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马登科博士，首都医科大学药学院化学生物学系，教授，博士生导师。2017年6月博士毕业于浙江大学化学系，师从麻生明教授（中科院院士）。2017年8月在香港科技大学Jianwei Sun教授课题组从事博士后研究。2019年10月在西班牙加泰罗尼亚化学研究所（ICIQ）Paolo Melchiorre教授课题组从事博士后研究，同时入选欧洲研究委员会玛丽居里学者人才计划。2022年4月入职首都医科大学药学院化学生物学系，开展独立研究工作。主要从事不对称催化与合成，光催化，合成电化学，以及药物分子发现、设计与合成等方面的研究。目前在Nat. Catal., J. Am. Chem. Soc., Angew. Chem. Int. Ed., Nat. Commun.等国际高水平期刊发表SCI论文30余篇，多篇文章入选热点文章（HOT paper/article），或被Synfacts, Thieme Chemistry, Nature ReviewsChemistry进行亮点评述，第一作者或责任作者文章包括：1篇Nat. Catal. (IF = 44.6, Q1)，1篇J. Am. Chem. Soc. (IF =15.6, Q1)，3篇Angew. Chem. Int. Ed.（IF = 16.9, Q1, one highlightedby Synfacts），1篇Green Chem. (IF = 9.2, Q1)，1篇Chin. Chem. Lett. (IF = 8.9, Q1)，2篇Org. Chem. Front.（IF = 4.7, Q1, one is Organic ChemistryFrontiers HOT articles for 2018），1篇Org. Lett.（IF = 5.0, Q1, highlighted by Synfacts），2篇Chin. J. Chem. (IF = 5.5, Q1)，1篇Chem. Commun. (IF = 4.2, Q2)，1篇J. Org. Chem. (IF = 3.6, Q1)，1篇Org. Biomol. Chem. (IF = 2.7, Q2)，1篇Synthesis（IF = 2.3, Q2, Reported by ThiemeChemistry as News-Archive: 2018），申请中国发明专利7项，获得授权发明专利2项，参编专著一部《Catalytic Asymmetric Synthesis》, 4th ed.，第九章“Asymmetric Photoredox Reactions withoutPhotocatalysts”。
欢迎具有有机合成和药物化学研究背景的人才加入！
（1）主持完成欧盟玛丽居里学者人才计划项目（Marie Skłodowska-Curie Individual Fellowships）1项，项目名称：光催化在药物开发中的应用-不对称合成生物活性的手性内酯和环己醇化合物（Photocatalysis in Drug Discovery – Asymmetric Preparation of Bioactive Chiral Lactones and Cyclohexanols），2020.03-2022.02，项目编号：894795，经费总额：160,932 欧元，折合人民币约118万元。
（2）主持国家自然科学基金青年科学基金项目1项，项目名称：基于单电子机理的不对称电化学enamine催化，2023.01-2025.12，项目编号：22201187，经费总额：30 万元，在研。
（1）主持完成欧盟玛丽居里学者人才计划项目（MarieSkłodowska-CurieIndividual Fellowships）1项，项目名称：光催化在药物开发中的应用-不对称合成生物活性的手性内酯和环己醇化合物（Photocatalysis in Drug Discovery –Asymmetric Preparation of Bioactive Chiral Lactones and Cyclohexanols），2020.03-2022.02，项目编号：894795，经费总额：160,932欧元，折合人民币约118万元。
（2）主持国家自然科学基金青年科学基金项目1项，项目名称：基于单电子机理的不对称电化学enamine催化，2023.01-2025.12，项目编号：22201187，经费总额：30万元，在研。
一、学术论文：
30. Dengke Ma*, and Youai Qiu*, Electrochemical strategies for advancing enantioselective enamine catalysis, Chin. Chem. Lett. 2025, DOI: 10.1016/j.cclet.2025.111892.
29. Tie Lei, Jun Tan, Yifei Zhang, and Dengke Ma*, Organocatalytic modular synthesis of 2-functionalized 2,5-dihydrofurans from γ-hydroxy enals, Org. Biomol. Chem. 2025, 23, 8170-8175.
28. Dengke Ma*, Application of Integrating Fundamental Knowledge and Cutting-Edge Developments in the Teaching of Organic Synthesis: Taking the Asymmetric Meinwald Rearrangement as an Example, Univ. Chem. 2026, 41 (X), DOI: 10.12461/pku.dxhx202502112.
27. Jun Tan, Chengyan Xie, Nasier Yusuipujiang, Mingyang Xu, Lixue Wang, and Dengke Ma*, An Efficient Semipinacol Rearrangement toward α,β-Unsaturated Ketones via Lewis Acid and Base Synergistic Catalysis, J. Org. Chem. 2025, 90, 8687–8692.
