcitability of the pyramidal neurons in theprefrontal cortex of autism-associated Shank3 mutant dogs, Molecular Autism,2024, 15, 9. DOI: 10.1186/s13229-024-00587-4
3. Rui Tian*, Yuan Li*, Hui Zhao*,Wen Lyu, Jianping Zhao, Xiaomin Wang, Heng Lu, Huijuan Xu, Wei Ren, Qing-quanTan, Qi Shi, Guo-dong Wang, Ya-ping Zhang, Liangxue Lai, Jidong Mi#, Yong-hui Jiang#, Yong Q. Zhang#.Modeling SHANK3-associated autism spectrum disorder in Beagle dogs viaCRISPR/Cas9 gene editing, Molecular Psychiatry, 2023, 28, 3739-3750. DOI: 10.1038/s41380-023-02276-9
4. Bang Li*, Hui Zhao*, ZhuchiTu*, Weili Yang*, Rui Han, Lu Wang, Xiaopeng Luo, Mingtian Pan, Xiusheng Chen,Jiawei Zhang, Huijuan Xu, Xiangyu Guo, Sen Yan, Peng Yin, Zhiguang Zhao,Jianrong Liu, Yafeng Luo, Yuefeng Li, Zhengyi Yang, Baogui Zhang, Zhiqiang Tan,Hao Xu, Tianzi Jiang, Yong-hui Jiang, Shihua Li, Yong Q. Zhang#, Xiao-Jiang Li#. CHD8 mutations increase gliogenesis to enlarge brain size in thenon-human primate, Cell Discovery, 2023, 9, 27. DOI:10.1038/s41421-023-00525-3
5. Hui Zhao*, Enqi Liu, Yong Q.Zhang#. Dog models of humanatherosclerotic vascular diseases. Mammalian Genome, 2022, 34, 262-269. DOI:10.1007/s00335-022-09965-w
6. Hui Zhao*, Jianping Zhao*, DiWu*, Zhaolin Sun*, Yang Hua, Min Zheng, Yumei Liu, Qi Yang, Xiahe Huang, YuanLi, Yueshan Piao, Yingchun Wang, Sin Man Lam, Huijuan Xu, Guanghou Shui,Yongjun Wang, Haifeng Yao, Liangxue Lai, Zhuo Du, Jidong Mi#, Enqi Liu#, Xunming Ji#, Yong Q. Zhang#. Dogs lacking Apolipoprotein E show advanced atherosclerosisleading to apparent clinical complications. Science China-Life Sciences, 2022,65, 1342-1356. DOI: 10.1007/s11427-021-2006-y
7. Hui Zhao*, Qiqi Wang*, TingYan, Yu Zhang, Hui-juan Xu, Hao-peng Yu, Zhuchi Tu, Xiangyu Guo, Yong-hui Jiang#, Xiao-jiang Li, Huihui Zhou#, Yong Q. Zhang#. Maternal valproic acid exposure leads to neurogenesis defectsand autism-like behaviors in non-human primates, Translational Psychiatry,2019, 9, 0-267. DOI: 10.1038/s41398-019-0608-1
8. Zhuchi Tu*, Hui Zhao*, BangLi*, Sen Yan, Lu Wang, Yongjin Tang, Zhujun Li, Dazhang Bai, Caijuan Li, YingqiLin, Yuefeng Li, Jianrong Liu, Hao Xu, Xiangyu Guo, Yong-hui Jiang#, Yong Q. Zhang# and Xiao-Jiang Li#.CRISPR/Cas9-mediated disruption of SHANK3 in monkey leads to drug-treatableautism-like symptoms, Human Molecular Genetics, 2019, 28, 561–571. DOI:10.1093/hmg/ddy367
9. Hui Zhao*, Yong-hui Jiang,and Yong Q. Zhang#. Modeling Autismin Non-human Primates: Opportunities and Challenges. Autism Research, 2018, 11,686-694. DOI: 10.1002/aur.1945
10. Hui Zhao*, Zhuchi Tu*,Huijuan Xu, Sen Yan, Huanhuan Yan, Yinghui Zheng, Weili Yang, Jiezhao Zheng,Zhujun Li, Rui Tian, Youming Lu, Xiangyu Guo, Yong-hui Jiang#, Xiao-Jiang Li#, Yong Q. Zhang#.Altered neurogenesis and disrupted expression of synaptic proteins inprefrontal cortex of SHANK3-deficient non-human primate, Cell Research, 2017,27, 1293-1297. DOI: 10.1038/cr.2017.95
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