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首都医科大学附属北京同仁医院，北京市眼科研究所所长，长江学者特聘教授/青年学者、国家优青、国家百千万人才工程及突出贡献中青年专家、青年北京学者，以通讯或第一作者在Nature/Science/Cell/JAMA系列子刊（Nat Genet、Nat Aging、Sci Adv、JAMA Pediatr），Cell Mol Immunol、PNAS、Genome Biol等发表80余篇SCI论文（ESI热点论文1篇，高被引论文3篇，封面3篇），代表论文被 Nature 系列杂志主编推荐为“研究亮点”，成果入选2024年度中国罕见病&儿科领域十大医学进展。主持国家重点研发计划、国家自然科学基金重点项目、优青等20余项课题，获国家科技进步二等奖1项、中华医学科技进步一等奖等省部级一等奖3项；入选全球前2%顶尖科学家榜单，担任中国老年学和老年医学学会眼科学分会副主委兼总干事、国际葡萄膜炎学会委员等。
团队现有18人，研究员4人，技术员2人，博士后1人，在读博士研究生7人，在读硕士研究生4人。团队近年在Nature Genetics、JAMA Pediatrics、Science Advances、Cellular & Molecular Immunology、Advanced Science、Genome Biology、Arthritis & Rheumatology、Investigative Ophthalmology & Visual Science等杂志发表SCI论文80余篇。
主持国家自然科学基金面上项目”RNA甲基转移酶METTLE3调控小胶质细胞可塑性介导葡萄膜炎发生的机制研究“。
主持国家自然科学基金面上项目”ATF4乳酸化修饰调控Th17/Treg平衡介导葡萄膜炎发生的作用及机制研究“。
主持国家自然科学基金重点项目“Ly6C+CCR2+小胶质细胞免疫记忆介导葡萄膜炎复发的作用机制研究”。
1. RNA甲基转移酶METTL3调控小胶质细胞可塑性介导葡萄膜炎发生的机制研究，2021-2024，国家自然科学基金面上项目
2. ATF4乳酸化修饰调控Th17/Treg平衡介导葡萄膜炎发生的作用及机制研究 ，2023-2026，国家自然科学基金面上项目
3.Ly6C+CCR2+小胶质细胞免疫记忆介导葡萄膜炎复发的作用机制研究，2026-2030，国家自然科学基金重点项目
获得奖励：
国家科技进步二等奖
中华医学科技奖一等奖
重庆市科技进步一等奖
教育部科技进步二等奖
重庆市十佳青年科技奖
代表性文章：
1. He YS, Cao F, Hu X, Liu YC, Tao SS, Wang P, HouS, Pan HF. Time Trends in the Burden of Environmental Heat and ColdExposure Among Children and Adolescents. JAMA Pediatr. 2025 Jan 1;179(1):55-64.
2. Liu X, Meng J, Liao X, Liu Y, Zhou Q, Xu Z, Yin S,Cao Q, Su G, He S, Li W, Wang X, Wang G, Li D, Yang P, Hou S. A de novomissense mutation in MPP2 confers an increased risk of Vogt-Koyanagi-Haradadisease as shown by trio-based whole-exome sequencing. Cell Mol Immunol. 2023Nov;20(11):1379-1392.
3. Li W, He S, Tan J, Li N, Zhao C, Wang X, Zhang Z,Liu J, Huang J, Li X, Zhou Q, Hu K, Yang P, Hou S. Transcription factorEGR2 alleviates autoimmune uveitis via activation of GDF15 to modulate theretinal microglial phenotype. Proc Natl Acad Sci U S A. 2024 Sep24;121(39):e2316161121.
4. Fan W, Wang X, Zeng S, Li N, Wang G, Li R, He S, LiW, Huang J, Li X, Liu J, Hou S. Global lactylome revealslactylation-dependent mechanisms underlying TH17 differentiation inexperimental autoimmune uveitis. Sci Adv. 2023 Oct 20;9(42):eadh4655.
5. Zeng S, Wang Y, Liu X, Feng H, Cao F, Chu B, Wu C,Fan W, Hu K, Lei F, Hou S. Apolipoprotein E drives microglia activationin the development of autoimmune uveitis through upregulation of peptidylprolyl isomerase F. Sci Adv. 2025.
6. Hou S, Du L, Lei B, Pang CP,Zhang M, Zhuang W, Zhang M, Huang L, Gong B, Wang M, Zhang Q, Hu K, Zhou Q, QiJ, Wang C, Tian Y, Ye Z, Liang L, Yu H, Li H, Zhou Y, Cao Q, Liu Y, Bai L, LiaoD, Kijlstra A, Xu J, Yang Z, Yang P. Genome-wide association analysis ofVogt-Koyanagi-Harada syndrome identifies two new susceptibility loci at 1p31.2and 10q21.3. Nat Genet. 2014 Sep;46(9):1007-11.
