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自2007年毕业于首都医科大学，就职于北京友谊医院泌尿外科，经过一阶段和二阶段住院医师规范化培训，完成一年住院总医师及半年外科住院总医师培训，擅长肾癌、前列腺癌、膀胱癌、肾盂输尿管癌的微创治疗及围手术期的辅助治疗、精准治疗等，开展前列腺激光、等离子剜除术，对于前列腺PSA增高患者给予无痛经会阴饱和前列腺穿刺术（开展日间手术），开展泌尿系结石开展各种微创治疗。2016年在美国耶鲁大学医学院作为访问学者学习一年。已经获得首都医科大学博士学位。
本团队，进行泌尿系肿瘤疾病的基础和临床研究，对于微创治疗、药物治疗、分子机制等方面进行探索。
主持一项北京市自然科学基金面上项目（编号7222034，ARDAP@SPION-MNPs复合纳米颗粒触发人肾癌干细胞铁死亡的机制研究，2022-1至2024-12）
主持一项北京市自然科学基金面上项目（编号7222034，ARDAP@SPION-MNPs复合纳米颗粒触发人肾癌干细胞铁死亡的机制研究，2022-1至2024-12）。
参研国自然等省部级课题多项。
1. Hongliang Shen, Zixiang Geng, Xiaoli Nie, Te Liu. Erianin Induces Ferroptosis of Renal Cancer Stem Cells via Promoting ALOX12/ P53 mRNA N6-methyladenosine Modification.J Cancer. 2023 Jan 22;14(3):367-378. doi: 10.7150/jca.81027
2. Michela Puxeddu, Hongliang Shen#, Ruoli Bai, Antonio Coluccia, Marianna Bufano, Marianna Nalli, Jessica Sebastiani, Diego Brancaccio, Eleonora Da Pozzo, Chiara Tremolanti, Claudia Martini, Viviana Orlando, Stefano Biagioni, Maria Stefania Sinicropi, Jessica Ceramella, Domenico Iacopetta , Addolorata Maria Luce Coluccia, Ernest Hamel, Te Liu, Romano Silvestri, Giuseppe La Regina. Discovery of pyrrole derivatives for the treatment of glioblastoma and chronic myeloid leukemia. Eur J Med Chem. 2021 Oct 5;221:113532. doi: 10.1016/j.ejmech.2021.113532.（共一）
3. Michela Puxeddu, Hongliang Shen#, Ruoli Bai, Antonio Coluccia, Marianna Nalli, Carmela Mazzoccoli, Eleonora Da Pozzo, Chiara Cavallini, Claudia Martini, Viviana Orlando, Stefano Biagioni, Cristina Mazzoni, Addolorata Maria Luce Coluccia, Ernest Hamel, Te Liu, Romano Silvestri, Giuseppe La Regina. Structure-activity relationship studies and in vitro and in vivo anticancer activity of novel 3-aroyl-1,4-diarylpyrroles against solid tumors and hematological malignancies. Eur J Med Chem. 2020 Jan 1;185:111828. doi: 10.1016/j.ejmech.2019.111828. （共一）
4. Yibing Si, Junfeng Liu, Hongliang Shen#, Chen Zhang, Yuanhao Wu, Yongyi Huang, Zhangbin Gong, Jun Xue, Te Liu. Fisetin decreases TET1 activity and CCNY/CDK16 promoter 5hmC levels to inhibit the proliferation and invasion of renal cancer stem cell. J Cell Mol Med. 2019 Feb;23(2):1095-1105. doi: 10.1111/jcmm.14010.（共一）
5. Darryl T Martin, Hongliang Shen, Jill M Steinbach-Rankins, Xi Zhu, Katelyn K Johnson, Jamil Syed, W Mark Saltzman, Robert M Weiss. Glycoprotein-130 Expression Is Associated with Aggressive Bladder Cancer and Is a Potential Therapeutic Target. Mol Cancer Ther. 2019 Feb;18(2):413-420. doi: 10.1158/1535-7163.
6. Zhang Hu, Zheng Jiajia, Shen Hongliang#, et al.Curcumin Suppresses In Vitro Proliferation and Invasion of Human Prostate Cancer Stem Cells by Modulating DLK1-DIO3 Imprinted Gene Cluster MicroRNAs. Genet Test Mol Biomarkers. 2018;22(1):43-50.(共一)
7. Hongliang Shen , Qingjun Liu, Mingyi Li, Peiqian Yang. The prognostic value of vascular endothelial growth factor in patients with renal cell carcinoma: a systematic review of the literature and meta-analysis. Clin Invest Med. 2017 Apr 26;40(2):E40-E48. doi: 10.25011
8. Shen Hongliang, Yang Peiqian, Liu Qingjun, et al. Nuclear expression and clinical significance of phosphohistidine phosphatase 1 in clear-cell renal cell carcinoma. J Int Med Res. 2015 ;43(6):747-57.
9. Liu Qingjun, Shen Hongliang#, Lin Jin, et al. Synergistic roles of p53 and HIF1α in human renal cell carcinoma-cell apoptosis responding to the inhibition of mTOR and MDM2 signaling pathways. Drug Des Devel Ther. 2016 ;10:745-55. （共一)
10. Shen Hongliang, Yang Peiqian, DU Lindong, et al. Horseshoe kidney with retrocaval ureter: one case report. Chin Med J (Engl). 2012;125(3):543-545
11. 基于mpMRI第二版PIRADS 分区经会阴前列腺穿刺的安全性和有效性，中华泌尿外科杂志. 2022, 43(6), 418-422
12.沈洪亮, 王旭东, 李明义等.非转移性肾癌患者术后Nomogram预后模型的研究. 中华泌尿外科杂志.2018; 39(4): 245-250.
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