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主要围绕构建疾病动物模型新技术及神经退行性疾病的基础与转化医学开展研究，包括创建了构建致死基因敲除动物模型的新技术；构建了新的阿尔茨海默病小鼠及灵长动物模型；创建了定量检测血液中错误折叠蛋白质的新技术，可望用于神经退行性疾病的早期及无创辅助诊断。代表性研究论文以第一或通讯作者（含共同）发表于Nature Methods，Nature Communications等知名学术期刊。入选2019年北京市科技新星计划，获首批首医青年学者称号等。
(1) 国家自然科学基金委员会, 面上项目, 81971005, Tau种蛋白诱发性阿尔茨海默病猕猴模型的创建, 2020-01-01 至 2023-12-31, 55万元, 在研, 主持；
(2) 北京市科学技术委员会, 北京市科技新星计划, Z191100001119056, 自发性阿尔茨海默病灵长动物模型的筛选及鉴定, 2019-11 至 2022-10, 50万元, 在研, 主持。
(1) Chen, Baian; Morales, Rodrigo; Barria, Marcelo A.; Soto, Claudio ; Estimating prion concentration in fluids and tissues by quantitative PMCA, Nature Methods, 2010, 7(7): 519-20 (期刊论文)
(2) Wu, Yi; Zhang, Jing; Peng, Boya; Tian, Dan; Zhang, Dong; Li, Yang; Feng, Xiaoyu; Liu, Jinghao; Li, Jun; Zhang, Teng; Liu, Xiaoyong; Lu, Jing; Chen, Baian; Wang, Songlin ; Generating viable mice with heritable embryonically lethal mutations using the CRISPR-Cas9 system in two-cell embryos, Nature Communications, 2019, 10(1): DOI:10.1038/s41467-019-10748-2 (期刊论文)
(3) Zhang, Jing; Wu, Na; Wang, Shubo; Yao, Zitong; Xiao, Fuchuan; Lu, Jing; Chen, Baian ; Neuronal loss and microgliosis are restricted to the core of Aβ deposits in mouse models of Alzheimer's disease, Aging Cell, 2021, 20(6): DOI: 10.1111/acel.13380 (期刊论文)
(4) Zhang, Jing; Chen, Baian; Lu, Jing; Wu, Yi; Wang, Shubo; Yao, Zitong; Zhu, Liming; Qiao, Yanhua; Sun, Quan; Qin, Wei; Zhao, Qiao; Jia, Jianping; Wei, Cuibai; Brains of rhesus monkeys display Aβ deposits and glial pathology while lacking Aβ dimers and other Alzheimer's pathologies, Aging Cell, 2019, 18(4): DOI: 10.1111/acel.12978 (期刊论文)
(5) Zhang Xiaoyang; Hou Yaqin; Peng Cheng; Wang Chu; Wang Xiang; Liang Zhigang; Lu Jing; Chen Baian; Dai Jiapei; Liu Boli; Cui Mengchao; Oligoethyleneoxy-Modified Tc-99m-Labeled beta-Amyloid Imaging Probes with Improved Brain Pharmacokinetics for Single-Photon Emission Computed Tomography, Journal of Medicinal Chemistry, 2018, 61(3): 1330-1339 (期刊论文)
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