个人信息
Personal Information
联系方式
Contact Information
个人简介
Personal Profile
马登科博士，首都医科大学药学院化学生物学系，教授，博士生导师。2017年6月博士毕业于浙江大学化学系，师从麻生明教授（中科院院士）。2017年8月在香港科技大学Jianwei Sun教授课题组从事博士后研究。2019年10月在西班牙加泰罗尼亚化学研究所（ICIQ）Paolo Melchiorre教授课题组从事博士后研究，同时入选欧洲研究委员会玛丽居里学者人才计划。2022年4月入职首都医科大学药学院化学生物学系，开展独立研究工作。主要从事不对称催化与合成，光催化，合成电化学，以及药物分子发现、设计与合成等方面的研究。目前已经在Nat. Catal., J. Am. Chem. Soc.,Angew. Chem. Int. Ed., Nat. Commun.等高水平期刊发表学术论文24篇，其中一作文章包括：1篇Nat. Catal. (IF=40.706)，1篇J. Am. Chem. Soc. (IF=16.383)，3篇Angew. Chem. Int. Ed. (IF=16.823，其中一篇被选为HOT paper并被Synfacts进行亮点评述)，2篇Org. Chem. Front.（其中一篇被选为2018年 Organic Chemistry Frontiers HOT articles），1篇Org. Lett.（被Synfacts进行亮点评述），1篇Chem. Commun.，1篇Chin. J. Chem.，1篇Synthesis（Reported by Thieme Chemistry as News-Archive: 2018）。主持完成欧盟玛丽居里学者人才项目1项，在研国自然青年基金项目1项，获得授权中国发明专利2项，参编专著一部《Catalytic Asymmetric Synthesis》, 4th ed.。
欢迎具有有机合成和药物化学研究背景的人才加入！
（1）主持完成欧盟玛丽居里学者人才计划项目（Marie Skłodowska-Curie Individual Fellowships）1项，项目名称：光催化在药物开发中的应用-不对称合成生物活性的手性内酯和环己醇化合物（Photocatalysis in Drug Discovery – Asymmetric Preparation of Bioactive Chiral Lactones and Cyclohexanols），2020.03-2022.02，项目编号：894795，经费总额：160,932 欧元，折合人民币约118万元。
（2）主持国家自然科学基金青年科学基金项目1项，项目名称：基于单电子机理的不对称电化学enamine催化，2023.01-2025.12，项目编号：22201187，经费总额：30 万元，在研。
（1）主持完成欧盟玛丽居里学者人才计划项目（MarieSkłodowska-CurieIndividual Fellowships）1项，项目名称：光催化在药物开发中的应用-不对称合成生物活性的手性内酯和环己醇化合物（Photocatalysis in Drug Discovery –Asymmetric Preparation of Bioactive Chiral Lactones and Cyclohexanols），2020.03-2022.02，项目编号：894795，经费总额：160,932欧元，折合人民币约118万元。
（2）主持国家自然科学基金青年科学基金项目1项，项目名称：基于单电子机理的不对称电化学enamine催化，2023.01-2025.12，项目编号：22201187，经费总额：30万元，在研。
一、学术论文：
25. Pengfei Li, Zile Zhu, Chengcheng Guo, Guangsheng Kou, Siyi Wang, Pengfei Xie, Dengke Ma, Tian Feng, Yanwei Wang and Youai Qiu*, Nickel-electrocatalysed C(sp3)–C(sp3) cross-coupling of unactivated alkyl halides, Nat. Catal. 2024, 7, 412-421. IF=42.7
24. Liu, Y.; Li, P.; Tan, J.; Kou, G.; Ma, D.;* Qiu, Y.* Electrochemical Nickel-Catalysed Defluoroalkylation of gem-Difluoroalkenes with Alkyl Halides. Green Chem. 2023, 25, 7952-7958. IF=9.3
23. Berger, M.; + Ma, D.; + Baumgartner, Y.; + Wong, T. H.-F.; Melchiorre, P.* Stereoselective Conjugate Cyanation of Enals by Combining Photoredox and Organocatalysis. Nat. Catal. 2023, 6, 332. (equal contribution) IF=42.7
22. Zhao, Z.; Liu, Y.; Wang, S.; Tang, S.; Ma, D.; Zhu, Z.; Guo, C.; Qiu, Y. Site-Selective Electrochemical C−H Carboxylation of Arenes with CO2. Angew. Chem., Int. Ed. 2023, 62, e202214710. IF=16.1
21. Li, P.; Guo, C.; Wang, S.; Ma, D.; Feng, T.; Wang, Y.; Qiu, Y. Facile and General Electrochemical Deuteration of Unactivated Alkyl Halides. Nat. Commun. 2022, 13, 3774. SCI, IF=16.1
