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首都医科大学附属北京朝阳医院神经内科主任，中华医学会神经病学分会委员，北京医学会神经病学分会副主任委员，北京神经内科学会副会长，中国卒中学会脑小血管病分会副主任委员，中国医院研究型学会脑小血管病专业委员会副主任委员，中华医学会北京神经病学分会常委兼神经重症专业组组长，北京神经内科学会神经重症专业委员会主任委员，国家远程医疗与互联网医学中心脑血管病与神经介入专业专家委员会主任委员，北京神经内科学会脑小血管病委员会副主任委员，国家卫健委脑小血管病委员会常委，北京医学会血栓和止血学会副主任委员等。
胡文立教授团队长期从事脑小血管病与认知功能障碍的基础与临床研究，建立脑小血管病影像学总负担评价体系，率先采用视觉等级划分标准发现WMH周围存在缺血半暗带，采用DCE-MRI技术观察脑小血管病血脑屏障破坏，发现血压变异性参与BG-EPVS的形成，使用PET动态扫描技术探讨WMH患者认知障碍的机制；首创霍乱毒素耦联钆对比剂的颅内成像技术；主导程序化撤机在神经危重症患者中的应用；研制和开发促醒系统设备等。
主持及参与国家级和北京市级项目10余项。
主持及参与国家级和北京市级项目10余项。
以第一/通讯作者发表SCI论文90余篇，中华核心期刊130余篇。
近五年主要研究成果：
1. Li X, Yang S, Li Y, Qin W, Yang L, Yuan J, Hu W*.The performance of patients with cerebral microbleeds in different cognitivetests: A cross-sectional study. Front Aging Neurosci. 2023;15: 1114426.
2. Yang S, Li X, Qin W, Yang L, Hu W*. AssociationBetween Large Numbers of Enlarged Perivascular Spaces in Basal Ganglia andMotor Performance in Elderly Individuals: A Cross-Sectional Study. Clin IntervAging. 2022;17: 903-913.
3. Li X, Yang S,Qin W, Yang L, Li Y, Hou Y, Huang Q, Hu W*. Cerebral Microbleeds WereRelated With Poor Cognitive Performances on the Dual Task Condition in OlderAdults. Front Aging Neurosci. 2022 Jan 10;13: 807753.
4. Guo H, Sun L, Shen X, Hu W*. A Retrospective Studyof the Clinical Characteristics of Japanese Encephalitis in Adults. J IntegrNeurosci. 2022;21(5): 125.
5. Yang S, Li X, Hu W*, Qin W, Yang L. EnlargedPerivascular Spaces in the Basal Ganglia Independently Related to GaitDisturbances in Older People With Cerebral Small Vessel Diseases. Front AgingNeurosci. 2022;14: 833702.
6. Yang S, Yin J, Qin W, Yang L, Hu W*. Poor SleepQuality Associated With Enlarged Perivascular Spaces in Patients With LacunarStroke. Front Neurol. 2022;12: 809217.
7. 胡文立*, 杨磊, 李譞婷等. 中国研究型医院学会脑小血管病专业委员会《中国脑小血管病诊治专家共识》编写组.中国脑小血管病诊治专家共识2021[J]. 中国卒中杂志, 2021, 16(7): 716-726.
8. Li M, Li Y, Zuo L, Hu W*, Jiang T. Increase ofblood-brain barrier leakage is related to cognitive decline in vascular mildcognitive impairment. BMC Neurol. 2021;21(1): 159.
9. Li X, Yuan J,Qin W, Yang L, Yang S, Li Y, Hu W*. Higher Total Cerebral Small VesselDisease Burden Was Associated With Mild Cognitive Impairment and OverallCognitive Dysfunction: A Propensity Score-Matched Case-Control Study. FrontAging Neurosci. 2021;13: 695732.
10. Li X, Yuan J, Qin W, Yang L, Yang S, Li Y, Hu W*.Cerebral Microbleeds Are Associated with Impairments in Executive Function andProcessing Speed. J Alzheimers Dis. 2021;81(1): 255-262.
11. Qin W, Wang X,Yang J, Hu W*. Coexistence of Anti-SOX1 and Anti-GABAB ReceptorAntibodies with Autoimmune Encephalitis in Small Cell Lung Cancer: A CaseReport. Clin Interv Aging. 2020;15: 171-175.
