1.北京市自然科学基金-首都临床医学创新联合基金申请书医工融合交叉项目，项目批准号：L2510032，2026.1.1-2028.12.31，金额50万（主持）

1.北京市自然科学基金-首都临床医学创新联合基金申请书医工融合交叉项目，项目批准号：L2510032，2026.1.1-2028.12.31，金额50万（主持）

2.国家自然科学基金重点项目，项目批准号：81830033，2019.1.1-2023.12.31， 金额15万（乙方负责人）

3. 国家自然科学基金委青年基金，项目批准号：81200995，2013.1。1-2015.12.31，金额 23万（主持）

4. 国家自然科学基金项目，项目批准号：30950003，2010.1-2010.12，金额 10万（主持）

5. 北京市自然科学基金面上项目，项目批准号：7192017，2019.1.1-2021.12.31，金额20万 （主持）

6. 北京市自然科学基金面上项目, 项目批准号： 5102007, 2010.1.1-2011.12.31,金额 11万（主持）

7. 北京市青年拔尖人才项目, 项目批准号：CIT&TCD201404179, 2014.1.1-2016.12.31,金额30万（主持）

8. 北京市教育委员会科技发展计划一般项目，项目批准号：KM201710025001， 2017。1.1-2019.12.31，金额20万（主持）

9. 北京市优秀人才培养资助项目，项目批准号：20081d0501800210，2008.1。1-2010.12.31，金额4万（主持）

发表论文  

1. Jing Ren#，Chao Wu#，MengxiaZeng，MingqinQu，Ge Gao，Ning Chen，Jingjing Yue，YuwenJiang，TongfeiZhao，Na Xiang，Fangang Meng，Lingling Lu* A novel functionfor a-synuclein as a regulator of NCK2 in olfactory bulb: Implications for itsrole in olfaction. Cell Biosci 14, 139 (2024). DOI: https://doi.org/10.1186/s13578-024-01313-6

2. Yi Li#,Ning Chen#,Chao Wu#, Yongquan Lu,Chunli Duan,Ge Gao, Hui Yang, Lingling Lu*，Galectin-1inhibited microglia activation andameliorated neurodegenerative process in PDmodel by modulating MAPK/IκB/NFκBaxis through its Carbohydrate-recognitiondomain. Brain behavior and immunity.83（2020）：214-225

3.  Lingling Lu, Huanzhen Jia, Ge Gao,Chunli Duan, JingRen, Yi Li, Hui Yang. Pink1 regulates tyrosine hydroxylaseexpression and dopaminesynthesis.  J AlzheimersDis. 2018;63(4):1361-1371

4.  Lingling Lu, Shasha Zhao, Ge Gao, Xiaohong Sun, Huanying Zhao,HuiYang.DJ-1/PARK7 but not its L166P mutant, linked to autosomalrecessiveParkinsonism, modulates the transcriptional activity of the orphannuclearreceptor Nurr1 in vitro and in vivo. Melecular Neurobiology. 2016,53(10):7363-7374.

5. Lingling Lu,Chunyan Zhang, Qing Cai, Qiang Lu, Chunli Duan, Yuangang Zhu, andHui Yang.Voltage-dependent anion channel involved in the alpha-synucleininduceddopaminergic neuron toxicity in rats. Acta Biochimica et BiophysicaSinica2013, 45(3):170-8

6. Lingling Lu, Xiaohong Sun, Yujun Liu, Huanying Zhao, Shasha Zhao,Hui Yang.DJ-1upregulates tyrosine hydroxylase gene expression by activatingitstranscriptional factor Nurr1 via the ERK1/2 pathway. Int J Biochem Cell Biol2012, 44(1): 65-71

7. Lingling Lu, Li Gu, Yuan Liang, Chunli Zhao, Huanying Zhao,Xiaohong Sun, ChunliDuan, Hui Yang. Dual effects of α-synuclein on neurotoxicityinduced by lowdosage of rotenone are dependent on exposure time indopaminergic neuroblastomacells. Science inChina Series C: Life Science，2010,53(5):590-597

8. Lingling Lu, Chunli Zhao, Yujun Liu, Xiaohong Sun,Chunli Duan, Man Ji, HuanyingZhao, Qunyuan Xu and Hui Yang. Therapeuticbenefit of TH-engineered mesenchymalstem cells for Parkinson's disease. BrainRes Protoc 2005, 15(1) : 46-51

9. HaoTian, Yongquan Lu, Jia Liu, Weijin Liu, LinglingLu,Chunli Duan, Ge Gao, Hui Yang. Leucine Carboxyl MethyltransferaseDownregulationand Protein Phosphatase Methylesterase Upregulation ContributeToward theInhibition of Protein Phosphatase 2A by α-Synuclein. Front AgingNeurosci.2018,10:173.

