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2009年毕业于北京大学生命科学学院,获理学博士学位;宾夕法尼亚大学医学院微生物学系访问学者。主要从事结核病相关基础与临床研究,担任中华医学会结核病学分会青年委员、中华医学会结核病学分会检验委员会委员、中国防痨协会结核病基础专业分会青年委员会常务委员、北京防痨协会结核病基础专业分会常务委员。主持国家自然科学基金青年项目、北京市自然科学基金面上项目、首都卫生发展科研专项项目、北京市医院管理局青年人才培养“青苗”计划等基金项目,以第一作者或通讯作者在Emerging microbes & infections、Antimicrobial Agents and Chemotherapy、Journal of Infection、International Journal of Antimicrobial Agents等期刊上发表SCI论文39篇,作为主要骨干参与了1项国家标准、2项行业标准的拟定和修改工作。作为北京儿童医院临床数据和样本资源库技术负责人,参与了样本库的ISO9001:2008质量管理体系认证和ISO9001:2015改版审核。
1. 北京市自然科学基金,结核分枝杆菌Rv0309通过E3泛素化酶STUB1抑制巨噬细胞自噬的机制研究,202301-202512
2. 首都医科大学培育项目,德拉马尼通过JAK2/STAT1下调CXCL10表达的抑炎机制研究,202301-202312
3. 首都医科大学培育项目,外排泵MmpL5参与结核分枝杆菌SQ109耐药的分子机制研究,202101-202112
4. 首都医科大学培育项目,miR-21-3p通过调控自噬促进结核分枝杆菌胞内存活的机制研究,202001-202012
5. 北京市医管中心“青苗”计划,鼻-鼻窦炎合并腺样体肥大患儿在腺样体切除术前后鼻部病原微生物谱动态变化及其对预后的影响,201801-201912
6. 北京市卫生健康委员会首发专项,REPLI-PCR方法在儿童结核病早期快速诊断的应用研究,201601-201812
7. 国家自然科学基金,高通量测序技术用于早期快速检测耐药结核的研究,201501-201712
1.Wang W, Li S, Ge Q, Guo H, Shang Y, Ren W, Wang Y, Xue Z, Lu J, Pang Y.Determination of critical concentration for drug susceptibility testing of Mycobacterium tuberculosis against para-aminosalicylic acid with clinical isolates with thyA, folC and dfrA mutations. Annals of Clinical Microbiology and Antimicrobials 2022;21(1)
2.Qiao M, Li S, Yuan J, Ren W, Shang Y, Wang W, Liu R, Zhang F, Li Q, Wu X, Lu J, Gao M, Pang Y.Delamanid suppresses CXCL10 expression via regulation of JAK/STAT1 signaling and correlates with reduced inflammation in tuberculosis patients. Front Immunol 2022;13:923492
3.Liu Y, Shi J, Li L, Wu T, Chu P, Pang Y, Guo Y, Gao M, Lu J.Spontaneous Mutational Patterns and Novel Mutations for Delamanid Resistance in Mycobacterium tuberculosis. Antimicrobial agents and chemotherapy 2022;66(12):e0053122
4.Li S, Guo J, Liu R, Zhang F, Wen S, Liu Y, Ren W, Zhang X, Shang Y, Gao M, Lu J, Pang Y. Predominance of Escherichia-Shigella in Gut Microbiome and Its Potential Correlation with Elevated Level of Plasma Tumor Necrosis Factor Alpha in Patients with Tuberculous Meningitis. Microbiol Spectr 2022;10(6):e0192622
5.Dong WZ, Shi J, Chu P, Liu RM, Wen SA, Zhang TT, Pang Y, Lu J.The putative NAD(P)H Nitroreductase, Rv3131, is the Probable Activating Enzyme for Metronidazole in Mycobacterium Tuberculosis. Biomedical and environmental sciences 2022;35(7):652-656
6.Chu P, Shi J, Dong F, Yang H, Zhao S, Liu G, Zheng H, Liu J, Li H, Lu J.Bacteremia tuberculosis among HIV-negative children in China. Pediatric Investigation 2022;6(3):197-206
7.Chu P, Chang Y, Zhang X, Han S, Jin Y, Yu Y, Yang Y, Feng G, Wang X, Shen Y, Ni X, Guo Y, Lu J.Epidemiology of extrapulmonary tuberculosis among pediatric inpatients in mainland China: a descriptive, multicenter study Emerging microbes & infections 2022;11(1):1090-1102
8.Li MC, Lu J, Lu Y, Xiao TY, Liu HC, Lin SQ, Xu D, Li GL, Zhao XQ, Liu ZG, Zhao LL, Wan KL.rpoB Mutations and Effects on Rifampin Resistance in Mycobacterium tuberculosis Infection and drug resistance 2021;14:4119-4128
9.Han S, Zhang Q, Ding Y, Chu P, Zhang J, Shi J, Jia S, Yang C, Lu J, Wang Y. One-Week Effects of Antibiotic Treatment on Gut Microbiota of Late Neonates With Pneumonia or Meningitis. Frontiers in pediatrics 2021;9:723617
