神经退行性疾病是神经元功能和结构的逐渐丧失导致认知障碍（如痴呆）、运动异常等。随着老龄化的加剧,神经退行性疾病患病人数逐年上升。目前神经退行性疾病的发病机制尚未明晰,治疗药物很少,且仅能缓解症状，无法逆转或阻止神经元的丧失。神经退行性疾病是全球主要致残原因之一，也是仅次于心血管疾病的第二大致死原因，给患者、家庭及社会带来了极大的痛苦和沉重的负担。因此开展神经退行性疾病研究,探索疾病发生发展机制,寻找有效的早期诊断、预防和治疗具有重要现实意义。本课题组利用模式生物线虫、小鼠等构建了阿尔兹海默症（AD），帕金森症（PD），肌萎缩侧索硬化症（ALS）等模型，开展基因、药物、益生菌等筛选，并探究机制，最终进行转化。

首医优秀青年人才项目A类

国家自然基金面上项目

Innovation (影响因子32.1）杂志青年编委

Innovationlife 联合创始人

Aging and Disease 杂志青年编委

Brain-X杂志青年编委

(#first author, *correspondingauthor)

近五年论文:

Chang Yuan, Junying Zhang,Wei Yao, Mingqin Qu, Lingqiang Zhang, Xiangming Wang*, Minmin Liang*. 2025. Bioengineered SuperoxideBuffering Extends Lifespan via Regulation of Mitochondrial Redox Homeostasisand UPRmt activation. Nano Research. In press. (中科院一区top，影响因子：9)

Ruijie Bai#, Tao Wang#,Rongrong Gu#, Yawei Cai#, Juntao Chen, Wen Cai, Dianshuang Zhou, Ying, Li, Jixun Luo, Xiangming Wang*, Zuobin Zhu*. 2025.Microbial Genetic Composition Regulates Host Social Behavior. GutMicrobes. 17(1):2536091. (中科院一区top，影响因子：11)

Ying Li#, Ruijie Bai#, YaoZhu#, Peng Shi#, Tao Wang, Dianshuang Zhou, Jianteng Zhou, Tao Zhu, XinrongZhang, Rongrong Gu, Xiaoyue Ding, Hao Chen*, Xiangming Wang*, Zuobin Zhu*. 2025. Genetic variation in gut microbe as a key regulator of host social behaviorin C. elegans. Gut Microbes, 17(1):2490828. (中科院一区top，影响因子：11)

Feiyan Zhu, Jiuyang He,Lingfei Kong, Zhanjun Guo, Pengpeng Liang, Jianlin Zhang*, Xiangming Wang*,Minmin Liang*. 2025. H-ferritin: A newcytoprotective antioxidant strategy via detoxification of hydrogen peroxide tooxygen. Nano Research.18, 94907189. (中科院一区top，影响因子：9)

Wenqian Wang#, Mingqin Qu#,Tong Zhang#, Yang Wang#, Ceping Zheng#, Fuping Lu, Xiangming Wang*,Fufeng Liu*. 2025. A microbiome war in our gut. The Innovation Life.3:100111.

Zhengdi Wang, Hailong Wen,Ceping Zheng, Xiangming Wang*, Sijie Yin*, Ningning Song*, Minmin Liang*.2025. Synergistic Co-Cu Dual-Atom Nanozyme with Promoted Catalase-like Activityfor Parkinson's Disease Treatment. ACS Appl Mater Interfaces. 17(1):583-593. (中科院二区，影响因子：8.2)

Xiangming Wang*, Kang Shen*. 2024. Newscissor for lysosome. The Innovation Life. 2(2):100064.

Zhan Cui, Fang-Yan Guo, LiLi, Fuping Lu, Cheng-Hua Jin*, Xiangming Wang*, Fufeng Liu*. 2024.  Brazilin-7-acetate, a novel potential drug ofParkinson's disease, hinders the formation of α-synuclein fibril, mitigatescytotoxicity, and decreases oxidative stress. Eur J Med Chem. 264:115965. (中科院二区，影响因子：5.9)

Qing Qin, Kang Shen*, XiangmingWang*. 2023. Targeting and surveillance mechanisms for tail-anchoredproteins. The Innovation Life. 1(1).100013-1-6.

Jianxin Xie, Wei Zou,Tugizova Madina, Kang Shen*, Xiangming Wang*. 2023. MBL-1 and EEL-1affect the splicing and protein levels of MEC-3 to control dendrite complexity.PLoS Genetics. 19(9). e1010941. (中科院二区top，影响因子：3.7)

Huichao Deng#, XinhuaQiao#, Ting Xie, Wenfeng Fu, Hang Li, Yanmei Zhao, Miaomiao Guo, Yaqian Feng,Ligong Chen, Yan Zhao, Long Miao, Chang Chen*, Kang Shen*, Xiangming Wang*.2021. SLC-30A9 is required for Zn2+ homeostasis, Zn2+ mobilization,and mitochondrial health. Proc. Natl. Acad. Sci. USA. 118(35).1-12. (中科院一区top，影响因子：9.1)

Yinsuo Zhao, Eli Song,Wenjuan Wang, Chung-Han Hsieh, Xinnan Wang, Wei Feng*, Xiangming Wang*, Kang Shen*. 2021. Metaxins are core components ofmitochondrial transport adaptor complexes. Nat. Commun. 12(1): 83. (中科院一区top，影响因子：15.7)

Qing Qin, Ting Zhao, WeiZou, Kang Shen*, Xiangming Wang*. 2020.An Endoplasmic Reticulum ATPase Safeguards Endoplasmic Reticulum Identity byRemoving Ectopically Localized Mitochondrial Proteins. Cell Rep. 33(6):108363. (中科院一区top，影响因子：6.9)

