依托首都医科大学、首都医科大学宣武医院、北京脑重大疾病研究院和国家工程研究中心等高水平平台，团队具备完善的学习与科研软硬件条件，能够为硕士、博士研究生提供从理论训练到临床转化的全链条支撑。具体包括：

1. 多平台协同与学科交叉优势：高校、三甲医院与科研院所一体化联动，形成神经科学、临床医学、生物信息学、医学工程等多学科交叉的研究生态，便于开展机制研究与临床问题导向的创新探索;

2. 完备的科研基础设施：配备规范化实验与技术平台，可满足分子与细胞、动物模型、影像与电生理、病理与生物样本处理、数据分析等方向的常规与进阶需求;

3. 临床资源与转化条件：依托宣武医院的优势专科与病例资源，具备临床队列建设、随访管理、样本采集与标准化质控体系，支持从临床需求提出、科学问题凝练到成果转化验证的闭环研究。依托国家工程研究中心的工程研发与验证能力，强化关键技术攻关、原型开发、系统集成与性能评估，为科研成果走向应用提供路径与条件;

4. 系统化培养与学术支持环境：建立覆盖文献研读、课题设计、方法学训练、数据管理、论文写作与学术交流的培养体系，提供稳定的学术讨论机制与开放合作渠道，促进学生快速进入研究前沿并形成独立科研能力。

1.国家科技重大专项子课题，2023ZD0505400，急性缺血性卒中血流再通基础上的神经保护研究，2024.08-2028.07

2.首都医科大学宣武医院“汇智”人才工程，HZ2025ZCBJ002，急性缺血性脑卒中再灌注基础上的急性期脑保护和二级预防研究，2025.01-2029.12

3.北京市杰出青年科学基金，JQ24041，急性缺血性脑卒中靶向亚低温神经保护研究，2024.07-2027.06

4.北京市首批医师科学家培训项目，BJPSTP-2024-04，2024.05-2025.05

5.国家自然科学基金，面上项目，82271507，血管再通基础上基于自体血体外循环技术的脑动脉内靶向低温治疗重症急性缺血性脑卒中患者的有效性和安全性研究，2023.01-2026.12

6.2021年首医优秀青年人才项目，B2108，急性缺血性脑卒中，2022.01-2024.12

7.国家自然科学基金，面上项目，82071468，mtUPR 介导的“神经元自救”在脑动脉内靶向亚低温治疗脑梗死中的机制研究，2021.01-2024.12

8.北京市医管局青苗计划，QML20190801，血管再通基础上的动脉血管内亚低温对急性缺血性脑损伤的神经保护作用机制研究，2020.01-2021.12

9.国家自然科学基金，青年科学基金项目，81701287，CD38-cADPR-Ca2+通路调控的线粒体跨细胞转移—区域性亚低温治疗缺血性脑卒中的重要机制，2018.01-2020.12

10.国家自然科学基金，地区联合项目，U1404809，TRPA1介导的中枢和外周敏化—A型肉毒毒素治疗三叉神经痛的重要机制，2015.01-2017.12

1.国家科技重大专项子课题，2023ZD0505400，急性缺血性卒中血流再通基础上的神经保护研究，2024.08-2028.07

2.首都医科大学宣武医院“汇智”人才工程，HZ2025ZCBJ002，急性缺血性脑卒中再灌注基础上的急性期脑保护和二级预防研究，2025.01-2029.12

3.北京市杰出青年科学基金，JQ24041，急性缺血性脑卒中靶向亚低温神经保护研究，2024.07-2027.06

4.北京市首批医师科学家培训项目，BJPSTP-2024-04，2024.05-2025.05

5.国家自然科学基金，面上项目，82271507，血管再通基础上基于自体血体外循环技术的脑动脉内靶向低温治疗重症急性缺血性脑卒中患者的有效性和安全性研究，2023.01-2026.12

6.2021年首医优秀青年人才项目，B2108，急性缺血性脑卒中，2022.01-2024.12

7.国家自然科学基金，面上项目，82071468，mtUPR 介导的“神经元自救”在脑动脉内靶向亚低温治疗脑梗死中的机制研究，2021.01-2024.12

8.北京市医管局青苗计划，QML20190801，血管再通基础上的动脉血管内亚低温对急性缺血性脑损伤的神经保护作用机制研究，2020.01-2021.12

9.国家自然科学基金，青年科学基金项目，81701287，CD38-cADPR-Ca2+通路调控的线粒体跨细胞转移—区域性亚低温治疗缺血性脑卒中的重要机制，2018.01-2020.12

10.国家自然科学基金，地区联合项目，U1404809，TRPA1介导的中枢和外周敏化—A型肉毒毒素治疗三叉神经痛的重要机制，2015.01-2017.12

重要学术论文

1. Jovin TG, Li C, Wu L, Chuanjie Wu, et al. Trial of Thrombectomy 6 to 24 Hours after Stroke Due to Basilar-Artery Occlusion. New England Journal of Medicine 2022;387:1373-1384.

