1. CircADAMTS6 在心肌细胞电重构导致的心房颤动中的作用及机制研究（81700295） ，国自然青年基金，2017.1-2020.1，负责人

2. 外泌体介导病理性心房成纤维细胞circ_0001409/miR-328/CACNA1c轴在心房重构中的机制研究，北京市医院管理局“青苗”人才计划（QMS20210301），2022.1-2024.12，负责人

3. 心房重构相关环状RNA-hsa_circ_0001204对射频消融术后房颤复发的预测价值，北京市医院管理局，首都卫生发展专项“青年优才”（2022-4-20312），2022.1-2024.12，负责人

4. 非编码RNA在心房颤动心肌重构的作用及机制研究（2-17M620836），中国博士后科学基金面上资助，2017.1-2017.11，负责人

5. 早期预警老年肿瘤患者心力衰竭的多维度整合策略的推广与实施（NO. BHTPP202004），北京市卫生健康委员会， 2020.12-2021.12，子课题负责人

6. 利用人诱导多功能干细胞源性心肌细胞（IPS-CM）探索肌型成纤维细胞源性外泌体在心房重构中的作用及机制（2020XXG-KFKT-02），教育部重点实验室开放课题， 2021.01-2022.12，负责人

7. LINC00632对miR-133／KCNQ1轴的调控作用在心房电重构中的作用机制，首都医科大学培育基金，2021.01-2021.12，负责人

8. 新型分子生物标记物ARCR对射频消融术后房颤复发的预测价值及临床应用初探，首都医科大学附属北京朝阳医院科创基金，2022.08-2024.08，负责人

主要发表（第一或通讯，含并列）：

1. Kun Zuo#, Chen Fang#, Yuanfeng Gao#, Yuan Fu, Hongjiang Wang, Jing Li, Jiuchang Zhong, Xinchun Yang*, Li Xu*. Suppression of the gut microbiota-bile acid-FGF19 axis in patients with atrial fibrillation. Cell Proliferation. 2023 Apr 26;e13488. 【Q1/8.755】

2. Yuanfeng Gao#, Xiaolin Xue#, Dayi Hu, Wenling Liu, Yue Yuan, Hongmei Sun, Lei Li, Katherine W. Timothy, Li Zhang, Cuilan Li*, Ganxin Yan*, Inhibition of Late Sodium Current by Mexiletine: A Novel Pharmotherapeutical Approach in Timothy Syndrome. Circulation Arrhythmia and Electrophysiology, 2013, 6(3): 614-622.【Q1/7.718】

3. Jane F Ferguson, Chenyi Xue, Yuanfeng Gao, Tian Tian, Jianting Shi, Xuan Zhang, Ying Wang, Yuhuang D Li, Zhi Wei, Mingyao Li, Hanrui Zhang, Muredach P Reilly*. Tissue-Specific Differential Expression of Novel Genes and Long Intergenic Noncoding RNAs in Humans With Extreme Response to Evoked Endotoxemia. Circ Genom Precis Med. 2018, 11(11):e001907.【Q1/7.465】

4. Xiaoming zhu#, Kuibao Li* and Yuanfeng Gao*. Adeno-associated virus-mediated in vivo suppression of expression of EPHX2 gene modulates the activity of paraventricular nucleus neurons in spontaneously hypertensive rats. Biochem Biophys Res Commun, 2022 Mar 23;606:121-127.【Q2/3.575】

5. Yuxia Pan#, Li Xu#, Xinchun Yang, Mulei Chen*, Yuanfeng Gao*. The common characteristics and mutual effects of heart failure and atrial fibrillation: initiation, progression, and outcome of the two aging-related heart diseases. Heart Failure Review. 2022,May;27(3):837-847. 【Q2/4.654】

6. Yuanfeng Gao#, Junxian Song#, Hong Chen*, Chengfu Cao, Chongyou Lee, TRPV1 Activation is Involved in the Cardioprotection of Remote Limb Ischemic Postconditioning in Ischemia-reperfusion Injury Rats. Biochem Biophys Res Commun, 2015, 463(4): 1034-1039. 【Q2/3.575】