10. JiaLiu,Weijin Liu, Yongquan Lu, Hao Tian, LinglingLu, Ge Gao, Xia Wu, Xiaomin Wang &Hui Yang. Piperlonguminerestores the balance ofautophagy and apoptosis by increasing BCL2phosphorylation in rotenone-inducedParkinson disease models. Autophagy. 2018,13:1-17.

11. JiaLiu, Xue Wang, Yongquan Lu, Chunli Duan, Ge Gao,  Lingling Lu, HuiYang.Pink1interacts with α-synuclein and abrogates α-synuclein-inducedneurotoxicity byactivating autophagy. Cell Death Dis. 2017, 8(9):e3056.

12.  MinChen，Jia Liu，YongquanLu，Chunli Duan，Lingling Lu，Ge Gao，Piu Chan， Shun Yu，Hui Yang. Age-dependent alpha-synuclein accumulationis correlatedwith elevation of mitochondrial TRPC3 in the brains of monkeys andmice. JNeural Transm 2017, 124:441–453

13. JiaLiu, Min Chen, Xue Wang, Yi Wang, Chunli Duan, Ge Gao, Lingling Lu, Xia Wu, Xiaomin Wang andHui Yang. Piperineinduces autophagy by enhancing protein phosphatase 2Aactivity in arotenone-induced Parkinson’s disease model. Oncotarget. 2016,7(38):60823-60843

14. TingtingDu, Le Wang, Chunli Duan, Lingling Lu, Jianliang Zhang, GeGao,Xiaobo Qiu, Xiaomin Wang, Hui Yang. GBA deficiency promotesSNCA/a-synucleinaccumulation through autophagic inhibition by inactivated PP2A. Autophagy, 2015  11（10） 1803—1820

15. JiameiShen, Tingting Du, Wang Xue, Chunli Duan, Ge Gao,Jianliang Zhang, LinglingLu, Hui Yang. α-Synuclein amino terminus regulatesmitochondrialmembrane permeability. Brain research, 591: 14-26

16. Hua Gao, Weiwei Yang, Zhifeng Qi, Lingling Lu, Chunli Duan, Chunli Zhao,Hui Yang. DJ-1 protects dopaminergicneurons against rotenone-induced apoptosisby enhancing ERK dependentmitophagy. J Mol Biol 2012, 423:232-8

17. ZhifengQi, Weiwei Yang, Yanying Liu, Tao Cui, Hua Gao,Chunli Duan, Lingling Lu,Chunli Zhao,Huanying Zhao, Hui Yang. Loss of PINK1 function decreases PP2Aactivity andpromotes autophagy in dopaminergic cells and a murine model.NeurochemInt 2011, 59(5): 572-81

18. Li Gu,Tao Cui, Chunxiang Fan, Huanying Zhao, Chunli Zhao, Lingling Lu, Hui Yang. Involvement ofERK1/2 signalingpathway in DJ-1-induced neuroprotection against oxidativestress. Biochem andBiophys Res Commun 2010, 383(4): 469-74

19. DongmeiLiu，Ling Jiu，Hao Wang，Huanying Zhao，ChunliZhao，Chunli Duan, Lingling Lu，Bo Wu，Shun Yu，Piu Chan，Yaohua Li，Hui Yang. Silencinga-synuclein gene expression enhancestyrosine hydroxylase activity in MN9Dcells. Neurochem Res 2008, 33(7): 1401-9

20. Na Li,Hui Yang, Lingling Lu, ChunliDuan, Chunli Zhao, Huanying Zhao. Spontaneous expression ofneural phenotype andNGF, TrkA, TrkB genes in marrow stromal cells. Biochem andBiophys Res Commun2007,356(3): 561-8

21. Na Li,Hui Yang, Lingling Lu, ChunliDuan, Chunli Zhao, Huanying Zhao. Comparison of the labelingefficiency ofBrdU, DiI and FISH labeling techniques in bone marrow stromalcells. Brain Res 2007,1215: 11-9 (IF: 2.623)

参编著作：

《迷走神经刺激术》参编，人民卫生出版社，2019年第一版第一次印刷。ISBN978-7-117-28935-1