2. Chuanjie Wu; Jiaqi Guo; Yunxia Duan; Jiachen He; Shuaili Xu; Guiyou Liu; Chen Zhou; Yuchuan Ding; Xianjun Zhu; Xunming Ji; Di Wu; Mitigating Early Phosphatidylserine Exposure in a Tmem30a-Dependent Way Ameliorates Neuronal Damages After Ischemic Stroke. MedComm (2020). 2025;6(4):e70140.

3. Chuanjie Wu; Chengbei Hou; Wenbo Zhao; Chuanhui Li; Xuehong Chu; Longfei Wu; Yuan Wang; Chen Zhou; Guiyou Liu; Wanying Zhang; Ming Li; Zhengfei Ma; Yuchuan Ding; Ran Meng; Xunming Ji*; Di Wu*; Lipoprotein(a), remote ischemic conditioning, and stroke recurrence in patients with symptomatic intracranial atherosclerotic stenosis. Neurotherapeutics. 2025;22(4):e00579.

4. Yuanyuan Liu; Chengbei Hou; Xiao Dong; Di Wu; Xuehong Chu; Jiaqi Luo; Wanwan Zhang; Erlan Yu; Chuanhui Li; Chen Zhou; Chuanjie Wu*; Xunming Ji*; Sex-Related Difference in Outcomes of Remote Ischemic Conditioning for Symptomatic Intracranial Atherosclerotic Stenosis. Cyborg Bionic Syst. 2025;6:0275.

5. Mengke Zhang; Ruiwen Che; Xin Liu; Chengbei Hou; Zhongyue Wang; Sen Hu; Shengqi Fu; Yuan Kan; Hailiang Sun; Jianmin Xu; Shiliang Ma; Sijie Li; Changhong Ren; Wenbo Zhao; Milan Jia; Jingang Wang; Chuanjie Wu*; Xunming Ji*; Clinical diagnosis of cerebral amyloid angiopathy related hemorrhage in China: Simplified Edinburgh criteria and Boston criteria version 2.0. Eur Stroke J. 2025; 10(4):1373-1382.

6. Xuehong Chu; Zhengfei Ma; Yifeng Liu; Jun Sun; Ning Wang; Chaoqun Li; Xiangyang Feng; Jianqiao Li; Benxiao Wang; Chen Zhou; Chuanhui Li; Wenbo Zhao; Xunming Ji; Chuanjie Wu; IRIS, a randomised, double-blind, placebo-controlled trial of interleukin-6 receptor inhibition undergoing endovascular treatment in acute anterior circulation ischaemic stroke: study rationale and design. Stroke Vasc Neurol. 2025; 10(4):514-519.

7. Erlan Yu; Xuehong Chu; Wanwan Zhang; Xiangbin Meng; Yaodong Yang; Xunming Ji*; Chuanjie Wu*; Large Language Models in Medicine: Applications, Challenges, and Future Directions. Int J Med Sci. 2025;22(11):2792-2801.

8. Wanwan Zhang; Erlan Yu; Wenbo Zhao; Chuanjie Wu*; Xunming Ji*;  Secondary prevention for intracranial atherosclerotic stenosis: Where we stand and challenges ahead. J Transl Int Med. 2025;12(6):537-539. 

9. Lina Jia; Chengbei Hou; Qing Mei; Bowei Zhang; Wenbo Zhao; Heng Zhao; Suhang Shang; Xiuhai Guo; Qingfeng Ma; Haiqing Song; Chuanhui Li; Ran Meng; Weihai Xu; Yilong Wang; Gelin Xu; Chuanjie Wu*; Xunming Ji*; Remote ischemic conditioning for the prevention of stroke-associated pneumonia (RICA-2): protocol for a multicenter, prospective, randomized, double-blind, sham-controlled phase III trial. Trials. 2025; 26(1): 419

10. Yuanyuan Liu; Xiao Dong; Xuehong Chu; Zhengfei Ma; Tingyu Yi; Changming Wen; Yifeng Liu; Jun Sun; Jing Xu; Wenbo Li; Lei Yang; Benxiao Wang; Lei Shi; Jianqiao Li; Xiaoman Zhang; Chaoqun Li; Wenhuo Chen; Chuanhui Li; Di Wu ; Chengbei Hou; Chen Zhou; Ming Li; Yi Xu; Chuanjie Wu*; Xunming Ji*; Albumin for patients with acute large-vessel occlusive stroke undergoing endovascular therapy (ARISE): the protocol of a randomized double-blind trial. Front Neurol. 2025;18:16:1570184.

11.Xiao Dong; Yuanyuan Liu; Xuehong Chu; Erlan Yu; Xiaole Jia; Xunming Ji; Chuanjie Wu*; Blood pressure management after endovascular thrombectomy: Insights of recent randomized controlled trials. CNS Neurosci Ther. 2024;30(8):e14907.

12. Hongrui Ma, Ruiwen Che, Qihan Zhang, Wantong Yu, Longfei Wu, Wenbo Zhao, Ming Li, Di Wu, Chuanjie Wu*, Xunming Ji*. The optimum anticoagulation time after endovascular thrombectomy for atrial fibrillation-related large vessel occlusion stroke: a real-world study. Journal of Neurology. 2023;270:2084–2095.

