团队成员的教育及研究背景包括材料学、骨关节外科、微生物检验、细胞及分子生物学，多学科交叉的人员组合为研究生培养及课题的开展提供有利的条件。

（1）主持在研：

1.    北京市自然科学基金面上项目，7262224，项目名称：时空响应ROS自适应骨植入物表面构建及有序调节抗菌骨生成微环境的作用机理，2026-01至2028-12

2.    济南市“新高校20条”资助项目引进创新团队，202333029，项目名称：软硬组织再生修复和功能重建生物材料及器械开发，2024-01至2026-12

（2）参与在研：

 北京市自然科学基金-昌平创新联合基金重点项目，L254032，项目名称：骨折后复杂区域疼痛综合征临床队列多组学研究与诊疗模型构建，2025-07 至2028-06，在研，参与

1. 承担国自然、北自然及卫健委课题共16项。骨干参与国自然重点、国自然原创、北自然重点等重要项目12项；具有材料学、细胞及分子生物学、微生物学、药代动力学的交叉学科研究经验。

2. 共发表研究论文100篇，其中第一及通讯作者发表论文71篇，近五年以通讯及第一作者发表论文共32篇。JCR１区论文16篇；

3. 申请专利35项，已授权24项，其中发明专利18项。注重成果应用，转化纳米纤维敷料成果1项，骨止血材料成果1项；骨干协助完成人工颈椎间盘成果转化1项，与企业合作2项伤口闭合器件已经进入注册审查阶段。

近5年主要研究论文：

（1）通讯作者（英文）：

1.    Wei Chen#, Zhe Yi#, Xinran Wang#, Shuai Wang, Weichen Wang, Aijie Zhang, Fei Liu, Rui Shi*, Yudong Zheng*, Bo Liu*. Composite hydrogel-microsphere delivery system promotes early nerve-mediated bone regeneration and late-stage mechanotransduction-driven bone remodeling via sequential release of NGF and Yoda1. Bioactive Materials. 57 (2026): 531-550.

2.    You Zhou*,Zhengkai Han,Yunjin Li,Yun Xue,Jingshuang Zhang,Xinyue Zhang*,Rui Shi*. Bioactive Hydrogel-Interface-Modified Porous Titanium Alloy Scaffolds for Enhancing Osseointegration. Langmuir. 2025, 41(44): 29648-29657. 

3.    Hang Luo, Xiaoxiao Ma, Jingjing Yuan, Yongqiang Feng,* Lingxue Kong, Rui Shi,* and Yu Chen*.Construction and Performance Study of a Janus Dressing with Sustainable Drainage Function[J]. ACS Applied Materials & Interfaces, 2025, 17(18): 26178-26190.

4.    Xiangxiao Meng#, Fei Liu#, Yichun Dou, Chao Shi, Jingshuang Zhang, Xieyuan Jiang*, Rui Shi*. Injectable In-situ Curable Hydrogel for Medullary Cavity Hemostasis. Frontiers in Bioengineering and Biotechnology. 2025.

5.    Fei Liu, Yun Xue, You Zhou, Jingshuang Zhang, Aoao Wang, and Rui Shi*. Trends and Advances in Antimicrobial Surface Modification for Orthopedic Implants (2014–2024). Tissue Engineering Part C: Methods. 2025, 31(1):11-25.

6.    Hang Luo, Jueying Yang, Zhuo Xiang, Rui Shi*, Yu Chen*. Functional electrospinning Janus dressings with asymmetric surface wettability. Applied Materials Today. 2024, 41: 102445.

7.     Lei Ji, Yun Xue, Dong Wang, Yu Fan, You Zhou, Chuanan Shen*, Rui Shi*, Jiatao Zhang*. Ultrasound-responsive ZnS:Ag QDs loaded TiO2 biointerfaces: In situ sonodynamic antimicrobial therapy for biomedical implants. Chemical Engineering Journal. 2024, 497: 155694.

