研究团队与临床密切合作，聚焦儿童血液疑难罕见病及难治复发血液肿瘤，实施先进的精准分层诊疗，积极开展难治复发患儿的二线治疗、靶向治疗，规模、疗效居全国前列；开展疾病相关基因突变等分子标记物临床价值研究，对患儿进行精准的分子分型和预后判断，为实施精准分子靶向治疗提供重要参考；积极探索复发分子机制研究，为复发/难治性患儿探寻新的治疗靶点提供理论依据。

作为负责人先后承担国家自然科学基金青年项目、面上项目、北京市自然科学基金面上项目、首都卫生发展科研专项等课题7项，作为研究骨干参与多项国家级、省部级等课题研究。

[1]国家自然科学基金青年科学基金项目，81200392，CASP8AP2 与ARS2 相互作用参与microRNA-210生成及其在儿童急性淋巴细胞白血病复发与耐药中的作用，2013.01-2015.12，23万元

[2]北京新阳光慈善基金会助医儿童白血病研究基金项目，2017002，儿童急性淋巴细胞白血病长期预后评估研究，2017.07-2019.06，20万元

[3]爱佑慈善基金会儿科专项计划项目，AYEK201802，血浆游离DNA（ccfDNA）基因突变检测在儿童朗格罕细胞组织细胞增生症中临床价值的研究，2018.01-2019.12，10万元

[4]首都医科大学科研培育基金项目，PYZ2018159，胞浆p27Kip1蛋白通过非常规途径分泌进行细胞间传递的分子机制及其在儿童急性淋巴细胞白血病复发与耐药作用的研究，2019.01-2019.12，5万元

[5]北京市自然科学基金面上项目，7202044，胞浆p27kip1蛋白经细胞间传递在儿童急淋白血病耐药与复发中的作用与机制研究，2020.01-2022.12，20万

[6]国家自然科学基金面上项目，81970135，胞浆p27Kip1蛋白经非常规途径分泌的分子机制及其在儿童急性淋巴细胞白血病复发与耐药中作用的研究，2020.01-2023.12，55万

[7]首都卫生发展科研专项，2022-2-1141，外周血基因突变检测在儿童朗格罕细胞组织细胞增生症临床危险度分层中应用价值的研究，2022.01-2024.12，32万元

[1]崔蕾*, 李志刚, 吴敏媛. 急性淋巴细胞白血病微小残留病的定量检测及临床应用. 国际输血及血液学杂志. 2006, 29(5):430-433.

[2]崔蕾, 李志刚*, 高超, 吴敏媛. 儿童急性淋巴细胞白血病IgH基因重排的定量检测研究. 中华检验医学杂志. 2007, 30(10): 1119-1122.

[3]崔蕾, 李志刚, 吴敏媛*. 青少年急性淋巴细胞性白血病. 中华儿科杂志. 2009, 47(10):797-800.

[4]崔蕾, 吴敏媛*.微小残留病检测在儿童急性淋巴细胞白血病中的临床价值及应用. 中国小儿血液与肿瘤杂志. 2010, 15(3): 97-100.

[5]Lei Cui, Zhi-Gang Li*, Min-Yuan Wu, Wei-Jing Li,Chao Gao, Guo-Ren Deng. Combined analysis of minimal residual disease at twotime points and its value for risk stratification in childhood B-lineage acutelymphoblastic leukemia. Leukemia Research. 2010, 34(10): 1314-1319.

[6]崔蕾, 张瑞东, 高超, 李伟京, 赵晓曦, 郑胡镛, 李志刚*, 吴敏媛*. 儿童急性淋巴细胞白血病早期治疗反应评估与预后价值. 中国实验血液学杂志, 2014, 22(2): 298-303.

[7]Lei Cui, Chao Gao, Rui-Dong Zhang, Ying Jiao,Wei-Jing Li, Xiao-Xi Zhao, Shu-Guang Liu, Zhi-Xia Yue, Hu-Yong Zheng, Guo-RenDeng, Min-Yuan Wu, Zhi-Gang Li*, Hong-Ti Jia*. Low expressions of ARS2 andCASP8AP2 predict relapse and poor prognosis in pediatric acute lymphoblasticleukemia patients treated on China CCLG-ALL 2008 protocol. Leukemia Research,2015, 39(2): 115-123.

