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首都医科大学教授,博士生导师,国家自然科学基金优秀青年基金(海外)项目获得者,中国中西医结合学会分子生药学专业委员会青年副主任委员。博士师从瑞典皇家工程院院士,中国工程院、美国国家科学院外籍院士Jens Nielsen教授,从事微生物合成生物学及代谢工程方向的研究。近五年在Nat. Catal.、Proc. Natl. Acad. Sci.、Metab. Eng.、Open Biol.等权威杂志上发表多篇学术成果,申请国际专利2项。以第一完成人获中国中西医结合学会科学技术一等奖一项。
1、国家自然科学基因优秀青年基金(海外)项目,主持
2、中药活性成分的解析、合成与活性评价, 中央本级重大增减支项目2060302, 2023至 2026, 主持
1、G Li, YHu, J Zrimec, H Luo, H Wang, A Zelezniak et al. Bayesian genome scalemodelling identifies thermal determinants of yeast metabolism. Naturecommunications, 2021, 12(1), 1-12.
2、Z Zhu*, Y Hu*, PG Teixeira, R Pereira, Y Chen, VSiewers et al. Multidimensional engineering of Saccharomyces cerevisiaefor efficient synthesis of medium-chain fatty acids. Nature Catalysis,2020, 3(1), 64-74.
3、Y Hu*, Z Zhu*, D Gradischnig, MWinkler, J Nielsen et al. Engineering carboxylic acid reductase for selectivesynthesis of medium-chain fatty alcohols in yeast. Proceeding of theNational Academy of Sciences. 2020, 117(37), 22974-22983.
4、Y Hu, Z Zhu, J Nielsen, V Siewers.Engineering Saccharomyces cerevisiae cells for production of fattyacid-derived biofuels and chemicals. Open biology, 2019, 9(5),190049.
5、Y Hu, Z Zhu, J Nielsen, V Siewers.Heterologous transporter expression for improved fatty alcohol secretion inyeast. Metabolic engineering, 2018, 45, 51-58.
6、YJ Zhou, Y Hu, Z Zhu, V Siewers, J Nielsen.Engineering 1-alkene biosynthesis and secretion by dynamic regulation in yeast.ACS synthetic biology, 2018, 7(2), 584-590.
7、Y Hu, YJ Zhou, J Bao, L Huang, JNielsen et al. Metabolic engineering of Saccharomyces cerevisiae forproduction of germacrene A, a precursor of beta-elemene. Journal ofIndustrial Microbiology and Biotechnology, 2017, 44(7), 1065-1072.
8、P Su, Y Tong, Q Cheng, Y Hu, M Zhang et al. Functionalcharacterization of ent-copalyl diphosphate synthase, kaurene synthase andkaurene oxidase in the Salvia miltiorrhiza gibberellin biosynthetic pathway. Scientificreports, 2016, 6(1), 1-8.
9、Q Cheng, P Su, Y Hu, Y He et al. RNAinterference-mediated repression of SmCPS (copalyldiphosphate synthase)expression in hairy roots of Salvia miltiorrhiza causes a decrease oftanshinones and sheds light on the functional role of SmCPS. Biotechnologyletters, 2014, 36(2), 363-369.
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