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1. 国家自然科学基金委员会,面上项目,82073021,CNPY2调控转移前微环境促进黑色素瘤肺转移的分子机制研究,2021/01-2024/12, 55万元,在研,主持
2. 北京市医院管理中心“青苗人才”,FGF19共受体KLB作为肝细胞癌治疗靶点的分子机制研究,2022/01-2023/12, 12万元,在研,主持
3. 北京市自然科学基金委,青年项目,7174307,趋化因子CXCL1调控黑色素瘤生长与转移的旁分泌调控作用机理研究,2017/01-2018/12,10万元,已结题,主持
4. 中国博士后科学基金特别资助,2016T90186,趋化因子X在黑色素瘤生长与转移中的调控作用机理研究,2016/03-2016/09,15万元,已结题,主持
5. 中国博士后科学基金面上资助,2015M571230,趋化因子X在黑色素瘤生长与转移中的调控作用机理研究,2015/05-2016/09,5万元,已结题,主持
6. 中华医学会吴阶平基金,LCYX003,基于药物基因组学的中国高血压人群精准用药研究及应用,2019/01-2020/12,5万元,已结题,主持
7. 首都医科大学附属北京朝阳医院, 多学科临床研究创新团队项目, CYYY-2022-013-D, 分泌型CNPY2的 临床转化研究, 2022-01 至 2024-12, 50万元, 在研, 主持
8. 北京市科学技术委员会, 生命科学前沿创新培育项目, Z201100005320010, 靶向蛋白降解的分子胶水的发现和应用, 2022-01 至 2023-12, 300万元, 在研, 参与
9. 北京市科学技术委员会, 生命科学前沿创新培育项目, Z211100003321009, 通过体内遗传筛选解析肿瘤细胞逃逸免疫监控的分子机制, 2021-01 至 2022-12, 300万元, 结题, 参与
10. 科技部, 重大新药创制, 2017ZX09101001, 药物一致性评价关键技术与标准研究(化学注射 剂一致性评价的探索研究), 2017-01 至 2020-12, 30万元, 结题, 参与
11. 科技部, 重大新药创制, 2017ZX09101001, 药物一致性评价关键技术与标准研究(特殊类别 药物生物等效性评价技术研究), 2017-01 至 2020-12, 220万元, 结题, 参与
(8) 北京市自然科学基金,青年基金, 7174307, 趋化因子CXCL1调控黑色素瘤生长与转移 的旁分泌调控作用机理研究, 2017-01 至 2018-12, 10万元, 结题, 主持
1. 国家自然科学基金委员会,面上项目,82073021,CNPY2调控转移前微环境促进黑色素瘤肺转移的分子机制研究,2021/01-2024/12, 55万元,在研,主持
2. 北京市医院管理中心“青苗人才”,FGF19共受体KLB作为肝细胞癌治疗靶点的分子机制研究,2022/01-2023/12, 12万元,在研,主持
3. 北京市自然科学基金委,青年项目,7174307,趋化因子CXCL1调控黑色素瘤生长与转移的旁分泌调控作用机理研究,2017/01-2018/12,10万元,已结题,主持
4. 中国博士后科学基金特别资助,2016T90186,趋化因子X在黑色素瘤生长与转移中的调控作用机理研究,2016/03-2016/09,15万元,已结题,主持
5. 中国博士后科学基金面上资助,2015M571230,趋化因子X在黑色素瘤生长与转移中的调控作用机理研究,2015/05-2016/09,5万元,已结题,主持
6. 中华医学会吴阶平基金,LCYX003,基于药物基因组学的中国高血压人群精准用药研究及应用,2019/01-2020/12,5万元,已结题,主持
1. Guo L, Wang X, Wang S, Hua L, Song N, Hu B, Tong Z. Efficacy of immune-checkpoint inhibitors in PD-L1 selected or unselected patients vs. control group in patients with advanced or metastatic urothelial carcinoma. Oncoimmunology. 2021 Mar 5;10(1):1887551.
2. Cui Y, Miao Y, Cao L, Guo L, Cui Y, Yan C, Zeng Z, Xu M, Han T. Activation of melanocortin-1 receptor signaling in melanoma cells impairs T cell infiltration to dampen antitumor immunity. Nat Commun. 2023;14(1):5740.
