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王梦阳,男,神经病学博士,神经外科博士后,主任医师,副教授,硕导,首都医科大学三博脑科医院神经内科主任,癫痫中心副主任,中华医学会神经内科分会神经调控协作组委员、中国抗癫痫协会教育工作委员会副主委、中国抗癫痫协会谭启富癫痫外科发展专项基金管理委员会术前评估组副组长、中国抗癫痫协会青年委员会委员、中国抗癫痫协会神经调控专委会委员、中国抗癫痫协会SEEG专委会委员、中国抗癫痫协会药物专委会委员、中国研究型医院协会脑小血管病专委会委员、中国医疗保健国际交流促进会老年健康医学分会委员、北京医学会神经内科分会委员、北京医学会脑电图及神经电生理学分会常委、北京抗癫痫协会理事、北京神经内科学会脑小血管病专委会常委,北京神经内科学会癫痫专委会常委、中国循环学会神经变性专委会额颞叶痴呆及相关疾病学组委员、北京神经变性学会额颞叶痴呆及相关疾病专委会委员、中国医师协会神经外科医师分会神经电生理学组委员、中国医药教育学会睡眠专业委员会委员、首都医科大学临床心理学系委员、河北省人民医院功能神经外科客座教授。1993-2002年就读于中国人民解放军第四军医大学,获得学士、硕士学位,2006-2009年就读于北京协和医科大学,师从吴立文教授,获神经病学博士学位,专业方向为癫痫遗传学。2014-2017年,在栾国明教授指导下做博士后工作,专业方向为痫网络相关研究。2009年起就职于三博脑科医院,从事脑电图分析、癫痫诊疗及术前评估、脑功能定位、神经心理评估、神经精神疾病的经颅磁刺激诊疗等工作。目前在国内外专业期刊发表学术论文70余篇,主编专著1部,参编4部
神经内科团队40人,是首批中国抗癫痫协会综合三级癫痫中心和脑电图培训基地,包括神经内科医师10名、脑电图及术中监测技师15名、神经心理技师3名、护士12名,在癫痫诊疗技术方面位于全国前列,同时在多系统萎缩及帕金森病诊疗方面也具有一定特色。科室注重临床与科研相结合,依托北京脑重大疾病研究院的科研平台“北京市脑重大疾病重点实验室”(批准成立于2010年,是科技部和北京市的省部共建国家重点实验室培育基地),先后获得北京自然科学基金、首都卫生发展基因、首都特色临床基金,并参与多项国自然重大及面上项目、科技部及北京市科委重大项目。先后以第一作者及通讯作者发表SCI论文20余篇。目前研究方向主要为:1.脑电信号处理及癫痫网络研究;2.多系统萎缩的免疫及影像研究。
目前科研项目:中国生物技术发展中心,重大项目,2022ZD0205000,认知地图的神经机制,2022-08-01至2027-12-31,854万元,在研,参与,课题骨干,获得科研经费164万元。
2007.3-2009.7 美国强生公司3期国际多中心临床研究----333369(Carisbamate) 主要研究者助理, 负责双盲期及开放期除患者筛选外的全部实际操作内容的实施和管理
2008.1-2009.7 国产普瑞巴林作为添加药物治疗难治性癫痫的3期多中心临床研究 主要研究者助理, 负责双盲期及开放期除患者筛选外的全部实际操作内容的实施和管理
2008.3-2009.7 日本卫材公司唑泥沙胺作为添加药物治疗难治性癫痫的3期多中心临床研究 主要研究者助理, 负责开放期的全部实际操作内容的实施和管理
2011.3 赚写北京自然基金标书,获得2012年北京自然项目资助,课题排名第二,题目为“ PI3K/AKT/mTOR信号通路在局灶性皮质发育不良Ⅱb型中的作用"。
2012 获国家重点专科建设项目子项目,题目"局灶性癫痫发作顺序与神经元网络---颅内电极研究",项目负责人
2012 获首都医科大学基础与临床研究基金,题目“mTOR基因在局灶性皮质发育不良Ⅱb型发病机制中的作用”,项目负责人
2012 获首都卫生发展科研专项项目基金,题目“反向斑点杂交技术在预测抗癫痫药物致皮肤严重不良反应中的应用”,项目负责人
