导师风采
鲁玲玲
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个人信息

Personal Information

  • 副教授
  • 导师类别:硕士生导师
  • 性别: 女
  • 学历:博士研究生
  • 学位:博士

联系方式

Contact Information

  • 所属院系:基础医学院
  • 所属专业: 神经生物学
  • 邮箱 : lllu@ccmu.edu.cn
  • 工作电话 : -

个人简介

Personal Profile

鲁玲玲,女,神经生物学博士、副教授。兼任中国研究型医院学会神经再生与修复专业委员会委员、北京神经内科学会基础与转化医学分会委员、《解放军医学杂志》青年编委。主要从事帕金森病发病机制研究,试图从致病基因、机体内外环境等不同角度和层面探究疾病的发生原因与发展规律,最终目标是为疾病的早诊皁治提供新思路。目前相关研究已发表论文70 余篇,其中 SCI 收录论文 20 余篇。研究成果引起广泛关注,其中单篇最高被引216次,单篇最高影响因子15.1。申请者主持国家自然科学基金、北京市自然科学基金及北京市教委等基金多项。入选“北京市委组织部优秀人才”及“北京市属高等学校高层次人才引进与培养三年行动计划-青年拔尖人才培育计划”。获北京及华北八省市解剖学会学术年会优秀论文奖,北京市神经科学会学术年会优秀展板一等奖,美国神经科学会 Travelaward,日本神经科学会学术年会优秀展板奖等。


  • 研究方向Research Directions
帕金森病的发病机制
2. 机电结构优化与控制 研究内容:在对机电结构进行分析和优化的基础上,运用控制理论进行结构参数的调整,使结构性能满足设计要求。1. 仿生结构材料拓扑优化设计, 仿生机械设计 研究内容:以仿生结构为研究对象,运用连续体结构拓扑优化设计理论和方法,对多相仿生结构(机构)材料进行2. 机电结构优化与控制 研究内容:在对机电结构进行分析和优化的基础上,运用控制理论进行结构参数的调整,使结构性能满足设计要求。1. 仿生结构材料拓扑优化设计, 仿生机械设计 研究内容:以仿生结构为研究对象,运用连续体结构拓扑优化设计理论和方法,对多相仿生结构(机构)材料进行整体布局设计。 整体布局设计。
研究成果

发表论文  

1.  Yi Li#,Ning Chen#,Chao Wu#, Yongquan Lu,Chunli Duan, Ge Gao, Hui Yang, Lingling Lu*,Galectin-1inhibited microglia activation and ameliorated neurodegenerative process in PDmodel by modulating MAPK/IκB/NFκB axis through its Carbohydrate-recognitiondomain. Brain behavior and immunity. 83(2020):214-225

2.       Lingling Lu, Huanzhen Jia, Ge Gao, Chunli Duan, JingRen, Yi Li, Hui Yang. Pink1 regulates tyrosine hydroxylase expression and dopaminesynthesis.  J Alzheimers Dis. 2018;63(4):1361-1371

3.     Lingling Lu, Shasha Zhao, Ge Gao, Xiaohong Sun, Huanying Zhao, HuiYang.DJ-1/PARK7 but not its L166P mutant, linked to autosomal recessiveParkinsonism, modulates the transcriptional activity of the orphan nuclearreceptor Nurr1 in vitro and in vivo. Melecular Neurobiology.  2016,53(10):7363-7374.

4.       Lingling Lu,Chunyan Zhang, Qing Cai, Qiang Lu, Chunli Duan, Yuangang Zhu, and Hui Yang.Voltage-dependent anion channel involved in the alpha-synuclein induceddopaminergic neuron toxicity in rats. Acta Biochimica et Biophysica Sinica2013, 45(3):170-8

5.     Lingling Lu, Xiaohong Sun, Yujun Liu, Huanying Zhao, Shasha Zhao,Hui Yang. DJ-1upregulates tyrosine hydroxylase gene expression by activating itstranscriptional factor Nurr1 via the ERK1/2 pathway. Int J Biochem Cell Biol 2012, 44(1): 65-71

6.     Lingling Lu, Li Gu, Yuan Liang, Chunli Zhao, Huanying Zhao,Xiaohong Sun, Chunli Duan, Hui Yang. Dual effects of α-synuclein on neurotoxicityinduced by low dosage of rotenone are dependent on exposure time indopaminergic neuroblastoma cells. Science inChina Series C: Life Science,2010,53(5): 590-597

7.     Lingling Lu, Chunli Zhao, Yujun Liu, Xiaohong Sun,Chunli Duan, Man Ji, Huanying Zhao, Qunyuan Xu and Hui Yang. Therapeuticbenefit of TH-engineered mesenchymal stem cells for Parkinson's disease. BrainRes Protoc 2005, 15(1) : 46-51

8.     HaoTian, Yongquan Lu, Jia Liu, Weijin Liu, LinglingLu, Chunli Duan, Ge Gao, Hui Yang. Leucine Carboxyl MethyltransferaseDownregulation and Protein Phosphatase Methylesterase Upregulation ContributeToward the Inhibition of Protein Phosphatase 2A by α-Synuclein. Front AgingNeurosci. 2018,10:173.