3. Zuogang Li, Lin Jia, Guo L, Chunming Rao; Junzhi Wang; Yongzhang Luo; Pharmacokinetics of PEGylated recombinant human endostatin (M2ES) in rats, Acta Pharmacol Sin, 2015, 36(7):847-854.
4. Guo L, Zuogang Li, Benshan Xu, Lihong Liu, Junzhi Wang, Yongzhang Luo. Pharmacokinetics of PEGylated Recombinant Human Endostatin in Rhesus Monkeys. Life Sci. 2019;238:116967
5. Guo L, Song N, He T, Qi F, Fu Y, Chen HD, Luo Y. Endostatin inhibits the tumorigenesis of hemangioendothelioma via downregulation of CXCL1. Mol Carcinog. 2015;54(11):1340-53.
6. Wang R, Guo L, Wang J, Wu X, Jia Z. Determination of concentration of methotrexate enantiomers in intracellular and extracellular fluids of HepG2 cells by liquid chromatography-tandem mass spectrometry. Cell Biochem Biophys. 2013;67(3):1343-51.
7. Guo L, Geng X, Liu L, Miao Y, Fu Y, Liu L, Li B, Luo Y. Quality, bioactivity study, and preclinical acute toxicity, safety pharmacology evaluation of PEGylated recombinant human endostatin. J Biochem Mol Toxicol. 2019;33(3):e22257.
8. Guo L, Wang X, Xu B, Lang R, Hu B. Prognostic significance of CTNNB1 mutation in recurrence of sporadic desmoid tumors. Future Oncol. 2021;17(4):435-442.
9. Guo L, Geng X, Chen Y, Li Z, Fu Y, Li B, Luo Y. Pre-clinical Toxicokinetics and Safety Study of M2ES, a PEGylated Recombinant Human Endostatin, in Rhesus Monkeys. Regul Toxicol Pharmacol. 2014;69(3):512-23.
10. Geng X, Guo L, Qi W, Sun L, Liu X, Miao Y, Lin Z, Fu Y, Luo Y, Li. A pre-clinical safety study of PEGylated recombinant human endostatin in Sprague Dawley rats. Regul Toxicol Pharmacol. 2018; 95:190-197.
11. Guo L, Wan Z, Xu B, Song N, Liu L. Blockade of angiogenin by thalidomide inhibits the tumorigenesis of murine hemangioendothelioma. Fundam Clin Pharmacol. 2019;33(6):659-669.
12. Guo L, Chen Y, Fu Y, Rao C, Wang J, Luo Y. Nuclear-translocated endostatin downregulates hypoxia inducible factor-1α activation through interfering with Zn (II) homeostasis. Mol Med Rep. 2015;11(5):3473-80.
13. Guo L, Xu B, Zhou D, Chang G, Fu Y, Liu L, Luo Y. Biophysical and biological characterization of PEGylated recombinant human endostatin. Clin Exp Pharmacol Physiol. 2019;46(10):920-927.
14. Guo L, Shumin Wang, Zirui Wan, Xiuli Zhao, Lihong Liu. Influence of CYP2D6*5 and *10 Polymorphism on the Pharmacokinetics of Nebivolol in Healthy Chinese Subjects. J Clin Pharm Ther. 2020;45(4):632-637.
15. Zirui Wan, Guo L, Pengfei Li, Lulu Ren, He Liu, Lihong Liu, Determinants of Gefitinib pharmacokinetics in Chinese healthy male subjects: a pharmacogenomics study of Cytochrome P450 enzymes and transporters. J Clin Pharm Ther. 2020;45(5):1159-1167).
16. Guo L, Shi M, Song N, Liu H, Liu L. Anchorage of curcumin onto PVP enhances anti-tumor effect of curcumin. Medicinal Chemistry Research, 2019, 28(5), 646–656.
17. Guo L, Xu B, Hu B, Liu H, Song Nan. Synthesis and biological evaluation of 4-substituted aryl-piperazine derivatives of 1,7,8,9-tetrachloro-10,10-dimethoxy-4-azatricyclo [5.2.1.02,6] dec-8-ene-3,5-dione as anti-cancer and anti-angiogenesis agents. 2022, Letters in Drug Design & Discovery.
18. Guo L, Hua L, Hu B, Wang J.Pre-clinical Efficacy and Safety Pharmacology of PEGylated Recombinant Human Endostatin. Curr Mol Med. 2023. doi: 10.2174/1566524023666230331091757.
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