1          胶质细胞在中枢神经系统稳态和功能中的维持机制，国家科技计划 ，项目号2022ZD0204704， 2022年01月 -2026年12月 

2          情绪情感演化与认知互作的神经环路机制，国家科技计划  项目号2021ZD0202805，2022年01月 -2026年12月 

1          胶质细胞在中枢神经系统稳态和功能中的维持机制，国家科技计划 ，项目号2022ZD0204704， 2022年01月 -2026年12月 

2          情绪情感演化与认知互作的神经环路机制，国家科技计划  项目号2021ZD0202805，2022年01月 -2026年12月 

在探索情绪情感的神经环路机制的研究中，揭示了 VTA 多巴胺能神经元在延迟满足这一心理过程中的神经基础，为提高自控能力和治疗注意力缺陷多动障碍提供了思路。发明了多种用于小鼠立体定位，病毒精准注射，微透镜埋置等国产化专利设备，推动和促进了我国神经环路的基础研究。发明了一种快速将外源基因导入整体大脑并实现表达的在体基因递送技术，有望为我国基因治疗领域开辟一个新的方向。

发表文章：

1.    Jie Li*, Shuang Liu*, ChenmengSong, Qun Hu,Zhikai Zhao, Tuantuan Deng, Yi Wang, TongZhu, Linzhi Zou, Shufeng Wang, JiaofengChen, Lian Liu, Hanqing Hou, KexinYuan, Hairong Zheng, Zhiyong Liu, XiaoweiChen, Wenzhi Sun, Bailong Xiao, and Wei Xiong# (2021), PIEZO2 mediates ultrasonic hearing via cochlear outer haircells in mice, Proceedingsof the National Academy of Sciences inpress

2.    Yajie Liang*, JiangLan Fan, Wenzhi Sun, Rongwen Lu,Ming Chen & Na Ji# (2021), A distinctpopulation of L6 neurons in mouse V1 mediate cross-callosal communication. Cerebral Cortex in press

3.    Zilong Gao*, Hanqing Wang*, Chen Lu, Sean Froudist-Walsh, Ming Chen,Xiao-Jing Wang#, Ji Hu#, WenzhiSun# (2021) Neural Basis of the Delayed Gratification, bioRxiv doi: https://doi.org/10.1101/2021.03.10.434739

4.    Juan Guo*, Mingzi Ran*, Zilong Gao, Xinxin Zhang, Dan Wang, HuimingLi, Shiyi Zhao, Wenzhi Sun#, Hailong Dong#, Ji Hu# (2021) Cell-type-specific imaging of neurotransmissionreveals a disrupted excitatory-inhibitory cortical network in isofluraneanaesthesia, EBioMedicine65, 103272.

5.    Samuel Lundt*, Nannan Zhang, Jun-Liszt Li, Zhe Zhang, LiZhang, Xiaowan Wang, Ruisi Bao, Feng Cai, Wenzhi Sun, Woo-Ping Ge,Shinghua Ding# (2021) Metabolomicand transcriptional profiling reveals bioenergetic stress and activation ofcell death and inflammatory pathways in vivo after neuronal deletion of NAMPT. Journal of Cerebral Blood Flow &Metabolism, 0271678X21992625.

6.     Nanxiang Xiong*#, Xiaofei Gao*, Hongyang Zhao, Feng Cai, Fang-cheng Zhang, YeYuan, Weichao Liu, Fangping He, Lauren G Zacharias, Hong Lin, Hieu S Vu, ChaoXing, Dong-Xiao Yao, Fei Chen, Benyan Luo, Wenzhi Sun, Ralph JDeBerardinis, Hao Xu, Woo-ping Ge# (2020) Using arterial-venous analysis to characterize cancermetabolic consumption in patients. Nature Communications 11 (1), 1-9.

7.     Gaolin Qiu*, Ying Wu, Zeyong Yang, Long Li, Xiaona Zhu,Yiqiao Wang, Wenzhi Sun, Hailong Dong, Yuanhai Li, Ji Hu# (2020),Dexmedetomidine Activation of Dopamine Neurons in the Ventral Tegmental AreaAttenuates the Depth of Sedation in Mice. Anesthesiology 133: 377–392.

8.     Xu Zhang*,Bo Lei*, Yuan Yuan*, Li Zhang, Lu Hu, Sen Jin, Bilin Kang, Xuebin Liao, WenzhiSun, Fuqiang Xu, Yi Zhong#, Ji Hu#, Hai Qi#(2020), Brain control of humoral immuneresponses amenable to behavioural modulation. Nature581: 204–208.

9.      Xiaofei Gao*,Zhaohuan Zhang, Tomoyuki Mashimo, Bo Shen, James Nyagilo, Hao Wang, Yihui Wang,Zhida Liu, Aditi Mulgaonkar, Xiao-Ling Hu, Sara GM Piccirillo, Ugur Eskiocak,Digant P Davé, Song Qin, Yongjie Yang, Xiankai Sun, Yang-Xin Fu, Hui Zong, WenzhiSun, Robert M Bachoo, Woo-ping Ge# (2020), Gliomas Interact withNon-glioma Brain Cells via Extracellular Vesicles. Cell Reports 30:2489-2500.

10.   Xiao Y*, Luo H, Yang WZ, Zeng Y, Shen Y, Ni X, Shi Z, ZhongJ, Liang Z, Fu X, Tu H, Sun W, ShenWL#, Hu J#, Yang J# (2020), A brain signalingframework for stress-induced depression and ketamine treatment elucidated byphosphoproteomics. Frontiers in Cellular Neuroscience 14: 48.

11.   FangWang*, Juen Zhang, Yuan Yuan, Ming Chen, Zilong Gao, Shulu Zhan, Chengyu Fan, WenzhiSun#, Ji Hu# (2020), Salience Processing by Glutamatergic Neurons in the VentralPallidum. Sci Bull 65:389-401.

