本团队长期聚焦于呼吸疾病领域， 团队以临床问题为导向，结合分子生物学、多组学分析及动物模型，致力于阐明疾病发生发展的关键机制，并探索潜在干预靶点，推动研究成果向临床应用转化，我们的大家庭有呼吸科临床大夫/专家，基础研究专家，病理科大夫/专家、临床研究方法学资深顾问、以及来自清华、复旦、中科院、英国曼切斯特大学的强大合作体系。

1. 北京自然科学基金面上项目，《Rcn3介导内质网应激-自噬联动调控巨噬细胞极化在急性肺损伤中的作用机制研究》

2. 膜生物学全国重点实验室开放基金， 《内膜互作在肺纤维化中的作用和机制》

3. 分子发育生物学国家重点实验室开放课题，《高密度脂蛋白HDL功能异常对肺血管内皮细胞的影响以及在急性肺损伤中的作用机制》

4.  国家自然科学基金面上项目，《Rcn3在肺损伤修复失调导致的特发性肺纤维化中的生物学作用和调控机制的研究》

5. 北京自然科学基金面上项目，《内质网蛋白Rcn3在急性肺损伤导致的呼吸窘迫综合症中的生物学作用和调控机制的研究》

6. 北京呼吸所自主创新项，《Rcn3对肺成纤维细胞调控在肺损伤修复失调导致的特发性肺纤维化中的作用机制及临床应用的研究》

1.      DanniZan; Zhuo Xu, Fangping Ding; Xiaoqian Shi, Hong Chen; Yingmin Ma, JiaweiJin*, The upregulation of RCN3 in sepsis facilitatesmonocyte-to-macrophage differentiation through modulating autophagy. Chin Med J(Engl). 2026.

2.       Fangping Din, Liu Yang, Wenhui Cao, JieSun, Fengwei Shi, Yingfei Wang, Caixia Hu, Weiwei Kang, Jing Han, Qingkun Song,Yingmin Ma*, Jiawei Jin*, Plasma RCN3 is a novel biomarker forthe early diagnosis of hepatopulmonary syndrome in cirrhotic patients. LUNG; 2025;203(1):50.

3.       Yang, L., Z. Xu, Z. Wang, F. Ding, Z. Wu,X. Shi, J. Wang, Y. Ma*, and J. Jin*, Increased pro-SFTPB in HDLpromotes the pro-inflammatory transition of HDL and represents a sign of poorprognosis in ARDS patients. Journal of Translational Medicine, 2025. 23(1): p.75. 

4.      DingF, Wang Z, Wang J*, Ma Y*, Jin J*. Serum S1P levelin interstitial lung disease (ILD) is a potential biomarker reflecting theseverity of pulmonary function. BMC Pulmonary Medicine; 2024;24.

5.      Wu M,Wang Z, Shi X, Zan D, Chen H, Yang S, Ding F, Yang L, Tan P, Ma RZ, Wang J, MaL, Ma Y, Jin J*. TGFβ1-RCN3-TGFBR1 loop facilitates pulmonaryfibrosis by orchestrating fibroblast activation. Respir Res. 2023 Sep14;24(1):222. 

6.      DingF, Yang L, Wang Y, Wang J, Ma Y, Jin J*.Serum Rcn3 level is a potential diagnostic biomarker for connective tissuedisease-associated interstitial lung disease and reflects the severity ofpulmonary function. BMC Pulm Med. 2023; 23(1):68. 

7.       Zhang Y, Shi X, Sheng H, Hu Y, Pang B, MaY, Jin J*.Changes in diaphragm contractility in cigarette smoking-exposed and smokingcessation rats are associated with alterations in mitochondrial morphology andhomeostasis. Basic Clin Pharmacol Toxicol.2022 131(5):392-405.

8.      Li Z,Luo Z, Shi X, Pang B, Ma Y*, Jin J*. The Levels of OxidizedPhospholipids in High-Density Lipoprotein During the Course of Sepsis and TheirPrognostic Value. Front Immunol. 2022May 3;13:893-929. 

9.      XiaoqianShi, Xiaojie An, Liu Yang; Zhipeng Wu, Danni Zan, Zhaohong Li, Baosen Pang, YanChen, Jiujie Li, Pingping Tan, Runlin Z. Ma, Qiuhong Fang, Yingmin Ma*, JiaweiJin*. Reticulocalbin 3 deficiency in alveolar epithelium attenuatedLPS-induced ALI via NFκB signaling. Am JPhysiol-Lung Cell Mol Physiol, 2021; 320(4):L627-L639. 

10.    Yang L, Luo Z, Shi X,Pang B, Ma Y, Jin J*. Different value of HDL-C in predicting outcome of ARDSsecondary to bacterial and viral pneumonia: A retrospective observationalstudy. Heart Lung. 2021 Jan-Feb;50(1):206-213.

11.    Haiyan Sheng, YijieZhang, Xiaoqian Shi, Yuhan Hu, Liu Yang, Baosen Pang, Jiawei Jin*, Yingmin Ma*.Functional, ultrastructural and transcriptomic changes in rat diaphragms withdifferent durations of cigarette smoke exposure. Int J COPD, 2020,15:3135-3145.

12.    Yang L, Liu S, Han S,Hu Y, Wu Z, Shi X, Pang B, Ma Y, Jin J*. The HDL from septic-ARDS patients withcomposition changes exacerbates pulmonary endothelial dysfunction and acutelung injury induced by cecal ligation and puncture (CLP) in mice. Respir Res.2020 Nov 4; 21(1):293.

13.    Jin J, Shi X, Li Y,Zhang Q, Guo Y, Li C, Tan P, Fang Q, Ma Y, Ma RZ. Reticulocalbin 3 Deficiencyin Alveolar Epithelium Exacerbated Bleomycin-induced Pulmonary Fibrosis. Am JRespir Cell Mol Biol. 2018 59(3): 320–333.

14.    Jin J, Li Y, Ren J,Lam SM, Zhang Y, Hou Y, Zhang X, Xu R, Shui G, Ma RZ. Neonatal RespiratoryFailure with Retarded Perinatal Lung Maturation in Mice Caused byReticulocalbin 3 Disruption. Am J Respir Cell Mol Biol. 2016, 54(3):410-23.