10.Song B, Zheng H, Han S, Tang L, Yang X, Chu P, Wang P, Lu J, Ge W, Ni X.Detection of nasal microbiota in pediatric patients with antrochoanal polyps by TLDA. International Journal of Pediatric Otorhinolaryngology 2020;130:109811
11.Dong W, Li S, Wen S, Jing W, Shi J, Ma Y, Huo F, Gao F, Pang Y, Lu J.In Vitro Susceptibility Testing of GSK656 against Mycobacterium Species Antimicrobial agents and chemotherapy 2020;64(2)
12.Dong G, Chu P, Guo J, Xie Y, Lu J.Nontuberculous mycobacterial and Nocardia infections mimicking pulmonary tuberculosis: a retrospective study of a general hospital patient population in China Journal of medical microbiology 2020;69(9):1145-1150
13.Zheng H, Tang L, Song B, Yang X, Chu P, Han S, Wang P, Lu J, Ge W, Ni X.Inflammatory patterns of antrochoanal polyps in the pediatric age group. Allergy, asthma, and clinical immunology: official journal of the Canadian Society of Allergy and Clinical Immunology 2019;15:39
14.Zhang Z, Lu J, Du Y, Xie F, Wang Y, Sun B, Pang Y.Comparison of in vitro synergistic effect between clarithromycin or azithromycin in combination with amikacin against Mycobacterium intracellulare. Journal of Global Antimicrobial Resistance 2019;18:183-186
15.Wang Z, Sun H, Ren Z, Xue B, Lu J, Zhang H.Feasibility and Performance of Loop-Mediated Isothermal Amplification Assay in the Diagnosis of Pulmonary Tuberculosis in Decentralized Settings in Eastern China. BioMed research international 2019;2019:6845756
16.Pang Y, Jing W, Lu J, Zong Z, Huo F, Dong L, Dai G, Li Y, Huang H, Chu N.No in vitro synergistic effect of bedaquiline combined with fluoroquinolones, linezolid, and clofazimine against extensively drug-resistant tuberculosis. Diagnostic microbiology and infectious disease 2019;94(4):361-364
17.Lu J, Zheng H, Chu P, Han S, Yang H, Wang Z, Shi J, Yang Z.Direct detection from clinical sputum samples to differentiate live and dead Mycobacterium Tuberculosis. Journal of clinical laboratory analysis 2019;33(3):e22716
18.Liu H, Dong F, Liu J, Liu J, Pang Y, Zhao S, Lu J, Li H.Successful management of Mycobacterium abscessus complex lung disease in an otherwise healthy infant. Infection and drug resistance 2019;12:1277-1283
19.Huo F, Lu J, Zong Z, Jing W, Shi J, Ma Y, Dong L, Zhao L, Wang Y, Huang H, Pang Y.Change in prevalence and molecular characteristics of isoniazid-resistant tuberculosis over a 10-year period in China. BMC infectious diseases 2019;19(1):689
20.Zhang Z, Lu J, Song Y, Pang Y.In vitro activity between linezolid and other antimicrobial agents against Mycobacterium abscessus complex. Diagnostic microbiology and infectious disease 2018;90(1):31-34
21.Shi J, Lu J, Wen S, Zong Z, Huo F, Luo J, Liang Q, Li Y, Huang H, Pang Y.In Vitro Activity of PBTZ169 against Multiple Mycobacterium Species. Antimicrobial agents and chemotherapy 2018;62(11)
22.Liu JR, Lu J, Dong F, Li HM, Liu H, Tang XL, Guo YL, Zhao SY.Low Bacterial Co-infection Invalidates the Early Use of Non-anti-Mycoplasma pneumoniae Antibiotics in Pediatric Refractory Mycoplasma pneumoniae Pneumonia Patients. Frontiers in pediatrics 2018;6:296
23.Zhang Z, Lu J, Liu M, Wang Y, Zhao Y, Pang Y.In vitro activity of clarithromycin in combination with other antimicrobial agents against Mycobacterium abscessus and Mycobacterium massiliense. International journal of antimicrobial agents 2017;49(3):383-386