2015 中国博士后基金项目(题目:应用图论分析颞叶癫痫附加症癫痫网络拓扑属性,项目编号2015M571069), 项目负责人
2015 北京市博士后工作资助项目(题目:应用图论分析内侧颞叶结构在颞外癫痫网络中的地位,编号2015-ZZ-61), 项目负责人
2016 北京脑科学专项,脑认知与脑医学领域项目,Z161100002616016,效应连接在表达皮层脑功能图谱研究及神经外科手术评估中的应用,2016-06至2019-05,240 万元,参加
2017 国家自然科学基金委员会,面上项目,81671285,电相关癫痫网络效应连接构建及再癫痫外科中的应用,2017-01至2020-12,68.4万元,参加
2018 国家自然科学基金委员会,重大项目,81790652,癫痫病人脑连接的个体化特征分析,2018-01-01至2022-12-31,312.5万元,参加
2019 首都医科大学国自然培育项目(题目:微电极技术对于伴海马硬化颞叶癫痫发作起始的电生理特性研究)2019-2021, 5万元,项目负责人
2020 海淀区卫生健发展研究基金(题目:立体定向脑电图评估适应证分类标准的建立及临床评价),2020.1.1-2021.12.31,5万元,项目负责人
2021 国家自然科学基金委员会,国际(地区)合作与交流项目,32020103009,基于人类颅内脑电的睡眠期记忆再激活的神经机制研究,2021-01-01至2025-12-31,260万元,在研,参与
2022 中国生物技术发展中心,重大项目,2022ZD0205000,认知地图的神经机制,2022-08-01至2027-12-31,854万元,在研,参与
2024 海淀区卫生健发展研究基金(题目:应用MRI和DTI定量分析筛选多系统萎缩影像学诊断标志物的研究),2024.1-2025.12.31,5万元,在研,项目负责人
1. Wang X, Teng P, Meng Q, Jiang Y, Wu J, Li T, Wang M, Guan Y, Zhou J, Sheng J, Gao JH, Luan G. Performance of optically pumped magnetometer magnetoencephalography: validation in large samples and multiple tasks[J]. J Neural Eng. 2024 Dec 19;21(6).
2. 彭鑫涛,孙卫进,马凯强,王雄飞,周健,王梦阳,王静,李天富,栾国明,关宇光.迷走神经刺激术治疗超难治性癫痫持续状态2例[J].临床神经外科杂志,2024,21(3):262-266.
3. 彭鑫涛,丁浩然,孙卫进,王雄飞,周健,王梦阳,王静,李天富,栾国明,关宇光.改良大脑半球离断术治疗儿童Sturge-Weber综合征并发癫痫的疗效分析[J].中华神经外科杂志,2024,40(9):891-896.
4. Yang Y, Wang J, Wang X, Tang C, Deng J, Yan Z, Deng Q, Chen D, Zhou J, Guan Y, Wang M*, Li T*, Luan G*. Long-term effects of vagus nerve stimulation on EEG aperiodic components in patients with drug-resistant epilepsy[J]. Ther Adv Neurol Disord. 2024 Sep 25;17:17562864241279124.
5. Lv P, Chen D, Zhang H, Zhou W, Wang M, Grewe P, Axmacher N, Wang L. Context-dependent Grid-like Representations of Theta Power in Human Entorhinal Cortex[J]. Neurosci Bull. 2024 Aug 7.
