主持或参与的科研项目情况

1.      国家自然科学基金委员会，面上项目，32373064，IncFII质粒驱动的mcr-8引起宿主菌适应性进化的代谢调控机制，2024-01至2027-12，50万元，在研，主持

2.      北京市自然科学基金委员会，面上项目，6222017，多黏菌素耐药蛋白MCR-8与肺炎克雷伯氏菌细胞膜互作机理研究和靶标鉴定，2022-01至2024-12，20万元，在研，主持

3.      北京市科技技术委员会、中关村科技园区管理委员会，Z211100007021009，北京市科技计划，肉制品中食源性致病菌对消毒剂耐受的评价规范研究，2021-08至2023-08，22.5万元，在研，子课题负责人

4.      科技部，国家重点研发计划，2017YFC1600300，“主要畜禽产品中关键危害物迁移转化机制及安全控制机理研究”中课题“畜禽体内微生物毒素的协同侵染规律与危害形成机制”，2018-01至2021-12，58.7万元，结题，子课题负责人

5.      科技部，国家重点研发计划，2017YFC1600500，“食品污染物暴露组解析和总膳食研究”中课题“外暴露解析与中国总膳食研究”，2018-01至2021-12，54万元，结题，子课题负责人

6.      北京市卫生健康委员会，首都卫生发展科研专项青年优才项目, 首发2018-4-3017，北京地区食品源病原菌多黏菌素耐药基因MCR-3的分子流行病学及耐药机制研究，2018-01至2020-12，20万元，结题，主持

7.      国家自然科学基金委员会，青年基金项目，31602107，基于蛋白质组学和代谢组学的mcr-1基因介导的多粘菌素耐药机制研究，2016-01至2017-12，15万元，结题，主持

8.      中国博士后科学基金委员会，一等资助项目，2015M580151，酰胺醇类耐药空肠弯曲菌的非标记定量蛋白质组学研究，2015-08至2017-04，8万元，结题，主持

9.      科技部，国家重点研发计划（973项目），2013CB127200，畜禽重要病原菌抗生素耐药性的形成、传播及控制研究，2013-01至2017-12，3600万元，结题，参与

10.  国家自然科学基金委员会，面上基金项目，31272604，磁性微球-聚醚类药物抗体复合物制备及性质研究，2013-01至2016-12，80万元，结题，参与

11.  国家自然科学基金委员会，面上基金项目，31672604，质粒介导多粘菌素耐药基因mcr-1在动物源大肠杆菌的分子传播机制，2017-01至2020-12，63万元，结题，参与

发表论文情况:

共同第一及通讯作者发表论文

1. Ling Wei#, QiyanChen#, Lu Yang, Tongzhen Ji, Wenjing Peng, Bing Shao*, Hui Li*. Emergence ofST1193 clone in maternal and neonatal ESBL-producing E. coli isolates.Infection and Drug Resistance, 2023, accepted. IF2022=3.9

2. Xuan Wu, Lu Yang,Yige Wu, Hui Li*, Bing Shao*. Spread of multidrug-resistant Pseudomonasaeruginosa in animal-derived foods in Beijing, China. International Journalof Food Microbiology, 2023, Oct 16;403:110296. doi:10.1016/j.ijfoodmicro.2023.110296. IF2022=5.4

3. Hui Li,Heli Li, Xuan Wu, Yongning Wu, Jing Zhang, Yumin Niu, Yongning Wu, JingguangLi, Yunfeng Zhao, Bing Lyu, Bing Shao*. Human dietary exposure tobisphenol-diglycidyl ethers in China: Comprehensive assessment through a totaldiet study. Environment International, 2022 Dec;170:107578. doi:10.1016/j.envint.2022.107578. Epub 2022 Oct 12. IF2022=11.8

4.Wenjing Peng(#), HuiLi(#), Xiaole Zhao, Bing Shao*, Kui Zhu*. Pyocyanin modulatesgastrointestinal transformation and microbiota. Journal of Agricultural and FoodChemistry, 2022 Mar 2;70(8):2722-2732. doi: 10.1021/acs.jafc.1c07726. Epub2022 Feb 16. IF2022=6.1

5. Hui Li,Yanchao Liu, Lu Yang, Xuan Wu, Yige Wu, Bing Shao*. Prevalence of Escherichiacoli and antibiotic resistance in animal-derived food samples — six districts,Beijing, China, 2020. China CDC Weekly, 2021 Nov 19;3(47):999-1004. doi:10.46234/ccdcw2021.243. IF2022=4.7

6. Hui Li,Yingyu Wang, Qiyan Chen, Xi Xia, Jianzhong Shen, Yang Wang, Bing Shao*.Identification of functional interactome of colistin resistance protein MCR-1in Escherichia coli. Frontiers in Microbiology, 2021 Jan 25;11:583185.doi: 10.3389/fmicb.2020.583185. eCollection 2020. IF2022=5.2