Xianzhuang Liu, XiangyangGuo, Liling Niu, Xixia Li, Fei Sun, Junjie Hu, Xiangming Wang*, Kang Shen*. 2019. Atlastin-1 regulates morphologyand function of endoplasmic reticulum in dendrites. Nat. Commun. 10(1):568. (中科院一区top，影响因子：15.7)

2019年以前论文:

Xing Liang, Xintong Dong,Moerman, D. G., Kang Shen*, XiangmingWang*. 2015. Sarcomeres Pattern Proprioceptive Sensory Dendritic Endingsthrough UNC-52/Perlecan in C. elegans.Dev.Cell. 33(4):388-400. (中科院一区top，影响因子：8.7)

Recommended by faculty of 1000, Preview in the same issue: Jiang N, ParrishJZ. Muscles get dendrites into shape. Developmental cell, 2015, 33, 369-370.

Xiangming Wang, Fanli Zhou, Sijing Lv, Peishan Yi, Zhiwen Zhu, Yihong Yang, Guoxin Feng,Wei Li, Guangshuo Ou*. 2013. Transmembrane protein MIG-13 links the Wntsignaling and Hox genes to the cell polarity in neuronal migration. Proc.Natl. Acad. Sci. USA. 110(27):11175-11180. (中科院一区top，影响因子：9.1)

Ting Zhu#, Xing Liang#, Xiangming Wang*, Kang Shen*. 2017. Dyneinand EFF-1 control dendrite morphology by regulating the localization pattern ofSAX-7 in epidermal cells. J. Cell Sci. 130(23):4063-4071. (中科院三区，影响因子：3.6)

Xianzhuang Liu, Xiangming Wang*, Kang Shen*. 2016. Receptortyrosine phosphatase CLR-1 acts in skin cells to promote sensory dendriteoutgrowth. Dev. Biol. 413(1):60-9. (中科院三区，影响因子：2.1)

Xiangming Wang*, Jianhong Liu, Zhiwen Zhu, Guangshuo Ou. 2015. The heparansulfate-modifying enzyme glucuronyl C5-epimerase HSE-5 controls Caenorhabditis elegans Q neuroblastpolarization during migration. Dev. Biol. 399(2): 306-14. (中科院三区，影响因子：2.1)

Xiangming Wang*, Xiaoyan Wang, Lianda Li, Danqiao Wang*. 2010. Lifespan extension in Caenorhabditis elegans by DMSO isdependent on sir-2.1 and daf-16. Biochem.Biophys. Res. Commun. 400(4):613-8. (中科院四区，影响因子：2.2)

Xiangming Wang#, Min Liu#, Weida Li, Christopher D. Suh, Zuoyan Zhu, Yishi Jin, QichangFan*. 2009. The function of a spindle checkpoint gene bub-1 in C. elegansdevelopment. PLoS One. 4(6): e5912. (中科院三区，影响因子：2.6)

Xiangming Wang, Christopher D. Suh, Zuoyan Zhu, Qichang Fan*. 2007. Minichromosomemaintenance protein 5 homologue in Caenorhabditiselegans plays essential role for postembryonic development. Biochem.Biophys. Res. Commun. 359(4):965-71. (中科院四区，影响因子：2.2)

Bin Zhang, Lilin Zhao, JingNing, Jacob D Wickham, Haokai Tian, Xiaoming Zhang, Meiling Yang, Xiangming Wang, Jianghua Sun. 2020.miR-31-5p regulates cold acclimation of the wood-boring beetle Monochamus alternatus via ascarosidesignaling. BMC Biol. 18(1):184. (中科院二区top，影响因子：4.5)

Rui Dong, Ting Zhu, LorenaBenedetti, Swetha Gowrishankar, Huichao Deng, Yiying Cai, Xiangming Wang, Kang Shen*, Pietro De Camilli*. 2018. The inositol 5-phosphatase INPP5K participates inthe fine control of ER organization. J. Cell Biol. 217(10):3577-3592. (中科院一区top，影响因子：6.4)

Shuai Zhang, Zhibin Fan,Ping Qiao, Yinsuo Zhao, Yanan Wang, Da Jiang, Xiangming Wang, Xiaojuan Zhu, Yu Zhang, Baiqu Huang, Jun Lu*,Xiaoxue Li*. 2018. miR-51 regulates GABAergic synapses by targeting Rab GEFGLO-4 and lysosomal trafficking-related GLO/AP-3 pathway in Caenorhabditis elegans. Dev.Biol. 436(1):66-74. (中科院三区，影响因子：2.1)

Ze Cheng#, Peishan Yi#, Xiangming Wang, Yongping Chai, GuoxinFeng, Yihong Yang, Xing Liang, Zhiwen Zhu, Wei Li*, Guangshuo Ou*. 2013. Conditionaltargeted genome editing using somatically expressed TALENs in C. elegans. Nat. Biotechnology. 31(10):934-7. (中科院一区top，影响因子：41.7)

Guoxin Feng#, Peishan Yi#,Yihong Yang#, Yongping Chai#, Dong Tian, Zhiwen Zhu, Jianhong Liu, Fanli Zhou,Ze Cheng, Xiangming Wang, Wei Li,Guangshuo Ou*. 2013. Developmental stage-dependent transcriptional regulatorypathways control neuroblast lineage progression. Development. 140:3838-3847. (中科院二区，影响因子：3.6)

Yongping Chai#, Wei Li#,Guoxin Feng, Yihong Yang, Xiangming Wang, Guangshuo Ou*. 2012. Liveimaging of cellular dynamics during Caenorhabditiselegans postembryonic development. Nat. Protoc. 7(12):2090-102. (中科院一区top，影响因子：16)