6. Cui TY, Luan W, Tang CY, Wang XF, Guan YG, Wang J, Wang MY, Li TF, Luan GM, Zhou J. The long-term outcomes in drug-resistant epilepsy patients who underwent subtotal hemispherotomy: A single-center retrospective cohort study[J]. Clin Neurol Neurosurg. 2024 Jul 31;245:108468.
7. Wang S, Liu QZ, Zhao R, Zhai X, Zhang K, Cai L, Li S, Yang Z, Shan Y, Ma K, Li Y, Hu J, Sui L, Cheng H, Li X, Su J, Zhao M, Wang X, Zhou J, Wang M, Li T, Zhang J, Liang S, Luan G, Guan Y; SWS-CC collaborations. Seizure, Motor, and Cognitive Outcomes After Epilepsy Surgery for Patients With Sturge-Weber Syndrome: Results From a Multicenter Study[J]. Neurology. 2024 ,103(1):e209525.
8. Yan Z, Yang Y, Wang J, Deng Q, Zhang L, Wang M, Zhou J, Guan Y, Luan G, Wang M*. Posterior cingulate epilepsy: Seizure semiology and intracranial electrical stimulation using SEEG[J]. Seizure. 2024;119:28-35.
9. Huang Q, Xie P, Zhou J, Ding H, Liu Z, Li T, Guan Y, Wang M, Wang J, Teng P, Zhu M, Ma K, Wu H, Luan G, Zhai F. Predictors of seizure outcomes in stereo-electroencephalography-guided radio-frequency thermocoagulation for MRI-negative epilepsy[J]. Ther Adv Chronic Dis. 2024 Mar 15;15:20406223241236258.
10. Yan T, Song X, Ding X, Guan Z, Niu D, Li J, Wang M, Wang M*. Associations of allergy-related outcomes with depression in the US adults[J]. Environ Sci Pollut Res Int. 2023;30(54):115373-115380.
11. Wang M, Yan Z, Wang J, Yang Y, Deng Q, Han Y, Zhang L, Yang H, Pan J, Wang M*. The characteristics and alteration of peripheral immune function in patients with multiple system atrophy[J]. Front Neurol. 2023;14:1223076.
12. 王静,田小霖,王雄飞,王梦阳,栾国明.基于立体定向脑电图记录恐惧情绪的神经网络研究[J].中国现代神经疾病杂志[J], 2023,23(3):189-195.
13. 田小霖,王静,王雄飞,周健,王梦阳,关宇光,李天富,栾国明.癫痫术前评估中相关脑成像技术的应用及研究进展[J].癫痫与神经电生理学杂志,2023,32(2):113-116,125.
14. Yang Y, Chen D, Wang J, Wang J, Yan Z, Deng Q, Zhang L, Luan G*, Wang M*, Li T*. Dynamic evolution of the anterior cingulate-insula network during seizures[J]. CNS Neurosci Ther. 2023 Dec;29(12):3901-3912.
15. Liping Z, Jing W, Yujiao Y, Qinqin D, Zhaofen Y, Xinshan L, Shidan Z, Jian Z, Yuguang G, Changqing L, Guoming L, Mengyang W*. Semiology characteristics and location of epileptogenic zone in motor seizures of axial and shoulder girdle muscles assessed by video stereoelectroencephalography study in 65 patients[J]. Epileptic Disord. 2023 Feb;25(1):57-64.
16. Yang Y, Han Y, Wang J, Zhou Y, Chen D, Wang M*, Li T*. Effects of altered excitation-inhibition imbalance by repetitive transcranial magnetic stimulation for self-limited epilepsy with centrotemporal spikes[J]. Front Neurol. 2023;14:1164082.
17. Yin K, Lei X, Yan Z, Yang Y, Deng Q, Lu Q, Zhang X, Wang M*, Liu Q*. Clinical and genetic features of GATOR1 complex-associated epilepsy[J]. J Med Genet. 2023 Jan 5:jmedgenet-2021-108364.