8.    Yun Xue, You Zhou, Chunyan Li, Jingshuang Zhang, Fei Liu and Rui Shi*. Causal relationship between Interleukin-27 expression levels and osteoporosis: a bidirectional mendelian randomization study. BMC Musculoskeletal Disorders. 2024, 25(1): 680.

9.    Chenlin Huang, Cheng Chi, Yu Zhao, Weiwei Liu, Liqun Zhang, Rui Shi*, Jiajia Xue*. A Periosteum-Bioinspired Electrospun Janus Membrane with Antibacterial and Osteogenic Dual Function. Macromolecular Bioscience. 2024, 24(6): e2300501. 

10.    Aoao Wang#, Xinbo Ma#, Yafeng Yang#, Guoliang Shi, Liwei Han, Xiantong Hu, Rui Shi*, Jun Yan*, Quanyi Guo* and Yantao Zhao*. Biophysical-driven piezoelectric and aligned nanofibrous scaffold promotes bone regeneration by reestablishing physiological electrical microenvironment. Nano Research. 2024, 17(8): 7376–7393.

11.   Chenlin Huang, Mingyue Xiao, Zehui Li, Zihong Fu, Rui Shi*. Bioinspired breathable biodegradable bioelastomer-based flexible wearable electronics for high-sensitivity human-interactive sensing. Chemical Engineering Journal. 2024, 486: 150013.

12.    Yichun Dou, Ling Zhang, Jiaqi Wang, Yun Xue, You Zhou, Yajun Liu*, Liqun Zhang*, Rui Shi*. Trends and Future Research in Skeletal Muscle Tissue Engineering in the Past Decade (2012–2022). Tissue Engineering Part C-Methods. 2024, 30(3): 130-141.

13.    Bolong Xu, Shanshan Li, Along Han, You Zhou, Mengxue Sun, Haokun Yang, Lirong Zheng, Rui Shi*, Huiyu Liu*. Engineering Atomically Dispersed Cu-N1S2 Sites via Chemical Vapor Deposition to Boost Enzyme-Like Activity for Efficient Tumor Therapy. Advanced Materials. 2024, 36(13): 2312024.

14.    Hui Wang, Jueying Yang, Wei Tian, Kelin Peng, Yun Xue, Haosen Zhao, Xilan Ma, Rui Shi*, Yu Chen*. A sodium alginate/carboxymethyl chitosan dual-crosslinked injectable hydrogel scaffold with tunable softness/hardness for bone regeneration. International Journal of Biological Macromolecules. 2024, 257: 128700.

15.    Bolong Xu, Shanshan Li, Rui Shi* and Huiyu Liu*. Multifunctional mesoporous silica nanoparticles for biomedical applications. Signal Transduction and Targeted Therapy. 2023, 8(1):435.

16.    Qingyuan Wu, Jie Zhang,Xueting Pan, Zhijun Huang, Haoyuan Zhang, Juan Guo, Yun Xue, Rui Shi,* andHuiyu Liu*. Vacancy Augmented Piezo-Sonosensitizer for Cancer Therapy. AdvancedScience. 2023, 10(26): 2301152. 

17.    Jingjing Ye, Min Gong, Jian Song, Shu Chen, QinghanMeng, Rui Shi#, Liqun Zhang# andJiajia Xue#. Integrating Inflammation-Responsive Prodrug with ElectrospunNanofibers for Anti-Inflammation Application. Pharmaceutics 2022, 14: 1273. 

18.    Kuan Hu#, Xiaohui Ma#, Lin Xie,Yiding Zhang, Masayuki Hanyu, Kotaro Nagatsu, Hisashi Suzuki , Rui Shi*, WeizhiWang*, Mingrong Zhang. Development of a stable peptide-based PET tracer fordetecting CD133- expressing cancer stem cells. ACS Omega.2021, 7(1): 334- 341.

19.    Xindan Zhang, Cheng Chi, Junjie Chen, Xiaodi Zhang,Min Gong, Xing Wang, Junhao Yan, RuiShi*, Liqun Zhang, Jiajia Xue*. Electrospun quad-axial nanofibers forcontrolled and sustained drug delivery. Materials & Design. 2021, 206:109732.

