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首都医科大学医学病毒学研究室,一直以来以蚊媒病毒为研究对象,围绕病毒的致病机制与免疫预防手段开展研究。近年来,先后获得多项国家自然科学基金、北京市自然科学基金面上项目以及科技部重点研发计划等课题的支持。研究成果先后在Nature Communications, Cell Report, PLoS Pathogens, Antiviral Research, Journal of Virology, Vaccine, PLOS Neglected Tropical Diseases等本领域主流杂志上发表。
团队有9名工作人员组成, PI为安静教授,另外有1名教授、2名副教授、4名讲师和1名副主任技师,此外团队还包含多名博士研究生和硕士研究生。实验室方面,在拥有通用实验室仪器设备和平台的基础上,团队还拥有感染动物生物安全II级实验室,这为开展病毒学研究提供了重要基础。
(1)国家自然科学基金委员会,面上项目,32370163,中性粒细胞诱导胎盘血管内皮细胞铁死亡在登革病毒致宫内发育迟缓中机制的研究,2024-01-01至2027-12-31,50万元,在研,主持
(2)国家自然科学基金委员会,青年科学基金项目,81902048,Sertoli细胞自噬支持寨卡病毒在睾丸持续复制机制的研究,2020-01-01至2022-12-31,20万元,结题,主持
1. Zhang Y, Sheng Z, Chen Q, Zhou A, Cao J, Xue F, Ye Y, Wu N, Gao N, Fan D, Liu L, Li Y, Wang P, Liang L, Zhou D, Zhang F, Li F, An J. Neutrophil infiltration leads to fetal growth restriction by impairing the placental vasculature in DENV-infected pregnant mice. EBioMedicine. 2023 Sep;95:104739.
2. Ziyang Sheng*; Man Li*; Rui Yang; Yonghua Liu; Xiaoxiong Yin; Jiarong Mao; Heidi E Brown; Jing An; Hongning Zhou#; Peigang Wang#; COVID-19 prevention measures reduce dengue spread in Yunnan Province, China, but do not reduce established outbreak, Emerging Microbes &Infections, 2022, 11(1): 240-249
3. Yingying Zhang; Ziyang Sheng# ; Na Gao; Na Wu; Peigang Wang; Dongying Fan; Deshan Zhou; Gong Cheng; Jing An#; Zika Virus Infection in the Ovary Induces a Continuously Elevated Progesterone Level and Compromises Conception in Interferon Alpha/Beta Receptor-Deficient Mice, Journal of Virology, 2022, 96(2): e0118921
4. Ziyang Sheng; Na Gao; Dongying Fan; Na Wu; Yingying Zhang; Daishu Han; Yun Zhang; Weilong Tan; Peigang Wang#; Jing An#; Zika virus disrupts the barrier structure and Absorption/Secretion functions of the epididymis in mice, PLoS Neglected Tropical Diseases, 2021, 15(3): e0009211
5. Ziyang Sheng; Hui Chen; Kaihao Feng; Na Gao; Ran Wang; Peigang Wang; Dongying Fan; Jing An; Electroporation-Mediated Immunization of a Candidate DNA Vaccine Expressing Dengue Virus Serotype 4 prM-E Antigen Confers Long-Term Protection in Mice, Virologica Sinica, 2019, 34(1): 88-96
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