18. Yan T, Ding X, Xie T, Lan T, Niu D, Li J, Guo D, Wang M, Wang M*. Physical activity (PA) influences the risk of depression associated with long working hours[J]. J Affect Disord. 2023 Jan 15;321:227-233.
19. Liu C, Hu Y, Zhou J, Guan Y, Wang M, Qi X, Wang X, Zhang H, Adilijiang A, Li T, Luan G. Retrospective Clinical Analysis of Epilepsy Treatment for Children with Drug-Resistant Epilepsy (A Single-Center Experience) [J]. Brain Sci. 2022 Dec 21;13(1):14.
20. Zhang H, Hu Y, Aihemaitiniyazi A, Li T, Zhou J, Guan Y, Qi X, Zhang X, Wang M, Liu C, Luan G. Long-Term Seizure Outcomes and Predictors in Patients with Dysembryoplastic Neuroepithelial Tumors Associated with Epilepsy[J]. Brain Sci. 2022 Dec 22;13(1):24.
21. Li XL, Wang S, Tang CY, Ma HW, Cheng ZZ, Zhao M, Sun WJ, Wang XF, Wang MY, Li TF, Qi XL, Zhou J, Luan GM, Guan YG. Translocation of High Mobility Group Box 1 From the Nucleus to the Cytoplasm in Depressed Patients With Epilepsy[J]. ASN Neuro. 2022 Jan-Dec;14:17590914221136662.
22. Li Y, Tan Z, Wang J, Cai Y, Wang M, Zhou W, Wang L. Responses of chemosensory perception to stimulation of the human brain[J]. Annals of neurology, 2023, 93(1), 175–183.
23. Hu Y, Zhang H, Adilijiang A, Zhou J, Guan Y, Qi X, Wang M, Wang J, Wang X, Liu C, Luan G. Seizure outcomes and prognostic factors in patients with gangliogliomas associated with epilepsy[J]. Front Surg. 2022 Aug 11;9:946201.
24. Li Y, Tan Z, Wang J, Wang M*, Wang L*. Neural Substrates of External and Internal Visual Sensations Induced by Human Intracranial Electrical Stimulation[J]. Front Neurosci. 2022 Jul 22;16:918767.
25. Zhang B, Wang J, Wang M, Wang X, Guan Y, Liu Z, Zhang Y, Liu C, Zhao M, Xie P, Zhu M, Li T, Luan G, Zhou J. Correlation Between Ictal Signs and Anatomical Subgroups in Temporal Lobe Seizures: A Stereoelectroencephalography Stud[J]y. Front Neurol. 2022 Jun 10;13:917079.
26. Liu D, Guan Y, Zhou J, Zhai F, Chen L, Li T, Wang M, Luan G. The influencing factors and changes of cognitive function within 40 Rasmussen encephalitis patients that received a hemispherectomy[J]. Neurol Res. 2022 Feb 17:1-8.
27. Tong X, Wang J, Qin L, Zhou J, Guan Y, Zhai F, Teng P, Wang M, Li T, Wang X, Luan G. Analysis of power spectrum and phase lag index changes following deep brain stimulation of the anterior nucleus of the thalamus in patients with drug-resistant epilepsy: A retrospective study[J]. Seizure. 2022 Jan 10;96:6-12.
28. Deng Q, Yan Z, Yang Y, Wang J, Han Y, Feng X, Wang M, Zhang L, Wang M*. Progressive multifocal leukoencephalopathy and peripheral neuropathy in a patient with Good's syndrome[J]. J Neurovirol. 2022 Jan 17.
29. Wang S, Pan J, Zhao M, Wang X, Zhang C, Li T, Wang M, Wang J, Zhou J, Liu C, Sun Y, Zhu M, Qi X, Luan G, Guan Y. Characteristics, surgical outcomes, and influential factors of epilepsy in Sturge-Weber syndrome[J]. Brain. 2021 Dec 21:awab470.
