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首都医科大学附属北京安贞医院,北京市心肺血管疾病研究所研究员,教授,博士研究生导师。国家自然科学基金项及目北京自然科学基金评审专家及国内外多家杂志特约审稿人。中国生物化学与分子生物学脂质与脂蛋白专业委员会委员,亚洲血管生物学专业委员会委员,中国研究型医院学会细胞外囊泡研究与应用专业委员会委员。先后主持国家级课题7项,省部级课题5项。在国际期刊中以第一作者和通讯作者发表SCI收录论文40余篇,包括PNAS,Circulation Research, Diabetes, Metabolism, Theranostics等, H index, 22。已脂导毕业博士1名,毕业硕士4名,其中3名继续博士深造;目前在读博士2名,硕士4名。

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项目名称 |
资助号 |
项目类别 |
项目经费 |
本人角色 |
起止时间 |
|
国家自然基金 面上项目 |
47万 |
负责人 |
2026.01- 2029.12 |
||
|
|
首发基金 自主创新项目 |
29.33万 |
负责人 |
2024.01- 2026.12 |
|
|
外泌体介导的心肌细胞-心肌成纤维细胞cross-talk在糖尿病心肌纤维化中的作用及机制研究 |
82270242 |
国家自然基金 面上项目 |
51万 |
负责人 |
2023.01- 2026.12 |
|
7192031 |
北京市市自然基金面上项目 |
20万 |
负责人 |
2019.01- 2021.12 |
|
|
血清外泌体miR-144与巨噬细胞脂质堆积:OSAHS |
81870335 |
国家自然基金 面上项目 |
57 |
主要参与人 |
2019.01- 2022.12 |
|
血清外泌体精氨酸酶1表达增加与血管内皮功能障碍:糖尿病小鼠血管功能损伤的新机制 |
31741064 |
国家自然基金 应急项目 |
15万 |
负责人 |
2018.01- 2018.12 |
|
心肌脂滴比较蛋白组学研究及心肌脂滴蛋白CGI-58 对心脏功能的影响 |
81471082 |
国家自然基金 面上项目 |
73万 |
负责人 |
2015.01- 2018.12 |
|
骨骼肌脂滴比较蛋白组学研究及骨骼肌脂滴蛋白OXPAT 对胰岛素抵抗的影响 |
81270932 |
国家自然基金 面上项目 |
70万 |
负责人 |
2013.01- 2016.12 |
|
SNAREs样蛋白SLPs对产油菌脂滴融合的影响 |
31100068 |
国家自然基金 青年基金项目 |
23万 |
负责人 |
2012.01- 2014.12 |
|
骨骼肌脂滴比较蛋白谱研究及apoA-I对骨骼肌脂滴的影响 |
5122028 |
北京自然基金 面上项目 |
11万 |
负责人 |
2012.01- 2014.12 |
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线粒体解偶联蛋白对糖尿病内皮细胞功能失调与内皮再生修复障碍的保护作用 |
2011-47 |
10万 |
负责人 |
2012.02- 2014.02 |
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脂联素对棕榈酸所致的血管功能损伤的保护作用及其分子机制 |
201104165 |
第 52 批博士后基金 二等资助 |
5万 |
负责人 |
2012.09- 2014.02 |
| 肠道菌-中性粒细胞的细胞外囊泡信号级联在内皮功能损伤与高血压发生发展中的作用与机制研究 | 国家自然基金 面上项目 | |
| 2024-2G-206 | 首都发展基金 自主创新项目 | |
| 血清外泌体精氨酸酶1表达增加与血管内皮功能障碍:糖尿病小鼠血管功能损伤的新机制 | 31741064 | 国家自然基金 应急项目 |
外泌体介导的心肌细胞-心肌成纤维细胞cross-talk在糖尿病心肌纤维化中的作 用及机制研究 | 82270242 | 国家自然基金 面上项目 |
红细胞外泌体与内皮功能障碍:慢性间歇性缺氧诱导高血压的新机制 | 7192031 | 北京市市自然基金面上项目 |
1. Zhang, H. N., C. X. Yu,P. J. Zhang, W. W. Chen, A. L. Jiang, F. Kong, J. T. Deng, J. Y. Zhang, and C.Y. Young. Curcumin downregulates homeobox gene NKX3.1 in prostate cancer cellLNCaP. Acta Pharmacol Sin 2007.28:423-430. (SCI, 7.16)
2.Zhang, H. N.,L. Li, P. Gao, H. Z. Chen, R. Zhang, Y. S. Wei, D. P. Liu, and C. C. Liang.2010. Involvement of the p65/RelA subunit of NF-kappa B in TNF-alpha-inducedSIRT1 expression in vascular smooth muscle cells. Biochem Bioph Res Co 2010.397:569-575. (SCI, 3.32)
3.Li, L*., H. N. Zhang*, H. Z. Chen*, P. Gao, L. H. Zhu, H. L.Li, X. Lv, Q. J. Zhang, R. Zhang, Z. Wang, Z. G. She, R. Zhang, Y. S. Wei, G.H. Du, D. P. Liu, and C. C. Liang. SIRT1 Acts as a Modulator of NeointimaFormation Following Vascular Injury in Mice. Circ Res 2011.108:1180-U1195. (SCI, 23.21)
4.Zhang, H.*, Y. Wang*, J. Li*, J. Yu, J.Pu, L. Li, S. Zhang, G. Peng, F. Yang, and P. Liu. 2011. Proteome of skeletalmuscle lipid droplet reveals association with mitochondria and apolipoproteina-I. JProteome Res. 2011.10:4757-4768. (SCI, 5.35)
5. Zhang H*#, Li J#, Li L#, Liu P, Wei Y, Qian Z#. Ceramide enhancescox-2 expression and vsmc contractile hyperreactivity via er stress signalactivation. Vascular Pharmacology. 2017. 96–98: 26–32 (SCI, 5.58)