20.    Jing Zheng, Naureen Rahman, Longfei Li, JingshuangZhang, Haozhe Tan, Yun Xue, Yu Zhao, Jiliang Zhai, Nan Zhao, Fujian Xu, Liqun Zhang,Rui Shi*, Yuri Lvov*, Jiajia Xue*.Biofunctionalization of electrospun fiber membranes by LbL-collagen/chondroitinsulfate nanocoating followed by mineralization for bone regeneration. MaterialsScience and Engineering C. 2021, 128: 112295. 

21.    Yunfei Zhang, Kuan Hu, Xuan Xing, Jingshuang Zhang,Ming-Rong Zhang, Xiaohui Ma*, Rui Shi*,and Liqun Zhang*. Smart Titanium Coating Composed of AntibioticConjugated Peptides as an Infection-Responsive Antibacterial Agent.Macromolecular Bioscience, 2021, 21(1): e2000194. DOI: 10.1002/mabi.202000194 

（2）第一作者（英文）：

1.  Rui Shi＃, Fei Liu＃, Qihuang Qin, Pinxue Li, Ziqi Huo, You Zhou and Chunyan Jiang*. Bioinspired piezoelectric patch design for sonodynamic therapy: a preclinical mechanistic evaluation of rotator cuff repair and functional regeneration. Frontiers in Bioengineering and Biotechnology. 2025, 13: 1565347.  

2.   Rui Shi＃, Fei Liu＃, Qihuang Qin, Pinxue Li, Ziqi Huo, You Zhou and Chunyan Jiang*. Bioinspired piezoelectric patch design for sonodynamic therapy: a preclinical mechanistic evaluation of rotator cuff repair and functional regeneration. Frontiers in Bioengineering and Biotechnology. 2025, 13: 1565347. 

3.     Rui Shi, Jingshuang Zhang, Weiyang Li, Yi Zhang, Zequn Ma*, Chengai Wu*. An effective surfacemodification strategy to boost PEEK osteogenesis using porous CaP generated inwell-tuned collagen matrix. Applied Surface Science. 2021, 555: 149571. 

4.     RuiShi, Jingshuang Zhang, Kun Niu, WeiyangLi, Ni Jiang, Jianlin Li, Qingsong Yu*, Chengai Wu*.Electrospun Artificial Periosteum loaded with DFO Contributes to Osteogenesisvia the TGF-β1/Smad2 Pathway. Biomaterials Science. 2021, 9: 2090- 2102.

二. 已授权专利（按申请日由近及远排列）：

1.    石锐，薛芸，姜春岩。一种含外泌体的肩袖补片及其制备方法，申请日：2023.01.17，申请号/专利号202310077942.9。授权公告日2025.08.29，公告号CN 116196478 B。（申请人：北京市创伤骨科研究所、北京积水潭医院）

2.    李品学，姜春岩，李旭，石锐。基于生物打印的肌腱-纤维软骨-骨复合修复材料及其应用，申请日：2024.08.07，申请号/专利号202411074802.7。授权公告日2025.05.27，公告号CN 118976153 B。（申请人：首都医科大学附属北京积水潭医院）

3.    石锐，薛芸。一种抗菌促成骨金属植入物及其制备方法与应用，申请日2021.12.13，申请号/专利号202111515715.7。授权公告日2025.04.11，公告号CN 116262148 B。（申请人：北京市创伤骨科研究所）

4.    张灵，石锐，张立群，姜春岩。一种具有压电效应的肩袖补片及制备方法，申请日：2023.01.15，申请号/专利号202310060746.0。授权公告日2024.07.19，公告号CN 116370708 B。（申请人：北京化工大学、北京市创伤骨科研究所、北京积水潭医院）

5.    石锐，张静爽。一种仿生型“三明治”结构人工骨膜及其制备方法，申请日2021.6.7，申请号/专利号202110631057.1。授权公告日2022.7.26，公告号CN113368308 B。（申请人：北京市创伤骨科研究所）