30. Ma K, Luan G, Wang X, Luo S, Qin L, Teng P, Guan Y, Zhao M, Wang J, Wang M, Gao JH. Magnetoencephalography STOUT Method Adapted to Radiofrequency Thermocoagulation for MR-Negative Insular Epilepsy: A Case Report[J]. Front Neurol. 2021 Oct 13;12:683299.
31. Yang Y, Wang W, Wang J, Wang M, Li X, Yan Z, Deng Q, Feng X, Luan G, Yang X, Li T. Scalp-HFO indexes are biomarkers for the lateralization and localization of the epileptogenic zone in preoperative assessment. J Neurophysiol[J]. 2021 Oct 1;126(4):1148-1158.
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34. Huang Q, Zhou J, Wang X, Li T, Wang M, Wang J, Teng P, Qi X, Zhu M, Luan G, Zhai F. Predictors and Long-term Outcome of Resective Epilepsy Surgery in Patients with Tuberous Sclerosis Complex: A Single-centre Retrospective Cohort Study[J]. Seizure. 2021 May;88:45-52.
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37. Han Y, Tong X, Wang X, Teng F, Deng Q, Zhou J, Guan Y, Yan Z, Chen L, Luan G, Wang M*. A concordance study determining language dominance between navigated transcranial magnetic stimulation and the Wada test in patients with drug-resistant epilepsy[J]. Epilepsy Behav. 2021 Apr;117:107711.
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44. 闫兆芬, 王静, 栾国明, 周健, 光宇光, 翟峰, 王梦阳*. 不同年龄阶段Rasmussen脑炎临床与脑电图特征[J].中国现代神经疾病杂志,2020,20(9):821-826.
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50. Cui Z, Wang Q, Gao Y, Wang J, Wang M, Teng P, Guan Y, Zhou J, Li T, Luan G, Li L. Dynamic Correlations between Intrinsic Connectivity and Extrinsic Connectivity of the Auditory Cortex in Humans[J]. Front Hum Neurosci. 2017 Aug 11;11:407.
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52. Wang MY#, Wang J, Zhou J, et al. Identifcation of the epileptogenic zone of temporal lobe epilepsy from stereo-electroencephalography signals: A phase transfer entropy and graph theory approach[J]. Neuroimage: Clinical 2017 16: 184-195.
53. Wang MY#, Li TF, Wang J, et al. Evaluating the prognosis of surgical treatment in atypical temporal lobe epilepsy-A study based on ictal onset patterns and extratemporal early propagations on stereoElectroencephalography[J]. Neuropsychiatry (London) 2017 7(6) 640-652.
54. Wang MY#, Liu XZ, Wang J, Wu LW. A novel mutation of the nicotinic acetylcholine receptor gene CHRNA4 in a Chinese patient with non-familial nocturnal frontal lobe epilepsy[J]. Epilepsy Res. 2014 ;108(10):1927-31.
55. Wang MY#, Liu XZ, Wang J, Luan GM. The clinical and EEG features and mutation analysis in a Chinese patient with severe hypoplasia of the cerebellum and pons. Neurology Asia[J]. 2014;19(3): 319.
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57. 王静,周健,关宇光,陈述花,王梦阳,栾国明.颅内电极脑电图发作前期脑电活动特点在癫(间)发作定位中的作用[J].中国微侵袭神经外科杂志,2018,23(1):6-9.
58. 王梦阳, 栾国明. 文献学习结合病例分析报告会在神经科临床教学中的应用[J]. 继续医学教育, 2017, 31(12):30-31.
59. 翟锋,周健,丁浩然,卢东爽,陈思畅,王静,王梦阳,李天富,栾国明.立体定向颅内电极植入后癫痫灶切除时机的选择[J].中华神经外科杂志,2017,33(6):574-577.