12.   Zheng-dong Zhao*, Zongming Chen*, Xinkuan Xiang*, Mengna Hu,Hengchang Xie, Xiaoning Jia, Fang Cai, Yuting Cui, Zijun Chen, Lechen Qian,Jiashu Liu, Congping Shang, Yiqing Yang, Xinyan Ni, Wenzhi Sun, Ji Hu,Peng Cao, Haohong Li#, Wei L Shen#  (2019), Zona incertaGABAergic neurons integrate prey-related sensory signals and induce anappetitive drive to promote hunting. NatureNeuroscience 22: 921-932.

13.   Yuan, Yuan*; Wu, Wei*; Chen, Ming; Cai, Fang; Fan, Chengyu; Shen, Wei;Sun, Wenzhi#; Hu, Ji#; (2019) Reward Inhibits Paraventricular CRHNeurons to Relieve Stress, Curr Biol, 2019, 2 9(7):1243-1251.

14.   Su XY*, Chen M*, YuanY, Li Y, Luo HQ, Sun W, Zhu MX, LiuMG#, Hu J#, Xu TL# (2019), Central processingof itch in the midbrain reward center. Neuron 102: 858-872

15.   Zhou H*, Zhang S, LV F, Sun W, Wang L, Fan C, Li J#& Hu J# (2019), Citrate‐assisted efficient local delivery ofnaked oligonucleotide into live mouse brain cells. Cell proliferation 52:e12622.

16.   Zhang S*, Lv F, Yuan Y, Fan C, Li J, Sun W, Hu J# (2019), Whole-Brain Mapping of MonosynapticAfferent Inputs to Cortical CRH Neurons. Frontiers in Neuroscience 13: e565.

17.  Richie CT*, Whitaker LR,Whitaker KW, Necarsulmer J, Baldwin HA, Zhang Y, Fortuno L, Hinkle JJ, KoivulaP, Henderson MJ, SunW, Wang K, Smith JC, Pickel J, N Ji, Hope BT, Harvey BK# (2017),Near-infrared fluorescent protein iRFP713 as areporter protein for optogenetic vectors, a transgenic Cre-reporter rat, andother neuronal studies. Journal ofNeuroscience Methods, 284, 1-14

18.  Lu R*, W Sun, Liang Y, Kerlin A, Bierfeld J, Seelig J, Wilson V, SchollB, Mohar B, Tanimoto M, Koyama M, Fitzpatrick D,Orger MB, Ji N# (2017), Video-rate volumetric functional imaging of the brainat synaptic resolution. Nature Neuroscience, 20, 620-628.

19. Sun W*, Tan Z, Mensh BD & Ji N # (2016), Thalamus provides layer 4 of primary visualcortex with tuned inputs. NatureNeuroscience, 19, 308-315.

20. Tan Z*, Sun W, Chen TW, Kim D& Ji N# (2015) Stimulus FeatureSelectivity for Ultraviolet Light in Mouse Primary Visual Cortex.  ScientificReports, 5: 12597. doi: 10.1038/srep12597.

21.  Wang K*, Sun W*, Richie CT, Harvey BK,Betzig E & Ji N# (2015), Direct wavefront sensing forhigh-resolution in vivo imaging in scattering tissue. Nature Communications, 6:7276. doi: 10.1038/ncomms8276.

22.  Wang C*, Liu R*, Milkie DE, SunW , Tan Z, Kerlin A, Chen TW, Kim DS & Ji N# (2014) Multiplexed aberration measurement for deep tissue imaging in vivo. NatureMethods, 11: 1037–1040

23.  SunW*, Wagnon JL, Mahaffey CL, Briese M, Ule J &Frankel WN# (2013) Aberrant Sodium Channel Activity in the Complex Seizure Disorder of Celf4Mutant Mice. Journal of Physiology, 591:241-255,(Highlighted in Future Neurology, 8(3):255-257)

24.  Wagnon JL*, Briese M*, Sun W, Mahaffey CL, Li Y, Curk Y, Rot G,Lin D, Ule J & Frankel WN# (2012) CELF4 regulates translation and local abundance of a vast set of mRNAs,including genes associated with regulation of synaptic function. PLoSGenetics, 8 (11), e1003067.

25. Wagnon JL*, Mahaffey CL, Sun W, YangY, Chao HT & Frankel WN# (2011) Etiology of a GeneticallyComplex Seizure Disorder in Celf4 Mutant Mice. Gene, Brain and Behavior, 10:765-777.

26. Sun W* & DanY# (2009) Layer-Specific NetworkOscillation and spatiotemporal Receptive Field in the Visual Cortex, Proceedings of the National Academy ofSciences, 106:17986-17991.

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29. Diao L*,Sun W, Deng Q & He S# (2004) Development of the mouseretina: emerging morphological diversity of the ganglion cells. Journalof Neurobiology, 61: 236-249.

30. Dong W*,Sun W, Zhang Y, Chen X & He S# (2004) Dendriticrelationship between starburst amacrine cells and direction-selective ganglioncells in the rabbit retina. Journal of Physiology, 556: 11-17.

31. He S#,Dong W, Deng Q, Weng S & Sun W (2003) Seeing More Clearly: RecentAdvances in Understanding Retinal Circuitry. Science, 302:408-411. (Review)

32. Sun W*#, Li N & He S (2002) Large-scale morphological survey ofrat retinal ganglion cells. Visual Neuroscience, 19:483-493.

33. Sun W*,Li N & He S# (2002) Large-scale morphological survey of mouseretinal ganglion cells. Journal of Comparative Neurology,451:115-126.

*:first author; #corresponding author.

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