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侯胜平，首都医科大学附属北京同仁医院教授、博士生导师，北京市眼科研究所所长；主持国家优秀青年基金、国家十三五重点研发计划课题等课题10余项；发表SCI论文110余篇，其中以通讯或第一作者在Nature Genetics、Science Advances、Advanced Science、Genome Biology、Cellular & Molecular Immunology、Ophthalmology、Arthritis & Rheumatology等杂志发表SCI论文50余篇，代表论文被Nature Reviews Rheumatology杂志主编推荐为“研究亮点”；获国家科技进步二等奖1项、中华医学科技奖等省部级一等奖3项。入选教育部长江学者奖励计划青年学者、国家百千万工程人才及突出贡献中青年专家等。
团队现有18人，博士后3人，在读博士研究生8人，在读硕士研究生6人。团队近年在Nature Genetics、Science Advances、Cellular & Molecular Immunology、Advanced Science、Genome Biology、Arthritis & Rheumatology、Investigative Ophthalmology & Visual Science等杂志发表SCI论文50余篇。
主持国家自然科学基金面上项目”RNA甲基转移酶METTLE3调控小胶质细胞可塑性介导葡萄膜炎发生的机制研究“。
主持国家自然科学基金面上项目”ATF4乳酸化修饰调控Th17/Treg平衡介导葡萄膜炎发生的作用及机制研究“。
1. Liu X, Meng J, Liao X, Liu Y, Zhou Q, Xu Z, Yin S, Cao Q, Su G, He S, Li W, Wang X, Wang W, Li D, Yang P*, Hou S*. A de novo missense mutation in MPP2 confers an increased risk of Vogt–Koyanagi–Harada disease as shown by trio-based whole-exome sequencing. Cell Mol lmmunol. 2023, doi: 10.1038/s41423-023-01088-9.
2. Fan W, Wang X, Zeng S, Li N, Wang G, Li R,He S, Li W, Huang J, Li X, Liu J, Hou S*. Global lactylome revealslactylation-dependent mechanisms underlving Th17 differentiation inexperimental autoimmune uveitis. Sci Adv. 2023, doi: 10.1126/sciadv.adh4655.
3. Wang X, Fan W, Li N, Ma Y, Yao M, Wang G, He S, Li W, Tan J, Lu Q, Hou S*. YY1 lactylationin microglia promotes angiogenesis through transcription activation-mediated upregulation of FGF2. Genome Biol. 2023 Apr 21;24(1):87. doi: 10.1186/s13059-023-02931-y.
4. Li R, LiuJ, Yi P, Yang X, Chen J, Zhao C, Liao X, Wang X, Xu Z, Lu H, Li H, Zhang Z, LiuX, Xiang J, Hu K, Qi H, Yu J, Yang P, Hou S*. Integrative Single-Cell Transcriptomics and Epigenomics Mapping of the Fetal Retina Developmental Dynamics. Adv Sci (Weinh). 2023 Jun;10(16):e2206623. doi:10.1002/advs.202206623.
5. Meng J, Li N, Liu X, Qiao S, Zhou Q, Tan J, Zhang T, Dong Z, Qi X, Kijlstra A, Mao L, Yang P*, Hou S*. NLRP3 Attenuates Intraocular Inflammation by Inhibiting AIM2-Mediated Pyroptosis Through the Phosphorylated Salt-Inducible Kinase 1/Sterol Regulatory Element Binding Transcription Factor 1 Pathway. Arthritis Rheumatol. 2023 May;75(5):842-855. doi: 10.1002/art.42420.
6. Shu N, Zhang Z, Wang X, Li R, Li W, Liu X, Zhang Q, Jiang Z, Tao L*, Zhang L*, Hou S*. Apigenin Alleviates Autoimmune Uveitis by Inhibiting Microglia M1 Pro-Inflammatory Polarization. Invest Ophthalmol Vis Sci. 2023 May 1;64(5):21.doi: 10.1167/iovs.64.5.21.
7. Wang G, LiX, Li N, Wang X, He S, Li W, Fan W, Li R, Liu J, Hou S*. Icariin alleviates uveitis by targeting peroxiredoxin 3 to modulate retinal microglia M1/M2 phenotypic polarization. Redox Biol. 2022 Jun;52:102297. doi:10.1016/j.redox.2022.102297.
8. Li W, TanJ, He S, Yue Y, Liu H, Li R, Wang X, Wang G, Fan W, Zhao C, Zhou Q, Yang P*, Hou S*. iPSC-based model of Vogt-Koyanagi-Harada disease for phenotype recapitulation and drug screening. Clin Immunol. 2023 Jan;246:109205. doi: 10.1016/j.clim.2022.109205.
9. Zhao C, LiuY, Meng J, Wang X, Liu X, Li W, Zhou Q, Xiang J, Li N, Hou S*. LGALS3BP in Microglia Promotes Retinal Angiogenesis Through PI3K/AKT Pathway During Hypoxia. Invest Ophthalmol Vis Sci. 2022 Jul 8;63(8):25. doi:10.1167/iovs.63.8.25.
10. Wang X, Fan W, Xu Z, Zhang Q, Li N, Li R, Wang G, He S, Li W, Liao D, Zhang Z, Shu N, Huang J, Zhao C, Hou S*. SOX2-positive retinal stem cells are identified in adult human pars plicata by single-cell transcriptomic analyses.MedComm. 2022 Dec 24;4(1):e198. doi: 10.1002/mco2.198.
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