12. Qin W, Wang S,Yang L, Yuan J, Niu S, Hu W*. Correlation between Bispectral Index andPrognosis of Patients with Acute Cerebral Infarction. Curr Neurovasc Res.2021;18(4): 389-394.
13. Ji M, Niu S, Mi H, Jang P, Li Y, Hu W*.Antidepressant functions of Jie Yu Chu Fan capsule in promoting hippocampalnerve cell neurogenesis in a mouse model of chronic unpredictable mild stress.Ann Transl Med. 2020;8(16): 1020.
14. Yuan J, Wang Y, Hu W*, Bruno A. The reliabilityand validity of a novel Chinese version simplified modified Rankin scalequestionnaire (2011). BMC Neurol. 2020;20(1): 127.
15. Qin W, Zhang X,Yang L, Li Y, Yang S, Li X, Hu W*. Predictive value of the sequentialorgan failure assessment (SOFA) score for prognosis in patients with severeacute ischemic stroke: a retrospective study. J Int Med Res. 2020;48(8): 300060520950103.
16. Yang L, Yu L, Kong Y, Zhang X, Li Y, Yang S, Gu H, Gao S,Hu W*. Relationship between white matter hyperintensities and chronickidney disease in patients with acute lacunar stroke. Neurol Sci. 2020;41(11): 3307-3313.
17. Yang L, Qin W, Li Y, Yang S, Gu H, Hu W. Differentiationof Pontine Infarction by Size. Open Med (Wars). 2020;15: 160-166.
18. Liu D, Li K, Ma X, Li Y, Bu Q, Pan Z, Feng X, Shi Q, ZhouL, Hu W*. Correlations Between the Microstructural Changes of the MedialTemporal Cortex and Mild Cognitive Impairment in Patients With Cerebral SmallVascular Disease (cSVD): A Diffusion Kurtosis Imaging Study. Front Neurol.2020;10: 1378.
19. Yuan J, Song X, Kuan E, Wang S, Zuo L, Ongur D, Hu W*,Du F. The structural basis for interhemispheric functionalconnectivity: Evidence from individuals with agenesis of the corpus callosum. NeuroimageClin. 2020;28: 102425.
20. Qin W, Yin J, Yang L, Yang S, Li Y, Li X, Hu W*.The Relationship Between Chronic Obstructive Pulmonary Disease and CerebralSmall Vessel Disease Assessed by Magnetic Resonance Imaging: A Case-ControlStudy from a Single Center in Beijing, China. Med Sci Monit. 2020;26: e925703.
21. Yuan J, Jia Z, Song Y, Hu W*. External Validationof the Diagnosis of TIA (DOT) Score for Identification of TIA in a ChinesePopulation. Front Neurol. 2019;10: 796.
22. Chen Y, Fan H, Xu C, Hu W*, Yu B. EfficientCholera Toxin B Subunit-Based Nanoparticles with MRI Capability for DrugDelivery to the Brain Following Intranasal Administration. Macromol Biosci.2019;19(2): e1800340.
23. Yu L, Yang L, Zhang X, Yuan J, Li Y, Yang S, Gu H, HuW*, Gao S. Age and recurrent stroke are related to the severity of whitematter hyperintensities in lacunar infarction patients with diabetes. ClinInterv Aging. 2018;13: 2487-2494.
24. Ji M, Li S, Dong Q, Hu W*. Impact of EarlyHigh-protein Diet on Neurofunctional Recovery in Rats with Ischemic Stroke. MedSci Monit. 2018;24: 2235-2243.
25. Yang S, Yuan J,Qin W, Yang L, Fan H, Li Y, Hu W*. Twenty-four-hour ambulatory bloodpressure variability is associated with total magnetic resonance imaging burdenof cerebral small-vessel disease. Clin Interv Aging. 2018;13: 1419-1427.
26. Wang W, Hu W*. Salvianolic acid B recoverscognitive deficits and angiogenesis in a cerebral small vessel disease ratmodel via the STAT3/VEGF signaling pathway. Mol Med Rep. 2018 Feb;17(2): 3146-3151.
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