本团队以HIV感染T细胞免疫应答为主要研究方向，团队目前技术员2名，承担HIV相关科研课题4项，临检项目3项。

1. 高层次公共卫生技术人才建设项目（北京市卫生健康委），2023.01-2025.12，21万元，在研，项目负责人

2. HIV 急性期治疗对肠道归巢 α4β7CD4+T 细胞的保护作用（北京市教育委员会科技计划一般项目，KM202010025015）, 2020.01-2022.12，15万元，在研，项目负责人

3. 北京市医管局青年人才培养“青苗”计划（北京市医管局，QML20181702），2019.01-2020.12，6 万元，已结题，项目负责人

4. 干细胞样记忆型 T 细胞在 HIV-1 感染者免疫重建中的作用（国家自然科学基金，81501732），2016.01-2018.12，21.6 万元，已结题，项目负责人

第一或通讯作者发表SCI论文12篇。

1. XiaofanLu#, Xin Zhang#, Allen Ka Loon Cheung, ChristianeMoog, Huan Xia, Zhen Li, Rui Wang,Yunxia Ji, Wei Xia, Zhiying Liu, LinYuan, Xiuwen Wang, Hao Wu, Tong Zhang*, Bin Su*. Abnormal shift in B memorycell profile is associated with the expansion of circulating T follicularhelper cells via ICOS signaling during acute HIV-1 infection. FrontImmunol., 2022 Feb 10;13: 837921. (IF:7.561)

2. XinZhang*, Xiaofan Lu*, Allen Ka Loon Cheung, Qiuyue Zhang,Zhiying Liu, Zhen Li, Lin Yuan, Rui Wang, Yan Liu, Bin Tang, Huan Xia,Hao Wu, Tong Zhang#, Bin Su#. Analysis of the characteristicsof TIGIT-expressing CD3-CD56+NK cells in controlling differentstages of HIV-1 infection. Front Immunol., 2021 Feb26;12:602492. (IF:7.561)

3. Xiaofan Lu*,Hanxiao Sun*, Haicong Li*, Wei Xia, Hao Wu, Daihong Chen, Meiyu Tan, Shijun Yu,Tong Zhang#,Huiming Shen#, Zhaoqin Zhu#.Validation of the BD FACSPresto system for the measurement of CD4 T-lymphocytesand hemoglobin concentration in HIV-negative and HIV-positive subjects. SciRep., 2020,10(1):19605. (IF:4.379)

4. XiaHuan, Jiang Wei, Zhang Xin, Qin Ling, Su Bin, Li Zhen, Sun Jianping, ZhangYonghong, Zhang Tong, Lu Xiaofan#,Wu Hao#. Elevated level of CD4+ T cell immune activation in acutelyHIV-1- infected stage associates with increased IL-2 production and cycling expression,and subsequent CD4+ T cell preservation. Front Immunol.,2018,9:616. (IF: 7.561)

5.  Zhang Xin*, Lu Xiaofan*, Moog Christiane, Yuan Lin, Liu Zhiying, Li Zhen, Xia Wei, Zhou Yuefang, Wu Hao#, Zhang Tong#, Su Bin#. KIR3DL1-negative CD8 T cells and KIR3DL1-negative natural killercells contributeto the advantageous control of early human immunodeficiency virus type 1 infection in HLA-B Bw4 homozygous individuals. FrontImmunol., 2018,9:1855. (IF=7.561)

6. Lu Xiaofan*, Song Bingbing*, Weng Wenjia, Xia Huan, Su Bin, Wu Hao, Zhang Tong, Li Wei#, Gao Yanqing#. CD4+T memory stem cells correlate with disease progression in chronically HIV-1-infected patients. Viral Immunol., 2017,30(9): 642-648. (IF:2.257)

7. Li Zhen*,Lu Xiaofan*, Hu Zhiliang, Luo Zhenwu, Jiang Wei, Wu Hao, Gao Yanqing, Yan Junling, Zhang Qiuyue, Song Aixin, HuangXiaojie, Mou Danlei, SuBin#, Zhang Tong#. Syphilis infectiondifferentially regulates the phenotype and function of γδ T cells in HIV-1-infected patients depends onthe HIV-1 disease stage. Front Immunol.,2017, 8: 991. (IF=7.561)

8. Lu Xiaofan*, Su Bin*, Xia Huan, ZhangXin, Liu Zhiying, JiYunxia, Yang Zixuan, Dai Lili,Mayr M.Luzia,  Moog Christiane, WuHao, Huang Xiaojie#,Zhang Tong#.  Lowdouble-negativeCD3+CD4-CD8- T cells are associated with incomplete restoration of CD4+ T cells and higherimmune activation in HIV-1 immunological non-responders.Front Immunol., 2016,7:579. (IF=7.561)

9. Lu Xiaofan*, Li Zhen*, Li Qunhui*, Jiao Yanmei, Ji Yunxia, Zhang Hongwei, Liu Zhuoming, Li Wei#, Wu Hao#. Preferential loss of gut-homing α4β7 CD4+T cells and their circulatingfunctional subsets in acuteHIV-1infection. Cell Mol Immunol., 2016,13(6):776-784. (IF=11.530)

10. Lu Xiaofan*, Liu Li*, Zhang Xu, Terrance Lau Chi Kong, Stephen Tsui Kwok Wing, Kang Yuanxi, Zheng Purong, Zheng Bojian, Liu Gang#,Chen Zhiwei#. F18, a novel small molecule NNRTI, inhibits HIV-1 replication using distinct bindingmotifs as demonstrated byresistance selection and docking analysis. Antimicrob. AgentsChemother., 2012,56(1):341-51.(IF=5.191)

11. Xue Hai*, Lu Xiaofan*, Zheng Purong, Liu Li, Han Chunyan, Hu Jinping, Liu Zijie, Ma Tao, Li Yan, Wang Lin, Chen Zhiwei#,Liu Gang#. Highly suppressing wild-type HIV-1 and Y181C mutant HIV-1 by 10-chloromethyl-11-demethyl-12-2 oxo-calanolide A with druggable profile. J.Med. Chem., 2010,53(3):1397-1401.(IF=7.446)

12. Lu Xiaofan, Chen Zhiwei. The developmentof anti-HIV-1 drugs. Acta Pharmaceutica Sinica, 2010,45(2):165-176.