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研究员职称,博士毕业于香港中文大学,本科和硕士毕业于北京大学医学部。目前任首都医科大学附属北京佑安医院流行病学研究室主任,北京大学医学部药学院硕士研究生导师,首都医科大学硕士研究生导师。发表国内外论文100余篇,参加并负责多项国家级和省部级科研项目。2014年被评为北京市委组织部优秀人才青年骨干个人,2015年被评为北京市卫生系统高层次卫生技术人才学科骨干,2021年被评为北京市卫生及系统高层次公共卫生技术人才学科带头人。
研究方向:
1.长期从事肿瘤微环境免疫分子对预后影响的临床研究。
2.开展三阴型乳腺癌免疫检查点分子作为预后分子标志物的可行性研究。
3.HIV/AIDS相关实体瘤的临床治理及药物间相互作用的研究。
曹宇,毕业于北京大学医学部公共卫生学院,助理研究员
伍江平,毕业于南方医科大学,助理研究员
1.2020-2023,北京市医院管理中心,免疫检查点调控蛋白在预测三阴型乳腺癌新辅助化疗临床疗效中的作用
2.2019-2023,北京市科学技术委员会,乳腺癌肿瘤微环境中 CD96、CD226、TIGIT 阳性淋巴细胞对术后复发影响的队列研究
3.2019-2022,北京市医院管理中心,鳞状细胞癌抗原、C 反应蛋白和其它危险因素对食 管鳞状上皮轻/中度异型增生转归影响的巢式病例对照研究
4.2018-2021,北京市科学技术委员会,乳腺癌患者外周血中免疫检查点分子 PD-1/PD-L1 反映组织中表达水平的临床应用价值研究—“双 盲”诊断试验
1.周全, 刘红, 宋清坤 (corr.). 采用标准化结构化病理诊断报告对提升胃炎活检小标本病理诊断质量的影响. 中华病理学杂志, 2021, 50(5) : 550-552.
2. Qingkun Song, Feng Shi Shuo Xiao, Yuchen Li, Yanjie Zhao, Hong Chang. The integration of proportion and cell counts of stromal, not intratumoral, PD-1+ tumorinfiltrating lymphocytes has prognostic significance in esophageal squamous cell carcinoma. Dis Esophagus . 2021 Jan 11;34(1):doaa035. doi: 10.1093/dote/doaa035. (IF 3.43)
3. Feng Shi, Shuo Xiao, Kaeli B Miller, Yanjie Zhao, Yuchen Li, Ying Gao, Hong Chang, Qingkun Song (corr.), Chenxu Qu. Interactive Effects of PD-L1 Expression in Tumor and Immune Cells on Prognosis of Esophageal Squamous Cell Carcinoma: A One-Center Retrospective Cohort Study. Onco Targets Ther . 2020 Jul 3;13:6565-6572. doi: 10.2147/OTT.S258332. eCollection 2020. (IF 4.15)
4. Wenping Wang, Jinshu Yin, Xueyan Wang, Tingting Ma, Tianfei Lan, Qingkun Song, Yifan Guo. Relationship between serum inhibitory activity for IgE and efficacy of Artemisia pollen subcutaneous immunotherapy for allergic rhinitis: a preliminary self-controlled study. Allergy Asthma Clin Immunol . 2020 Mar 4;16:18. doi: 10.1186/s13223-020-0416-4. eCollection 2020.
5. Yanjie Zhao, Ping Wang, Jiangping Wu, Ruibin Wang, Qingkun Song (corr.). Evaluation of Factors Associated with Anxiety and Depression in Chinese Visiting Scholars in the United States During the COVID-19 Pandemic Assessed by Online Questionnaires. Med Sci Monit . 2020 Sep 23;26:e926602. doi: 10.12659/MSM.926602. (IF 2.65)
6. Yanjie Zhao, Xiaochen Zhang, Maria E Zubizarreta, Yankai Xia, Yang Li, Xiaoxiao Zhang, Minjia Sheng, Qingkun Song (corr.), Shuo Xiao. A Survey Study Reveals the Positive Impact of Oncofertility Knowledge and Attitude on Oncofertility Practice Among Oncologists in China. J Adolesc Young Adult Oncol . 2020 Oct 29. doi: 10.1089/jayao.2020.0110. (IF 2.22)
7. Yanjie Zhao, Feng Shi, Quan Zhou, Yuchen Li, Jiangping Wu, Ruibin Wang, Qingkun Song (corr.). Prognostic significance of PD-L1 in advanced non-small cell lung carcinoma. Medicine (Baltimore) . 2020 Nov 6;99(45):e23172. doi: 10.1097/MD.0000000000023172. (IF 1.89)
8. Zejuan Wang, Gang Chen, Xiaona Liu, Chen Liu, Qingkun Song, Jin Wang. The motivations, barriers, and sociodemographic characteristics of healthy Chinese volunteers in phase I research. Eur J Clin Pharmacol . 2021 Apr;77(4):557-568. doi: 10.1007/s00228-020-03040-6.
