主持及参与课题情况

(1) 国家自然科学基金委员会, 面上项目, 81971092, DPP4抑制剂通过AMPK/SIRT1途径改善糖尿病合并缺 血性卒中的作用机制研究, 2020-01-01 至 2023-12-31, 55万元, 在研, 参与

(2) 国家自然科学基金委员会, 地区科学基金项目, 81960330, 高分辨磁共振和血流动力学分析对血管内 治疗颅内动脉瘤的预后评价和机理研究, 2020-01-01 至 2023-12-31, 34万元, 在研, 参与

(3) 国家自然科学基金委员会, 青年科学基金项目, 81801156, 编织型辅助栓塞支架的血流导向作用及其 在中小型(小于10mm)动脉瘤术后转归中的血流动力学机制研究, 2019-01-01 至 2021-12-31, 21万元, 在研, 主持

(4) 国家自然科学基金委员会, 青年科学基金项目, 81801158, 应用动态增强磁共振技术预测颅内夹层动 脉瘤的壁间血肿在血管内治疗术后转归的研究, 2019-01-01 至 2021-12-31, 21万元, 在研, 参与

(5) 国家自然科学基金委员会, 面上项目, 81671139, 脑动静脉畸形发病基因及遗传/表型关系的研究, 20 17-01-01 至 2020-12-31, 60万元, 结题, 参与

(6) 北京市医院管理中心, “培育计划”, PX2022022, 基于人工智能的颅内动脉瘤精准辅助微创诊疗系统 研究, 2022-01 至 今, 15万元, 在研, 主持

(7) 北京市医院管理中心, “青苗”人才计划, QML20190503, 计算流体力学方法在颅内宽颈动脉瘤个体化 支架辅助栓塞应用中的作用, 2020-01 至 2021-12, 12万元, 结题, 主持

(8) 国家科学技术部, 国家重点研发计划, 2016YFC1300802, 颅内动脉瘤破裂出血早期规范治疗和未破裂动脉瘤出血风险的研究, 2016-09 至 2020-12, 882万元, 结题, 参与

(9) 北京市卫生健康委员会, 首都卫生发展科研专项青年优才项目, 首发2018-4-1077, 支架血流导向能力在颅内动脉瘤栓塞术后转归过程中的影响分析, 2018-01 至 2020-12, 19.613万元, 结题, 主持

(10)国家自然科学基金委员会, 面上项目, 82272092, 基于连续影像随访数据的颅内动脉瘤生长风险的人工智能研究2023-01-01 至 2026-12-31, 52万元, 在研, 主持

(1) Liu,Jian，Xiang, Jianping，Zhang, Ying，Wang, Yang，Li, Haiyun，Meng, Hui，Yang, Xinjian，Morphologic and hemodynamic analysis of paraclinoid aneurysms:ruptured versus unruptured.，J Neurointerv Surg，2014.11.01，6（9）：658~663

(2) Liu,Jian，Jing, Linkai，Zhang, Ying，Song, Ying，Wang, Yang，Li, Chuanhui，Wang, Yanmin，Mu, Shiqing，Paliwal, Nikhil，Meng, Hui，Linfante, Italo，Yang, Xinjian(*)，SuccessfulRetreatment of Recurrent Intracranial Vertebral Artery Dissecting Aneurysmsafter Stent-assisted Coil Embolization: A Self-controlled Hemodynamic Analysis.，World Neurosurg，2016.10.11

(3) Liu,Jian，Jing, Linkai，Wang, Chao，Zhang, Ying，Yang, Xinjian(*)，Recanalization, Regrowth, and Delayed Rupture of a Previously CoiledUnruptured Anterior Communicating Artery Aneurysm: A Longitudinal HemodynamicAnalysis.，World Neurosurg，2016.5.01，89：726.e5~726.e10

(4) Liu,Jian，Jing, Linkai，Wang, Chao，Paliwal, Nikhil，Wang, Shengzhang，Zhang, Ying，Xiang, Jianping，Siddiqui, Adnan H，Meng, Hui，Yang, Xinjian，Effect of hemodynamics onoutcome of subtotally occluded paraclinoid aneurysms after stent-assisted coilembolization.，J Neurointerv Surg，2016.11.01，8（11）：1140~1147