20. Wang, Y.; Tang, S.; Yang, G.; Wang, S.; Ma, D.; Qiu, Y. Electrocarboxylation of Aryl Epoxides with CO2 for the Facile and Selective Synthesis of β-Hydroxy Acids. Angew. Chem., Int. Ed. 2022, 61, e202207746. IF=16.1
19. Wang, Y.; Zhao, Z.; Pan, D.; Wang, S.; Jia, K.; Ma, D.; Yang, G.; Xue, X.; Qiu, Y. Metal-Free Electrochemical Carboxylation of Organic Halides in the Presence of Catalytic Amounts of an Organomediator, Angew. Chem., Int. Ed. 2022, 61, e202210201. IF=16.1
18. Wong, H.-F. T.; Ma, D.; Di Sanza, R.; Melchiorre, P.* Photoredox Organocatalysis for the Enantioselective Synthesis of 1,7-Dicarbonyl Compounds. Org. Lett. 2022, 24, 1695. IF=4.9
17. Le Saux. E.; + Ma, D.; + Bonilla, P. ; Holden, C. M. ; Lustosa, D. ; Melchiorre, P.* A General Organocatalytic System for Enantioselective Radical Conjugate Additions to Enals. Angew. Chem., Int. Ed. 2021, 60, 5357. (equal contribution) (HOT paper & Highlighted by Synfacts 2021, 17, 325.) IF=16.1
16. Wong, T. H. M.; Li, X.; Ma, D.; Sun, J.* HNTf2-Catalyzed Synthesis of Hydrodibenzofurans by an Epoxidation/Semipinacol Rearrangement Cascade. Org. Lett. 2020, 22, 1951. SCI, IF=4.9.
15. Ma, D.; Miao, C.; Sun, J.* Catalytic Enantioselective House−Meinwald Rearrangement: Efficient Construction of All-Carbon Quaternary Stereocenters. J. Am. Chem. Soc. 2019, 141, 13783. IF=14.5
14. Ma, D.; Zhang, Z.; Chen, M.; Lin, Z.; Sun, J.* Organocatalytic Enantioselective Functionalization of Unactivated Indole C(sp3)‒H Bonds. Angew. Chem., Int. Ed. 2019, 58, 15916. IF=16.1
13. Zhang, Z.; Yan, J.; Ma, D.; Sun, J.* Electrochemical Synthesis of β-Hydroxy-, β-Alkoxy-, and β-Carbonyloxy Sulfones by Vicinal Difunctionalization of Olefins. Chin. Chem. Lett. 2019, 30, 1509. IF=9.4
12. Yang, W.; + Ma, D.; + Zhou, Y.; Dong, X.; Lin, Z.; Sun, J.* NHC‐Catalyzed Electrophilic Trifluoromethylation: Efficient Synthesis of γ‐Trifluoromethyl α,β‐Unsaturated Esters. Angew. Chem., Int. Ed. 2018, 57, 12097. (equal contribution) IF=16.1
11. Ma, D.; Song, Y.; Fu, C.; Zhang, F.; Guo, Y.; Huang, X.;* Ma, S.* E-Selective N-heterocyclic Carbene-catalyzed Reaction of Aldehydes and Butadienoates: Effect of Water and Chloroform as the Proton Shuttle. Org. Chem. Front. 2018, 5, 2560. (Organic Chemistry Frontiers HOT articles for 2018) IF=4.9
10. Chen, M.;+ Han, Y.; + Ma, D.; + Wang, Y.; Lai, Z.; Sun, J.* Organocatalytic Enantioselective Synthesis of Chiral Diarylmethylamines from Racemic Alcohols. Chin. J. Chem. 2018, 36, 587. (equal contribution) IF=5.5
9. Ma, D.; Duan, X.; Fu, C.; Huang, X.;* Ma, S.* Dimethylprinol vs. Diphenylprinol in CuBr2-catalyzed Enantioselective Allenylation of Terminal Alkynols. Synthesis 2018, 50, 2533. (Reported by Thieme Chemistry as News-Archive: 2018, https://www.thieme.de/en/thieme-chemistry/organocatalytic-enantioselective-synthesis-of-disubstituted-allenols-132083.htm) IF=2.2