[8]刘飞飞, 刘潇, 王凯玲, 李伟京, 邓国仁, 高超, 赵晓曦, 吴敏媛, 崔蕾*, 李志刚*. 儿童急性淋巴细胞白血病CASP8AP2基因启动子甲基化水平及其临床意义. 中国实验血液学杂志, 2015, 23(1): 6-11.

[9]刘潇, 李伟京, 赵晓曦, 高超, 赵玮, 姜锦, 张瑞东, 谢静, 石慧文, 王彬, 张永红, 马晓莉, 周翾, 吴敏媛, 崔蕾*, 李志刚*. SIL-TAL1融合基因阳性的儿童急性T淋巴细胞白血病的临床特征及其治疗研究. 中国实验血液学杂志, 2016, 24(3): 681-686.

[10]崔蕾, 李志刚*. 儿科学科研型研究生培养的实践与体会医学教育研究与实践.2017,25(6):898-901.

[11]Fei-FeiLiu #, Kai-Ling Wang #, Li-Ping Deng, Xiao Liu, Min-Yuan Wu, Tian-You Wang, LeiCui*, Zhi-Gang Li*.Transcription factor E2F3a regulates CASP8AP2 transcription and enhancessensitivity to chemotherapeutic drugs in acute lymphoblastic leukemia. Cancer Cell International. 2018 Mar 20;18:40.

[12]Dong Wang#, Lei Cui#, Zhi-Gang Li, Li Zhang,Hong-Yun Lian, Hong-Hao Ma, Yun-Ze Zhao, Xiao-Xi Zhao, Tian-You Wang, RuiZhang*. Clinical research of pulmonary Langerhans cell histiocytosis in Children.Chinese Medical Journal. 2018 Aug 5;131(15):1793-1798.

[13]Yue Xu#, Lei Cui#, Anthony Dibello, Lihui Wang,Juhyung Lee, Layla Saidi, Jin-Gu Lee , Yihong Ye*. DNAJC5 facilitatesUSP19-dependent unconventional secretion of misfolded cytosolic proteins. CellDiscovery. 2018 Mar 6;4:11.

[14]Lei Cui#, Zhi-Gang Li#, Yi-Huan Chai#, Jie Yu#,Ju Gao#, Xiao-Fan Zhu#, Run-Ming Jin#, Xiao-Dong Shi#, Le-Ping Zhang#, Yi-Jin Gao#,Rui-Dong Zhang, Hu-Yong Zheng, Shao-Yan Hu,Ying-Hui Cui, Yi-Ping Zhu, Yao Zou, MargaretH. L. Ng, Yan Xiao, Jun-Hui Li, Yong-Hong Zhang, Hai-Long He, Ying Xian, Tian-YouWang*, Chi-Kong Li*, Min-Yuan Wu*. Outcome of children with newly diagnosedacute lymphoblastic leukemia treated with CCLG-ALL 2008: The first nation-wideprospective multicenter study in China. American Journal of Hematology. 2018 Jul;93(7):913-920.

[15]王婵娟, 崔 蕾*, 李伟京, 赵晓曦, 高 超, 吴敏媛, 王天有, 李志刚*. Ig/TCR基因重排在儿童急性T淋巴细胞白血病中的表达模式特点. 中国循证儿科杂志. 2019, 14(2): 106-111.

[16]崔蕾, 张莉, 廉红云, 王一卓, 武万水, 王天有, 李志刚*, 张 蕊*. 儿童朗格罕细胞组织细胞增生症BRAF V600E突变对预后的影响. 中国循证儿科杂志. 2020, 15(2):102-107.

[17]LeiCui, Li Zhang, Hong-Hao Ma, Chan-Juan Wang, Dong Wang, Hong-Yun Lian, Wei-JingLi, Qing Zhang, Na Li, Tian-You Wang*, Zhi-Gang Li*, Rui Zhang*. Circulatingcell-free BRAF V600E during chemotherapy is associated with prognosis ofchildren with Langerhans cell histiocytosis. Haematologica. 2020 Sep1;105(9):e444-447.

