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2013－2019年就读于北京大学生命科学学院（博士）。2019年－2023年进入首都医科大学基础医学院从事博士后阶段研究。2023年加入首都医科大学基础医学院生理学系任副教授。研究方向为神经元突触结构形成和突触传递调控的分子机制的研究，发现RPH3A, PORCN, ABHD6等突触蛋白调控突触后NMDA和AMPA受体的膜表达和膜转运，进而调控NMDA和AMPA受体介导的突触传递。近五年以第一作者或通讯作者在NatureCommunications, PNAS, eLife 和Progress in Neurobiology等杂志上发表研究论文。
(1) 国家自然科学基金委员会, 青年科学基金项目, 32100763, 囊泡富集蛋白SNX5通过相分离调控SNARE蛋白复合物介导的囊泡释放, 2022-01-01 至 2024-12-31, 30万元, 在研, 主持
(1) Lei Yang; Mengping Wei; Yangzhen Wang; Jingtao Zhang;Sen Liu; Mengna Liu; Shanshan Wang; Ke Li; Zhaoqi Dong; Chen Zhang ;Rabphilin-3A undergoes phase separation to regulate GluN2A mobility and surfaceclustering, Nature Communications, 2023, 14(379): DOI:10.1038/s41467-023-36046-6(共同第一作者)
(2) Yang, Lei; Li, Rong-Chang; Xiang, Bin; Li, Yi-Chen;Wang, Li-Peng; Guo, Yun-Bo; Liang, Jing-Hui; Wang, Xiao-Ting; Hou, Tingting;Xing, Xin; Zhou, Zeng-Quan; Ye, Haihong; Feng, RenQing; Lakatta, Edward G.;Chai, Zhen; Wang, Shi-Qiang ; Transcriptional regulation of intermolecular Ca2+signaling in hibernating ground squirrel cardiomyocytes: Themyocardinjunctophilin axis, Proc Natl Acad Sci USA, 2021, 118(14):DOI:10.1073/pnas.2025333118 (共同第一作者)
(3) Lei Yang; Jingtao Zhang; Sen Liu; Yanning Zhang; LiWang; Xiaotong Wang; Shanshan Wang; Ke Li; Mengping Wei; Chen Zhang ;Establishment of transgenic fluorescent mice for labeling synapses andscreening synaptogenic adhesion molecules, Elife, 2024, 13(e81884): DOI:10.7554/eLife.81884(共同第一作者)
(4) Mengping Wei; Lei Yang; Feng Su; Ying Liu; Xinyi Zhao;Lin Luo; Xinyue Sun; Sen Liu;Zhaoqi Dong; Yong Zhang; Yun Stone Shi; JingLiang; Chen Zhang ; ABHD6 drives endocytosis of AMPA receptors to regulatesynaptic plasticity and learning flexibility, Progress in Neurobiology, 2024,233(102559): DOI:10.1016/j.pneurobio.2023.-102559 (共同第一作者)
(5) Wei, Mengping; Wang, Meng; Wang, Jue; Su, Feng; Wang, Yangzhen; Sun,Meng; Wang, Shanshan; Liu, Mengna; Wang, Hongyi; Lu, Mingyang; Li, Wei; Gong,Yutian; Yang, Lei; Zhang, Chen; PORCN Negatively Regulates AMPARFunction Independently of Subunit Composition and the AminoTerminal andCarboxy-Terminal Domains of AMPARs, Frontiers in Cell and DevelopmentalBiology, 2020, 8(829): DOI:10.3389/fcell.2020.00829 (共同通讯作者)
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