9.     JiaLiu, Weijin Liu, Yongquan Lu, Hao Tian, LinglingLu, Ge Gao, Xia Wu, Xiaomin Wang &Hui Yang. Piperlonguminerestores the balance of autophagy and apoptosis by increasing BCL2phosphorylation in rotenone-induced Parkinson disease models. Autophagy. 2018,13:1-17.

10.  JiaLiu, Xue Wang, Yongquan Lu, Chunli Duan, Ge Gao,  Lingling Lu, HuiYang.Pink1 interacts with α-synuclein and abrogates α-synuclein-inducedneurotoxicity by activating autophagy. Cell Death Dis. 2017, 8(9):e3056.

11.  MinChen,Jia Liu,YongquanLu,Chunli Duan,Lingling Lu,Ge Gao,Piu Chan, Shun Yu,Hui Yang. Age-dependent alpha-synuclein accumulationis correlated with elevation of mitochondrial TRPC3 in the brains of monkeys andmice. J Neural Transm 2017, 124:441–453

12.  JiaLiu, Min Chen, Xue Wang, Yi Wang, Chunli Duan, Ge Gao, Lingling Lu, Xia Wu, Xiaomin Wang and Hui Yang. Piperineinduces autophagy by enhancing protein phosphatase 2A activity in arotenone-induced Parkinson’s disease model. Oncotarget. 2016, 7(38):60823-60843

13.  TingtingDu, Le Wang, Chunli Duan, Lingling Lu, Jianliang Zhang, Ge Gao,Xiaobo Qiu, Xiaomin Wang, Hui Yang. GBA deficiency promotes SNCA/a-synucleinaccumulation through autophagic inhibition by inactivated  PP2A. Autophagy, 2015  11(10) 1803—1820

14.  JiameiShen, Tingting Du, Wang Xue, Chunli Duan, Ge Gao, Jianliang Zhang, LinglingLu, Hui Yang. α-Synuclein amino terminus regulates mitochondrialmembrane permeability. Brain research, 591: 14-26

15.  Hua Gao, Weiwei Yang, Zhifeng Qi, Lingling Lu, Chunli Duan, Chunli Zhao, Hui Yang. DJ-1 protects dopaminergicneurons against rotenone-induced apoptosis by enhancing ERK dependentmitophagy. J Mol Biol 2012, 423:232-8

16.  ZhifengQi, Weiwei Yang, Yanying Liu, Tao Cui, Hua Gao, Chunli Duan, Lingling Lu, Chunli Zhao,Huanying Zhao, Hui Yang. Loss of PINK1 function decreases PP2A activity andpromotes autophagy in dopaminergic cells and a murine model. NeurochemInt 2011, 59(5): 572-81

17.  Li Gu,Tao Cui, Chunxiang Fan, Huanying Zhao, Chunli Zhao, Lingling Lu, Hui Yang. Involvement of ERK1/2 signalingpathway in DJ-1-induced neuroprotection against oxidative stress. Biochem andBiophys Res Commun 2010, 383(4): 469-74

18.  DongmeiLiu,Ling Jiu,Hao Wang,Huanying Zhao,ChunliZhao,Chunli Duan,                        Lingling Lu,Bo Wu,Shun Yu,Piu Chan,Yaohua Li,Hui Yang. Silencing a-synuclein gene expression enhancestyrosine hydroxylase activity in MN9D cells. Neurochem Res 2008, 33(7): 1401-9

19.  Na Li,Hui Yang, Lingling Lu, ChunliDuan, Chunli Zhao, Huanying Zhao. Spontaneous expression of neural phenotype andNGF, TrkA, TrkB genes in marrow stromal cells. Biochem and Biophys Res Commun2007,356(3): 561-8

20.  Na Li,Hui Yang, Lingling Lu, ChunliDuan, Chunli Zhao, Huanying Zhao. Comparison of the labeling efficiency ofBrdU, DiI and FISH labeling techniques in bone marrow stromal cells. Brain Res 2007,1215: 11-9 (IF: 2.623)

21.    PINK1 suppresses alpha-synuclein-induced neuronal injury:a novel mechanism in protein phosphatase 2A activation. Weiwei Yang, Xue Wang, Jia Liu, ChunliDuan, Ge Gao, Lingling Lu, Shun Yu, Hui Yang Oncotarget. 2018Jan 2; 9(1): 37–53. 

参编著作:

《迷走神经刺激术》参编,人民卫生出版社,2019年第一版第一次印刷。ISBN978-7-117-28935-1

 


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