五年来作为副导师指导了1名正畸学博士（发表SCI论文2篇），2名正畸学硕士和2名正畸在职博士研究生临床和科研工作，指导了3名进修医师。

1. 主持首都卫生发展科研专项自主创新项目：（2020.7-2023.6）具有防治牙釉质白斑病损能力的新型智能防龋正畸粘结系统的研发   项目编号：首发2020-2-2142 经费：39万元

2.   参与首都医科大学附属北京口腔医院创新团队建设项目  白玉兴,张宁,谢贤聚,方东煜,张莉,张珂,马雁崧,仇玲玲,马金玲,赵梅    2022--2025 300万元

3.   参与北京市教委科技计划项目 季铵盐改性正畸粘接剂抗菌和菌群调节功能的研究      张宁,王红梅,谢贤聚,张珂,方东煜,马雁崧,曹丽,谷颖之,于文琪,赵星  2019--2022  15万元

4.   参与北京市医院管理局“登峰”人才培养计划   杨凯,陈莉,徐辉,贾海潮,张若芳,张宁,郭力嘉,张海萍,仇玲玲,任超超,张珂,杨芸,方东煜,茹楠,刘杉杉,马雁崧  2019--2023 30万元

1.   主持首都卫生发展科研专项自主创新项目：（2020.7-2023.6）具有防治牙釉质白斑病损能力的新型智能防龋正畸粘结系统的研发   项目编号：首发2020-2-2142 经费：39万元

2.  主持国家自然科学青年基金项目：（2015-2017）纳米磷酸钙联合季铵盐改性正畸粘接系统的机制研究 项目编号：81400540  经费：25万元

3.  主持北京市医管局“青苗计划”：（2016-2017）正畸牙移动过程中牙周膜干细胞的免疫调控作用 经费：6万元 QML20151401

4.  主持首都医科大学基础-临床科研合作基金：（014年4月-2016年4月）含有纳米磷酸钙颗粒和抗菌季铵盐单体的正畸粘接系统对牙菌斑微生态系和牙釉质矿化平衡的影响 经费：5万元

5.  参与首都医科大学附属北京口腔医院创新团队建设项目      2022--2025    

6.  参与北京市教委科技计划项目（2021年及以后立项）季铵盐改性正畸粘接剂抗菌和菌群调节功能的研究      2019--2022  

7.  参与北京市医院管理局“登峰”人才培养计划     2019--2023

8.  参与院学科建设基金   Myobrace Interceptive Class III对乳牙期、替牙早期前牙反合矫治效果的三维评价 2018--2019 

9.  参与北京市自然科学基金   IGF-1对大鼠正畸牙根吸收的作用及机制研究        2017--2019 

10.参与临床医学发展专项-“扬帆计划”        2016--2019 

11.参与医院管理局“登峰”人才培养计划      2015--2019

12.参与国家自然科学基金 不同速率的手术辅助前颌骨扩展(SARMP)对BMP/Smad信号通路相关因子表达影响的研究    2015--2019 

13.参与国家自然科学基金 PTHrP/PTH1R信号系统在正畸矫治力所致牙根吸收中的调控机理研究  2015--2018    

14.参与北京市自然科学基金   下颌位置异常对头颈部肌肉相关感觉传入信息的影响      2013--2016

15.参与国家自然科学基金 功能性下颌偏斜对头颈部肌梭r-运动纤维及其相关神经递质影响的研究      2013--2016     

16.参与国家自然科学基金 口腔正畸骨粘接体支抗系统的设计与机制的研究         2012--2015   

17.参与北京市人事局新世纪百千万人才工程 含有纳米磷酸钙颗粒和抗菌季铵盐单体的正畸粘接系统对牙菌斑微生态系和牙釉质矿化平衡的影响      2013--2016 

五年内的重要学术论文：

1.   Zhang N, Zhang K*, Weir MD, XuDJ, Reynolds MA, Bai YX*, Xu HHK*. Effects of water-aging for 6 months on thedurability of a novelantimicrobial and protein-repellent dental bonding agent. InternationalJournal of Oral Science (2018) 10:18 https://doi.org/10.1038/s41368-018-0019-9 IF=2.75

2.   Zhang N, ZhangK#, Xie XJ, Dai ZX, Zhao ZQ, Imazato S, Al-Dulaijan YA,Al-Qarni FD, Weir MD,  Reynolds MA, Bai YX*,Wang L*, Xu HHK*. Nanostructured Polymeric Materials with Protein-Repellent andAnti-Caries Properties for Dental Applications. Nanomaterials 2018, 8(6), 393. IF=4.034

3.   Yue SC#, Wu JL#*, Zhang Q, Zhang K*, Weir MD, Imazato S, BaiYX*, Xu HHK. Novel dental adhesive resin with crackself-healing, antimicrobial and remineralization properties. J Dent. 2018 May18. pii: S0300-5712(18)30126-X. doi: 10.1016/j.jdent.2018.05.009. IF=3.28 引用2次