6.    石锐，韩骁，田伟。人工颈椎间盘，申请日2021.5.25，申请号/专利号202121135780.2。授权公告日2021.12.14，公告号CN215130944 U。（申请人：北京市创伤骨科研究所、北京积水潭医院）

7.    石锐，薛芸。聚氧乙烯聚氧丙烯-壳聚糖嵌段共聚物、骨止血材料及其制备方法，申请日2021.3.24，申请号/专利号202110316641.8。授权公告日2022.4.1，公告号CN113061255 B。（申请人：北京市创伤骨科研究所）

8.    石锐。聚氨酯膜及其制备方法和应用，申请日2021.3.5，申请号/专利号202110248822.1。授权公告日2022.4.22，公告号CN113005773 B。（申请人：北京市创伤骨科研究所）

9.    石锐。皮肤逐层梯度缓释护理膜，申请日2021.2.3，申请号/专利号202110150386.4。授权公告日：2021.8.23，公告号：CN112957347B。（申请人：北京市创伤骨科研究所）

10.    石锐，刘波。伤口闭合修护组件，申请日2021.2.2，申请号/专利号202120309250.9。授权公告日2021.12.14，公告号CN215129372 U。（申请人：北京市创伤骨科研究所）

11.    石锐，韩骁，田伟。一种组合式弹性人工椎间盘，申请日2020.11.30，申请号/专利号202022827977.4。授权公告日2021.10.19，公告号CN 214414985U。（申请人：北京市创伤骨科研究所、北京积水潭医院）

12.    石锐，刘波，宋文超。一种皮肤牵张器组件，申请日2020.9.30，申请号/专利号202022208598.7。授权公告日2021.8.17，公告号CN213963491 U。（申请人：北京积水潭医院）

13.    李波，石锐，杨明辉，朱仕文，吴新宝，田伟。一种功能化的髓内钉内固定系统，申请日2020.7.3，申请号/专利号202021290949.7。授权公告日2021.6.22，公告号CN213489209 U。（申请人：北京积水潭医院、北京市创伤骨科研究所）

14.    石锐，李伟阳，田伟。一种负载去铁胺的人工骨膜及其制备方法，申请日2019.11.1，申请号/专利号201911061833.8。授权公告日2021.9.7，公告号CN 110665065 B。（申请人：北京市创伤骨科研究所）

15.    石锐，池骋，张静爽，李伟阳，田伟。一种多层同轴纤维骨修复膜材料及其制备方法， 申请日2017.8.18，申请号/专利号201710710641.X。授权公告日2020.7.14，公告号CN107625995 B。（申请人：北京市创伤骨科研究所）

16.    张立群，池骋，石锐，宫敏。一种四层同轴纤维伤口敷料及其制备方法。申请日2017.8.18，申请号/专利号201710710659.X。授权公告日2020.7.24，公告号CN 107397973 B。（申请人：北京化工大学）

17.    石锐，田伟。一种炎症响应型引导组织再生膜的制备方法，申请日2017.5.19，申请号/专利号201710355584.8。授权公告日2018.9.7，公告号CN 107213524 B。（申请人：北京市创伤骨科研究所、北京积水潭医院）

18.    张立群，叶静静，石锐，田伟。一种感染响应型引导组织再生膜的制备方法，申请日2016.12.30，申请号/专利号201611265580.2。授权公告日2020.1.10，公告号CN106693072 B。（申请人：北京化工大学、北京积水潭医院）

19.    石锐，耿欢，田伟，张立群。一种广谱抗菌型伤口护理膜及其制备方法，申请日2016.6.27，申请号/专利号201610483839.4。授权公告日2017.12.26，公告号CN 106166305 B。（申请人：北京市创伤骨科研究所、北京化工大学）

20.    张立群，宫敏，石锐，吴新宝，田伟。一种包含多载药缓释系统骨修复材料的制备方法，申请日2016.12.30，申请号/专利号201611265584.0。授权公告日2021.1.12，公告号CN 106730035 B。（申请人：北京化工大学、北京积水潭医院）