9. Jin Zhao, Yanbin Zhang, Xueying Yang, Zijun Wang, Qingkun Song, Ping Gong, Shuaihong Zhao, Feiran Liu, Zhenning Zhang, Wenpei Bai, Yan Li. Risk factors of pleural effusion after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in late-stage and recurrent ovarian cancer. Ann Palliat Med . 2021 Jan;10(1):385-391. doi: 10.21037/apm-20-2334.
10. Wang RB, Li YC, Zhou Q, Lv SZ, Yuan KY, Wu JP, Zhao YJ, Song QK, Zhu B.Overexpression of CD155 is associated with PD-1 and PD-L1 expression on immune cells, rather than tumor cells in the breast cancer microenvironment. World J Clin Cases. 2020 Dec 6;8(23):5935-5943.
11. Wang B, Li K, Song QK, et al. Micronodular thymic tumor with lymphoid stroma: A case report and review of the literature. World J Clin Cases. 2019 Dec 6;7(23):4063-4074.
12. Yuchen Li, Quan Zhou, Qingkun Song (corr.), et al. Overexpression of an Immune Checkpoint (CD155) in Breast Cancer Associated with Prognostic Significance and Exhausted Tumor-Infiltrating Lymphocytes: A Cohort Study. Journal of Immunology Research. 2020, 3948928, DOI: 10.1155/2020/3948928 (IF 4.82)
37. 康勋, 张锡友, 陈峰, 李丹丹, 董倩倩, 宋清坤, 钟晓松, 李文斌. CAR-T 治疗 B 细胞淋巴瘤不良反应的 Meta 分析. 中国癌症杂志. 2019, 29(8):568-575.
14. Li Y, Song Q, Day BW. Phase I and phase II sonidegib and vismodegib clinical trials for the treatment of paediatric and adult MB patients: a systemic review and metaanalysis. Acta Neuropathol Commun. 2019 Jul 30;7(1):123.
15. Zhao L, Li YC, Wu JP, Zhao YJ, Wang RB, Jiang M, Song QK (corr.). Increased risk of esophageal squamous cell carcinoma associated with frequent and long-term consumption of salted meat and salted fat. J Int Med Res. 2019 Jul 15;47(8):3841-3849. (IF 1.351)
16. Zhang H, Xie P, Li Z, Huang R, Feng W, Kong Y, Xu F, Zhao L, Song Q, Li J, Zhang B, Fan J, Qiao Y, Xie X, Zheng S, He J, Wang K. A nomogram for predicting the HER2 status in female patients with breast cancer in China: a nationwide, multicenter, 10-year epidemiological study. Diagn Pathol. 2019 May 4;14(1):35.
17. Qingkun Song, Feng Shi, Maya Adair, Hong Chang, Xiudong Guan, Yanjie Zhao, Yuchen Li, Guangjiang Wu, Jiangping Wu. Cell counts rather than proportion, of CD8/PD-1 tumor infiltrating lymphocytes in tumor microenvironment associatedwith pathological characteristics of Chinese invasive ductal breast cancer. J Immunol Res 2019 Mar 31;2019:8505021. (IF 3.404)
18. Li J, Xu YW, Jiang JJ, Song QK. Bovine colostrum and product intervention associated with relief of childhood infectious diarrhea. Sci Rep. 2019;9(1):3093.
19. 吴广江, 宋清坤, 马颖欣, 肖敏, 薛文英. 术后患者肺部感染危险因素的分析. 北京医学. 2019, 41(5):385-388.
20. 王睿斌, 赵艳杰, 宋清坤 (corr.), 盛敏佳. 二甲双胍对糖尿病小鼠肝库普弗细胞炎症反应的抑制作用和吞噬功能的改善作用. 吉林大学学报(医学版). 2019, 45(1):39-44.
21. Wang R, Shi F, Zhao L, Zhao Y, Wu G, Song QK (corr.). High expression of Ecadherin and Ki-67 associated with functional/dysfunctional phenotypes of tumorinfiltrating lymphocytes among Chinese patients with operable breast cancer. J Int Med Res. 2018;46(12):5219-5227. (IF 1.351)
22. 沈佚葳, 李琦, 郭筱薇, 田琳琳, 李继红, 宋清坤, 刘福全. 医院学科建设与人才队伍合理性之间的关系. 中华医学科研管理杂志. 2018,31(4):292-296.