[18]LeiCui, Chao Gao, Chan-Juan Wang, Shu-Guang Liu, Min-Yuan Wu, Rui-Dong Zhang*,Zhi-Gang Li*. Low expression of CTBP2 and CASP8AP2 predicts risk of relapse inchildhood B-cell precursor acute lymphoblastic leukemia: a retrospective cohortstudy. Pediatric Hematology and Oncology. 2020Nov;37(8):732-746.

[19]LeiCui, Chao Gao, Chan-Juan Wang, Xiao-Xi Zhao, Wei-Jing Li, Zhi-Gang Li, Hu-YongZheng, Tian-You Wang, Rui-Dong Zhang*. Combined analysis of IKZF1 deletions andCRLF2 expression on prognostic impact in pediatric B-cell precursor acutelymphoblastic leukemia. Leukemia Lymphoma. 2021 Feb;62(2):410-418.

[20]HuiShi#, Han He#, Lei Cui#, Egle Kvedaraite#, Zhilei Bian#, Tao Huang#,Christopher Z. W. Lee, Zhigang Li, Jian He, Yandong Gong, Zongcheng Li, JieZhou, Yang Zeng, Xianlong Li, Yanli Ni, Zhijie Bai, Chen Liu, Na Li, HonghaoMa, Dong Wang, Yu Lan*, Florent Ginhoux*, Rui Zhang*, Bing Liu*. Transcriptomiclandscape of circulating mononuclear phagocytes in Langerhans cellhistiocytosis at the single-cell level. Blood. 2021Oct 7;138(14):1237-1248.

[21]DongWang, Xi-Hua Chen, Ang Wei, Chun-Ju Zhou, Xue Zhang, Hong-Hao Ma, Hong-YunLian1, Li Zhang, Qing Zhang, Xiao-Tong Huang, Chan-Juan Wang, Ying Yang, WeiLiu, Tian-You Wang*, Zhi-Gang Li*, Lei Cui*, Rui Zhang*. Clinical features andtreatment outcomes of pediatric Langerhans cell histiocytosis with macrophage activationsyndrome-hemophagocytic lymphohistiocytosis. Orphanet Journal of Rare Diseases.2022 Apr 4;17(1):151.

[22]Ja-FengYao, Dong Wang, Hong-Hao Ma, Hong-Yun Lian, Li Zhang, Tian-You Wang, Zhi-GangLi, Jin Jiang, Lei Cui*, Rui Zhang. Characteristics and Treatment Outcomes ofPediatric Langerhans Cell Histiocytosis with Thymic Involvement. The Journal ofPediatrics. 2022 May;244:194-202.e5.

[23]Chan-JuanWang#, Ming-Zhu Jia#, Li-Ping Deng#, Wei-Jing Li, Qing Zhang, Tong-Jia Zhang,Shu-Yan Li*, Lei Cui*, Zhi-Gang Li*. Interaction between CASP8AP2 andZEB2-CtBP2 Regulates the Expression of LEF1. Pediatric Hematology Oncology. 2022Sep;39(6):549-560.

[24]LeiCui#, Chan-Juan Wang#, Hong-Yun Lian, Li Zhang, Hong-Hao Ma, Dong Wang, Fen-FenChen, Qing Zhang, Ying Yang, Ang Wei, Xiao-Tong Huang, Ting Zhu, Tian-YouWang*, Zhi-Gang Li*, Rui Zhang*. Clinical outcomes and prognostic risk factorsof Langerhans cell histiocytosis in children: Results from the BCH-LCH 2014protocol study. American Journal ofHematology.2023 Apr;98(4):598-607.

[25]Fen-FenJin#, Chan-Juan Wang#, Lei Cui*, Fei-Fei Liu, Kai-Ling Wang, Wei-Jing Li,Zhi-Gang Li. Interaction of E2F3a and CASP8AP2 Regulates Histone Expression andChemosensitivity of Leukemic Cells. Journal of Pediatric Hematology Oncology.2023 Apr 1;45(3):e339-e344.

[26]Ming-ZhuJia#, Wei-Jing Li#, Chan-Juan Wang, Qing Zhang, Chao Gao, Xiao-Tong Huang, TingZhu, Rui-Dong Zhang*, Lei Cui*, Zhi-Gang Li*. Tracing back of relapse clones byIg/TCR gene rearrangements reveals complex patterns of recurrence in pediatricacute lymphoblastic leukemia. International Journal of Laboratory Hematology. 2023Oct;45(5):717-725.