60. 关宇光,栾伟,陈思畅,刘长青,赵萌,李天富,王梦阳,周健,王静,栾国明.岛周大脑半球离断术治疗药物难治性癫(疒间)[J].中国微侵袭神经外科杂志,2017,22(5):209-211.
61. 王梦阳#,陈述花,王静等. Ⅱ型局灶性皮质发育不良的立体定向脑电图特点[J]. 中华神经外科杂志. 2016, 32(8):825-830.
62. 王梦阳#,栾国明. 癫痫定位诊断临床教学模式的思考与实践[J]. 继续医学教育. 2016, 30(11):33-34.
63. 王梦阳#,刘兴洲. PI3K/Akt/mTOR信号通路在FCDⅡb型发病机制中的作用[J].中华神经医学杂志.2014,13(4).
64. 王芳,潘思培,刘兴洲,王梦阳,经贺,胡井颖.局灶性癫痫患者发作间期痫样放电昼夜变化规律的研究[J].中华行为医学与脑科学杂志,2013,22(5):406-408.
65. 王梦阳#,林华,吴立文.遗传性癫痫伴热性惊厥附加症发病年龄及发作频率与基因型的关系[J]. 中风与神经疾病杂志.2012,29(6).
66. 王梦阳#.Rasmussen脑炎免疫学机制研究进展[J]. 癫癎与神经电生理学杂志.2012,21(2).
67. 王梦阳#, 吴立文, 刘兴洲. 中文版青少年癫癎患者生活质量问卷信度及效度检验. 癫癎与神经电生理学杂志. 2011, 20(4): 210-17.
68. 王梦阳#, 刘兴洲, 陈述花, 张玮, 隋伟, 王静, 王海祥, 李学秀. 携带新生SCN1A突变的婴儿严重肌阵挛癫痫1例. 第四届北京三博国际神经科学论坛. 2010:130-131.
69. 王梦阳#,吴立文,林华,王铮,黄尚志.一个中国北方遗传性癫痫伴热性惊厥附加症家系的基因定位研究.癫痫与神经电生理学杂, [J]2010,19:77-81.
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71. 王梦阳#,吴立文,卢强,等.国际抗癫痫联盟国际癫痫综合征分类可分类率比较及架构分析. 中华神经科杂志[J],2009,42:440-445.
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74. 李威威,王梦阳*.非离子通道基因与癫痫[J]. 中风与神经疾病杂志.2012,29(6).
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78. 陈晏, 吴立文, 房岳, 王梦阳, 许琪, 沈岩. 夜发性额叶癫痫三家系临床和遗传学特征[J].2009,42:386-389.
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81. 王梦阳#.GPⅡb/Ⅲa受体拮抗剂在缺血性脑血管病中的应用现状.中国卒中杂志天坛国际脑血管病会议2007专刊.2007,2:300-303.
主编专著:
1. 栾国明,王梦阳.立体定向脑电图与癫痫——病例精解, 科学出版社, 474千字, 2021.
参编专著:
1. 王梦阳, 董立羚译. 特发性全面性癫痫. 任连坤主译. 癫痫发作和综合征的诊断与治疗.北京: 中国协和医科大学出版社. 第一版, 2008, 248-319.
2. 王梦阳译. 婴儿重症肌阵挛性癫痫.刘兴洲主译. 癫痫性脑病及其远期预后.北京:人民卫生出版社. 第一版,2010, 29-39.
3. 王梦阳, 栾国明. 经颅磁刺激. 韩济生 主编. 神经科学. 北京:北京大学医学出版社. 第四版,2022,1566-1579.
4. 王梦阳译. 癫痫和大脑皮质发育畸形.婴儿、儿童、青少年期癫痫综合征.北京:人民卫生出版社. 第六版,2024,505-523.
5. 梁树立,王梦阳.癫痫外科分期手术.癫痫外科学.张建国、栾国明主编.人民卫生出版社.第三版, 2023,751-761.

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