国家自然科学基金面上项目，82271061，角膜驻留巨噬细胞通过AIM/CD36通路对损伤后角膜缘干细胞保护的机制研究

，2023-1至 2026-12，主持

近五年重要学术论文

1: Opposing Roles of Blood-Borne Monocytes and Tissue-Resident Macrophages in Limbal Stem Cell Damage after Ocular Injury.Cells. 2023,12(16):2089. Chengxin Zhou#, Fengyang Lei#, Mirja Mittermaier, Bruce Ksander, Reza Dana, Claes H Dohlman,Demetrios G Vavvas, James Chodosh , Eleftherios I Paschalis SCI(IF=6.0)

2: Sustained Inhibition of VEGF and TNF-α Achieves Multi-Ocular Protection and Prevents Formation of Blood Vessels afterSevere Ocular Trauma. Pharmaceutics . 2023,15(8):2059. Chengxin Zhou, Fengyang Lei , Jyoti Sharma, Pui-Chuen Hui, NatalieWolkow, Claes H Dohlman, Demetrios G Vavvas, James Chodosh, Eleftherios I Paschalis SCI(IF=5.4)

3: Critical media attributes in E-beam sterilization of corneal tissue. Acta Biomaterialia. 2022,138:218-227. Sina Sharifi, HannahSharifi, Ali Akbari, Fengyang Lei, Claes H Dohlman, Miguel Gonzalez-Andrades, Curtis Guild, Eleftherios I Paschalis, JamesChodosh SCI(IF=9.7)

4: Nonmicroglia peripheral immune effects of short-term CSF1R inhibition with PLX5622. Proc Natl Acad Sci U S A ..2021,118(4):e2020660118. Fengyang Lei, Naiwen Cui, Chengxin Zhou, James Chodosh, Demetrios G Vavvas, Eleftherios IPaschalis SCI(IF=11.1)

5: Glaucoma after Ocular Surgery or Trauma: The Role of Infiltrating Monocytes and Their Response to Cytokine Inhibitors.American Journal of Pathology. 2020,190(10):2056-2066. Xiaoniao Chen, Fengyang Lei, Chengxin Zhou, James Chodosh, LiqiangWang, Yifei Huang, Claes H Dohlman, Eleftherios I Paschalis SCI(IF=6)

6: CSF1R inhibition by a small-molecule inhibitor is not microglia specific; affecting hematopoiesis and the function ofmacrophages. Proc Natl Acad Sci U S A . . 2020,117(38):23336-23338. Fengyang Lei, Naiwen Cui, Chengxin Zhou, JamesChodosh, Demetrios G Vavvas, Eleftherios I Paschalis SCI(IF=11.1)

7: Microglia Regulate Neuroglia Remodeling in Various Ocular and Retinal Injuries. Journal of Immunology. 2019,202(2):539-549.Eleftherios I Paschalis#, Fengyang Lei#, Chengxin Zhou, Xiaohong Nancy Chen, Vassiliki Kapoulea, Pui-Chuen Hui, Reza Dana,James Chodosh, Demetrios G Vavvas, Claes H Dohlman SCI(IF=5.4)

8: Stem cell-derived tissue-associated regulatory T cells suppress the activity of pathogenic cells in autoimmune diabetes. JCIInsight. 2019,4(7) :e126471. Mohammad Haque, Fengyang Lei, Xiaofang Xiong, Jugal Kishore Das 1, Xingcong Ren, Deyu Fang,Shahram Salek-Ardakani, Jin-Ming Yang, Jianxun Song SCI(IF=8)

9: The Role of Microglia and Peripheral Monocytes in Retinal Damage after Corneal Chemical Injury. American Journal ofPathology. 2018,188(7):1580-1596. Eleftherios I Paschalis#, Fengyang Lei#, Chengxin Zhou, Vassiliki Kapoulea, AristomenisThanos, Reza Dana, Demetrios G Vavvas, James Chodosh, Claes H Dohlman SCI(IF=6)

10: Permanent neuroglial remodeling of the retina following infiltration of CSF1R inhibition-resistant peripheral monocytes. ProcNatl Acad Sci U S A . . 2018,115(48):E11359-E11368.. Eleftherios I Paschalis#, Fengyang Lei#, Chengxin Zhou, VassilikiKapoulea, Reza Dana, James Chodosh, Demetrios G Vavvas, Claes H Dohlman SCI(IF=11.1)