4.    Zhang K#, Wang S#, Zhou C#, Cheng L,Gao X, Xie X, Sun J, Wang H, Weir MD, Reynolds MA, Zhang N*, Bai Y, Xu HHK*. Advancedsmart biomaterials for hard tissue engineering and  regeneration. Bone Research 2018 Oct 22;6:31.doi: 10.1038/s41413-018-0032-9. eCollection 2018. IF=12.35

5.   Yousif A. Al-Dulaijan1,2, Michael D. Weir1, MaryAnne S. Melo1, Jirun Sun3, Thomas W. Oates1, Zhang K* Hockin H. K*.Xu1,5,6. Protein-repellent nanocomposite with rechargeable calcium andphosphate for long-term ion release. DentMater. 2018 Sep 27. pii: S0109-5641(18)30317-8. doi:10.1016/j.dental.2018.09.005 IF=4.4

6.   Zhang K#, Baras B,Lynch CD, Weir MD, Melo MAS, Li Y, Reynolds MA, Bai Y*, Wang L*, Wang S*, XuHHK. Developing a New Generation of Therapeutic Dental Polymers to InhibitOral Biofilms and Protect Teeth. Materials.2018 Sep 17;11(9). pii: E1747. doi: 10.3390/ma11091747. IF=2.972

7.   Yuncong Li1,2*, Xiaoyi Hu1*, Jianping Ruan1,Dwayne D. Arola3, Ji Chao2, Michael D. Weir2, Thomas W. Oates2, XiaofengChang1, Zhang K*, Hockin H.K. Xu2,5,6. Bonding durability, antibacterial activity and biofilm pH of noveladhesive containing antibacterial monomer and nanoparticles of amorphouscalcium phosphate with artificial saliva aging for six months. J Dent.J Dent. 2019 Feb;81:91-101. doi:10.1016/j.jdent.2018.12.013. Epub 2018 Dec 30. IF=3.28

8.   Jianru Yi, Quan Dai, Michael D. Weir, Mary A. S.Melo, Christopher D. Lynch, Thomas W. Oates, Ke Zhang*, Zhihe Zhao*, Hockin H. K. Xu*. A Nano-CaF2-containingorthodontic cement with antibacterial and remineralization capabilities tocombat enamel white spot lesions. J Dent. 2019 Jul 18. pii:S0300-5712(19)30154-X. doi: 10.1016/j.jdent.2019.07.010. IF=3.28

9.   Zixiang Dai, Min Liu, Yansong Ma, Li Cao, HockinH. K. Xu, Ke Zhang*, YuxingBai*. Effects of fluoride and calcium phosphate materials onremineralization of mild and severe white spot lesions. BioMed ResearchInternational. https://doi.org/10.1155/2019/1271523IF=2.197

10.    Bashayer H.Baras, Jirun Sun, Mary Anne S. Melo, Franklin R. Tay, Thomas W. Oates, Ke Zhang#, Michael D. Weir#,Hockin H. K. Xu#. Novel root canal sealer with dimethylaminohexadecylmethacrylate, nano-silver and nano-calcium phosphate to kill bacteria insideroot dentin and increase dentin hardness. Dent Mater. 2019 Aug 3. pii:S0109-5641(19)30690-6. doi: 10.1016/j.dental.2019.07.014. IF=4.4

11.    Zeqing Zhao, Jin Liu, Michael D. Weir, Ning Zhang, LiZhang, Xianju Xie, Charles Zhang, KeZhang, Yuxing Bai and Hockin H. K. Xu. Human periodontal ligament stemcells on calcium phosphate scaffold delivering platelet lysate to enhance boneregeneration. RSC Adv., 2019,9, 41161-41172 https://doi.org/10.1039/C9RA08336G IF=3.1

12.      Hong Chen, Yunhao Tang, Michael D. Weir, Lei Lei, Radi Masri,Christopher D. Lynch, Thomas W. Oates, KeZhang*, Tao Hu*, Hockin H. K. Xu*. Effects of S. mutansgene-modification and antibacterial calcium phosphate nanocomposite onsecondary caries and marginal enamel hardness. RSC Adv., 2019,9,41672-41683 https://doi.org/10.1039/C9RA09220JIF=3.1

13.       Zhang K#, He S, Dai Z,Cao L, Yue S, Bai Y, Zheng M*.Axin 1 knockdown inhibits osteoblastic apoptosisinduced by Porphyromonas gingivalis lipopolysaccharide. Archives of OralBiology 2020 Apr;112:104667. doi: 10.1016/j.archoralbio.2020.104667. Epub 2020Jan 28. IF=1.931

14.      Chen, H.;Yang, H.; Weir, M. D.; Schneider, A.; Ren, K.; Homayounfar, N.; Oates, T. W.; Zhang,K.; Liu, J.; Hu, T.; Xu, H. H., An antibacterial and injectable calciumphosphate scaffold delivering human periodontal ligament stem cells for bonetissue engineering. RSC Advances 2020, 10, (66), 40157-40170. IF=3.1

