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高源，中药学博士，副教授，就职于首都医科大学中医药学院。主要从事中药药理和毒理学研究。首次发现了传统无毒中药淫羊藿、补骨脂及其制剂致免疫特异质型肝损伤，实验证实了淫羊藿、补骨脂配伍可导致更加严重的肝脏损伤，是一种新的条件性的配伍增毒现象，丰富和发展了传统中药配伍禁忌的内容。目前主持国家自然科学青年基金1项、参加重点研发计划、重点项目等国家级项目多项。以第一（共一）作者在Acta Pharm Sin B，Cell Death Dis，Cell Commun Signal，Front Med等发表SCI收录论文8篇。
国家自然科学基金委员会，青年科学基金项目，82004057，基于NLRP3炎症小体的淫羊藿补骨脂配伍加重特异质肝损伤的作用机制研究，2021-01至2023-12,24万元，在研，主持。
国家自然科学基金委员会，青年科学基金项目，82004057，基于NLRP3炎症小体的淫羊藿补骨脂配伍加重特异质肝损伤的作用机制研究，2021-01至2023-12,24万元，在研，主持。
（1）Gao Yuan#; Wang Zhilei#; Tang Jinfa; Liu Xiaoyi; Shi Wei; Qin Nan; Wang Xiaoyan; Pang Yu; Li Ruisheng; Zhang Yaming; Wang Jiabo; Niu Ming*; Bai Zhaofang*; Xiao Xiaohe*; New incompatible pair of TCM: Epimedii Folium combined with Psoraleae Fructus induces idiosyncratic hepatotoxicity under immunological stress conditions, Frontiers of Medicine, 2020, 14(1): 68-80.
（2）Gao Yuan#; Xu Guang#; Ma Li#; Shi Wei#; Wang Zhilei; Zhan Xiaoyan; Qin Nan; He Tingting; Guo Yuming; Niu Ming; Wang Jiabo; Bai Zhaofang*; Xiao Xiaohe*; Icarisid I specifically facilitates ATP or nigericin-induced NLRP3 inflammasome activation and causes idiosyncratic hepatotoxicity, Cell Communication and Signaling, 2021, 19(1): 13.
（3）Wang Zhilei#; Xu Guang#; Gao Yuan#; Zhan Xiaoyan; Qin Nan; Fu Shubin; Li Ruisheng; Niu Ming; Wang Jiabo; Liu Youping*; Xiao Xiaohe*; Bai Zhaofang*; Cardamonin from a medicinal herb protects against LPS-induced septic shock by suppressing NLRP3 inflammasome, Acta Pharmaceutica Sinica B, 2019, 9(4): 734-744.
（4）Shi Wei#; Xu Guang#; Zhan Xiaoyan#; Gao Yuan#; Wang Zhilei; Fu Shubin; Qin Nan; Hou Xiaorong; Ai Yongqiang; Wang Chunyu; He Tingting; Liu Hongbin; Chen Yuanyuan; Liu Yan; Wang Jiabo; Niu Ming; Guo Yuming; Xiao Xiaohe*; Bai Zhaofang*; Carnosol inhibits inflammasome activation by directly targeting HSP90 to treat inflammasome-mediated diseases, Cell Death & Disease, 2020, 11(4): 252.
（5）Yuan Gao#; Wei Shi#; Hongyu Yao#; Yongqiang Ai; Ruisheng Li; Zhilei Wang; Tingting Liu; Wenzhang Dai; Xiaohe Xiao; Jun Zhao*; Ming Niu*; Zhaofang Bai*; An Integrative Pharmacology Based Analysis of Refined Liuweiwuling Against Liver Injury: A Novel Component Combination and Hepaprotective Mechanism, Frontiers in Pharmacology, 2021, 12:747010. doi: 10.3389/fphar.2021.747010.
（6）Yuan Gao, Jiabo Wang*. Commentary: Indirect action pattern: a remote and cross-organ pharmacological mechanism for drug innovation, Acta Pharmaceutica Sinica B, 2022, 12(8): 3448-3450.
（7）Zhi-e Fang#, Chunyu Wang#, Ming Niu, Tingting Liu, Lutong Ren, Qiang Li, Zhiyong Li, Ziying Wei, Li Lin, Wengqing Mu, Yuan Gao*, Xiaoxiao He*, Zhaofang Bai*. Integration of Transcriptomic and Metabolomic Data to Compare the Hepatotoxicity of Neonatal and Adult Mice Exposed to Aristolochic Acid I, Frontiers in Genetics, 2022, 25;13:840961.
（8）Yuan Gao, Wei Shi, Can Tu, Peng Li , Guanyu Zhao, Xiaohe Xiao*, Jiabo Wang *, Zhaofang Bai *. Immunostimulatory Activity and Structure-Activity Relationship of Epimedin B from Epimedium brevicornu Maxim., Frontiers in Pharmacology, 2022, 13:1015846. doi: 10.3389/fphar.2022.1015846.
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