6. Zhen Gao*, HuinaZhang*, Jian Liu, Chi Wai Lau, Pingsheng Liu, Zhen Yu Chen, Hung KayLee, George L Tipoe, Hing Man Ho, Xiaoqiang Yao, Yu Huang#. Cyclooxygenase-2-dependentoxidative stress mediates palmitate-induced impairment of endothelium-dependentrelaxations in mouse arteries. 2014. 91(4):474-82. BiochemPharmacol. 2014 Oct 15;91(4):474-82.(SCI, 5.85)
7. Zhang H, Liu J, Qu D, Wang L, Luo JY, Lau CW, Liu P, Gao Z, TipoeGL, Lee HK, Ng CF, Wan Ma RC, Yao X, Huang Y. Inhibition of miR-200c restoresendothelial function in diabetic mice through suppression of COX-2. Diabetes.2016 May;65; 16. 1196-1207 (SCI, 9.34)
8.Li L, Zhang H*,Wang W, Hong Y, Wang J, Zhang S, Xu S, Shu Q, Li J, Yang F, Zheng M, Qian Z,Liu P*. Comparative proteomics revealsabnormal binding of ATGL and dysferlin on lipid droplets from pressureoverload-induced dysfunctional rat hearts.Sci Rep. 2016. Jan 22;6:19782. (SCI, 4.99)
9. Huina Zhang#*, Jian Liu#, Dan Qu, Li Wang, Chi MingWong, Chi-Wai Lau, Yuhong Huang, Yi Fan Wang, Huihui Huang, Yin Xia, Li Xiang,Zongwei Cai, Pingsheng Liu, Yongxiang Wei, Xiaoqiang Yao, Ronald Ching Wan Mai,Yu Huang*. Serum exosomes mediate delivery of arginase 1 as a novel mechanismfor endothelial dysfunction in diabetes. PNAS, 2018 July; 115; 29. E6927-E6936,(SCI, 11.2)
10. Huina Zhang#,Fan Yang#, Yichen Guo, Li Wang, Fang Fang, Hao Wu, Shaoping Nie, Yifan Wang,Man-Lung Fung, Yu Huang, Haiteng Deng, Yanwen Qin, Xinliang Ma*, Yongxiang Wei*.The contribution of chronic intermittent hypoxia to OSAHS: from the perspectiveof serum extracellular microvesicle proteins. Metabolism-clinical andexperimental, 2018,85,97–108. (SCI, 15.1)
11. LuPeng, Yu Li, Xinwei Li, Yunhui Du, Linyi Li, Chaowei Hu, Jing Zhang, Yanwen Qin, Yongxiang Wei*, Huina Zhang*. Extracellular Vesicles Derived fromIntermittent Hypoxia–Treated Red Blood Cells Impair Endothelial FunctionThrough Regulating eNOS Phosphorylation and ET-1 Expression. CardiovascularDrugs and Therapy, 2021, 35, 901–913 (SCI,3.95)
12. Lu Peng#, Xinwei Li, Yu Li,Wen Zhao, Shaoping Nie, Huahui Yu, Yue Qi, Yanwen Qin*, Huina Zhang*.Increasedconcentrations of myeloperoxidase in serum and serum extracellular vesicles areassociated with type 2 diabetes mellitus. Clinica Chimica Acta,2021,522:70-76. (SCI, 6.31)
13. Yu Li#, HuinaZhang#, Yunhui Du, Lu Peng, Yanwen Qin, HuirongLiu, Xinliang Ma*, Yongxiang Wei*. Extracellular vesicle microRNAcargoes from intermittent hypoxia-exposed cardiomyocytes and their effect onendothelium. Biochem Bioph Res Co, 2021, 548, 182e188 (SCI, 3.32)
14. Huina Zhang1#*, Jinghui Dong2#, Chi-Wai Lau3, Yu Huang3*. Berberinereverses nitroglycerin tolerance through suppressingPKCaactivity in vascular smooth muscle cells. Cardiovascular Drugs and Therapy,202208;36 (4), 633-643. (SCI, 3.95)
15. Linghai Li#,Jinghui Wang, Ding Li, Huina Zhang*. Morphineincreases myocardial triacylglycerol through regulating adipose triglyceridelipase S406 phosphorylation. Life Sciences 2021 2021 Oct 15;283:119866. (SCI, 7.36)