24.Pang Y, Lu J, Su B, Zheng H, Zhao Y.Misdiagnosis of tuberculosis associated with some species of nontuberculous mycobacteria by GeneXpert MTB/RIF assay. Infection 2017;45(5):677-681
25.Pang Y, Lu J, Huo F, Ma Y, Zhao L, Li Y, Liang Q, Chu N, Gao M, Huang H.Prevalence and treatment outcome of extensively drug-resistant tuberculosis plus additional drug resistance from the National Clinical Center for Tuberculosis in China: A five-year review. The Journal of infection 2017;75(5):433-440
26.Lu J, Li H, Dong F, Shi J, Yang H, Han S, Chu P, Zhao Y, Song W, Guo Y, Zhao S.The Feasibility of Xpert MTB/RIF Testing to Detect Rifampicin Resistance among Childhood Tuberculosis for Prevalence Surveys in Northern China. BioMed research international 2017;2017:5857369
27.Li H, Lu J, Liu J, Zhao Y, Ni X, Zhao S.Linezolid is Associated with Improved Early Outcomes of Childhood Tuberculous Meningitis. The Pediatric infectious disease journal 2016;35(6):607-610
28.Zhang Z, Lu J, Wang Y, Pang Y, Zhao Y.Automated liquid culture system misses isoniazid heteroresistance in Mycobacterium tuberculosis isolates with mutations in the promoter region of the inhA gene.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 2015;34(3):555-560
29.Zhang Z, Lu J, Liu M, Wang Y, Qu G, Li H, Wang J, Pang Y, Liu C, Zhao Y.Genotyping and molecular characteristics of multidrug-resistant Mycobacterium tuberculosis isolates from China. The Journal of infection 2015;70(4):335-345
30.Pang Y, Lu J, Yang J, Wang Y, Cohen C, Ni X, Zhao Y.A novel method for diagnosis of smear-negative tuberculosis patients by combining a random unbiased Phi29 amplification with a specific real-time PCR. Tuberculosis 2015;95(4):411-414
31.Lu J, Chu P, Wang H, Jin Y, Han S, Han W, Tai J, Guo Y, Ni X.Candidate Gene Association Analysis of Neuroblastoma in Chinese Children Strengthens the Role of LMO1 PloS one 2015;10(6):e0127856
32.Zhang Z, Lu J, Wang Y, Pang Y, Zhao Y.Prevalence and molecular characterization of fluoroquinolone-resistant Mycobacterium tuberculosis isolates in China.Antimicrobial agents and chemotherapy 2014;58(1):364-369
33.Lu J, Liu M, Wang Y, Pang Y, Zhao Z.Mechanisms of fluoroquinolone monoresistance in Mycobacterium tuberculosis. FEMS Microbiol Lett 2014;353(1):40-48
34.Pang Y, Lu J, Wang Y, Song Y, Wang S, Zhao Y.Study of the rifampin monoresistance mechanism in Mycobacterium tuberculosis. Antimicrobial agents and chemotherapy 2013;57(2):893-900
35.Mou HQ, Lu J, Zhu SF, Lin CL, Tian GZ, Xu X, Zhao WJ.Transcriptomic analysis of Paulownia infected by Paulownia witches'-broom Phytoplasma. PloS one 2013;8(10):e77217
36.Lu J, Du ZX, Kong J, Chen LN, Qiu YH, Li GF, Meng XH, Zhu SF.Transcriptome analysis of Nicotiana tabacum infected by Cucumber mosaic virus during systemic symptom development PloS one 2012;7(8):e43447
37.Lu J, Wang X, Xia B, Jin C Solution structure of Apo-YjaB from Escherichia coli. Proteins 2009;76(1):261-265
38.Lu J, Yang F, Li Y, Zhang X, Xia B, Jin C.Reversible conformational switch revealed by the redox structures of Bacillus subtilis thiol peroxidase. Biochemical and biophysical research communications 2008;373(3):414-418
39.Lu J, Yang F, Li Y, Xia B, Jin C.1H, 13C, and 15N resonance assignments of the reduced and oxidized forms of Bacillus subtilis thiol peroxidase Biomolecular NMR assignments 2008;2(2):183-186
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