目前本研究团队依托于首都医科大学附属北京天坛医院重症医学科，与神经外科、神经放射科、核医学科及首都医科大学生物工程学院和中科院计算机所的相关人员建立了密切合作关系， 在临床病例收集、影像数据处理分析等方面已经积累了丰富的经验。

导师团队中，导师本人自博士研究生阶段至今主要从事 ICU 镇静、 镇痛领域的临床与基础研究工作， 其中主要对 ICU 躁动、 谵妄与睡眠剥夺的前沿问题有着较为敏锐和准确的把控。 近几年来尤其关注 ICU 外科患者术后谵妄等术后认知功能障碍， 围绕谵妄的神经影像机制以及人工智能申请并获批国家自然科学基金青年项目、 北京市医院管理中心青苗人才项目以及北京市医院管理中心科研培育项目各 1 项。目前，以第一作者以及共同第一作者发表 SCI 论文 14 篇，累计影响因子 80.6 分。于 2019年荣获中华医学会重症医学分会颁发的“全国重症青年科学家” 。在躁动、 谵妄以及睡眠剥夺方面的主要工作如下：（1） 在睡眠剥夺方面，申请人以第一作者于重症管理领域国际重要期刊《Critical Care》（IF: 19.334，中科院一区）发表相关论文，见代表性论文①。该研究结果受到关注，美国 NBCtoday 和英国 Biomed Central 分别进行报道，同时被美国科学促进会（AAAS）在其科学新闻发布（EurekAlert）网站中转载；（2）围绕术后谵妄问题获批国自然青年项目， 期间运用多模态 MRI 技术， 以单侧额叶胶质瘤患者为对象， 深入探讨了脑认知功能网络代偿重塑对 POD 发病的调控作用； 并基于脑影像学特征构建了该人群 POD 的预测模型。 主要相关文章发表于《Frontiers in Aging Neuroscience》， （IF: 5.702， 中科院二区）、 《Neurosurgical Review》 、 《Journal of Neurosurgery》 等杂志；（3）作为第一作者撰写的 meta 分析发表于《Journal of Clinical Anesthesia》（IF： 9.375， 中科院一区）。 该研究基于 18 项高质量前瞻性队列研究，就老年患者 POD对远期认知功能预后的影响做了深入探索，发现 POD 与术后远期认知功能障碍，甚至痴呆的发生存在密切关联;（4） 另外，在躁动和谵妄临床研究方面， 目前参与了两项关于神经外科术 后 躁 动 和 POD 的前 瞻 性 临 床 研 究 （ ClinicalTrials.gov 注 册编 号 分 别 为NCT02318199 和 NCT03087838），并发表多篇相关论文。

1. 国家自然科学基金青年项目，81801042，基于神经影像特征的额叶胶质瘤患者术后谵妄预测模型的构建与临床应用研究，2019/1-2021/12，21万元，结题，主持

2. 北京市医院管理中心青年人才培养“青苗”计划，（QMS20190507），基于多模态磁共振影像的右美托咪定预防额叶胶质瘤术后谵妄的神经机制研究，2019/1-2021/12,6万，结题，主持。

3. 北京市属医院科研培育计划项目（PX2023021）， 基于面部表情行为模式的神经重症患者谵妄的识别研究，2023/1-2025/12, 15万，在研，主持。

4. 北京市属医院科研培育计划项目（PX2023018）， 经颅磁刺激技术对额叶胶质瘤患者术后谵妄及远期认知预后的影响：一项随机对照研究，2023/1-2025/12, 15万，在研，参与。

1.  Zhang GB, Li HY, Lv JM, Zhang XK, Wang YG, Duan YY, Chen HY, Zhuo ZZ, Liu YO, Huang HW#. Evidence for cognitive compensation mechanism in the postoperative delirium: a prospective multi-modal neuroimaging cohort study. Brain Imaging Behav. 2025 Sep 8. doi: 10.1007/s11682-025-01048-z. Epub ahead of print. PMID: 40916012.

2. Zhang GB, Lv JM, Yu WJ, Li HY, Wu L, Zhang SL, Shi GZ, Huang HW#. The associations of post-stroke delirium with outcomes: a systematic review and meta-analysis. BMC Med. 2024 Oct 15;22(1):470. doi: 10.1186/s12916-024-03689-1

3. Zhang GB, Li HY, Yu WJ, Ying YZ, Zheng D, Zhang XK, Wang YG, Shi GZ, Huang HW#. Occurrence and risk factors for post-stroke delirium: A systematic review and meta-analysis. Asian J Psychiatr. 2024 Sep;99:104132. doi: 10.1016/j.ajp.2024.104132

4. Zhang G, Qi B, Li H, Zhang X, Chen J, Li H, Jing B, Huang H#. A longitudinal multimodal MRI study of the visual network in postoperative delirium. Brain Imaging Behav. 2024 Dec;18(6):1394-1406. doi: 10.1007/s11682-024-00929-z. Epub 2024 Sep 19. PMID: 39298114.