13. Nan Yang; Hangil Lee; Chuanjie Wu. Intravenous thrombolysis for acute ischemic stroke: From alteplase to tenecteplase. Brain Circ 2023;9:61-3.

14. Fang Xue, Ho Jun Yun , Liwei Peng, Chuanjie Wu. Where are we heading in postChina angioplasty and stenting for symptomatic intracranial severe stenosis era? Brain Circ 2023;9:3-5.

15. Miaowen Jiang, Ming Li, Yuan Gao, Longfei Wu, Wenbo Zhao, Chuanhui Li, Chengbei Hou, Zhengfei Qi, Kun Wang, Shiqiang Zheng , Zhichen Yin, ChuanjieWu*, Xunming Ji*. The intra-arterial selectivecooling infusion system: A mathematical temperature analysis and in vitroexperiments for acute ischemic stroke therapy. CNS Neurosci Ther. 2022;28(9):1303-1314.

16. Wen Hui, Chuanjie Wu, WenboZhao, Huan Sun, Jun Hao, HongyanLiang, Xian Wang, Ming Li, Ashutosh P. Jadhav, YouliHan, Xunming Ji*. Efficacy and Safety of Recanalization Therapy for Acute Ischemic StrokeWith Large Vessel Occlusion. Stroke. 2020;51:2026–2035.

17. Longfei Wu, Di Wu, Tuo Yang, Jin Xu, Jian Chen, Luling Wang, Shuaili Xu, Wenbo Zhao, ChuanjieWu*, Xunming Ji*. Hypothermic neuroprotection against acute ischemic stroke: The 2019 update. JCBFM.2020;40(3):461-481.

18. Chuanjie Wu; Fang Xue; Yajun Lian; Jing Zhang; Di Wu; Nanchang Xie; Wansheng Chang; Fan Chen; Lijun Wang; Wenjing Wei; Kun Yang; Wenbo Zhao; Longfei Wu; Haiqing Song; Qingfeng Ma; Xunming Ji*; Relationship between elevated plasma trimethylamine N-oxide levels and increased stroke injury. Neurology, 2020, 94(7): e667-e677.

19. Chuanjie Wu; Chenghe Sun; Lijun Wang; Yajun Lian; Nanchang Xie; Shengming Huang; Wenbo Zhao; Ming Ren; Di Wu; Jianping Ding; Haiqing Song; Yuping Wang; Qingfeng Ma*; Xunming Ji*; Low-Dose Tirofiban Treatment Improves Neurological Deterioration Outcome After Intravenous Thrombolysis. Stroke, 2019, 50(12): 3481-3487.

20. Chuanjie Wu; Wenbo Zhao; Hong An; Longfei Wu; Jian Chen; Mohammed Hussain; Yuchuan Ding; Chuanhui Li; Wenjing Wei; Jiangang Duan; Chunmei Wang;Qi Yang; Di Wu; Liqiang Liu; Xunming Ji*; Safety, feasibility, and potential efficacy of intraarterial selective cooling infusion for stroke patients treated with mechanical thrombectomy. Journal of Cerebral Blood Flow and Metabolism. 2018, 38(12): 2251-2260.

21. Chuanjie Wu; Chuanhui Li; Wenbo Zhao; Nanchang Xie; Feng Yan; Yajun Lian; Li Zhou; Xiaoya Xu; Yong Liang; Lu Wang; Ming Ren; Sijie Li; Xuan Cheng;Lu Zhang; Qingfeng Ma; Haiqing Song; Ran Meng; Xunming Ji*; Elevated trimethylamine N-oxide related to ischemic brain lesions after carotid artery stenting. Neurology, 2018, 90(15): e1283-e1290.

22. Chuanjie Wu; Dongsheng Guan; Ming Ren; Zhengfei Ma; Changming Wan; Yinglin Cui; Ping Zhong; Wenbo Zhao; Chuanhui Li; Feng Yan; Jinqiu Xie; Fang Xue; Yajun Lian; Hongbo Liu; Cui Wang; Xunming Ji; Nanchang Xie*; Aminophylline for treatment of postdural puncture headache: A randomized clinical trial. Neurology, 2018, 90(17): e1523-e1529.

学术论著：

《亚低温神经保护治疗学》，副主编，人民卫生出版社，2022年

重要奖项：

1.卒中脑损伤新机制与靶向低温救治新技术研发及推广应用   北京市科技进步   一等奖   202503

2.脑动脉内靶向亚低温神经保护技术的创研与应用推广  北京医学科技奖   二等奖   2022

3.A型肉毒毒素治疗经典三叉神经痛的临床疗效及作用机制   河南省科学技术进步奖   三等奖   2021

4.基于血流再通的缺血性卒中脑保护救治关键技术研发及应用推广   北京市科学技术进步奖   二等奖   202008

5.缺血性脑卒中非药物防治新技术的创研与应用   中华医学科技奖   一等奖   202001