7. Bing Shao(#), HuiLi(#), Jianzhong Shen, Yongning Wu*. Nontargeted detection methods for foodsafety and integrity. Annual Review of Food Science and Technology, 2019Mar 25;10:429-455. doi: 10.1146/annurev-food-032818-121233. Epub 2019 Jan 17. IF2022=12.4

8. Hui Li(#),Yingyu Wang(#), Qingshi Meng (#), Yang Wang, Guoliang Xia, Xi Xia*, JianzhongShen*. Comprehensive proteomic and metabolomic profiling of mcr-1-mediatedcolistin resistance in Escherichia coli. International Journal ofAntimicrobial Agents, 2019 Jun;53(6):795-804. doi: 10.1016/j.ijantimicag.2019.02.014.Epub 2019 Feb 24. (IF2022=10.8)

9. Yaoting Zhang(#),Hui Li(#), Jing Zhang, Bing Shao*. Determination of Alternaria toxins indrinking water by ultra-performance liquid chromatography tandem massspectrometry. Environmental Science and Pollution Research, 2019Aug;26(22):22485-22493. doi: 10.1007/s11356-019-05483-6. Epub 2019 Jun 3. IF2022=5.8

10. Hui Li(#),Lu Yang(#), Zhihai Liu, Wenjuan Yin, Dejun Liu, Yingbo Shen, Timothy Walsh ,Bing Shao*, Yang Wang*. Molecular insights into functional differences betweenmcr-3- and mcr-1-mediated colistin resistance. Antimicrobial Agents andChemotherapy, 2018 Aug 27;62(9):e00366-18. doi: 10.1128/AAC.00366-18. Print2018 Sep. IF2022=4.9

11. Hui Li,Yingyu Wang, Qin Fu, Yang Wang, Xiaowei Li, Congming Wu, Zhangqi Shen, QijingZhang, Peibin Qin, Jianzhong Shen*, Xi Xia*. Integrated genomic and proteomicanalyses of high-level chloramphenicol resistance in Campylobacter jejuni. ScientificReports, 2017, Dec 5, 7(1):16973. doi: 10.1038/s41598-017-17321-1. IF2022=4.6

12. Xiaoqing Zhu(#),Xiaoming Wang(#), Hui Li(#), Yanhong Shang, Yushan Pan, Congming Wu,Yang Wang, Xiangdang Du*, Jianzhong Shen. Novel lnu(G) gene conferringresistance to lincomycin by nucleotidylation, located on Tn6260 fromEnterococcus faecalis E531. Journal of Antimicrobial Chemotherapy, 2017,72(4):993-997.

13. Hui Li,Yingyu Wang, Xiaowei Li, Qin Fu, Yawen Shan, Tianhe Liu, Xi Xia*. Determinationof valnemulin in swine and bovine tissues by ultra-high performance liquidchromatography–tandem mass spectrometry. Journal of Chromatography B,2016, 1014:102–106.

14. Hui Li(#),Xi Xia(#), Xiaowei Li, Gaowa Naren, Qin Fu, Yang Wang, Congming Wu, ShuangyangDing, Suxia Zhang, Haiyang Jiang, Jiancheng Li, Jianzhong Shen*. Untargetedmetabolomic profiling of amphenicols–resistant Campylobacter jejuni byultra-high performance liquid chromatography–mass spectrometry. Journal ofProteome Research, 2015, 14(2):1060-8.

15. Hui Li,Xi Xia, Yanan Xue, Shusheng Tang, Xilong Xiao, Jiancheng Li*, Jianzhong Shen*.Simultaneous determination of amoxicillin and prednisolone in bovine milk usingultra-high performance liquid chromatography tandem mass spectrometry. Journalof Chromatography B, 2012, 900: 59-63.

16. Hui Li, GuoquanWu, Shusheng Tang, Xilong Xiao, Jiancheng Li*. Pharmacokinetics andpharmacodynamics of a novel amoxicillin/sulbactam/prednisolone intramammaryinfusion in lactating cows after repeated administrations. VeterinarniMedicina, 59, 2014 (5): 221–229.

发明授权专利:

1.      李会，邵兵，吴萱，吴一戈.一种抗体或其抗原结合片段及其制备方法和应用.中国发明专利，ZL 2022 1 1112994.7，申请日2022-07-15，公告日2023-07-31，申请号CN2022111129947

2.      李会，邵兵，吴一戈，吴萱. 一种复杂食品基质中虾原肌球蛋白的定量检测方法. 申请日2023-08-02，申请号CN2023109602532.