5. Haoyi Li, Dao Zheng, Yonggang Wang, Yuzhe Ying, Dali Sui, Song Lin, Zhongli Jiang, Huawei Huang#, Guobin Zhang#; Decision‐making tree for surgical treatment in meningioma a geriatric cohort study. Neurosurgical Review. 2023,46(1):196. 

6.  Hua-Wei Huang*; Xiao-Kang Zhang*; Hao-Yi Li; Yong-Gang Wang; Bin Jing; You Chen; Mayur B Patel; E Wesley Ely; Ya-Ou Liu; Jian-Xin Zhou#; Lin Song#; Guo-Bin Zhang#; Higher Grade Glioma Increases the Risk of Postoperative Delirium: Deficient Brain Compensation might be a Potential Mechanism of Postoperative Delirium, Frontiers in Aging Neuroscience, 2022, 14: 822984.

7.Guobin Zhang*; Xiaokang Zhang*; Huawei Huang*; Yonggang Wang; Haoyi Li; Yunyun Duan; Hongyan Chen; Yaou Liu; Bin Jing#; Yanmei Tie#; Song Lin#; Probing individual-level structural atrophy in frontal glioma patients, Neurosurgical Review, 2022, 45(4): 2845-2855

8. Huang, Hua-Wei*; Li, Hao-Yi*; Zhang, Xiao-Kang; Shi, Guang-Zhi; Xu, Ming; Ru, Xiao-Juan; Chen, You; Mayur B. Patel; Eugene Wesley Ely; Lin, Song; Zhang, Guo-Bin#; Zhou, Jian-Xin#. Association of postoperative delirium with cognitive outcomes: A meta-analysis. Journal of Clinical Anesthesia, 2021 Nov; 77(11):1373-1381.

9. Huang, Hua-Wei*; Zhang, Guo-Bin*; Li, Hao-Yi*; Wang, Chun-Mei; Wang, Yu-Mei; Sun, Xiu-Mei; Chen, Jing-Ran; Chen, Guang-Qiang; Xu, Ming; Zhou, Jian-Xin#. Development of an early prediction model for postoperative delirium in neurosurgical patients admitted to the ICU after elective craniotomy (E-PREPOD-NS): A secondary analysis of a prospective cohort study. Journal of Clinical Neuroscience, 2021 Aug; 90:217-224. 

10. Huang, Hua-Wei*; Zhang, Guo-Bin*; Xu, Ming; Chen, Guang-Qiang; Zhang, Xiao-Kang; Zhang, Jun-Ting; Wu, Zhen; Zhou, Jian-Xin#. The impact of tracheostomy timing on clinical outcomes and adverse events in intubated patients with infratentorial lesions: early versus late tracheostomy. Neurosurgical Review, 2021 Jun; 44(3): 1513-1522.

11. Li, Hao-Yi*; Huang, Hua-Wei*; Zhang, Xiao-Kang; Wang, Yong-Gang; Ren, Xiao-Hui; Cui, Yong; Sui, Da-Li; Lin, Song#; Jiang, Zhong-Li#; Zhang, Guo-Bin#. Postoperative Long-Term Independence Among the Elderly With Meningiomas: Function Evolution, Determinant Identification, and Prediction Model Development. Frontiers in Oncology, 2021 Mar; 11:639259.

12.Hua-Wei Huang*, XiuMei Sun*, Zhong-Hua Shi, Guang-Qiang Chen, Lu Chen, Jan O Friedrich, Jian-Xin Zhou*; Effect of High-Flow Nasal Cannula Oxygen Therapy Versus Conventional Oxygen Therapy and Noninvasive Ventilation on Reintubation Rate in Adult Patients After Extubation: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Journal of Intensive Care Medicine. 2018,33(11):609-623. 

13. Hua-Wei Huang*; Li-Mei Yan*; Yan-Lin Yang; Xuan He; Xiu-Mei Sun; Yu-Mei Wang; Guo-Bin Zhang; Jian-Xin Zhou# ; Bi-frontal pneumocephalus is an independent risk factor for early postoperative agitation in adult patients admitted to intensive care unit afterelective craniotomy for brain tumor: A prospective cohort study, PLoS One, 2018, 13(7): e0201064 

14. Huang HW*;  Zhang GB;  Zhou JX; J Thorac Dis 2016; Nov;8(11):E1505-E1507

15. Hua-Wei Huang*; Bo-Lu Zheng; Li Jiang; Zong-Tong Lin; Guo-Bin Zhang#; Ling Shen#; Xiu-Ming Xi#; Effect of oral melatonin and wearing earplugs and eye masks on nocturnal sleep in healthy subjects in a simulated intensive care unit environment: which might be a more promising strategy for ICU sleep deprivation?, Critical Care, 2015, 19(1): 124 

16.Huang H*;  Jiang L;  Shen L;  Zhang G;  Zhu B;  Cheng J;  Xi X; Impact of oral melatonin on critically ill adult patients with ICU sleep deprivation: study protocol for a randomized controlled trial.Trials 2014 Aug 18;15:327

17. Huang H*;  Huang S;  Zhu P;  Xi X; Continuous versus intermittent infusion of cefepime in neurosurgical patients with post-operative intracranial infections.Int J Antimicrob Agents 2014 Jan;43(1):68-72