7. Huang J, Wang X, Li N, Fan W, Li X, Zhou Q, Liu J,Li W, Zhang Z, Liu X, Zeng S, Yang H, Tian M, Yang P, Hou S. YY1Lactylation Aggravates Autoimmune Uveitis by Enhancing Microglial Functions viaInflammatory Genes. Adv Sci (Weinh). 2024 May;11(19):e2308031.
8. Li X, Wang G, Wang X, Li W, Li N, Liu X, Fan W, HeS, Han Y, Su G, Cao Q, Yang P, Hou S. OR11H1 Missense Variant Confersthe Susceptibility to Vogt-Koyanagi-Harada Disease by Mediating Gadd45gExpression. Adv Sci (Weinh). 2024 Mar;11(11):e2306563.
9. Li R, Liu J, Yi P, Yang X, Chen J, Zhao C, Liao X,Wang X, Xu Z, Lu H, Li H, Zhang Z, Liu X, Xiang J, Hu K, Qi H, Yu J, Yang P, HouS. Integrative Single-Cell Transcriptomics and Epigenomics Mapping of theFetal Retina Developmental Dynamics. Adv Sci (Weinh). 2023 Jun;10(16):e2206623.
10. Wang X, Huang J, Fan W, Li N, Yang H, Yang W, Li W,Li R, Liu J, Li X, Zhou Q, Hou S. Lactate-binding protein DNMT3A inHRMECs promotes angiogenesis by upregulating VEGFA through HIF-1α lactylation.Genome Biol. 2025 Oct 30;26(1):377.
11. Fan W, Zeng S, Wang X, Wang G, Liao D, Li R, He S,Li W, Huang J, Li X, Liu J, Li N, Hou S. A feedback loop driven by H3K9lactylation and HDAC2 in endothelial cells regulates VEGF-induced angiogenesis.Genome Biol. 2024 Jun 25;25(1):165.
12. Wang X, Fan W, Li N, Ma Y, Yao M, Wang G, He S, LiW, Tan J, Lu Q, Hou S. YY1 lactylation in microglia promotesangiogenesis through transcription activation-mediated upregulation of FGF2.Genome Biol. 2023 Apr 21;24(1):87.
13. Liu X, Zeng S, Meng J, Zhou Q, Cao F, Chu B, Wu C,Wang Y, Feng H, Bi X, Chen X, Yang W, Tian M, Yang H, Hu K, Hou S.BARD1-mediated stabilization of METTL14 promotes retinal neovascularization bym6A-modifying MXD1 mRNA on a YTHDF2-dependent manner. Theranostics. 2025 Apr13;15(11):5481-5498.
14. Zhou Q, Liu X, Lu H, Li N, Meng J, Huang J, ZhangZ, Liu J, Fan W, Li W, Li X, Liu X, Zuo H, Yang P, Hou S. m6A-methylaseMETTL3 promotes retinal angiogenesis through modulation of metabolicreprogramming in RPE cells. J Neuroinflammation. 2024 Nov 6;21(1):289.
15. Cao F, He YS, Sang N, Liu YC, Hu X, Ni QY, Tao LM, HouSP, Jiang ZX, Pan HF. Age-standardized incidence, prevalence, and mortalityrates of autoimmune diseases in women of childbearing age from 1990 to 2019.Autoimmun Rev. 2023 Nov;22(11):103450.
16. Shu N, Zhang Z, Wang X, Li R, Li W, Liu X, Zhang Q,Jiang Z, Tao L, Zhang L, Hou S. Apigenin Alleviates Autoimmune Uveitisby Inhibiting Microglia M1 Pro-Inflammatory Polarization. Invest Ophthalmol VisSci. 2023 May 1;64(5):21.
17. Liu X, Zuo H, Wu C, Li N, Zhou Q, Cao F, Chu B,Zeng S, Feng H, Wang Y, Lei F, Hu K, Hou S. Muscone Attenuates UveitisThrough the PI3K/AKT Signaling Pathway. Invest Ophthalmol Vis Sci. 2025 May1;66(5):21.
18. Li J, Jiang M, Wang Q, ……, Hou S, ……Pei G,Liu GH. The X-Age Project to construct a Chinese aging clock. Nat Aging. 2025Sep;5(9):1669-1685.
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