7. Yuan Fu; Hao Sun; Zongsheng Guo; Li Xu; Xinchun Yang; Lefeng Wang; Kuibao Li; Mulei Chen*; Yuanfeng Gao*, A risk score model to predict in-hospital mortality of patients with end-stage renal disease and acute myocardial infarction. Internal and emergency medicine, 2021 Jun;16(4):905-912. 【Q2/5.472】

8. Shichao Li#, Yuanfeng Gao#, Ye Liu, Jing Li, Xiyan Yang, Roumu Hu, Jia Liu, Yuan Zhang, Kun Zuo, Kuibao Li, Xiandong Yin, Mulei Chen, Jiuchang Zhong*, Xinchun Yang*. Myofibroblast-derived Exosomes Contribute to Development of a Susceptible Substrate for Atrial Fibrillation. Cardiology. 2020;145:324-332. 【Q3/2.342】

9. Changyang Su#, Zheng Liu#, Yuanfeng Gao#, Ye Liu; Rou-Mu Hu, Jia Liu, Xiyan Yang, Shichao Li, Yuan Zhang, Kun Zuo, Boli C, Jing Li, Kuibao Li, Xiandong Yin, Mulei Chen*, Xinchun Yang*. Study on the relationship between telomere length changes and recurrence of atrial fibrillation after radiofrequency catheter ablation. Journal of Cardiovascular Electrophysiology. 2019, 30(7), 1117-1124.【Q3/2.942】

10. Yuanfeng Gao, Wenling Liu, Cuilan Li*, Xiaoliang Qiu, Xuguang Qin, Baojing Guo, Xueqin Liu, Jianfeng Li, Yue Yuan, Xiaomei Li, Lu Liang, Lei Li, Kui Hong, Jielin Pu, Jinqiu Liu, Qing Wang, Li Zhang, Da-yi Hu*, Common Genotypes of Long QT Syndrome in China and the Role of ECG Prediction. Cardiology. 2016, 133(2): 73-78.【Q3/2.342】

11. Yuanfeng Gao#, Liu Y#, Fu Y#, Wang Q, Liu Z, Hu R, Yang X and Chen M*. The potential regulatory role of hsa_circ_0004104 in the persistency of atrial fibrillation by promoting cardiac fibrosis via TGF-β pathway. BMC cardiovascular disorders. 2021 Jan 9;21(1):25. 【Q4/2.174】

12. Qianhui Wang #, Li Xu #, Ying Dong, Yuan Fu, Yuxia Pan, Qianran Luan, Ye Liu, Zheng Liu, Xinchun Yang, Mulei Chen*, Yuanfeng Gao*. Plasma Galectin-3 is associated with progression from paroxysmal to persistent atrial fibrillation. BMC Cardiovascular Disorders. 2021 May 2;21(1):226.【Q4/2.174】

13. Chuang Li#, Kuizheng He#, Yixing Yang, Kuibao Li, Mulei Chen, Lefeng Wang, Yuanfeng Gao*, Xiaorong Xu*. Discordance of circulating non-HDL cholesterol with LDL cholesterol concerning long-term prognosis in statin-treated individuals with previous coronary artery bypass grafting following percutaneous coronary intervention. Reviews in Cardiovascular Medicine. 2023.Apr. 12. (accepted)【Q2/4.430】

其它发表（第一或通讯，含并列）：

14. Jia Liu #, Mei-Li Zheng #, Mulei Chen, Kuibao Li, Xiaoming Zhu*, Yuanfeng Gao*. Effect of ApoEε4 gene polymorphism on the correlation between serum uric acid and left ventricular hypertrophy remodeling in patients with coronary heart disease. Frontiers in Cardiovascular Medicine. 2022 Dec 21;9:1055790.【Q2/5.846】

