个人信息
Personal Information
联系方式
Contact Information
个人简介
Personal Profile
侯胜平，北京同仁医院教授，博导，北京市眼科研究所所长，长江学者特聘教授、国家优青、青年长江学者、国家百千万人才工程及突出贡献中青年专家、国务院政府特殊津贴专家、青年北京学者，以通讯或第一作者在Nature/Science/Cell/JAMA系列子刊、PNAS等发表80余篇SCI论文（ESI热点论文1篇，高被引论文3篇，封面3篇），代表论文被 Nat Rev Rheumatol杂志主编推荐为“研究亮点”。主持国家重点研发计划、国家自然科学基金重点项目、国家优青等20余项课题，获国家科技进步二等奖1项、中华医学科技奖等省部级一等奖3项；担任中国老年学和老年医学学会眼科学分会副主委兼总干事等。
团队现有18人，研究员4人，技术员2人，博士后2人，在读博士研究生8人，在读硕士研究生6人。团队近年在Nature Genetics、JAMA Pediatrics、Science Advances、Cellular & Molecular Immunology、Advanced Science、Genome Biology、Arthritis & Rheumatology、Investigative Ophthalmology & Visual Science等杂志发表SCI论文50余篇。
主持国家自然科学基金面上项目”RNA甲基转移酶METTLE3调控小胶质细胞可塑性介导葡萄膜炎发生的机制研究“。
主持国家自然科学基金面上项目”ATF4乳酸化修饰调控Th17/Treg平衡介导葡萄膜炎发生的作用及机制研究“。
1. RNA甲基转移酶METTL3调控小胶质细胞可塑性介导葡萄膜炎发生的机制研究 国家自然科学面上项目
2. ATF4乳酸化修饰调控Th17/Treg平衡介导葡萄膜炎发生的作用及机制研究 国家自然科学面上项目
1. Liu X, Meng J, Liao X, Liu Y, Zhou Q, Xu Z, Yin S, Cao Q, Su G, He S, Li W, Wang X, Wang W, Li D, Yang P*, Hou S*. A de novo missense mutation in MPP2 confers an increased risk of Vogt–Koyanagi–Harada disease as shown by trio-based whole-exome sequencing. Cell Mol lmmunol. 2023, doi: 10.1038/s41423-023-01088-9.
2. Fan W, Wang X, Zeng S, Li N, Wang G, Li R,He S, Li W, Huang J, Li X, Liu J, Hou S*. Global lactylome revealslactylation-dependent mechanisms underlving Th17 differentiation inexperimental autoimmune uveitis. Sci Adv. 2023, doi: 10.1126/sciadv.adh4655.
3. Wang X, Fan W, Li N, Ma Y, Yao M, Wang G, He S, Li W, Tan J, Lu Q, Hou S*. YY1 lactylationin microglia promotes angiogenesis through transcription activation-mediated upregulation of FGF2. Genome Biol. 2023 Apr 21;24(1):87. doi: 10.1186/s13059-023-02931-y.
4. Li R, LiuJ, Yi P, Yang X, Chen J, Zhao C, Liao X, Wang X, Xu Z, Lu H, Li H, Zhang Z, LiuX, Xiang J, Hu K, Qi H, Yu J, Yang P, Hou S*. Integrative Single-Cell Transcriptomics and Epigenomics Mapping of the Fetal Retina Developmental Dynamics. Adv Sci (Weinh). 2023 Jun;10(16):e2206623. doi:10.1002/advs.202206623.
5. Meng J, Li N, Liu X, Qiao S, Zhou Q, Tan J, Zhang T, Dong Z, Qi X, Kijlstra A, Mao L, Yang P*, Hou S*. NLRP3 Attenuates Intraocular Inflammation by Inhibiting AIM2-Mediated Pyroptosis Through the Phosphorylated Salt-Inducible Kinase 1/Sterol Regulatory Element Binding Transcription Factor 1 Pathway. Arthritis Rheumatol. 2023 May;75(5):842-855. doi: 10.1002/art.42420.
6. Shu N, Zhang Z, Wang X, Li R, Li W, Liu X, Zhang Q, Jiang Z, Tao L*, Zhang L*, Hou S*. Apigenin Alleviates Autoimmune Uveitis by Inhibiting Microglia M1 Pro-Inflammatory Polarization. Invest Ophthalmol Vis Sci. 2023 May 1;64(5):21.doi: 10.1167/iovs.64.5.21.
7. Wang G, LiX, Li N, Wang X, He S, Li W, Fan W, Li R, Liu J, Hou S*. Icariin alleviates uveitis by targeting peroxiredoxin 3 to modulate retinal microglia M1/M2 phenotypic polarization. Redox Biol. 2022 Jun;52:102297. doi:10.1016/j.redox.2022.102297.
8. Li W, TanJ, He S, Yue Y, Liu H, Li R, Wang X, Wang G, Fan W, Zhao C, Zhou Q, Yang P*, Hou S*. iPSC-based model of Vogt-Koyanagi-Harada disease for phenotype recapitulation and drug screening. Clin Immunol. 2023 Jan;246:109205. doi: 10.1016/j.clim.2022.109205.
9. Zhao C, LiuY, Meng J, Wang X, Liu X, Li W, Zhou Q, Xiang J, Li N, Hou S*. LGALS3BP in Microglia Promotes Retinal Angiogenesis Through PI3K/AKT Pathway During Hypoxia. Invest Ophthalmol Vis Sci. 2022 Jul 8;63(8):25. doi:10.1167/iovs.63.8.25.
10. Wang X, Fan W, Xu Z, Zhang Q, Li N, Li R, Wang G, He S, Li W, Liao D, Zhang Z, Shu N, Huang J, Zhao C, Hou S*. SOX2-positive retinal stem cells are identified in adult human pars plicata by single-cell transcriptomic analyses.MedComm. 2022 Dec 24;4(1):e198. doi: 10.1002/mco2.198.
11. Cao F, Pan HF, Hou S*. A novel metric of autoimmunedisease burden and its estimated incidence across different stages in lifecycle of women. Autoimmun Rev. 2024; 23(12):103671.
12. He YS, Cao F, Hu X, Hou S*. Time Trends in theBurden of Environmental Heat and Cold Exposure Among Children and Adolescents.JAMA Pediatr. Published online November 4, 2024.doi:10.1001/jamapediatrics.2024.4392
13. Li W, He S, Tan J, Li N, Zhao C, Wang X, Zhang Z, Liu J, Huang J, Li X, Zhou Q, Hu K, Yang P, Hou S*. Transcription factor EGR2alleviates autoimmune uveitis via activation of GDF15 to modulate the retinalmicroglial phenotype. Proc Natl Acad Sci U S A. 2024;121(39):e2316161121.
14. Hou S, Du L, Lei B, Pang CP, Zhang M, Zhuang W, Zhang M, Huang L, Gong B, Wang M, Zhang Q, Hu K, Zhou Q, Qi J, Wang C, Tian Y, Ye Z, Liang L, Yu H, Li H, Zhou Y, Cao Q, Liu Y, Bai L, Liao D, Kijlstra A, Xu J, Yang Z, Yang P. Genome-wide association analysis of Vogt-Koyanagi-Harada syndrome identifies two new susceptibility loci at 1p31.2 and 10q21.3. Nat Genet. 2014 Sep;46(9):1007-11. doi: 10.1038/ng.3061. Epub 2014 Aug 10. PMID: 25108386.
文件上传中...