16. HuinaZhang*#, Lu Peng, Yifan Wang, Wen Zhao,Wayne Bond Lau, Yajing Wang, Yu Li, Yunhui Du, Linyi Li, Yu Huang, ShaopingNie, Yanwen Qin, Xinliang Ma, Yongxiang Wei. Extracellular vesicle-derivedmiR-144 as a novel mechanism for chronic intermittent hypoxia-induced endothelialdysfunction. Theranostics 2022; 12(9):4237-4249. (SCI, 13.40)
17. Xinwei Li1#, Wen Zhao1#, LuPeng1, Yu Li1, Shaoping Nie2 , Huahui Yu1 , Yanwen Qin1 and Huina Zhang*. Elevated serum extracellular vesiclearginase 1 in type 2 diabetes mellitus: a cross-sectional studyin middle-aged and elderly population. BMC Endocrine Disorders(2022) 22:62 (SCI, 3.26)
18. Wen Zhao#, Xinwei Li#, Xinxin Li, Lu Peng, YuLi, Yunhui Du, Jianxun He, Yanwen Qin and Huina Zhang*. Significantincrease of serum extracellular vesicle-packaged growth differentiationfactor 15 in type 2 diabetes mellitus: a cross-sectional study. EuropeanJournal of Medical Research (2023) 28:37 (SCI, 4.98)
19. Xinwei Li#,Wen Zhao#, Xinxin Li#,Xueying Chen, Yu Li, Jianxun He, Yanwen Qing,Linghai Li*, Huina Zhang1* The association of SPARC with hypertension and its function inendothelial-dependent relaxation. Atherosclerosis 2024 Jan:388:117390. (SCI, 5.6)
20. Yu Li, Yunhui Du, Yang Liu, Xiuhuan Chen, Xinxin Li, YanruDuan, Yanwen Qin, Huirong Liu, Xinliang Ma, Shaoping Nie*, Huina Zhang* Cardiomyocyte-derived small extracellular vesicle:a new mechanism driving diabetic cardiac fibrosis and cardiomyopathy Theranostics 2024; 14(15): 5926-5944 (SCI, 13.4)
21. Xueying Chen#, Han Guo#, Xinwei Li, Yang Liu, Xinxin Li,Zhengshuo Cui, Huijuan Ma, Jianxun He, Zhechun Zeng, Huina Zhang*.Elevated SerumExtracellular Vesicle-Packaged SPARC in Hypertension: A Cross-Sectional Studyin a Middle-Aged and Elderly Population. Journal of Clinical Hypertension, 2025; 27:e14954(SCI, 3.0)
22. Xinxin Li,Jinghua Cui, Zanbo Ding, Ziyan Tian, Yiming Kong, Linghai Li, Yang Liu, WenZhao, Xueying Chen, Han Guo, Zhengshuo Cui, Xinwei Li, Jing Yuan*, HuinaZhang*. Klebsiella Pneumoniae-Derived Extracellular VesiclesImpair Endothelial Function by Inhibiting SIRT1. CellCommunication and Signaling. 2025;23(21)(SCI, 8.9)
23. Wen Zhao,Yang Liu, Zhengshuo Cui, Xinxin Li, Han Guo, Xueying Chen, Huina Zhang#.Growth differentiation factor 15 protects against diabeticendothelial dysfunction by AMP-activated protein kinase mediation. VascularPharmacology 161 (2025) 107554 (SCI, 3.6)
24. Xuezhou Zhang,Baoan Hong, Wei Yu, Qi Miao, Wei Wang, Yuxuan Wang, Zhipeng Sun, Yuxuan Bo,Jiqing Zhang, Huina Zhang*, Ning Zhang*. Comprehensive pan-canceranalysis reveals CD70 as a promising therapeutic target and biomarker in clearcell renal cell carcinoma. International Journal of BiologicalMacromolecules 307 (2025) 142079 (SCI, 8.7)
25.Yang Liu, Xinxin Li, Zhengshuo Cui, Han Guo, Xueying Chen, Zihang Zhang, Jieqiong Tang, Wen Zhao, Huina Zhang*.Streptococcus mutans-derived extracellular vesicles disrupt endothelialfunction via eNOS and endothelin-1 modulation. Biochemicaland Biophysical Research Communications. Biochem Biophys Res Commun. 2025 Dec 23:797:153181. (SCI, 3.2)

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