23. Wang R, Sheng M, Shi F, Zhao Y, Zhao L, Wu J, Wu G, Song Q (corr.). Dysfunctional phagocytosis capacity, granulocyte recruitment and inflammatory factor secretion of Kupffer cells in diabetes mellitus reversed by Lidocaine. Diabetes Metab Syndr Obes. 2018 Nov 26;11:827-834. (IF 3.319)
24. Song Y, Yin J, Chang H, Zhou Q, Peng H, Ji W, Song Q. Comparison of four staining methods for detecting eosinophils in nasal polyps. Sci Rep. 2018;8(1):17718.
25. Guan X, Luo L, Begum G, Kohanbash G, Song Q, Rao A, Amankulor N, Sun B, Sun D, Jia W. Elevated Na/H exchanger 1 (SLC9A1) emerges as a marker for tumorigenesis and prognosis in gliomas. J Exp Clin Cancer Res. 2018;37(1):255.
26. Shi F, Chang H, Zhou Q, Zhao YJ, Wu GJ, Song QK (corr.). Distribution of CD4+ and CD8+ exhausted tumor-infiltrating lymphocytes in molecular subtypes of Chinese breast cancer patients. Onco Targets Ther. 2018;11:6139-6145. (IF 3.046)
271. Guan X, Zhang C, Zhao J, Sun G, Song Q, Jia W. CMTM6 overexpression is associated with molecular and clinical characteristics of malignancy and predicts poor prognosis in gliomas. EBioMedicine. 2018;35:233-243.
28. Yan-Jie Zhao, Jian Zhang, Feng Shi, Zhi-Ping Hu, Jiang-Ping Wu, Guang-Jiang Wu, Rui-Bin Wang, Quan Zhou, Hong Chang, Ying-Nan Li, and Qing-Kun Song (corr.).Expression of PD-1 on CD4+ Tumor-Infiltrating Lymphocytes in Tumor Microenvironment Associated with Pathological Characteristics of Breast Cancer. J Immunol Res. 2018;2018:5690258. (IF 3.404)
29. Feng Shi, Fengcai Yan, Mulan Jin, Hong Chang, Quan Zhou, Lin Zhao, Zhiping Hu, Qingkun Song (corr.). Pre-diagnostic consumption of preserved vegetable and prognosis of invasive esophageal squamous cell carcinoma: a prospective cohort study in one of high risk areas, China. J Int Med Res. 2018;46(10):4306-4314. (IF 1.351)
30. 周全, 石峰, 赵洪禹, 李雁,宋清坤(corr.). 腹膜黏液性肿瘤的临床病理分析. 中华病理学杂志,2018,47( 3 ): 192-195.
31. Zhou X, Qiao G, Wang X, Song Q, et al. CYP1A1 genetic polymorphism is a promising predictor to improve chemotherapy effects in patients with metastatic breast cancer treated with docetaxel plus thiotepa vs. docetaxel plus capecitabine. Cancer Chemother Pharmacol. 2018;81(2):365-372.
32. Wang XY, Ma TT, Wang XY, Zhuang Y, Wang XD, Ning HY, Shi HY, Yu RL, Yan D, Huang HD, Bai YF, Shan GL, Zhang B, Song QK, et al. Prevalence of polleninduced allergic rhinitis with high pollen exposure in grasslands of northern China. Allergy. 2018;73(6):1232-1243.
33. 赵艳杰,宋清坤(corr.),李军,何永明,曲宸绪. 食管鳞状细胞癌高发区人群食用腌肉与食管鳞状细胞癌风险的关系. 吉林大学学报(医学版). 2018,44(03):656-660.
34. Qingkun Song, Jun Ren, Xinna Zhou, Xiaoli Wang, Guohong Song, Amy Hobeika, Yanhua Yuan,Herbert Kim Lyerly. Circulating CD8+CD28- suppressor T cells tied to a poorer prognosis among metastatic breast cancer patients receiving adoptive T cell therapy: a cohort study. Cytotherapy. 2018; 20(1):126-133. (IF 4.297)
35. Yanjie Zhao, Lin Zhao, Zhiping Hu, Jiangping Wu, Jun Li, Chenxu Qu, Yongming He, Qingkun Song (corr.). Peanut consumption associated with a reduced risk of esophageal squamous cell carcinoma: A case-control study in a high-risk area in China. Thoracic Cancer. 2018;9(1):30-36. (IF 2.524).
36. 伍江平, 赵艳杰, 宋清坤(corr.), 李军, 何永明, 曲宸绪. 食用腊油与食管癌风险的病例对照研究. 肿瘤代谢与营养电子杂志. 2018,5(02):175-178
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