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芮宏亮,男,博士,副主任医师,副教授。毕业于北京大学医学部及香港科技大学,获博士学位。师从肾脏病专家谌贻璞教授。
2005-2009年于中日友好医院肾病中心工作,2010-2020年在首都医科大学附属北京安贞医院肾内科工作,2021年-至今于首都医科大学附属北京中医医院 北京市中医药研究所工作。作为负责人获得国家自然科学基金项目2项,省级科研基金项目3项和北京市科技新星。发表文章50余篇,其中SCI收录20篇。擅长慢性肾脏病诊治,主要研究方向包括膜性肾病的免疫机制,冷球蛋白血症肾损伤、遗传性间质性肾病等。
1. 国家自然科学基金, GSK3-ULK1介导的自噬在中国被毛孢拮抗肾间质纤维化中的作用研究(编号:81441134)
2. 北京市自然科学基金,靶向抑制MEKK4延缓马兜铃酸致肾间质纤维化的进展,(编号7132090)
3. 国家自然科学基金青年基金项目, Ras/Raf/MEK/ERK信号通路在醛固酮致肾间质纤维化中的作用研究(编号 7152048)
4. 北京市科技新星计划 A 类 (2006)
1. Na Zhang, Haoran Dai, Xuan Dong, Wenbin Liu, Hanxue Jiang, Qihan Zhao, Yu Gao, Zhendong Feng, Zhaocheng Dong, Yuehong Hu, Guangrui Huang, Hongliang Rui*, Baoli Liu*. Level of interleukin 35 in patients with idiopathic membranous nephropathy and its predictive value for remission time. Front Immunol. 2022, 13:926368.
2.Yu Gao, Haoran Dai, Na Zhang, Hanxue Jiang, Zihan Zhang, Zhendong Feng, Zhaocheng Dong, Wenbin Liu, Fei Liu, Xuan Dong, Qihan Zhao, Xiaoshan Zhou, Jieli Du, Naiqian Zhang, Hongliang Rui*, Baoli Liu*. The Ameliorative Effect of Mahuang Fuzi and Shenzhuo Decoction on Membranous Nephropathy of Rodent Model is Associated With Autophagy and Wnt/β-Catenin Pathway. Front Pharmacol. 2022, 13:820130.
3.Guo-qin Wang*, Hong-liang Rui*, Hong-rui Dong, Li-Jun Sun, Min Yang, Yan-yan Wang, Nan Ye, Zhi-rui Zhao, Xue-jiao Liu, Xiao-yi Xu, Yi-pu Chen, Hong Cheng. SMRT sequencing revealed to be an effective method for ADTKD-MUC1 diagnosis through follow-up analysis of a Chinese family. Sci Rep. 2020, 25; 10(1):8616.
4.Jing Zhao, Hong-liang Rui*, Min Yang, Li-Jun Sun, Hong-rui Dong, Hong Cheng.CD36-mediated Lipid Accumulation and Activation of NLRP3 Inflammasome Lead to Podocyte Injury in Obesity-Related Glomerulopathy. Mediators Inflamm. 2019, 2019:3172647.
5.芮宏亮, 程虹, 王国勤, 徐潇漪, 栾海霞, 杨敏, 王艳艳, 叶楠, 董鸿瑞, 孙丽君, 谌贻璞*. 冷球蛋白血症相关性肾小球肾炎30例临床及病理分析, 中国实用内科杂志,2018,38(6): 553~558.
6.芮宏亮, 程虹*, 谌贻璞, 不同检测条件影响冷球蛋白检测结果的实验研究, 中华检验医学杂志, 2016, 39(12): 901~905.
7.Hong-liang Rui, Yan-yan Wang, Hong Cheng*, Yi-pu Chen, JNK-dependent AP-1 activation is required for aristolochic acid-induced TGF-β1 synthesis in human renal proximal epithelial cells, Am J Physiol Renal Physiol, 2012, 302(12): F1569-1575.
8.Hong-liang Rui, Ernest Fan, Hai-meng Zhou, Zhen Xu, Yi Zhang, Sheng-cai Lin*, SUMO-1 modification of the C-terminal KVEKVD of Axin is required for JNK activation but has no effect on Wnt signaling, J Biol Chem, 2002, 277(45): 42981-42986.
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