(5) Liu,Jian，Fan, Jixing，Xiang, Jianping，Zhang, Ying，Yang, Xinjian，Hemodynamic characteristics of large unruptured internal carotidartery aneurysms prior to rupture: a case control study.，J Neurointerv Surg，2016.4.01，8（4）：367~372

(6) Jing,Linkai，Liu, Jian，Zhang, Ying，Paliwal, Nikhil，Meng, Hui，Wang, Shengzhang，Yang, Xinjian(*)，Analysis of Multiple Intracranial Aneurysms with Different Outcomesin the Same Patient After Endovascular Treatment.，WorldNeurosurg，2016.7.01，91：399~408

(7) JianLiu, Yisen Zhang, Yang Wang, Shiqing Mu, Xinjian Yang ,Stenting AfterCoiling Using a Single Microcatheter for Treatment of Ruptured IntracranialFusiform Aneurysms with Parent Arteries Less Than 1.5 mm in Diameter.,WorldNeurosurgery, 2017 Mar;99:809.e7-809.e10.

(8) LiuJian, Zhang Yisen, Wang Anxin, Zhang Ying, Li Yiying, Yang Xinjian.Haemodynamic analysis for recanalisation of intracranial aneurysms afterendovascular treatment: an observational registry study in China. BMJ Open. 2017 May 12;7(5):e014261.

(9) Li W, LiuJ, Zhang Y, Wang K, Tian Z, Zhang Q, Jiang C, Yang X, Wang Y. FlowDiversion and Outcomes of Vertebral Fusiform Aneurysms after Stent-OnlyTreatment: A Hemodynamic study., World Neurosurg, 2017 Nov;107:202-210.

(10) Zhang,Yisen(#)，Yang, Ming，Zhang, Hongqi，Zhang, Xiaolong，Li, Youxiang，Jiang, Chuhan，Liu, Jian(*)，Yang, Xinjian(*)，Stent-Assisted Coiling May Prevent the Recurrence of Very SmallRuptured Intracranial Aneurysms: A Multicenter Study.，WorldNeurosurg，2017.1.3

(11) Zhang,Yisen(#)，Jing, Linkai，Zhang, Ying，Liu, Jian(*)，Yang, Xinjian(*)，Low wall shearstress is associated with the rupture of intracranial aneurysm with knownrupture point: case report and literature review.，BMCNeurol，2016.11.18，16（1）：231~231

(12) Zhang,Yisen(#)，Tian, Zhongbin，Jing, Linkai，Zhang, Ying， Liu, Jian(*)，Yang, Xinjian(*) ，Bifurcation Type and Larger Low Shear Area Are Associated withRupture Status of Very Small Intracranial Aneurysms.，FrontNeurol，2016.01.01，7：169~169

(13) TianZ, Mu S, Li W, Zhu W, Zhang Y, Yang X, Liu J. Recurrence of aninternal carotid artery aneurysm after complete exclusion by a Willis coveredstent. Interventional neuroradiology : journal of peritherapeuticneuroradiology, surgical procedures and related neurosciences.2019:1591019919854184.

(14) LiW, Wang Y, Zhang Y, Wang K, Zhang Y, Tian Z, Yang X, Liu J. Efficacy of LVIS vs. Enterprise Stent forEndovascular Treatment of Medium-Sized Intracranial Aneurysms: A HemodynamicComparison Study. Front Neurol. 2019 May 28;10:522. doi:10.3389/fneur.2019.00522. PMID: 31191428; PMCID: PMC6546800.

(15) Liu J, Zhang Y, Li W, Wang K, Zhang Y, Yang X. Treatment of true posterior communicating artery aneurysms: Endovascular experience in a single center. Interv Neuroradiol. 2020 Feb;26(1):55-60.

(16) HanY, Liu J, Tian Z, Lv M, Yang X, Wu Z, Gao BL. Factorsaffecting recurrence and management of recurrent cerebral aneurysms afterinitial coiling. Interv Neuroradiol. 2020 Jun;26(3):300-308.

(17) Li WQ; Tian ZB; Zhu W; Zhang YS; Wang K; Zhang Y; Wang Y; Yang XJ; Liu J. Hemodynamic Analysis of Postoperative Rupture of Unruptured Intracranial Aneurysm after Placement of Flow-Diverting Stents: A Matched Case-Control Study. AJNR, Am J Neuroradiol. 2019 Nov;40(11):1916-1923.

