1. 胰岛素信号通路N6-甲基腺嘌呤（m6A）异常修饰与2型糖尿病的关联研究，北京市自然科学基金面上项目（7232233）

2. 靶向胰岛素PI3K/Akt信号传导通路的环状RNAs与血糖异常转化的关联及作用机制研究，国家自然科学基金面上项目（81773511）

3. 应激相关miRNAs表达水平及遗传变异与胰岛素抵抗的关联研究，国家自然科学基金面上项目（81573214）

4. miR-34c、miR-144与胰岛素抵抗的关联及相关功能研究，北京市自然科学基金面上项目（7162020）

5. 脂代谢相关miRNAs与冠心病关系的分子流行病学研究，北京市教委科技计划面上项目（KM201510025006）

重要学术论文

[1] Chen N, Liu YH, Hu LK, MaLL, Zhang Y, Chu X, Dong J, Yan YX*.Association of variability in metabolic parameters with the incidence of type 2 diabetes: evidence from a functional community cohort. Cardiovasc Diabetol.2023; 22(1): 183.

[2] Chen N#, Wu LJ#,Xiao HB, Liu YH, Hu LK, Ma LL, Chu X, Dong J, Yan YX*. Occupational stress is associated with insulinresistance and incident type 2 diabetes: a prospective cohort study offunctional community. Clin Chim Acta. 2023; 544: 117356.

[3] Li YL, Li L, Liu YH, Hu LK, Yan YX*. Identification of metabolism-related proteins as biomarkers of insulin resistance and potentialmechanisms of m6A modification. Nutrients. 2023; 15(8): 1839.

[4] Chen N#, Hu LK#,Sun Y, Dong J, Chu X, Lu YK, Liu YH, Ma LL, Yan YX*. Associations of waist-to-height ratio with the incidenceof type 2 diabetes and mediation analysis: two independent cohort studies. ObesRes Clin Pract. 2023; 17(1): 9–15.

[5] Dong J#, Hu LK#,Lu YK, Liu YH, Chu X*, Yan YX*.Association of serum uric acid with the risk of developing hypertension: a prospective cohort study with mediation analysis. Hypertens Res. 2023; 46(2):345-56.

[6] Hu LK#, Liu YH#,Yang K, Chen N, Ma LL, Yan YX*.Associations between long-term exposure to ambient fine particulate pollution with the decline of kidney function and hyperuricemia: a longitudinal cohortstudy. Environ Sci Pollut Res. 2023; 30(14): 40507-18. 

[7]Dong J#, Liu YH#,Lu YK, Hu LK, Chen N, Ma LL, Chu X*,Yan YX*. Association betweensurrogate indicators of insulin resistance and risk of type 2 diabetes combinedwith hypertension among Chinese adults: two independent cohort studies. Nutr Metab (Lond). 2022; 19(1):85.

[8]Yan YX#*, Dong J#, Li YL,Lu YK, Yang K, Wang T, Zhang X, Xiao HB*. CircRNA hsa_circ_0071336 is associated with type 2diabetes through targeting the miR-93-5p/GLUT4 axis. FASEB J. 2022; 36(5):e22324. 

[9] Lu YK#, Dong J#, Li YL,Liu YH, Hu LK, Chu X*, Yan YX*.Association between insulin resistance and incidence of carotid atheroscleroticplaque: a cohort study. Nutr Metab CardiovascDis. 2022; 32(4): 981-93.

[10] Lu YK#, Dong J#, Sun Y, Hu LK, Liu YH, Chu X*, Yan YX*. Gender-specificpredictive ability for the risk of hypertension incidence related to baselinelevel or trajectories of adiposity indices: a cohort study of functionalcommunity. Int J Obes (Lond). 2022; 46(5): 1036-43.

[11] Wang T#, Yang K#, Zhang X#, Luo J, XuR, Wang X, Yang Y, Bai X, Ma Y*, Yan Y*,Jiao L*. Endovascular therapy for symptomatic intracranial artery stenosis:a systematic review and network meta-analysis. Transl Stroke Res. 2022. 13(5):676-685.

[12] Liu YH#, Lu YK#, Liu XT, Li YL, Hu LK, Gao HY,Yang K*, Yan YX*. Association of household solid fuel use and long-termexposure to PM2.5 with arthritis in middle-aged and older populationin China: a cohort study. Ecotoxicol Environ Saf. 2022; 230: 113104.

[13] Yan YX*,Xiao HB, Lu YK, Sun Y, Wang S, Dong J, Wu LJ*. hsa_circ_0111707 is associated with risk of stress-related type2 diabetes via sponging miR-144-3p. Front Endocrinol (Lausanne). 2022; 12:790591.

[14] Chen N#, Zhang XY#, Ma LL, ZhaoGD, Yan YX*. Trends of cancer mortality in Xi'an City, China: 2005-2020. J Cancer Res Clin Oncol. 2022. 148(10): 2781-92.

[15] Sun Y, Lu YK, Gao HY, Yan YX*.Effect of metabolites levels on type 2 diabetes mellitus and glycemic traits: a Mendelian randomization study. J Clin Endocrinol Metab. 2021; 106(12): 3439–47. 

[16] Lu YK#, Chu X#, Wang S, Sun Y, Zhang J, Dong J, Yan YX*. Identification of circulatinghsa_circ_0063425 and hsa_circ_0056891 as novel biomarkers for detection of type2 diabetes. J Clin Endocrinol Metab. 2021; 106(7): e2688-99.

[17] Yan YX*,Xiao HB, Zhang J, Wang S, Dong J, Wu LJ*. Pri-miR-144 rs9279 is associated withtype 2 diabetes and regulation of stress response. J Cell Physiol. 2021;236(1): 561-69.