8. Luo, H.; Ma, D.; Ma, S.* Preparation of Buta-2,3-dien-1-ol. Org. Synth. 2017, 94, 153.
7. Ma, D.; Fu, C.; Ma, S.* Diastereoselective Construction of Cyclopent-2-enone-4-ols from Aldehydes and 1,2-Allenones Catalyzed by N-Heterocyclic Carbene. Chem. Commun. 2016, 52, 14426. IF=4.3
6. Dai, J.; Ma, D.; Fu, C.; Ma, S.* Gram Scale Total Synthesis of 2-Hydroxy-3-methylcarbazole, Pyrano[3,2-a]carbazole and Prenylcarbazole Alkaloids. Eur. J. Org. Chem. 2015, 5655. IF=2.5
5. Ma, D.; Qiu, Y.; Dai, J.; Fu, C.; Ma, S.* N-Heterocyclic Carbene-Promoted Annulation Reaction of Allenals with Chalcones: Synthesis of Polysubstituted Pyranyl Aldehydes. Org. Lett. 2014, 16, 4742. (Highlighted by Synfacts 2014, 10, 1139.) IF=4.9
4. Ma, D.; Dai, J.; Qiu, Y.; Fu, C.;* Ma, S.* Gram Scale Synthesis of 7-Methoxy-O-methylmukonal, Clausine-O, Clausine-K, Clausine-H, 7-Methoxymukonal, and Methyl 2-hydroxy-7-methoxy-9H-carbazole-3-carboxylate. Org. Chem. Front. 2014, 1, 782. IF=4.9
3. Qiu, Y.; Ma, D.; Kong, W.; Fu, C.; Ma, S.* Regiocontrolled 1,2-Migration in Cyclization of 1-(indol-2-yl)-3-alkyn-1-ols: (Ph3P)Au+ vs. PtCl4. Org. Chem. Front. 2014, 1, 62. IF=4.9
2. Qiu, Y.; Ma, D.; Fu, C.;* Ma, S.* An Efficient Au-catalyzed Synthesis of Isomukonidine, Clausine L, Mukonidine, Glycosinine, Mukonal, and Clausine V from Propadienyl Methyl Ether. Org. Biomol. Chem. 2013, 11, 1666. IF=2.9
1. Qiu, Y.; Ma, D.; Fu, C.; Ma, S.* General Approach to Benzo[b]thiophenes, Benzo[b]furans, and Dibenzofurans via Gold-catalyzed Cyclization of 1-Heteroarylalka-2,3-dienyl acetates. Tetrahedron 2013, 69, 6305. IF=2.1
二、授权专利：
1. 孙建伟; 马登科; 有机催化吲哚非活化sp3碳氢键不对称官能团化的方法与应用, 2020-11-13, 中国, 专利号: ZL201910625678.1
2. 麻生明; 马登科; 傅春玲; 一种高非对映选择性的环戊-2-烯酮-4-醇化合物及其制备方法, 2019-07-02, 中国, 专利号: ZL201611009921.X
三、专著：
Ma, D.; Wong, T. H.-F.;Melchiorre, P.* Asymmetric Photoredox Reactions without Photocatalysts, In Catalytic Asymmetric Synthesis, 4th ed.; Akiyama, T.; Ojima, I., Ed.; John Wiley & Sons: Hoboken, NJ, 2022; Chapter 9.
四、重要奖项
1. 欧盟玛丽居里学者——EuropeanCommission: Marie Skłodowska-Curie Individual Fellowships，2020
2. 西班牙胡安·德拉切尔瓦奖学金项目——Juan de la Cierva Fellowship，有效入选，2020
文件上传中...