26. Jun Tan, Chengyan Xie, Youai Qiu, Dengke Ma*, Simple Units Integration Brings New Reactivity: Neighboring Group Effect in the Synthesis of Polyfunctionalized 5-Alkenyl-3-furanones from γ-Hydroxyl Enal, Chin. J. Chem. 2025, 43, 1643—1650. (Selected as inside cover.)
25. Pengfei Li, Zile Zhu, Chengcheng Guo, Guangsheng Kou, Siyi Wang, Pengfei Xie, Dengke Ma, Tian Feng, Yanwei Wang and Youai Qiu*, Nickel-electrocatalysed C(sp3)–C(sp3) cross-coupling of unactivated alkyl halides, Nat. Catal. 2024, 7, 412-421. IF=42.7
24. Liu, Y.; Li, P.; Tan, J.; Kou, G.; Ma, D.;* Qiu, Y.* Electrochemical Nickel-Catalysed Defluoroalkylation of gem-Difluoroalkenes with Alkyl Halides. Green Chem. 2023, 25, 7952-7958. IF=9.3
23. Berger, M.; + Ma, D.; + Baumgartner, Y.; + Wong, T. H.-F.; Melchiorre, P.* Stereoselective Conjugate Cyanation of Enals by Combining Photoredox and Organocatalysis. Nat. Catal. 2023, 6, 332. (equal contribution) IF=42.7
22. Zhao, Z.; Liu, Y.; Wang, S.; Tang, S.; Ma, D.; Zhu, Z.; Guo, C.; Qiu, Y. Site-Selective Electrochemical C−H Carboxylation of Arenes with CO2. Angew. Chem., Int. Ed. 2023, 62, e202214710. IF=16.1
21. Li, P.; Guo, C.; Wang, S.; Ma, D.; Feng, T.; Wang, Y.; Qiu, Y. Facile and General Electrochemical Deuteration of Unactivated Alkyl Halides. Nat. Commun. 2022, 13, 3774. SCI, IF=16.1
20. Wang, Y.; Tang, S.; Yang, G.; Wang, S.; Ma, D.; Qiu, Y. Electrocarboxylation of Aryl Epoxides with CO2 for the Facile and Selective Synthesis of β-Hydroxy Acids. Angew. Chem., Int. Ed. 2022, 61, e202207746. IF=16.1
19. Wang, Y.; Zhao, Z.; Pan, D.; Wang, S.; Jia, K.; Ma, D.; Yang, G.; Xue, X.; Qiu, Y. Metal-Free Electrochemical Carboxylation of Organic Halides in the Presence of Catalytic Amounts of an Organomediator, Angew. Chem., Int. Ed. 2022, 61, e202210201. IF=16.1
18. Wong, H.-F. T.; Ma, D.; Di Sanza, R.; Melchiorre, P.* Photoredox Organocatalysis for the Enantioselective Synthesis of 1,7-Dicarbonyl Compounds. Org. Lett. 2022, 24, 1695. IF=4.9
17. Le Saux. E.; + Ma, D.; + Bonilla, P. ; Holden, C. M. ; Lustosa, D. ; Melchiorre, P.* A General Organocatalytic System for Enantioselective Radical Conjugate Additions to Enals. Angew. Chem., Int. Ed. 2021, 60, 5357. (equal contribution) (HOT paper & Highlighted by Synfacts 2021, 17, 325.) IF=16.1
16. Wong, T. H. M.; Li, X.; Ma, D.; Sun, J.* HNTf2-Catalyzed Synthesis of Hydrodibenzofurans by an Epoxidation/Semipinacol Rearrangement Cascade. Org. Lett. 2020, 22, 1951. SCI, IF=4.9.