15. Qianhui Wang #, Wei Huai #, Xiaoguang Ye#, Yuxia Pan, Xinchun Yang, Mulei Chen, Qing-Bian Ma, Yuanfeng Gao*, Yuan Zhang*. Circulating plasma galectin-3 predicts new-onset atrial fibrillation in patients after acute myocardial infarction during hospitalization. BMC Cardiovasc Disord. 2022 Sep 3;22(1):392. 【Q4/2.174】

16. Qianhui Wang#, Zheng Liu#, Ying Dong, Xinchun Yang, Mulei Chen* and Yuanfeng Gao*. Leukocyte telomere length predicts progression from paroxysmal to persistent atrial fibrillation after catheter ablation. Frontiers in Cardiovascular Medicine. 2022 Jan 24;8:813390. 【Q2/5.846】

17. Wenkai Liao#, Li Xu#, Yuxia Pan, Jie Wei, Peijia Wang, Xinchun Yang, Mulei Chen*; Yuanfeng Gao*. Association of Atrial Arrhythmias with Thrombospondin-1 in Patients with Acute Myocardial Infarction. BMC Cardiovascular Disorders. 2021 Oct 20;21(1):507. 【Q4/2.174】

18. Yuanfeng Gao#, Chongyou Lee#; Junxian Song; Sufang Li; Yuxia Cui; Yongzhen Liu; Jie Wang; Fengmin Lu; Hong Chen*; Digenic mutations on SCAP and AGXT2 predispose to premature myocardial infarction. Oncotarget, 2017, 8(59): 100141-100149. 【发表年Q2/5.642】

19. Yuanfeng Gao; Cuilan Li*; Robby Wu; Xiaoliang Qiu; Ruijuan Liang; Lei Li; Li Zhang; Dayi Hu Genotype-phenotype analysis of three Chinese families with Jervell and Lange-Nielsen syndrome. Journal of Cardiovascular Disease Research. 2012. 3(2): 67-75.

20. 杨曦艳#，杨新春，陈牧雷，高元丰*. 外周血白细胞端粒长度与急性心肌梗死后新发房性心律失常的相关性. 中国循环杂志 2021 年 8 月 第 36 卷 第 8 期 809-813页.

21. 高元丰, 陈红. 家族性高胆固醇血症诊断进展. 中华老年心脑血管病杂志. 2016. (07)

22. 高元丰, 李翠兰. 诱导多能干细胞技术在遗传性心律失常研究中的应用. 心血管病学进展. 2013. (01): 15-18.

23. 高元丰, 刘文玲, 胡大一等. 钠通道相关遗传性心律失常的SCN5A基因筛查. 中国心脏起搏与心电生理杂志. 2013. (02): 107-110.

24. 李翠兰, 高元丰. 系统生物学与心律失常. 中国医学前沿杂志(电子版). 2013. (06): 37-42.

25. 高元丰, 李翠兰. Jervell和Lange-Nielsen综合征发病机制与治疗策略. 心血管病学进展. 2012. (04): 445-448.

授权发明专利

1.Hong Chen，Yuanfeng Gao,Junxian Song，Chongyou Lee，Sufang Li. SCAP gene mutant and the application thereof,2018.11.26，澳大利亚，2016351311

2. 陈红，高元丰，宋俊贤，李忠佑，李素芳。“SCAP突变体及其应用”2018.12.11， 中国，ZL201510980242.6

3.陈牧雷，高元丰，杨新春等。家族性高胆固醇血症相关基因及其检测试剂盒与应用，2022-07-22，中国，ZL202110700765.6

发表专著

《整合运动药理学》 联合副主编 编委

获得学术奖励

高元丰（4/15）；获奖项目名称《国人遗传性心律失常和心肌病基因筛查、致病机制与治疗探索》，中国医疗保健国际交流促进会，华夏医学科技奖，三等奖，2019年（李翠兰 刘文玲 胡大一 高元丰 刘雯 仇晓亮 薛小临 王震 刘欣 刘杰 葛庆 谢文丽 梁鹏 王洪涛 朱天刚）