15.      Liu Jin,Dai Quan, Weir MD, Schneider A, Zhang C, Hack GD, Oates TW, Zhang Ke*,Li Ang*, Xu HHK*. Biocompatible Nanocomposite Enhanced Osteogenic andCementogenic Differentiation of Periodontal Ligament Stem Cells In Vitro forPeriodontal Regeneration. Materials (Basel). 2020, 13(21):4951-4973. IF=3.05

16.       Chen H, YangYM, Weir MD, Dai Q, Lei L, Homayounfar N, Oates TW, Yang K, Zhang K*, HuT*, Xu HHK*. Regulating oral biofilm from cariogenic state to non-cariogenicstate via novel combination of bioactive therapeutic composite andgene-knockout. Microorganisms 2020, 8, 1410, doi:10.3390/microorganisms8091410. IF=4.15

17.       Dai Z, Xie X,Zhang N, Li S, Yang K, Zhu M, Weir MD, Xu HHK, Zhang K*, Zhao Z*, Bai Y*.Novel nanostructured resin infiltrant containing calcium phosphatenanoparticles to prevent enamel white spot lesions. J Mech Behav Biomed Mater.2021 Nov 23;126:104990. doi: 10.1016/j.jmbbm.2021.104990. Epub ahead of print.PMID: 34871957. IF=3.9

18.       GengtaoQiu1,2,3*, Mingguang Huang1*, Jin Liu2,4, Tao Ma5, Abraham Schneider5,6, ThomasW. Oates2, Christopher D. Lynch7, Michael D. Weir*, Ke Zhang*, Liang Zhao*,Hockin H. K. Xu. Human periodontal ligament stem cell encapsulation inalginate-fibrin-platelet lysate microbeads for dental and craniofacialregeneration. J Dent. 2022 Jul 8;124:104219. doi:10.1016/j.jdent.2022.104219.

19.       Yu W, Li S,Zhang G, Xu HHK, Zhang K*, Bai Y*. New frontiers of oral sciences: Focus onthe source and biomedical application of extracellular vesicles. Frontiersin Bioengineering and Biotechnology doi: 10.3389/fbioe.2022.1023700 

20.       AlSahafi R, Mitwalli H, Alhussein A, Balhaddad AA, Alquria TA, Melo MAS,Lynch CD, Oates TW, Zhang K*, Xu HHK*, Weir MD*. Novel rechargeablenano-calcium phosphate and nano-calcium fluoride resin cements. J Dent.2022 Sep 29;126:104312. doi: 10.1016/j.jdent.2022.104312. Epub ahead of print.PMID: 36184005.

21.       Cao L, Xie X,Yu W, Xu HHK, Bai Y*, Zhang K*, Zhang N*. Novel protein-repellent andantibacterial polymethyl methacrylate dental resin in water-aging for 6 months.BMC Oral Health. 2022 Oct 29;22(1):457. doi: 10.1186/s12903-022-02506-6. PMID:36309721; PMCID: PMC9618229. 

22.       Zhu M, Zhao Z,Xu HHK, Dai Z, Yu K, Xiao L, Schneider A, Weir MD, Oates TW, Bai Y*, Zhang K*. Effectsof Metformin Delivery via Biomaterials on Bone and Dental Tissue Engineering.Int J Mol Sci. 2022 Dec 14;23(24):15905. doi: 10.3390/ijms232415905. 

23.       Zhao Z, Liu J, Weir MD, Schneider A, Ma T, Oates TW, Xu HHK, Zhang K*,Bai Y*. Periodontal ligament stemcell-based bioactive constructs for bone tissue engineering. Front Bioeng Biotechnol. 2022 Dec 2;10:1071472. doi:10.3389/fbioe.2022.1071472. 

24.       Yu K, Zhang Q,Dai Z, Zhu M, Xiao L, Zhao Z*, Bai Y*, Zhang K*. Smart Dental MaterialsIntelligently Responding to Oral pH to Combat Caries: A Literature Review.Polymers (Basel). 2023 Jun 8;15(12):2611. doi: 10.3390/polym15122611. PMID:37376255.

25.       Yaxi Sun,Zeqing Zhao, Qingchen Qiao, Shengnan Li, Wenting Yu, Xiuchen Guan, AbrahamSchneider, Michael D. Weir, Hockin H.K. Xu, Ke Zhang, Yuxing Bai.  Injectable periodontal ligament stemcell-metformin-calcium phosphate scaffold for bone regeneration and vascularizationin rats. Dental Materials. 2023, https://doi.org/10.1016/j.dental.2023.07.008.

26.       Zhao Z, Sun Y,Qiao Q, Weir MD, Schneider A, Masri R, Lynch CD, Zhang N*, Zhang K*, Bai Y*, XuH. Calvaria defect regeneration via human periodontal ligament stem cellsand prevascularized scaffolds in athymic rats. J Dent. 2023 Sep 2:104690.doi: 10.1016/j.jdent.2023.104690. Epub ahead of print. PMID: 37666466.

副主编著作：

2020      正畸并发症与预防策略  专著      国内       张宁,白玉兴,王红梅,谢贤聚,车晓霞,沙海亮,张珂,谷颖之,曹丽,戴子翔(学),尹克(学)