(18) ZhuW, Li W, Tian Z, Zhang Y, Wang K, Zhang Y, LiuJ*, Yang X*. Stability Assessment of Intracranial Aneurysms Using MachineLearning Based on Clinical and Morphological Features. Transl Stroke Res. 2020Dec;11(6):1287-1295. doi: 10.1007/s12975-020-00811-2. Epub 2020 May 19. PMID:32430796.

(19) Li W, Wang S, Tian Z, Zhu W,Zhang Y, Zhang Y, Wang Y, Wang K, Yang X, LiuJ. Discrimination of intracranial aneurysm rupturestatus: patient-specific inflow boundary may not be a must-have condition inhemodynamic simulations.Neuroradiology. 2020 Nov;62(11):1485-1495..

(20) TianZ, Zhang M, Li G, et al. Hemodynamic differences by increasing low profilevisualized intraluminal support (LVIS) stent local compaction acrossintracranial aneurysm orifice. Interv Neuroradiol. 2020 Oct;26(5 ):557-565

(21) TianZ, Liu J(*), KumarJ, Li W, Zhang Y, Zhang Y, Wang K, Wang S, Ren Z, Yang X(*). Significant flow velocity reduction at theintracranial aneurysm neck after endovascular treatment leads to favourableangiographic outcome: a prospective study. Stroke Vasc Neurol. 2021 Feb1:svn-2020-000413. doi: 10.1136/svn-2020-000413. Epub ahead of print. PMID:33526635.

(22) Zhu W, Li W, Tian Z, Zhang M,Zhang Y, Wang K, Zhang Y, Yang X, Liu J. Nomogram for Stability Stratificationof Small Intracranial Aneurysm Based on Clinical and Morphological RiskFactors. Front Neurol. 2021 Jan 15;11:598740. doi:10.3389/fneur.2020.598740. PMID: 33519680; PMCID: PMC7845661.

(23) LiW, Zhu W, Wang A, Zhang G, Zhang Y, Wang K, Zhang Y, Wang C, Zhang L, Zhao H,Wang P, Chen K, Liu J, Yang X. Effect of Adjusted AntiplateletTherapy on Preventing Ischemic Events After Stenting for IntracranialAneurysms. Stroke. 2021 Sep20:STROKEAHA120032989. doi: 10.1161/STROKEAHA.120.032989. Online ahead ofprint.

(24) LiuJ, Li W, Zhang Y, Wang K, Yang X, Zhang Y. Hemodynamic analysis forendovascular treatment in small unruptured intracranial aneurysms: a matchedcomparison study of flow diverter versus LVIS. Chin Neurosurg J. 2021 Dec1;7(1):49. doi: 10.1186/s41016-021-00266-w. PMID: 34852851; PMCID: PMC8638548.

(25) ZhangM, Tian Z, Zhang Y, Zhang Y, Wang K, Leng X, Yang X, Xiang J, Liu J. How to perform intra-aneurysmal coil embolization after Pipeline deployment: a studyfrom a hemodynamic viewpoint. J Neurointerv Surg. 2022 Feb8:neurintsurg-2021-018361. doi: 10.1136/neurintsurg-2021-018361. Epub ahead ofprint. PMID: 35135848.

(26)Li W, Tian Z, Zhu W, Zhang YS, Wang K, Zhang Y, Wang Y, Yang X, Liu J. Hemodynamic Analysis of Postoperative Rupture of Unruptured Intracranial Aneurysms after Placement of Flow-Diverting Stents: A Matched Case-Control Study. AJNR Am J Neuroradiol. 2019 Nov;40(11):1916-1923. doi: 10.3174/ajnr.A6256. Epub 2019 Oct 17. PMID: 31624118; PMCID: PMC6975104.

(27)Turhon M, Li M, Kang H, Huang J, Zhang F, Zhang Y, Zhang Y, Maimaiti A, Gheyret D, Axier A, Aisha M, Yang X, Liu J. Development and validation of a deep learning model for prediction of intracranial aneurysm rupture risk based on multi-omics factor. Eur Radiol. 2023 Oct;33(10):6759-6770. doi: 10.1007/s00330-023-09672-3. Epub 2023 Apr 26. PMID: 37099175.