15. Ma, D.; Miao, C.; Sun, J.* Catalytic Enantioselective House−Meinwald Rearrangement: Efficient Construction of All-Carbon Quaternary Stereocenters. J. Am. Chem. Soc. 2019, 141, 13783. IF=14.5
14. Ma, D.; Zhang, Z.; Chen, M.; Lin, Z.; Sun, J.* Organocatalytic Enantioselective Functionalization of Unactivated Indole C(sp3)‒H Bonds. Angew. Chem., Int. Ed. 2019, 58, 15916. IF=16.1
13. Zhang, Z.; Yan, J.; Ma, D.; Sun, J.* Electrochemical Synthesis of β-Hydroxy-, β-Alkoxy-, and β-Carbonyloxy Sulfones by Vicinal Difunctionalization of Olefins. Chin. Chem. Lett. 2019, 30, 1509. IF=9.4
12. Yang, W.; + Ma, D.; + Zhou, Y.; Dong, X.; Lin, Z.; Sun, J.* NHC‐Catalyzed Electrophilic Trifluoromethylation: Efficient Synthesis of γ‐Trifluoromethyl α,β‐Unsaturated Esters. Angew. Chem., Int. Ed. 2018, 57, 12097. (equal contribution) IF=16.1
11. Ma, D.; Song, Y.; Fu, C.; Zhang, F.; Guo, Y.; Huang, X.;* Ma, S.* E-Selective N-heterocyclic Carbene-catalyzed Reaction of Aldehydes and Butadienoates: Effect of Water and Chloroform as the Proton Shuttle. Org. Chem. Front. 2018, 5, 2560. (Organic Chemistry Frontiers HOT articles for 2018) IF=4.9
10. Chen, M.;+ Han, Y.; + Ma, D.; + Wang, Y.; Lai, Z.; Sun, J.* Organocatalytic Enantioselective Synthesis of Chiral Diarylmethylamines from Racemic Alcohols. Chin. J. Chem. 2018, 36, 587. (equal contribution) IF=5.5
9. Ma, D.; Duan, X.; Fu, C.; Huang, X.;* Ma, S.* Dimethylprinol vs. Diphenylprinol in CuBr2-catalyzed Enantioselective Allenylation of Terminal Alkynols. Synthesis 2018, 50, 2533. (Reported by Thieme Chemistry as News-Archive: 2018, https://www.thieme.de/en/thieme-chemistry/organocatalytic-enantioselective-synthesis-of-disubstituted-allenols-132083.htm) IF=2.2
8. Luo, H.; Ma, D.; Ma, S.* Preparation of Buta-2,3-dien-1-ol. Org. Synth. 2017, 94, 153.
7. Ma, D.; Fu, C.; Ma, S.* Diastereoselective Construction of Cyclopent-2-enone-4-ols from Aldehydes and 1,2-Allenones Catalyzed by N-Heterocyclic Carbene. Chem. Commun. 2016, 52, 14426. IF=4.3
6. Dai, J.; Ma, D.; Fu, C.; Ma, S.* Gram Scale Total Synthesis of 2-Hydroxy-3-methylcarbazole, Pyrano[3,2-a]carbazole and Prenylcarbazole Alkaloids. Eur. J. Org. Chem. 2015, 5655. IF=2.5
5. Ma, D.; Qiu, Y.; Dai, J.; Fu, C.; Ma, S.* N-Heterocyclic Carbene-Promoted Annulation Reaction of Allenals with Chalcones: Synthesis of Polysubstituted Pyranyl Aldehydes. Org. Lett. 2014, 16, 4742. (Highlighted by Synfacts 2014, 10, 1139.) IF=4.9
4. Ma, D.; Dai, J.; Qiu, Y.; Fu, C.;* Ma, S.* Gram Scale Synthesis of 7-Methoxy-O-methylmukonal, Clausine-O, Clausine-K, Clausine-H, 7-Methoxymukonal, and Methyl 2-hydroxy-7-methoxy-9H-carbazole-3-carboxylate. Org. Chem. Front. 2014, 1, 782. IF=4.9
3. Qiu, Y.; Ma, D.; Kong, W.; Fu, C.; Ma, S.* Regiocontrolled 1,2-Migration in Cyclization of 1-(indol-2-yl)-3-alkyn-1-ols: (Ph3P)Au+ vs. PtCl4. Org. Chem. Front. 2014, 1, 62. IF=4.9
2. Qiu, Y.; Ma, D.; Fu, C.;* Ma, S.* An Efficient Au-catalyzed Synthesis of Isomukonidine, Clausine L, Mukonidine, Glycosinine, Mukonal, and Clausine V from Propadienyl Methyl Ether. Org. Biomol. Chem. 2013, 11, 1666. IF=2.9
1. Qiu, Y.; Ma, D.; Fu, C.; Ma, S.* General Approach to Benzo[b]thiophenes, Benzo[b]furans, and Dibenzofurans via Gold-catalyzed Cyclization of 1-Heteroarylalka-2,3-dienyl acetates. Tetrahedron 2013, 69, 6305. IF=2.1
二、授权专利：
1. 孙建伟; 马登科; 有机催化吲哚非活化sp3碳氢键不对称官能团化的方法与应用, 2020-11-13, 中国, 专利号: ZL201910625678.1
2. 麻生明; 马登科; 傅春玲; 一种高非对映选择性的环戊-2-烯酮-4-醇化合物及其制备方法, 2019-07-02, 中国, 专利号: ZL201611009921.X
三、专著：
Ma, D.; Wong, T. H.-F.;Melchiorre, P.* Asymmetric Photoredox Reactions without Photocatalysts, In Catalytic Asymmetric Synthesis, 4th ed.; Akiyama, T.; Ojima, I., Ed.; John Wiley & Sons: Hoboken, NJ, 2022; Chapter 9.
四、重要奖项
1. 欧盟玛丽居里学者——EuropeanCommission: Marie Skłodowska-Curie Individual Fellowships，2020
2. 西班牙胡安·德拉切尔瓦奖学金项目——Juan de la Cierva Fellowship，有效入选，2020
3. 北京市海外高层次引进人才，2023
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