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目前主持科技部十四五重点研发计划 “脑损伤神经移位模型的建立与功能恢复的中枢神经机制研究” ,课题编号2022YFC3602805,目前卒中是神经系统的高发疾病而且致残率很高,造成肢体偏瘫的结局,本研究建立模拟中枢神经系统损伤导致肢体瘫痪的动物模型,研究多模式神经移位联合功能康复后脑可塑性机制及加速功能重组的关键影响因素,为神经功能康复重建找到新的研究方向。利用脑深部电极、神经示踪、 dMRI 和 fMRI 等多模态技术,以大鼠为实验动物,构建脑运动皮质区损伤及运动神经通路(内囊)损伤致肢体瘫痪模型,采用多神经移位调控,研究促进痉挛肢体运动功能恢复的中枢神经机制及周围神经调控后大脑皮层的可塑性改变。
1. Liu CQ#, Hu Y , Zhou J, Guan YG, Wang MY, Qi XL, Wang XF, Zhang HW, Adilijiang A, Li TM, Luan G. Retrospective ClinicalAnalysis of Epilepsy Treatment for Children with Drug-Resistant Epilepsy (ASingle-Center Experience). BRAIN SCI. 2022 Dec 21. doi.org/10.3390/brainsci13010014.
2. Zhang HW, Hu Y, Adilijiang A, LiTM, Zhou J, Guan YG, QiXL, Zhang XF, Wang XF, Liu CQ*, Luan G. Long-Term SeizureOutcomes and Predictors in Patients with Dysembryoplastic NeuroepithelialTumors Associated with Epilepsy. BRAINSCI. 2022Dec 22. doi.org/10.3390/ brainsci13010024.
3. Hu Y, Zhang HW, Adilijiang A,Zhou J, Guan YG, Qi XL, Wang MY, Wang J, Wang XF, Liu CQ*,Luan GM. Seizure outcomes and prognoLiu CQtic factors in patientswith gangliogliomas associated with epilepsy. FRONT SURG. 2022 Aug 11.doi:10.3389/ fsurg. 2022.946201.
4. Hu Y, Cai P, Zhang HW, Adilijiang A, Peng J, Li Y, CheSL, Lan F, Liu CQ*. A comparationbetween frame-based and robot-assisted in stereotactic biopsy. FRONT NEUROL. 2022 Jul18. doi: 10.3389/fneur.2022.928070.
5. 刘长青,程前,关宇光,栾国明. 机器人引导立体脑电射频毁损治疗下丘脑错构瘤所致癫痫. 中国临床神经外科杂志. 2019, 24(8):489-491.
6. 刘长青,程前,关宇光,栾国明. 运动皮层电刺激治疗丘脑痛3例并文献复习.中国临床神经外科杂志. 2019,24(6):336-338.
7. Liu CQ#, Luan G, Guan YG, Cheng Q,Chen SC. The seizure and cognitive outcome of 499 patients with childhoodintractable epilepsy after different treatment. J Epilespsy, November 2017;3(6):474-478.
8. 刘长青, 陈思畅, 关宇光, 周健, 翟峰, 栾国明. Sturge-Weber综合征所致难治性癫痫的手术治疗.中国临床神经外科杂志.2017, 22(6):379-381.
9. Li L#, Liu CQ#, Deng J#, Luo H, Guan Y, Zhou J, Qi X, Li T, Xu ZQ, Luan G.Altered expression of neuropeptide Y receptors caused by focal corticaldysplasia in human intractable epilepsy. Oncotarget. 2016; 7(13): 15329-15338. (共同一作)
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